@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0537: (2016-03-16 )
MALKKVLTIAGSDTSAGAGMQADLKTFQELDTYGMVALTAIVTMDKDTWSHDVTPLPMDVFEKQLETALSIGPDAIKTGMLGTEEIIKRAGEVYEASNAQYFVVDPVMVCKGEDEVLNPGNTEAMIKYLLPKATVVTPNLFEAGQLSGLGKLNSIEDMKKAATIIFDKGAQHVIIKGGKALDQDKSYDLYYDGQTFYQLTTDMFQQSYNHGAGCTFAAATTAYLANGKSPKEAVISAKAFVASAIKNGWKMNDFVGPVDHGAYNRIEHIDVEVTEV
Atome Classification :
(23 SA)
.........10........20........30........40....-....50........60........-70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240......--.250.......260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
K
K
V
L
T
I
AGSDTSAGAG
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
TMD-KDTWSHDVTPL
P
M
D
V
F
E
K
Q
L
E
T
A
L-S-I
G
P
D
A
I
K
TGML
G
T
E
E
I
I
K
RA
G
E
VYEASNA
Q
Y
F
V
VD
P
V
M
V
CKGEDEVLNPG
N
T
E
A
M
I
K
Y
LLPK
A
T
VVTP
N
L
FEAGQLSGLGKL
N
S
I
E
D
M
K
K
A
A
T
I
I
FDKGA
Q
H
V
I
IKGGKALDQDKS
Y
D
L
Y
YDG
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
SYNHGAGC
T
F
A
A
A
T
T
A
Y
LANGK
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
KNG--WKMNDFVGPVDHGAYNR
I
E
H
I
D
V
E
V
TEV
2
PsiBlast_PDB
98.67
100%
-96
- C2 -
4C5K
4
?
A:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
1
PsiBlast_PDB
98.42
100%
-94
* C2 *
4C5J
3
?
A:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
22
PsiBlast_CBE
98.02
100%
-96
- C2 -
4C5N
4
?
B:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
-------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
25
PsiBlast_CBE
97.99
100%
-95
- C2 -
4C5M
5
?
B:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
21
PsiBlast_CBE
97.93
100%
-99
- C2 -
4C5N
5
?
D:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
-------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
33
PsiBlast_CBE
97.88
100%
-94
- C2 -
4C5J
4
?
B:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
28
PsiBlast_CBE
97.76
100%
-94
- C2 -
4C5K
5
?
D:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
32
PsiBlast_CBE
97.63
100%
-93
- C2 -
4C5J
4
?
C:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
4
PsiBlast_PDB
97.37
100%
-95
- C2 -
4C5M
5
?
A:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
---
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
31
PsiBlast_CBE
96.88
100%
-94
- C2 -
4C5J
4
?
D:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
-----
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
23
PsiBlast_CBE
96.84
100%
-94
- C2 -
4C5M
6
?
D:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
---
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
30
PsiBlast_CBE
96.79
100%
-94
- C2 -
4C5K
4
?
B:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
24
PsiBlast_CBE
96.71
100%
-94
- C2 -
4C5M
5
?
C:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
---
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
27
PsiBlast_CBE
96.60
100%
-92
- C2 -
4C5L
1
?
C:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
5
PsiBlast_PDB
96.52
100%
-95
- C2 -
4C5N
2
?
A:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
--------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
29
PsiBlast_CBE
96.37
100%
-94
- C2 -
4C5K
4
?
C:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
------
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
26
PsiBlast_CBE
96.37
100%
-96
- C2 -
4C5L
2
?
D:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
3
PsiBlast_PDB
95.21
100%
-96
- C2 -
4C5L
3
?
A:
[2-276]
-
A
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
-
K
D
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
-
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
N
A
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
L
G
K
L
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
------
K
S
Y
D
L
Y
Y
D
G
Q
T
F
Y
Q
L
T
T
D
M
F
--
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
--
W
K
M
N
D
F
V
G
P
V
D
H
G
A
Y
N
R
I
E
H
I
D
V
E
V
T
E
V
6
PsiBlast_PDB
77.95
51%
-82
- C2 -
2I5B
1
PDXK_BACSU
A:
[3-264]
--
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
-
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
L
K
T
V
D
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
--
F
P
L
N
Q
Y
V
G
P
T
K
H
S
A
--------------
36
PsiBlast_CBE
77.61
51%
-79
- C2 -
2I5B
1
PDXK_BACSU
C:
[3-264]
--
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
-
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
L
K
T
V
D
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
--
F
P
L
N
Q
Y
V
G
P
T
K
H
S
A
--------------
35
PsiBlast_CBE
77.56
51%
-81
- C2 -
2I5B
1
PDXK_BACSU
D:
[2-264]
-
S
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
-
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
M
D
E
L
K
T
V
D
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
K
A
V
D
V
L
Y
D
G
E
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
--
F
P
L
N
Q
Y
V
G
P
T
K
H
S
A
--------------
39
PsiBlast_CBE
65.45
31%
-77
- C2 -
1JXI
3
THID_SALTY
B:
[29-283]
------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
-
E
-
N
T
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
-
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
DT
L
E
V
G
K
G
I
G
P
V
H
H
----------------
9
PsiBlast_PDB
64.62
31%
-76
- C2 -
1JXI
3
THID_SALTY
A:
[29-283]
------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
-
E
-
N
T
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
-
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
----------
D
W
L
F
T
R
E
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
DT
L
E
V
G
K
G
I
G
P
V
H
H
----------------