@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0534: (2016-03-16 )
MNQAVIVAAKRTAFGKYGGTLKHLEPEQLLKPLFQHFKEKYPEVISKIDDVVLGNVVGNGGNIARKALLEAGLKDSIPGVTIDRQCGSGLESVQYACRMIQAGAGKVYIAGGVESTSRAPWKIKRPHSVYETALPEFYERASFAPEMSDPSMIQGAENVAKMYDVSRELQDEFAYRSHQLTAENVKNGNISQEILPITVKGEIFNTDESLKSHIPKDNFGRFKPVIKGGTVTAANSCMKNDGAVLLLIMEKDMAYELGFEHGLLFKDGVTVGVDSNFPGIGPVPAISNLLKRNQLTIENIEVIEINEAFSAQVVACQQALNISNTQLNIWGGALASGHPYGASGAQLVTRLFYMFDKETMIASMGIGGGLGNAALFTRF
Atome Classification :
(20 SA)
.........10......-.-.20........30........40...-.....50...--..---.--.--.---60...---.....70........80........90........100.......110.......120.------......--.--------.130---...-......140--..-------......150--.....----------------....160.......170.......180-........190.......-----200-------.----------.-----..-.....210.......220....--.---------..230.......240.......250.......260.......270.......280.......290.......300.......310....--...320---.---......330.......340.......350...-----.--.---..---360-........-.-370.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
Q
A
V
I
V
A
A
KRTAFGKY-G-GTLKHL
E
P
E
Q
L
L
K
P
L
F
Q
H
F
K
E
K
Y
P
E
V
-
I
S
K
I
D
D
V
V
LG--NV---V--G--N---
G
G
N
I
A
---
R
K
A
L
L
E
AGLKDSIPG
V
T
I
D
R
Q
CGS
G
L
E
S
V
Q
Y
A
C
R
M
I
QAGA
G
K
V
Y
I
AGGVESTSRA
P
--
W
------
K
IKRP
H
--
S
--------
V
Y
-----
E
T
A
-
L
P
E
F
Y
E
R
A---SF-------APEMSD
P
----
S
M
I
Q
G
----------------
A
E
N
V
A
K
M
Y
D
V
S
R
E
L
Q
D
E
F
A
Y
RSHQL
T
--
A
E
NVKNGNIS
Q
E
I
L
P
I
T
V
-----K---------G----------
E
-----
I
F-N
T
D
E
S
L
K
S
HIPKDNFGRFKPVI--K---------GGT
V
T
A
A
N
S
CMKND
G
A
V
L
L
L
I
MEKD
M
A
Y
E
LGFEHGLLFKD
G
V
T
V
GVDSNFPGIG
P
V
P
A
I
S
N
L
L
K
RNQL
T
I
E
N
I
E
V
I
E
IN
E
A
F
S
A
Q
V
V
A
C
--
Q
Q
A
LNI---S---N
T
Q
L
N
I
W
GGALASGHPYGA
S
G
A
Q
L
V
T
R
L
F
Y
M
F-----D--K---E
T
---
M
---
I
A
SMGIGG-G-LGNA
A
L
FTRF
123
HHSearch
95.29
38%
-78
- C5 -
1ULQ
-
?
A:
[3-399]
--
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
-
G
-
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
--
C
A
---
N
--
Q
--
A
GED
N
R
N
V
A
---
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
--
Y
------
A
V
P
K
P
E
--
R
--------
G
F
-----
P
T
G
N
L
V
M
Y
D
T
T
L
---
G
W
RFVN
P
K
M
Q
A
L
Y
G
T
E
----
S
M
G
E
T
----------------
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
--
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
-----
K
RGK
E
-----
E
----------
I
-----
L
V
-
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
--
R
E--------
G
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
--
L
R
E
W
S
L
SM-
E
---
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
--
K
--
V
---
Q
F
---
G
---
L
A
-
T
M
C
I
G
V
G
-
Q
G
I
A
V
V
V
E
G
-
116
HHSearch
93.85
34%
-75
- C5 -
2WU9
7
THIK2_ARATH
A:
[29-418]
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
-
N
L
N
P
S
E
V
G
D
I
V
V
G
--
T
V
---
L
--
A
--
P
G
S
Q
R
A
S
E
C
---
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
--
M
------
A
W
E
G
S
V
--
N
---------------
P
-----
A
V
K
K
-----
F
A
-------
Q
A
Q
N
C
L
L
----
P
M
G
V
T
----------------
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
--
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
-----
K
---------
L
V
D
PKTG
D
E
K
P
I
-----
T
V
-
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
--
K
K--------
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
--
R
N
K
L
G
L
---
D
---
P
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
--
G
KD
C
---
R
F
---
G
---
V
V
-
S
M
C
I
G
T
G
-
M
G
A
A
A
V
F
E
R
-
23
PsiBlast_CBE
93.61
35%
-77
- C5 -
4E1L
11
?
B:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
F
-
G
-
G
V
F
K
N
T
S
A
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
-
L
S
E
I
D
E
V
I
I
G
--
N
V
---
L
QT
G
--
L
---
G
Q
N
V
A
---
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
--
Y
-------------------------------------
I
V
P
T
A
---
R
F
-------
G
S
K
M
G
-----------TDG
L
I
D
A
FN
Q
Y
H
M
G
I
T
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
--
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
I
RRG
K
---------
I
----------
E
-----
T
I
-
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
--
K
K--------
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
--
K
N
E
L
Q
I
---
D
---
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-----
Q
--
K
R
KV
E
T
---
G
---
L
A
T
L
C
I
G
G
-
G
-
Q
G
I
S
M
V
V
S
R
-
21
PsiBlast_CBE
92.47
35%
-80
- C5 -
4E1L
4
?
D:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
F
-
G
-
G
V
F
K
N
T
S
A
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
-
L
S
E
I
D
E
V
I
I
G
--
N
V
---
L
QT
G
--
L
---
G
Q
N
V
A
---
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
--
Y
-------------------------------------
I
--------------------------------Q
Y
H
M
G
I
T
---------
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
--
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
IRRG
K
---------
I
----------
E
-----
T
I
-
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
--
K
K--------
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
--
K
N
E
L
Q
I
---
D
---
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-----
Q
--
K
R
KV
E
T
---
G
---
L
A
T
L
C
I
G
G
-
G
-
Q
G
I
S
M
V
V
S
R
-
22
PsiBlast_CBE
92.46
35%
-81
- C5 -
4E1L
3
?
C:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
F
-
G
-
G
V
F
K
N
T
S
A
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
-
L
S
E
I
D
E
V
I
I
G
--
N
V
---
L
QT
G
--
L
---
G
Q
N
V
A
---
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
--
Y
-------------------------------------
I
V
P
------------------------------Y
H
M
G
I
T
----------
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
--
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
LG---
K
---------
I
----------
E
-----
T
I
-
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
--
K
K--------
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
--
K
N
E
L
Q
I
---
D
---
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-----
Q
--
K
R
KV
E
T
---
G
---
L
A
T
L
C
I
G
G
-
G
-
Q
G
I
S
M
V
V
S
R
-
122
HHSearch
92.09
35%
-77
- C5 -
3GOA
2
FADA_SALTY
A:
[1-386]
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
-
K
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
S
L
T
A
A
T
L
D
D
I
Y
W
G
--
C
V
---
Q
--
Q
--
T
LEQ
G
F
N
I
A
---
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
V
P
--
M
------
S
H
G
V
D
---
F
--------
H
P
-----
G
----
L
S
-----------------------
G
----
M
M
G
L
T
----------------
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
--
F
K
T
E
I
I
P
T
G
G
-----
H
D
ADG
V
----
L
----------
K
-----
Q
F
-
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
--
D
PV-------
S
G
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
--
I
K
D
L
G
L
---
M
EQI
D
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
--
D
--
A
---
Q
F
---
G
---
L
A
-
T
M
C
I
G
-
L
G
Q
G
I
A
T
V
F
E
R
-
11
PsiBlast_PDB
91.64
33%
-76
- C5 -
2WUA
-
?
A:
[48-436]
-
D
D
V
V
I
V
A
A
Y
R
S
P
L
C
K
A
-
K
R
G
G
L
K
D
T
Y
P
D
D
I
L
A
P
V
L
K
A
L
I
E
K
T
N
I
N
-
P
A
E
V
G
D
I
V
V
G
--
S
V
---
L
--
G
--
A
---
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
P
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
A
N
P
MA
W
EGSVNP
K
V
K
T
M
A
--
Q
--------
A
Q
-----
D
C
L
-
L
P
------------------------------
M
G
I
T
----------------
S
E
N
V
A
Q
K
F
S
I
T
R
Q
E
Q
D
Q
A
A
V
G
S
H
R
K
T
--
A
A
A
T
A
A
G
R
F
K
D
E
I
I
P
I
K
T
-----
K
I
V
D
PKT---
G
----------
D
E
K
P
V
-
T
I
-
S
V
D
D
G
I
R
P
G
T
S
L
A
D
L
A
K
L
K
P
V
F
R-
K
---------
D
G
S
T
T
A
G
T
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
I
A
L
Q
K
G
L
P
I
L
G
V
F
R
T
F
A
A
V
G
V
P
P
S
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
Q
I
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
--
Q
K
K
L
E
I
---
D
---
P
Q
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
GR
D
--
C
---
R
F
---
G
---
V
V
S
M
C
I
G
T
-
G
-
M
G
A
A
A
V
F
E
R
-
119
HHSearch
91.63
32%
-69
- C5 -
2IIK
-
THIK_HUMAN
A:
[35-422]
A
A
D
V
V
V
V
H
G
R
R
T
A
I
C
R
A
G
R
-
G
G
F
K
D
T
T
P
D
E
L
L
S
A
V
M
T
A
V
L
K
D
V
-
N
L
R
P
E
Q
L
G
D
I
C
V
G
--
N
V
---
L
--
Q
PG
A
---
G
A
I
M
A
---
R
I
A
Q
F
L
S
D
I
P
E
T
V
P
L
S
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
S
I
A
G
G
I
R
N
G
S
Y
D
I
G
M
A
C
G
V
E
S
M
S
L
A
D
------------
G
N
I
--
T
--------
S
R
-----------
L
M
E
K
E
----
K
A
-------
R
--
D
C
L
I
----
P
M
G
I
T
----------------
S
E
N
V
A
E
R
F
G
I
S
R
E
K
Q
D
T
F
A
L
A
S
Q
Q
K
A
--
A
R
A
Q
S
K
G
C
F
Q
A
E
I
V
P
V
T
T
-----
T
V
H
D
DKG
T
K
R
S
----------
I
-----
T
V
-
T
Q
D
E
G
I
R
P
S
T
T
M
E
G
L
A
K
L
K
P
A
F
--
K
K--------
D
G
S
T
T
A
G
N
S
S
Q
V
S
D
G
A
A
A
I
L
L
A
R
R
S
K
A
E
E
L
G
L
P
I
L
G
V
L
R
S
Y
A
V
V
G
V
P
P
D
I
M
G
I
G
P
A
Y
A
I
P
V
A
L
Q
K
A
G
L
T
V
S
D
V
D
I
F
E
I
N
E
A
F
A
S
Q
A
A
Y
C
--
V
E
K
L
R
L
---
P
---
P
E
K
V
N
P
L
G
G
A
V
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
I
T
L
L
N
E
L
K
R
R
G-
K
--
R
---
A
Y
---
G
---
V
V
S
M
C
I
G
T
-
G
-
M
G
A
A
A
V
F
E
Y
-
3
PsiBlast_PDB
91.59
35%
-69
- C5 -
4DD5
-
THLA_PEPD6
A:
[6-396]
M
R
E
V
V
I
A
S
A
A
R
T
A
V
G
S
F
-
G
-
G
A
F
K
S
V
S
A
V
E
L
G
V
T
A
A
K
E
A
I
K
R
A
N
I
T
-
P
D
M
I
D
E
S
L
L
G
--
G
V
---
L
TA
G
--
L
---
G
Q
N
I
A
---
R
Q
I
A
L
G
A
G
I
P
V
E
K
P
A
M
T
I
N
I
V
C
G
S
G
L
R
S
V
S
M
A
S
Q
L
I
A
L
G
D
A
D
I
M
L
V
G
G
A
E
N
M
S
M
S
P
--
Y
------
L
V
--
P
S
--
A
--------
R
Y
GARM
G
D
A
A
-
F
V
D
S
M
I
K
D
---
G
L
-------
S
D
I
F
N
N
Y
----
H
M
G
I
T
----------------
A
E
N
I
A
E
Q
W
N
I
T
R
E
E
Q
D
E
L
A
L
A
S
Q
N
K
A
--
E
K
A
Q
A
E
G
K
F
D
E
E
I
V
P
V
V
I
-----
K
---------------------D
T
---
V
V
-
D
K
D
E
Y
I
K
P
G
T
T
M
E
K
L
A
K
L
R
P
A
F
--
K
K--------
D
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
V
V
M
A
K
E
K
A
E
E
L
G
I
E
P
L
A
T
I
V
S
Y
G
T
A
G
V
D
P
K
I
M
G
Y
G
P
V
P
A
T
K
K
A
L
E
A
A
N
M
T
I
E
D
I
D
L
V
E
A
N
E
A
F
A
A
Q
S
V
A
V
--
I
R
D
L
N
I
---
D
---
M
N
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
C
S
G
A
R
I
L
T
T
L
L
Y
E
M
K
R
R
--
D
--
A
---
K
T
---
G
---
L
A
T
L
C
I
G
G
-
G
-
M
G
T
T
L
I
V
K
R
-
12
PsiBlast_PDB
91.31
33%
-72
- C5 -
2C7Y
-
THIK2_ARATH
A:
[50-438]
-
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
L
N
-
P
S
E
V
G
D
I
V
V
G
--
T
V
---
L
--
A
--
P
---
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
---------------------------------------
K
F
A
Q
A
Q
---
N
C
-------
L
L
P
M
G
V
T
----
S
---------------------
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
--
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
-----
K
L
V
D
PKT---
G
----------
D
E
K
P
I
-
T
V
-
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
--
K
K--------
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
--
R
N
K
L
G
L
---
D
---
P
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
GK
D
--
C
---
R
F
---
G
---
V
V
S
M
C
I
G
T
-
G
-
M
G
A
A
A
V
F
E
R
-
13
PsiBlast_PDB
91.26
33%
-74
- C5 -
2C7Z
-
THIK2_ARATH
A:
[50-438]
-
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
L
N
-
P
S
E
V
G
D
I
V
V
G
--
T
V
---
L
--
A
--
P
---
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
MA
W
------
E
----------------------------
K
K
F
A
Q
A
Q
---
N
C
-------
L
L
P
M
G
V
T
----
S
---------------------
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
--
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
-----
K
L
V
D
PKT---
G
----------
D
E
K
P
I
-
T
V
-
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
--
K
K--------
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
--
R
N
K
L
G
L
---
D
---
P
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
GK
D
--
C
---
R
F
---
G
---
V
V
S
M
C
I
G
T
-
G
-
M
G
A
A
A
V
F
E
R
-
1
PsiBlast_PDB
91.20
37%
-68
- C5 -
1ULQ
-
?
A:
[3-396]
--
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
-
G
-
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
G
V
P
-
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
---
A
--
G
E-
D
---
N
R
N
V
A
---
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
--
Y
------
A
V
P
K
P
E
--
R
GF
P
T
G
N
L
V
M
Y
-----
D
T
T
-
L
G
W
R
F
V
N
P
---
K
M
-------
Q
A
L
Y
G
T
E
----
S
M
G
E
T
----------------
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
--
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
-----
K
---------
R
GK
E
-------
E
-----
I
L
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
--
R
E--------
G
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
M
---
E
---
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
-----
R
--
R
---
R
K
---
V
Q
F
G
L
A
T
M
C
I
G
V
-
G
-
Q
G
I
A
V
V
----
50
PsiBlast_CBE
91.07
33%
-72
- C5 -
1WDM
1
FADA_PSEFR
D:
[8-389]
----
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
--
C
V
NQT
L
--
E
--
Q
---
G
W
N
I
A
---
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
------------
V
S
M
M
H
--
G
--------
V
D
-----
P
N
---
P
H
M
S
L
Y
A
---
A
K
-------
A
S
G
M
--------
M
G
L
T
----------------
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
--
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
G
-----
Y
---------
D
----------
E
NGFLK
I
F
-
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
NP
K
---------
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
--
L
K
D
L
K
V
LDK
M
---
N
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-----
K
--
Q
---
N
G
GTF
G
---
L
S
T
M
C
I
G
L
-
G
-
Q
G
I
A
T
V
F
E
R
-
2
PsiBlast_PDB
90.97
34%
-74
- C5 -
3SS6
6
?
A:
[4-390]
M
H
N
V
V
I
T
A
A
V
R
S
P
I
G
T
F
-
G
-
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
A
V
K
R
G
G
V
E
-
P
H
E
V
D
E
V
I
L
G
--
H
C
---
I
QR
T
--
D
---
E
A
N
T
A
---
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
--
Y
------
A
L
K
Q
H
R
------------
W
-----
G
Q
R
-
L
Q
H
G
E
I
R
D
---
T
V
-------
W
E
V
L
E
D
P
IHHI
M
M
G
E
T
----------------
A
E
N
L
V
E
Q
Y
E
I
T
R
E
E
Q
D
E
V
A
L
R
S
H
T
L
A
--
L
K
A
I
E
S
G
Y
F
D
D
Q
I
V
P
I
T
I
-----
K
---------
E
----------
R
R
K
E
V
-
V
F
-
S
K
D
E
H
P
R
A
D
I
T
A
E
K
L
A
G
L
K
P
A
F
R-
K
---------
D
G
S
V
T
A
G
N
A
S
G
L
N
D
G
S
A
V
L
V
L
M
S
E
E
K
A
K
E
K
G
L
Q
P
L
A
R
I
V
G
Y
S
V
A
G
V
D
P
K
I
M
G
I
G
P
A
P
A
I
R
K
G
L
E
K
V
D
W
S
L
E
D
A
D
L
L
E
I
N
E
A
F
A
A
Q
Y
L
A
V
--
E
K
E
L
D
L
---
D
---
R
E
K
V
N
V
N
G
S
G
V
G
L
G
H
P
I
G
C
T
G
A
R
I
T
V
S
L
I
H
E
L
-----
K
--
R
RG
L
E
K
---
G
---
I
A
S
L
C
V
G
G
-
G
-
I
G
-
V
A
L
F
---
125
HHSearch
90.91
33%
-79
- C5 -
2IB8
8
THIL_HUMAN
A:
[7-395]
L
K
E
V
V
I
V
S
A
T
R
T
P
I
G
S
F
-
L
-
G
S
L
S
L
L
P
A
T
K
L
G
S
I
A
I
Q
G
A
I
E
K
A
-
G
I
P
K
E
E
V
K
E
A
Y
M
G
--
N
V
---
L
--
Q
GG
E
---
G
Q
A
P
T
---
R
Q
A
V
L
G
A
G
L
P
I
S
T
P
C
T
T
I
N
K
V
C
A
S
G
M
K
A
I
M
M
A
S
Q
S
L
M
C
G
H
Q
D
V
M
V
A
G
G
M
E
S
M
S
N
V
P
--
Y
------
V
M
N
R
G
S
TP
Y
--------
G
G
V
----
K
L
E
-
D
L
I
V
K
--
D
---
G
L
-------
T
D
V
Y
N
K
I
----
H
M
G
S
C
----------------
A
E
N
T
A
K
K
L
N
I
A
R
N
E
Q
D
A
Y
A
I
N
S
Y
T
R
S
--
K
A
A
W
E
A
G
K
F
G
N
E
V
I
P
V
T
V
-----
T
V
KGQ
P
----
D
----------
V
-----
V
V
-
K
E
D
E
E
Y
K
-
R
V
D
F
S
K
V
P
K
L
K
T
V
F
--
Q
KE-------
N
G
T
V
T
A
A
N
A
S
T
L
N
D
G
A
A
A
L
V
L
M
T
A
D
A
A
K
R
L
N
V
T
P
L
A
R
I
V
A
F
A
D
A
A
V
E
P
I
D
F
P
I
A
P
V
Y
A
A
S
M
V
L
K
D
V
G
L
K
K
E
D
I
A
M
W
E
V
N
E
A
F
S
L
V
V
L
A
N
--
I
K
M
L
E
I
---
D
---
P
Q
K
V
N
I
N
G
G
A
V
S
L
G
H
P
I
G
M
S
G
A
R
I
V
G
H
L
T
H
A
L
K----
Q
--
G
---
E
Y
---
G
---
L
A
S
I
C
N
G
G
-
G
-
G
A
S
A
M
L
I
Q
K
L
7
PsiBlast_PDB
90.67
35%
-68
- C5 -
4O9C
-
THIL_CUPNH
A:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
-
G
-
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
-
P
E
Q
V
S
E
V
I
M
G
--
Q
V
---
L
TA
G
--
S
---
G
Q
N
P
A
---
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
--
H
------
V
L
P
G
S
R
--
D
--------
G
F
-----
R
M
G
-
D
A
K
L
V
D
T
M
I
V
D
G
L
-------
W
D
V
Y
N
Q
Y
----
H
M
G
I
T
----------------
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
--
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R--
K
---------
G
----------
D
P
V
---
A
F
-
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D-
K
---------
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
--
H
Q
Q
M
G
W
---
D
---
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
--
D
--
A
---
K
K
---
G
---
L
A
S
L
C
I
G
G
-
G
-
M
G
V
A
L
A
V
E
R
-
14
PsiBlast_PDB
90.66
33%
-71
- C5 -
2WU9
7
THIK2_ARATH
A:
[30-418]
-
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
L
N
-
P
S
E
V
G
D
I
V
V
G
--
T
V
---
L
--
A
--
P
---
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
MA
W
-----------
E
--
G
--------
S
V
-----
N
P
A
-
V
K
K
F
A
Q
A
Q
---
N
C
-------
L
L
P
M
G
V
T
----
S
---------------------
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
--
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
-----
K
L
V
D
PKT---
G
----------
D
E
K
P
I
-
T
V
-
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
--
K
K--------
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
--
R
N
K
L
G
L
---
D
---
P
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
GK
D
--
C
---
R
F
---
G
---
V
V
S
M
C
I
G
T
-
G
-
M
G
A
A
A
V
F
E
R
-
52
PsiBlast_CBE
90.65
33%
-70
- C5 -
1WDL
1
FADA_PSEFR
D:
[8-389]
----
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
--
C
V
NQT
L
--
E
--
Q
---
G
W
N
I
A
---
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
------------
V
S
M
M
H
--
G
--------
V
D
-----
P
N
---
P
H
M
S
L
Y
A
---
A
K
-------
A
S
G
M
--------
M
G
L
T
----------------
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
--
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
G
-----
Y
---------
D
----------
E
NGFLK
I
F
-
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
NP
K
---------
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
--
L
K
D
L
K
V
LDK
M
---
N
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-----
K
--
Q
---
N
G
GTF
G
---
L
S
T
M
C
I
G
L
-
G
-
Q
G
I
A
T
V
F
E
R
-
25
PsiBlast_CBE
90.64
35%
-69
- C5 -
4O99
1
THIL_CUPNH
C:
[4-391]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
-
G
-
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
-
P
E
Q
V
S
E
V
I
M
G
--
Q
V
---
L
TA
G
--
S
---
G
Q
N
P
A
---
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
--
H
------
V
L
P
G
S
R
--
D
--------
G
F
-----
R
M
G
-
D
A
K
L
V
D
T
M
IVD
G
L
-------
W
D
V
Y
N
Q
Y
----
H
M
G
I
T
----------------
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
--
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
PQR--
K
---------
G
----------
D
PV---
A
F
-
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D-
K
---------
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
--
H
Q
Q
M
G
W
---
D
---
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
KRR--
D
--
A
---
K
K
---
G
---
L
A
S
L
C
I
G
G
-
G
-
M
G
V
A
L
A
V
E
R
-
121
HHSearch
90.59
33%
-89
- C5 -
3SVK
-
?
A:
[7-406]
-
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
-
G
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
L
R
R
R
Y
P
D
L
D
E
T
L
I
S
D
M
I
L
G
--
V
V
---------------
D
I
A
---
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
---
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
---------------------
W
--------
A
-------
T
--
D
P
E
T
N
Y
R
I
---
G
F
-------------
V
----
P
Q
G
I
G
----------------
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
--
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
R
D
-----
Q
---------
N
----------
G
LV---
I
L
-
D
H
D
E
H
M
R
P
D
T
T
M
E
G
L
A
K
L
K
T
A
F
--
D
QKYHWVEKI
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
--
Q
K
D
L
N
I
---
P
---
D
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
--
N
--
A
---
R
R
---
A
---
L
I
-
T
L
C
I
G
G
G
-
M
G
V
A
T
I
I
E
R
-