@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0501: (2016-03-16 )
MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRYFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQKVYRMQGVEIDDKHVEVMVRQMLRKVRIIEAGDTKLLPGSLVDIHNFTDANREAFKHRKRPATAKPVLLGITKASLETESFLSAASFQETTRVLTDAAIKGKRDDLLGLKENVIIGKLIPAGTGMRRYSDVKYEKTAKPVAEVESQTEVTE
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190...-....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......-310.......320.......330.......340.......350.......360.......370.......380.......390---.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530..---------.....540.......550.......-560.......570.......580.......590.......600.......610.----....---..620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.....---------------..730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840....----..-.850.......860.......870...---....880..-.....890.......900.......910.......920.......930.......940.......950........960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180........1190......1200....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
DVN
N
F
H
Y
M
K
IGLA
S
P
E
K
IRSWSFGEVKKPETINYRTLKPEKDG
L
F
C
E
R
IFGPTKDWECSCGK
Y
K
R
V
R
Y
K
G
M
VCDRCG
V
E
V
T
K
S
K
V
R
R
E
RMG
H
I
E
LAAPVS
H
I
W
Y
FKGI
P
S
RM
G
L
L
LDM
S
P
R
A
L
E
E
V
I
Y
F
A
S
Y
V
V
VDPGPTGL
E
K
K
T
L
L
S
E
A
E
F
R
D
Y
Y
D
KY
P
G
Q
F
V
A
K
M
G
A
E
G
I
K
D
L
L
E
EID
L
D
E
E
L
K
L
L
R
D
E
L
-
E
S
A
T
G
Q
R
L
T
R
A
I
K
R
L
E
V
V
E
S
F
R
NSGNKP
S
W
M
I
L
D
VLPIIPPEI
R
P
M
V
Q
LDGGRFATS
D
L
N
D
L
Y
R
R
V
INR
N
N
R
L
K
R
L
L
DLGAP
G
I
I
VQ
N
E
K
R
M
L
Q
E
A
V
D
A
L
IDNGRRGRPVTGPG-NR
P
L
K
S
L
S
H
M
L
KGKQG
R
F
R
Q
N
L
LGKRVDYSG
R
S
V
I
A
VGPS
L
K
M
Y
QCGL
P
K
E
M
A
L
E
L
F
K
P
F
V
M
K
E
L
V
Q
R
E
I
A
T
N
I
K
N
A
K
S
K
I
E
R
---
M
D
D
E
V
W
D
V
L
E
E
V
I
R
EHPVLLNRAP
T
L
H
R
LGIQAFEPTLVEG
R
A
I
R
L
H
P
L
V
T
T
A
YNADFDGD
Q
M
A
V
HVPLS
K
E
A
Q
A
E
A
R
M
L
M
L
A
A
Q
N
ILNPKDGKPVVTPSQ
D
M
V
L
G
N
Y
Y
L
T
L
ERKDAVNTGAIFN
N
T
N
E
V
L
K
A
Y
AN
G
F
V
H
L
H
---------
T
R
I
G
V
H
ASSFNNPTFT
E
E
QN
K
K
I
L
A
-
T
S
V
G
K
I
I
F
N
E
IIPDSFAYINEP
T
Q
E
N
L
ERKTPN
R
Y
F
IDPTTLG
E
G
G
L
K
E
Y
FE
N
E
----
E
L
I
E
---
P
F
N
K
K
F
L
G
N
I
I
A
E
V
F
N
RFSI
T
D
T
S
M
M
L
D
R
M
K
D
LG
F
K
FSSKA
G
I
T
V
G
V
A
D
I
V
VLP
D
K
Q
Q
I
L
D
E
H
E
K
L
V
D
R
I
T
K
Q
FNRGLI
T
E
E
E
R
Y
N
A
V
V
E
IWTD
A
K
D
Q
I
Q
G
E
L
M
Q
S
LDKT---------------N
P
I
F
M
MSDSGARGNA
S
N
F
T
Q
L
A
GMRGLMAAPSG
K
I
I
E
L
PI
T
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
THGARKG
L
A
D
T
A
LKTAD
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
V
I
V
REEDCGTDR
G
L
L
V
S
D
I
K
E
G
T
E
M
I
E
P
F
I
E
R
----
I
E-GRYSKETIRHPET
D
E
I
I
IRPDELI
T
P
E
---
I
A
K
K
I
T
D
AG-
I
E
Q
M
Y
I
R
S
A
FTCNARH
G
V
C
E
K
C
YGKNLATGE
K
V
E
V
G
E
A
V
G
T
I
A
A
Q
SIGEPGT
Q
L
T
M
R
T
FHTGGVA
G
-
S
D
I
T
Q
G
L
P
R
I
Q
E
I
F
E
ARNPKGQ
A
V
I
T
E
I
E
G
V
V
E
D
I
K
L
AKDRQ
Q
E
I
V
V
KGA
N
E
T
R
S
Y
L
ASGT
S
R
I
I
V
EIGQPVQRG
E
V
LTEGSIEPK
N
Y
L
S
VAGL
N
A
T
E
S
Y
L
L
K
E
V
Q
K
V
Y
R
MQGVEI
D
D
K
H
V
E
V
M
V
R
Q
M
L
R
K
V
R
I
I
EAGDTKLLPG
S
L
V
D
IHNFTDA
N
R
E
A
F
K
HRKRPATAK
P
V
L
L
G
I
T
KASL
E
T
E
S
F
L
S
A
A
S
F
Q
E
T
T
R
V
L
T
D
A
AIKGKRDDLLGLKEN
V
I
I
G
K
LIPAGTG--MRRYSDVKYEKTAK
P
V
A
E
V
ESQTEVTE
42
PsiBlast_CBE
92.14
49%
-65
- C9 -
4G7H
3
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
34
PsiBlast_CBE
92.08
49%
-66
- C9 -
4OIO
7
RPOC_THET8
D:
[454-1498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
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T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
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K
K
Q
Y
L
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E
A
D
R
K
L
L
Q
I
E
Q
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Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
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L
M
Q
K
P
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G
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T
F
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S
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L
T
V
L
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F
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A
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K
G
G
A
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T
A
L
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Y
L
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L
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V
V
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A
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T
N
Y
I
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V
P
-
L
F
Q
P
---
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
--------------
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
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Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
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A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
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R
L
I
A
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G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
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S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
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L
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P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------
35
PsiBlast_CBE
91.92
49%
-66
- C9 -
4OIN
7
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
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V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
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G
A
P
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I
I
I
R
N
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K
R
M
L
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D
A
L
L
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N
G
R
R
G
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N
P
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P
L
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D
I
L
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Q
G
R
F
R
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N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
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R
M
L
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R
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I
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D
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L
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V
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K
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A
G
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A
L
A
A
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V
A
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A
P
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K
V
AG
R
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T
S
V
G
R
L
K
Y
V
F
A
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P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
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----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
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L
I
Q
LDV
P
Q
E
K
N
S
L
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D
L
V
Y
Q
A
F
L
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L
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M
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A
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L
L
D
A
L
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L
L
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M
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L
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L
W
T
E
T
T
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K
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Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
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S
G
A
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G
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P
Q
Q
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Q
L
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L
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K
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A
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G
R
V
L
A
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V
E
V
L
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V
R
L
E
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G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
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Y
G
V
C
Q
K
C
Y
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Y
D
L
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M
A
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P
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S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
---------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
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I
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I
D
G
V
V
R
I
E
E
--
T
E
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K
L
S
V
F
V
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S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
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G
A
I
D
P
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Q
L
L
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A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
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A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
41
PsiBlast_CBE
91.73
49%
-65
- C9 -
4G7O
6
RPOC_THET8
D:
[454-1498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
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V
V
R
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N
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P
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W
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L
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V
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G
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R
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A
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D
L
N
D
L
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L
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N
R
N
N
R
L
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K
L
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A
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R
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L
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A
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L
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R
R
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A
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N
P
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D
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P
L
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D
I
L
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G
K
Q
G
R
F
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N
L
L
G
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R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
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Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
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K
A
A
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M
L
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RD
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L
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A
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A
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A
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--
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----
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------
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A
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A
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P
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YPF------------
N
P
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A
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P
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T
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--------------
I
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I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------
43
PsiBlast_CBE
91.72
49%
-65
- C9 -
4G7H
6
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
Q
RD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
AG
R
E
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
31
PsiBlast_CBE
91.63
49%
-65
- C9 -
4OIR
7
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
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R
A
P
T
L
H
R
L
G
I
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A
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Q
P
V
L
V
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G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
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D
Q
M
A
V
H
V
P
L
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F
A
Q
A
E
A
R
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Q
M
L
S
A
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N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
A
P
I
K
V
AG
R
E
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LD
V
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
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L
M
Q
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G
L
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Y
F
I
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G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
---------------
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
33
PsiBlast_CBE
91.55
49%
-66
- C9 -
4OIP
9
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
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Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
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G
Q
S
I
Q
L
H
P
L
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C
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A
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N
A
D
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D
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D
Q
M
A
V
H
V
P
L
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F
A
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A
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A
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Q
M
L
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A
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N
L
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A
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L
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K
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A
G
L
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A
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P
E
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A
L
A
A
H
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R
G
E
V
A
L
N
A
P
I
K
V
AG
R
E
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
40
PsiBlast_CBE
91.53
49%
-66
- C9 -
4G7O
6
RPOC_THET8
N:
[454-1498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
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A
F
Q
P
V
L
V
E
G
Q
S
I
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L
H
P
L
V
C
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A
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N
A
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F
D
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D
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M
A
V
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V
P
L
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A
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A
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A
R
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Q
M
L
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A
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N
L
L
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P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
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Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
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T
F
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L
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L
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Y
F
I
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S
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G
A
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K
G
G
A
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T
A
L
R
T
A
D
S
G
Y
L
T
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K
L
V
D
V
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H
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V
V
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A
D
C
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T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
-------
V
A
G
A
A
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------
39
PsiBlast_CBE
91.11
49%
-65
- C9 -
4G7Z
4
RPOC_THET8
D:
[454-1498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
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L
H
P
L
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C
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A
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N
A
D
F
D
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D
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M
A
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H
V
P
L
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F
A
Q
A
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A
R
I
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M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAG
R
E
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
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P
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S
S
F
R
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L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
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T
A
L
R
T
A
D
S
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Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
K
R
A
D
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
--------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------
30
PsiBlast_CBE
91.09
49%
-67
- C9 -
4Q5S
5
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
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R
A
R
R
A
K
A
R
K
R
L
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V
V
R
A
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L
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G
N
R
P
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M
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A
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P
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L
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L
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M
V
Q
V
D
G
G
R
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A
T
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L
N
D
L
Y
R
R
L
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N
R
N
N
R
L
K
K
L
L
A
Q
G
A
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I
I
I
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N
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K
R
M
L
Q
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A
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D
A
L
L
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G
R
R
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A
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T
N
P
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L
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L
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K
Q
G
R
F
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N
L
L
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K
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G
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V
I
V
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L
K
L
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L
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M
A
L
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L
L
K
K
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A
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N
L
L
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A
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P
L
A
K
P
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R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
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M
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T
A
R
L
L
D
A
L
K
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I
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D
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V
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E
K
K
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L
L
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M
G
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R
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Y
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L
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L
W
T
E
T
T
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K
V
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Q
A
V
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K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
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Q
L
C
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L
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V
L
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V
E
V
L
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R
L
E
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G
R
Y
L
S
M
D
D
V
H
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
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Y
G
V
C
Q
K
C
Y
G
Y
D
L
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M
A
R
P
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G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
---------------
Q
G
L
P
R
V
I
E
L
F
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A
R
R
P
K
A
K
A
V
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G
V
V
R
I
E
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--
T
E
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K
L
S
V
F
V
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S
E
G
F
S
K
E
Y
K
L
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E
A
R
L
L
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K
D
G
D
Y
V
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A
G
Q
P
L
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G
A
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D
P
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Q
L
L
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A
K
G
P
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A
V
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R
Y
L
V
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E
I
Q
K
V
Y
R
A
Q
G
V
K
L
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D
K
H
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V
V
R
Q
M
M
K
Y
V
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V
T
D
P
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D
S
R
L
L
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G
Q
V
L
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K
W
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V
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A
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N
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R
L
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K
T
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L
L
M
G
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T
K
S
W
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A
A
S
F
Q
N
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L
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A
A
I
A
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K
K
D
E
L
I
G
L
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N
V
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L
G
R
L
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A
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G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
32
PsiBlast_CBE
91.05
49%
-65
- C9 -
4OIQ
7
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
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M
-
K
H
P
S
R
A
R
R
A
K
A
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K
R
L
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V
V
R
A
F
L
D
S
G
N
R
P
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W
M
I
L
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A
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P
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L
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P
D
L
R
P
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V
D
G
G
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F
A
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D
L
N
D
L
Y
R
R
L
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N
R
N
N
R
L
K
K
L
L
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G
A
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I
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R
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L
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P
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L
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L
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G
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F
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L
L
G
K
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V
D
Y
S
G
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V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
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R
M
L
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R
QRD
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K
D
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A
L
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V
V
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K
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A
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A
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A
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AG
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S
V
G
R
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K
Y
V
F
A
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P
------
D
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A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
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--
T
V
R
Y
M
G
----
K
R
L
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-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
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D
E
K
V
A
W
E
L
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Q
LDV
P
Q
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K
N
S
L
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D
L
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Y
Q
A
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L
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K
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M
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T
T
E
K
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A
V
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K
N
F
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N
YPF------------
N
P
L
Y
V
M
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S
G
A
R
G
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P
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Q
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L
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L
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V
L
A
R
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L
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L
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E
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L
S
M
D
D
V
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L
L
I
K
A
A
E
A
G
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I
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V
P
V
R
S
P
L
T
C
Q
T
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Y
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V
C
Q
K
C
Y
G
Y
D
L
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A
R
P
V
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E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
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M
-------------
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
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K
E
A
R
L
L
V
K
D
G
D
Y
V
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A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
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A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
38
PsiBlast_CBE
90.74
49%
-65
- C9 -
4G7Z
4
RPOC_THET8
N:
[454-1498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
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M
-
K
H
P
S
R
A
R
R
A
K
A
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K
R
L
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V
V
R
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F
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N
R
P
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W
M
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L
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P
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L
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A
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L
N
D
L
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R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
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A
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I
I
R
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L
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A
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G
R
R
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N
P
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D
I
L
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Q
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L
L
G
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R
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S
V
I
V
V
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L
K
L
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Q
C
G
L
P
K
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A
L
E
L
F
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F
L
L
K
K
M
E
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K
G
I
A
P
N
V
K
A
A
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R
M
L
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R
QRD
I
K
D
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V
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D
A
L
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K
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A
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L
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R
L
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A
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L
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A
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V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
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-
T
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P
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R
I
L
F
A
R
I
------
V
A
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A
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D
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KVAW
E
L
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LDV
P
Q
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K
N
S
L
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A
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A
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A
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N
F
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N
YPF------------
N
P
L
Y
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A
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S
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A
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G
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P
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Q
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L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
-------
V
A
G
A
A
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
--------
56
PsiBlast_CBE
89.67
49%
-65
- C9 -
2A6H
3
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
-----------
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
13
PsiBlast_PDB
89.44
49%
-65
- C9 -
2A6H
3
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
-----------
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
44
PsiBlast_CBE
89.30
49%
-63
- C9 -
3WOD
1
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
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G
L
Y
Y
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Q
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R
K
E
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K
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A
G
L
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F
A
T
P
E
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A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
K
V
A
W
E
L
I
Q
LD
V
P
Q
E
K
N
S
L
K
D
L
V
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Q
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F
L
R
L
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M
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K
T
A
R
L
L
D
A
L
K
Y
Y
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F
T
F
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G
I
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I
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I
D
D
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V
I
P
E
E
K
K
Q
Y
L
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A
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K
L
L
Q
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Q
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Y
E
M
G
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R
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Y
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Q
I
L
Q
L
W
T
E
T
T
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K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
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L
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A
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L
Y
G
R
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L
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E
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V
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L
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G
R
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L
S
M
D
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V
H
L
L
I
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A
A
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A
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I
Q
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V
P
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S
P
L
T
C
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Y
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V
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C
Y
G
Y
D
L
S
M
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R
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V
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I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
----------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
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A
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A
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V
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R
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--
T
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K
L
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V
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V
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L
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D
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Y
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G
V
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L
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H
I
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V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
22
PsiBlast_CBE
89.25
54%
-77
- C9 -
4YLP
1
RPOC_ECOLI
J:
[17-939]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
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R
T
F
K
P
E
R
D
G
L
F
C
A
R
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F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
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V
I
C
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K
C
G
V
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V
T
Q
T
K
V
R
R
E
R
M
G
H
I
E
L
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P
T
A
H
I
W
F
L
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S
L
P
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R
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G
L
L
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P
L
R
D
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L
Y
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Y
V
V
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G
M
T
N
L
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Q
Q
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L
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Y
L
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F
G
D
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A
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M
G
A
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A
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Q
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L
L
K
S
M
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C
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Q
L
R
E
E
L
N
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T
N
S
E
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K
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K
K
L
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I
K
L
L
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A
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V
Q
S
G
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K
P
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W
M
I
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L
P
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Y
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R
L
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G
L
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A
A
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M
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R
---
E
E
A
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V
W
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L
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A
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F
D
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D
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M
A
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P
L
T
L
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L
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A
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A
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M
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P
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S
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L
A
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L
H
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R
A
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W
M
I
V
P
K
G
L
P
Y
-------------------------------
S
I
V
N
Q
----
A
L
-------
G
K
K
A
I
S
K
M
L
N
T
C
Y
R
I
L
G
L
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P
T
V
I
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A
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Q
I
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A
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A
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G
A
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M
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K
K
H
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E
A
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A
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D
R
V
S
K
A
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D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
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G
L
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P
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F
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G
L
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L
Q
Y
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H
G
A
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K
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L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
T
P
V
I
E
G
G
D
V
K
E
P
L
R
D
R
----
V
L
-
G
R
V
T
A
E
D
V
L
K
P
G
T
A
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L
V
P
R
N
T
L
L
H
E
Q
---
W
C
D
L
L
E
E
N
S
-
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
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G
H
I
I
N
K
G
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A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.16
54%
-78
- C9 -
4YLP
1
RPOC_ECOLI
D:
[17-939]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
Y
R
T
F
K
P
E
R
D
G
L
F
C
A
R
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F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
G
V
I
C
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C
G
V
E
V
T
Q
T
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V
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R
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R
M
G
H
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L
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P
T
A
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I
W
F
L
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S
L
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L
L
L
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P
L
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L
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G
M
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Q
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L
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L
N
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N
S
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K
R
K
K
L
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L
L
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A
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G
N
K
P
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W
M
I
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V
L
P
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L
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L
R
P
L
V
P
L
D
G
G
R
F
A
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D
L
Y
R
R
V
I
N
R
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R
L
K
R
L
L
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A
A
P
D
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M
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Q
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L
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L
K
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L
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Y
G
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L
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G
L
A
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A
A
K
K
M
V
E
R
---
E
E
A
V
V
W
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L
D
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V
I
R
E
H
P
V
L
L
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R
A
P
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L
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G
I
Q
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G
K
A
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C
A
A
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D
F
D
G
D
Q
M
A
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P
L
T
L
E
A
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L
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A
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A
L
M
M
S
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L
S
P
A
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V
P
S
Q
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V
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G
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M
V
L
T
G
P
K
E
A
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L
Y
R
S
G
L
A
S
L
H
---------
A
R
V
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Y
E
K
D
A
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G
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L
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V
G
R
A
I
L
W
M
I
V
P
K
G
L
P
Y
-------------------------------
S
I
V
N
Q
----
A
L
-------
G
K
K
A
I
S
K
M
L
N
T
C
Y
R
I
L
G
L
K
P
T
V
I
F
A
D
Q
I
M
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T
G
F
A
Y
A
A
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S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
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I
S
E
A
E
A
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V
A
E
I
Q
E
Q
F
Q
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G
L
V
T
A
G
E
R
Y
N
K
V
I
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A
A
A
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D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
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M
R
G
L
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P
D
G
S
I
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I
T
A
N
F
R
E
G
L
N
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L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
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T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
T
P
V
I
E
G
G
D
V
K
E
P
L
R
D
R
----
V
L
-
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
---
W
C
D
L
L
E
E
N
S
-
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
87.98
49%
-63
- C9 -
4WQT
2
RPOC_THET8
I:
[454-1499]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
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A
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K
R
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V
V
R
A
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L
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G
N
R
P
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W
M
I
L
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A
V
P
V
L
P
P
D
L
R
----------
A
T
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D
L
N
D
L
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R
R
L
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N
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N
N
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K
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A
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A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
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P
------
D
E
A
L
L
A
-
V
A
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G
I
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--
T
V
R
Y
M
G
----
K
R
L
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-
T
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P
G
R
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L
F
A
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------
V
A
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A
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D
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KVAW
E
L
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P
Q
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K
N
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L
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N
F
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YPF------------
N
P
L
Y
V
M
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G
A
R
G
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P
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Q
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R
L
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Y
L
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M
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DVH
L
L
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A
A
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A
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P
V
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P
L
T
C
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A
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P
G
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L
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M
R
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F
-----------
T
Q
G
L
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L
F
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P
K
A
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V
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F
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K
L
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D
Y
V
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A
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P
L
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Q
L
L
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A
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A
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Y
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R
A
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M
M
K
Y
V
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D
P
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L
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L
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K
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V
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A
L
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A
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V
A
W
K
P
L
L
M
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S
A
L
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W
L
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A
A
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F
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L
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A
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K
K
D
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L
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L
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V
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A
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SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
-------
16
PsiBlast_PDB
87.92
49%
-66
- C9 -
2O5I
6
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
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M
-
K
H
P
S
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A
R
R
A
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V
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L
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R
P
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L
L
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A
L
N
APIKVAGRE
T
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V
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R
L
K
Y
V
F
A
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P
------
D
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A
L
L
A
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A
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G
I
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V
--
T
V
R
Y
M
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----
K
R
L
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-
T
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P
G
R
I
L
F
A
R
I
------
V
A
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A
V
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D
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KVAW
E
L
I
Q
LDV
P
Q
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K
N
S
L
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L
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A
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N
P
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A
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A
G
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L
A
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L
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L
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S
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L
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G
L
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A
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A
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A
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L
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M
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Q
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L
N
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K
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L
L
M
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N
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A
A
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K
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L
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L
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SD
F
V
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V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
4
PsiBlast_PDB
87.85
54%
-79
- C9 -
4YLN
1
RPOC_ECOLI
D:
[17-939]
------
F
D
A
I
K
I
A
L
A
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P
D
M
I
R
S
W
S
F
G
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K
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A
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A
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P
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-------------------------------
S
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----
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-------
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E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
T
P
V
I
E
G
G
D
V
K
E
P
L
R
D
R
----
V
L
-
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
---
W
C
D
L
L
E
E
N
S
-
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
87.82
54%
-76
- C9 -
4YLO
1
RPOC_ECOLI
J:
[17-939]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
Y
R
T
F
K
P
E
R
D
G
L
F
C
A
R
I
F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
G
V
I
C
E
K
C
G
V
E
V
T
Q
T
K
V
R
R
E
R
M
G
H
I
E
L
A
S
P
T
A
H
I
W
F
L
K
S
L
P
S
R
I
G
L
L
L
D
M
P
L
R
D
I
E
R
V
L
Y
F
E
S
Y
V
V
I
E
G
G
M
T
N
L
E
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
E
W
M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
R
A
I
T
G
S
N
-
K
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
---
E
E
A
V
V
W
D
I
L
D
E
V
I
R
E
H
P
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
E
P
V
L
I
E
G
K
A
I
Q
L
H
P
L
V
C
A
A
Y
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
T
L
E
A
Q
L
E
A
R
A
L
M
M
S
T
N
N
I
L
S
P
A
N
G
E
P
I
I
V
P
S
Q
D
V
V
L
G
L
Y
Y
M
T
R
D
C
V
N
A
K
G
E
G
M
V
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
---------
A
R
V
K
V
R
I
T
E
Y
E
K
D
A
N
G
E
L
V
A
K
T
S
L
K
D
T
T
V
G
R
A
I
L
W
M
I
V
P
K
G
L
P
Y
-------------------------------
S
I
V
N
Q
----
A
L
-------
G
K
K
A
I
S
K
M
L
N
T
C
Y
R
I
L
G
L
K
P
T
V
I
F
A
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
T
P
V
I
E
G
G
D
V
K
E
P
L
R
D
R
----
V
L
-
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
---
W
C
D
L
L
E
E
N
S
-
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.72
54%
-75
- C9 -
4YLO
1
RPOC_ECOLI
D:
[17-939]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
Y
R
T
F
K
P
E
R
D
G
L
F
C
A
R
I
F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
G
V
I
C
E
K
C
G
V
E
V
T
Q
T
K
V
R
R
E
R
M
G
H
I
E
L
A
S
P
T
A
H
I
W
F
L
K
S
L
P
S
R
I
G
L
L
L
D
M
P
L
R
D
I
E
R
V
L
Y
F
E
S
Y
V
V
I
E
G
G
M
T
N
L
E
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
E
W
M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
R
A
I
T
G
S
N
-
K
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
H
Q
C
G
L
P
K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
---
E
E
A
V
V
W
D
I
L
D
E
V
I
R
E
H
P
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
E
P
V
L
I
E
G
K
A
I
Q
L
H
P
L
V
C
A
A
Y
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
T
L
E
A
Q
L
E
A
R
A
L
M
M
S
T
N
N
I
L
S
P
A
N
G
E
P
I
I
V
P
S
Q
D
V
V
L
G
L
Y
Y
M
T
R
D
C
V
N
A
K
G
E
G
M
V
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
---------
A
R
V
K
V
R
I
T
E
Y
E
K
D
A
N
G
E
L
V
A
K
T
S
L
K
D
T
T
V
G
R
A
I
L
W
M
I
V
P
K
G
L
P
Y
-------------------------------
S
I
V
N
Q
----
A
L
-------
G
K
K
A
I
S
K
M
L
N
T
C
Y
R
I
L
G
L
K
P
T
V
I
F
A
D
Q
I
M
Y
T
G
F
A
Y
A
A
R
S
G
A
S
V
G
I
D
D
M
V
I
P
E
K
K
H
E
I
I
S
E
A
E
A
E
V
A
E
I
Q
E
Q
F
Q
S
G
L
V
T
A
G
E
R
Y
N
K
V
I
D
I
W
A
A
A
N
D
R
V
S
K
A
M
M
D
N
L
Q
T
E
TVINRDGQEEKQVSF
N
S
I
Y
M
M
A
D
S
G
A
R
G
S
A
A
Q
I
R
Q
L
A
G
M
R
G
L
M
A
K
P
D
G
S
I
I
E
T
P
I
T
A
N
F
R
E
G
L
N
V
L
Q
Y
F
I
S
T
H
G
A
R
K
G
L
A
D
T
A
L
K
T
A
N
S
G
Y
L
T
R
R
L
V
D
V
A
Q
D
L
V
V
T
E
D
D
C
G
T
H
E
G
I
M
M
T
P
V
I
E
G
G
D
V
K
E
P
L
R
D
R
----
V
L
-
G
R
V
T
A
E
D
V
L
K
P
G
T
A
D
I
L
V
P
R
N
T
L
L
H
E
Q
---
W
C
D
L
L
E
E
N
S
-
V
D
A
V
K
V
R
S
V
V
S
C
D
T
D
F
G
V
C
A
H
C
Y
G
R
D
L
A
R
G
H
I
I
N
K
G
E
A
I
G
V
I
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.39
54%
-80
- C9 -
4YLN
1
RPOC_ECOLI
J:
[17-939]
------
F
D
A
I
K
I
A
L
A
S
P
D
M
I
R
S
W
S
F
G
E
V
K
K
P
E
T
I
N
Y
R
T
F
K
P
E
R
D
G
L
F
C
A
R
I
F
G
P
V
K
D
Y
E
C
L
C
G
K
Y
K
R
L
K
H
R
G
V
I
C
E
K
C
G
V
E
V
T
Q
T
K
V
R
R
E
R
M
G
H
I
E
L
A
S
P
T
A
H
I
W
F
L
K
S
L
P
S
R
I
G
L
L
L
D
M
P
L
R
D
I
E
R
V
L
Y
F
E
S
Y
V
V
I
E
G
G
M
T
N
L
E
R
Q
Q
I
L
T
E
E
Q
Y
L
D
A
L
E
E
F
G
D
E
F
D
A
K
M
G
A
E
A
I
Q
A
L
L
K
S
M
D
L
E
Q
E
C
E
Q
L
R
E
E
L
N
E
T
N
S
E
T
K
R
K
K
L
T
K
R
I
K
L
L
E
A
F
V
Q
S
G
N
K
P
E
W
M
I
L
T
V
L
P
V
L
P
P
D
L
R
P
L
V
P
L
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
V
I
N
R
N
N
R
L
K
R
L
L
D
L
A
A
P
D
I
I
V
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
R
A
I
T
G
S
N
-
K
R
P
L
K
S
L
A
D
M
I
K
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
T
V
G
P
Y
L
R
L
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C
G
L
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K
K
M
A
L
E
L
F
K
P
F
I
Y
G
K
L
E
L
R
G
L
A
T
T
I
K
A
A
K
K
M
V
E
R
---
E
E
A
V
V
W
D
I
L
D
E
V
I
R
E
H
P
V
L
L
N
R
A
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T
L
H
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L
G
I
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A
F
E
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V
L
I
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K
A
I
Q
L
H
P
L
V
C
A
A
Y
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
T
L
E
A
Q
L
E
A
R
A
L
M
M
S
T
N
N
I
L
S
P
A
N
G
E
P
I
I
V
P
S
Q
D
V
V
L
G
L
Y
Y
M
T
R
D
C
V
N
A
K
G
E
G
M
V
L
T
G
P
K
E
A
E
R
L
Y
R
S
G
L
A
S
L
H
---------
A
R
V
K
V
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Y
-------------------------------
S
I
V
N
Q
----
A
L
-------
G
K
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A
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M
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Y
R
I
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TVINRDGQEEKQVSF
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R
----
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L
-
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---
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L
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R
T
F
H
I
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
87.37
49%
-65
- C9 -
3AOI
3
RPOC_THET8
D:
[454-1499]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
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Q
Q
L
L
K
E
L
D
L
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A
L
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K
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K
H
P
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R
A
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L
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D
L
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P
-----------
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A
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A
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F
T
Q
V
V
D
Q
K
T
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K
A
I
E
E
A
R
-------
48
PsiBlast_CBE
87.35
49%
-66
- C9 -
3AOI
5
RPOC_THET8
I:
[454-1499]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
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Q
L
L
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A
L
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A
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P
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A
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Q
V
V
D
Q
K
T
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K
A
I
E
E
A
R
-------
47
PsiBlast_CBE
87.02
49%
-65
- C9 -
3AOI
2
RPOC_THET8
N:
[454-1499]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
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A
L
E
K
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L
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A
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G
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L
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-----------
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A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
-------------
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
-------
53
PsiBlast_CBE
86.58
49%
-66
- C9 -
2O5I
5
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
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R
L
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Q
P
V
L
V
E
G
Q
S
I
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L
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P
L
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C
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A
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N
A
D
F
D
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D
Q
M
A
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V
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L
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A
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A
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A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
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L
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L
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F
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A
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A
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A
L
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A
D
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Y
L
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L
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V
T
H
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V
V
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A
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T
T
N
Y
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V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
------------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
52
PsiBlast_CBE
86.47
49%
-62
- C9 -
2O5J
7
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
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E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
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P
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L
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Q
S
I
Q
L
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L
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C
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A
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N
A
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D
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D
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M
A
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L
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Q
M
L
S
A
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N
L
L
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P
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A
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P
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L
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L
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K
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A
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A
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A
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A
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E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
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D
L
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Q
A
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A
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D
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L
L
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L
W
T
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T
T
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K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
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L
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L
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T
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N
Y
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-
L
F
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P
D
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L
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L
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KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
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R
Y
L
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M
D
DVH
L
L
I
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A
A
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A
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Q
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P
V
R
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P
L
T
C
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C
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C
Y
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Y
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L
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A
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A
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A
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D
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L
F
E
A
R
R
P
K
A
K
-----------------------------------------------------------
A
I
D
P
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Q
L
L
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A
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G
P
E
A
V
E
R
Y
L
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A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
17
PsiBlast_PDB
85.56
49%
-63
- C9 -
2O5J
7
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
S
G
E
T
F
E
V
P
V
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
H
T
G
G
V
A
G
A
A
D
I
T
Q
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
-----------------------------------------------------------
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
29
PsiBlast_CBE
82.39
49%
-57
- C9 -
4WQS
3
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
--------------------
R
S
S
F
R
E
G
L
T
V
L
E
Y
F
I
S
S
H
G
A
R
K
G
G
A
D
T
A
L
R
T
A
D
S
G
Y
L
T
R
K
L
V
D
V
T
H
E
I
V
V
R
E
A
D
C
G
T
T
N
Y
I
S
V
P
-
L
F
Q
P
D
E
V
T
R
S
L
R
L
R
KRAD
I
E
A
G
L
Y
G
R
V
L
A
R
E
V
E
V
L
G
V
R
L
E
E
G
R
Y
L
S
M
D
DVH
L
L
I
K
A
A
E
A
G
E
I
Q
E
V
P
V
R
S
P
L
T
C
Q
T
R
Y
G
V
C
Q
K
C
Y
G
Y
D
L
S
M
A
R
P
V
S
I
G
E
A
V
G
I
V
A
A
Q
S
I
G
E
P
G
T
Q
L
T
M
R
T
F
-------------
G
L
P
R
V
I
E
L
F
E
A
R
R
P
K
A
K
A
V
I
S
E
I
D
G
V
V
R
I
E
E
--
T
E
E
K
L
S
V
F
V
E
S
E
G
F
S
K
E
Y
K
L
P
K
E
A
R
L
L
V
K
D
G
D
Y
V
E
A
G
Q
P
L
T
R
G
A
I
D
P
H
Q
L
L
E
A
K
G
P
E
A
V
E
R
Y
L
V
E
E
I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
E
V
T
D
P
G
D
S
R
L
L
E
G
Q
V
L
E
K
W
D
V
E
A
L
N
E
R
L
I
A
E
G
K
T
P
V
A
W
K
P
L
L
M
G
V
T
K
S
A
L
S
T
K
S
W
L
S
A
A
S
F
Q
N
T
T
H
V
L
T
E
A
A
I
A
G
K
K
D
E
L
I
G
L
K
E
N
V
I
L
G
R
L
I
P
A
G
T
G
SD
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
E
E
A
R
K
E
A
----
51
PsiBlast_CBE
80.24
49%
-65
- C9 -
2PPB
9
RPOC_THET8
N:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
M
G
A
E
A
I
Q
Q
L
L
K
E
L
D
L
E
A
L
E
K
E
L
L
E
E
M
-
K
H
P
S
R
A
R
R
A
K
A
R
K
R
L
E
V
V
R
A
F
L
D
S
G
N
R
P
E
W
M
I
L
E
A
V
P
V
L
P
P
D
L
R
P
M
V
Q
V
D
G
G
R
F
A
T
S
D
L
N
D
L
Y
R
R
L
I
N
R
N
N
R
L
K
K
L
L
A
Q
G
A
P
E
I
I
I
R
N
E
K
R
M
L
Q
E
A
V
D
A
L
L
D
N
G
R
R
G
A
P
V
T
N
P
G
S
D
R
P
L
R
S
L
T
D
I
L
S
G
K
Q
G
R
F
R
Q
N
L
L
G
K
R
V
D
Y
S
G
R
S
V
I
V
V
G
P
Q
L
K
L
H
Q
C
G
L
P
K
R
M
A
L
E
L
F
K
P
F
L
L
K
K
M
E
E
K
G
I
A
P
N
V
K
A
A
R
R
M
L
E
R
QRD
I
K
D
E
V
W
D
A
L
E
E
V
I
H
G
K
V
V
L
L
N
R
A
P
T
L
H
R
L
G
I
Q
A
F
Q
P
V
L
V
E
G
Q
S
I
Q
L
H
P
L
V
C
E
A
F
N
A
D
F
D
G
D
Q
M
A
V
H
V
P
L
S
S
F
A
Q
A
E
A
R
I
Q
M
L
S
A
H
N
L
L
S
P
A
S
G
E
P
L
A
K
P
S
R
D
I
I
L
G
L
Y
Y
I
T
Q
V
R
K
E
K
K
G
A
G
L
E
F
A
T
P
E
E
A
L
A
A
H
E
R
G
E
V
A
L
N
APIKVAGRE
T
S
V
G
R
L
K
Y
V
F
A
N
P
------
D
E
A
L
L
A
-
V
A
H
G
I
V
D
L
Q
D
V
V
--
T
V
R
Y
M
G
----
K
R
L
E
-
T
S
P
G
R
I
L
F
A
R
I
------
V
A
E
A
V
E
D
E
KVAW
E
L
I
Q
LDV
P
Q
E
K
N
S
L
K
D
L
V
Y
Q
A
F
L
R
L
G
M
E
K
T
A
R
L
L
D
A
L
K
Y
Y
G
F
T
F
S
T
T
S
G
I
T
I
G
I
D
D
A
V
I
P
E
E
K
K
Q
Y
L
E
E
A
D
R
K
L
L
Q
I
E
Q
A
Y
E
M
G
F
L
T
D
R
E
R
Y
D
Q
I
L
Q
L
W
T
E
T
T
E
K
V
T
Q
A
V
F
K
N
F
E
E
N
YPF------------
N
P
L
Y
V
M
A
Q
S
G
A
R
G
N
P
Q
Q
I
R
Q
L
C
G
L
R
G
L
M
Q
K
P
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----
18
PsiBlast_PDB
79.10
49%
-64
- C9 -
2PPB
8
RPOC_THET8
D:
[454-1502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
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----