@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0562: (2016-03-16 )
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMEKGTITGRMVIKF
Atome Classification :
(28 SA)
......--..-.-10-........20........30........40....---....50-.-.---------.----...--...60........70........80.--.......90........100.--......-110----.-----...-----------------....120.-...-...130-----.......140--.........150....--..--..160.-......170.......180.......190.......200.......210....-...220....-...230...-....240.......250.......260....-...270........280.......290.......300......-.310.-------......320.......330....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
A
A
V
V
--TK-D-
H
K
-
V
SIEDK
K
L
R
ALKPGE
A
L
V
Q
TEYCG
V
C
HT
D
L
H
V
KN---ADFGD--V-T---------
G
----
V
TL--G
H
E
G
I
G
K
V
I
E
V
A
E
D
V
E
SLKIGD
R
V
S
I
--
A
W
M
F
E
SCGRCEYCTT
G
R
E
T
L
C
--
R
S
V
K
NA-
G
Y
-----T-----VDG-----------------AMA
E
Q
V
I
V
-TA
D
-
Y
A
VKVP-----EKLDPAAA----S
S
I
T
CAGV
T
T
Y
-
K
A
V
K
--VS--NVKPG
Q
-
W
L
G
V
FGIG
G
L
G
N
L
A
L
Q
Y
A
K
NVMG
A
K
I
V
A
F
DIND
D
K
L
A
F
A
K
ELGA
D
A
IINSKD
V
-
D
P
V
A
E
V
M
K
LT-DNKGL
D
A
T
V
-
V
T
S
V
AKT
P
F
N
Q
A
V
D
V
V
KAG
A
R
V
V
A
VGLPVDK-MNLD
I
-
P
R
L
V
L
D
G
I
E
V
V
G
S
L
VG
T
R
Q
D
L
R
E
A
F
E
F
A
AENKVT
P
K
V
-
Q
L
R
K
L
-------
E
E
I
N
D
I
F
E
E
M
E
KGTIT
G
R
M
V
I
KF
24
PsiBlast_CBE
98.03
69%
-99
- C1 -
4GKV
6
ADHP_ECOLI
B:
[1-334]
M
K
A
A
V
V
--
T
K
-
D
-
H
H
-
V
D
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
---
G
D
F
G
D
--
K
-
T
---------
G
----
V
I
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
--
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
--
R
S
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
C
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
S
A
A
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
V
K
--
L
S
--
K
I
R
P
G
Q
-
W
I
A
I
Y
G
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
H
T
E
-
D
A
A
K
I
V
Q
E
K
T
-
G
--
G
A
H
A
A
V
-
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
-
M
S
L
D
I
-
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
-
A
L
R
P
L
-------
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
2
PsiBlast_PDB
97.99
69%
-101
- C1 -
4GKV
4
ADHP_ECOLI
A:
[1-334]
M
K
A
A
V
V
--
T
K
-
D
-
H
H
-
V
D
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
---
G
D
F
G
D
--
K
-
T
---------
G
----
V
I
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
--
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
--
R
S
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
C
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
S
A
A
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
V
K
--
L
S
--
K
I
R
P
G
Q
-
W
I
A
I
Y
G
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
H
T
E
-
D
A
A
K
I
V
Q
E
K
T
-
G
--
G
A
H
A
A
V
-
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
-
M
S
L
D
I
-
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
-
A
L
R
P
L
-------
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
22
PsiBlast_CBE
97.64
69%
-99
- C1 -
4GKV
4
ADHP_ECOLI
D:
[1-334]
M
K
A
A
V
V
--
T
K
-
D
-
H
H
-
V
D
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
---
G
D
F
G
D
--
K
-
T
---------
G
----
V
I
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
--
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
--
R
S
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
C
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
S
A
A
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
V
K
--
L
S
--
K
I
R
P
G
Q
-
W
I
A
I
Y
G
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
H
T
E
-
D
A
A
K
I
V
Q
E
K
T
-
G
--
G
A
H
A
A
V
-
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
-
M
S
L
D
I
-
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
-
A
L
R
P
L
-------
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
23
PsiBlast_CBE
96.49
69%
-100
- C1 -
4GKV
6
ADHP_ECOLI
C:
[1-334]
M
K
A
A
V
V
--
T
K
-
D
-
H
H
-
V
D
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
---
G
D
F
G
D
--
K
-
T
---------
G
----
V
I
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
--
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
--
R
S
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
C
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
S
A
A
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
V
K
--
L
S
--
K
I
R
P
G
Q
-
W
I
A
I
Y
G
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
H
T
E
-
D
A
A
K
I
V
Q
E
K
T
-
G
--
G
A
H
A
A
V
-
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
-
M
S
L
D
I
-
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
-
A
L
R
P
L
-------
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
3
PsiBlast_PDB
89.19
62%
-94
- C1 -
4EEZ
3
?
A:
[1-338]
M
K
A
A
V
V
R
H
N
P
-
D
-
G
Y
-
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
---
G
D
F
G
N
--
K
-
A
---------
G
----
T
V
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
--
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
--
R
E
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
A
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
P
I
E
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
I
K
--
V
S
--
G
V
K
P
G
D
-
W
Q
V
I
F
G
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
T
I
N
S
G
D
V
-
N
P
V
D
E
I
K
K
I
T
-
G
G
L
G
V
Q
S
A
I
-
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
V
P
N
T
E
-
M
T
L
S
V
-
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
-
A
T
R
K
L
-------
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
21
PsiBlast_CBE
88.95
62%
-98
- C1 -
4EEX
3
?
B:
[1-338]
M
K
A
A
V
V
RH
N
P
-
D
-
G
Y
-
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
---
G
D
Y
G
N
--
K
-
A
---------
G
----
T
V
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
--
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
--
R
E
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
A
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
P
I
E
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
I
K
--
V
S
--
G
V
K
P
G
D
-
W
Q
V
I
F
G
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
I
I
N
S
G
D
V
-
N
P
V
D
E
I
K
K
I
T
-
G
G
L
G
V
Q
S
A
I
-
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
L
P
N
T
E
-
M
T
L
S
V
-
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
-
A
T
R
K
L
-------
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
25
PsiBlast_CBE
88.73
62%
-98
- C1 -
4EEZ
3
?
B:
[1-338]
M
K
A
A
V
V
RH
N
P
-
D
-
G
Y
-
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
---
G
D
F
G
N
--
K
-
A
---------
G
----
T
V
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
--
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
--
R
E
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
A
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
P
I
E
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
I
K
--
V
S
--
G
V
K
P
G
D
-
W
Q
V
I
F
G
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
T
I
N
S
G
D
V
-
N
P
V
D
E
I
K
K
I
T
-
G
G
L
G
V
Q
S
A
I
-
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
V
P
N
T
E
-
M
T
L
S
V
-
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
-
A
T
R
K
L
-------
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
1
PsiBlast_PDB
86.84
62%
-97
- C1 -
4EEX
3
?
A:
[1-338]
M
K
A
A
V
V
R
H
N
P
-
D
-
G
Y
-
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
---
G
D
Y
G
N
--
K
-
A
---------
G
----
T
V
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
--
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
--
R
E
V
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
M
A
E
E
A
I
V
-
V
A
D
-
Y
A
V
K
V
P
-----
D
G
L
D
P
I
E
A
----
S
S
I
T
C
A
G
V
T
T
Y
-
K
A
I
K
--
V
S
--
G
V
K
P
G
D
-
W
Q
V
I
F
G
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
I
I
N
S
G
D
V
-
N
P
V
D
E
I
K
K
I
T
-
G
G
L
G
V
Q
S
A
I
-
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
L
P
N
T
E
-
M
T
L
S
V
-
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
-
A
T
R
K
L
-------
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
27
PsiBlast_CBE
82.85
48%
-101
- C1 -
1RJW
5
ADH3_GEOSE
C:
[1-336]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
31
PsiBlast_CBE
82.25
48%
-101
- C1 -
3PII
5
ADH3_GEOSE
B:
[1-334]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
--
26
PsiBlast_CBE
81.08
48%
-100
- C1 -
1RJW
6
ADH3_GEOSE
D:
[1-336]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
5
PsiBlast_PDB
81.07
48%
-100
- C1 -
3PII
5
ADH3_GEOSE
A:
[1-334]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
--
4
PsiBlast_PDB
80.71
48%
-101
- C1 -
1RJW
4
ADH3_GEOSE
A:
[1-336]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
48
PsiBlast_CBE
79.95
40%
-96
- C1 -
3S2I
5
?
B:
[3-338]
M
K
A
A
V
V
--
R
A
F
G
-
A
P
-
L
T
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
---
G
D
W
P
V
--
K
-
P
---------
T
----
L
P
F
IP
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
R
V
K
E
G
D
R
V
G
V
--
P
W
L
Y
S
A
C
G
Y
C
E
H
C
L
Q
G
W
E
T
L
C
--
E
K
Q
Q
N
T
-
G
Y
-----
S
-----
V
N
G
-----------------
G
Y
G
E
Y
V
V
A
-
D
P
N
-
Y
V
G
L
L
P
-----
D
K
V
G
F
V
E
I
----
A
P
I
L
C
A
G
V
T
V
Y
-
K
G
L
K
--
V
T
--
D
T
R
P
G
Q
-
W
V
V
I
S
G
I
G
G
L
G
H
V
A
V
Q
Y
A
R
-
A
M
G
L
R
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
T
-
D
P
A
A
W
L
Q
K
---
E
I
G
G
A
H
G
V
L
-
V
T
A
V
S
P
K
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
D
-
F
G
T
P
I
-
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
A
T
V
-
S
T
A
K
L
-------
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
28
PsiBlast_CBE
79.95
48%
-100
- C1 -
1RJW
6
ADH3_GEOSE
B:
[1-336]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
46
PsiBlast_CBE
79.82
40%
-96
- C1 -
3S2I
3
?
D:
[3-338]
M
K
A
A
V
V
--
R
A
F
G
-
A
P
-
L
T
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
---
G
D
W
P
V
--
K
-
P
---------
T
----
L
P
F
IP
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
R
V
K
E
G
D
R
V
G
V
--
P
W
L
Y
S
A
C
G
Y
C
E
H
C
L
Q
G
W
E
T
L
C
--
E
K
Q
Q
N
T
-
G
Y
-----
S
-----
V
N
G
-----------------
G
Y
G
E
Y
V
V
A
-
D
P
N
-
Y
V
G
L
L
P
-----
D
K
V
G
F
V
E
I
----
A
P
I
L
C
A
G
V
T
V
Y
-
K
G
L
K
--
V
T
--
D
T
R
P
G
Q
-
W
V
V
I
S
G
I
G
G
L
G
H
V
A
V
Q
Y
A
R
-
A
M
G
L
R
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
T
-
D
P
A
A
W
L
Q
K
---
E
I
G
G
A
H
G
V
L
-
V
T
A
V
S
P
K
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
D
-
F
G
T
P
I
-
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
A
T
V
-
S
T
A
K
L
-------
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
29
PsiBlast_CBE
79.71
48%
-103
- C1 -
3PII
4
ADH3_GEOSE
D:
[1-334]
M
K
A
A
V
V
--
E
Q
F
K
-
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
---
G
D
W
P
V
--
K
-
P
---------
K
----
L
P
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
--
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
--
E
H
Q
K
N
A
-
G
Y
-----
S
-----
V
D
G
-----------------
G
Y
A
E
Y
C
R
A
-
A
A
D
-
Y
V
V
K
I
P
-----
D
N
L
S
F
E
E
A
----
A
P
I
F
C
A
G
V
T
T
Y
-
K
A
L
K
--
V
T
--
G
A
K
P
G
E
-
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
-
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
-
D
-
A
A
K
F
M
K
-
E
-
K
V
G
G
V
H
A
A
V
-
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
-
M
P
I
P
I
-
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
-
E
V
Q
P
L
-------
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
--
41
PsiBlast_CBE
79.70
42%
-102
- C1 -
3MEQ
10
?
B:
[26-363]
M
K
A
A
V
V
--
R
A
-
F
-
G
K
P
L
T
I
D
E
V
P
I
P
Q
P
G
P
G
Q
I
Q
V
A
I
Q
A
S
G
V
C
H
T
D
L
H
A
A
E
---
G
D
W
P
V
--
K
-
P
---------
N
----
P
P
F
IP
G
H
E
G
V
G
F
V
S
A
V
G
S
G
V
K
H
V
K
E
G
D
R
V
G
I
--
P
W
L
Y
T
A
C
G
H
C
R
H
C
L
G
G
W
E
T
L
C
--
E
E
Q
L
N
T
-
G
Y
-----
S
-----
V
N
G
-----------------
G
F
A
E
Y
V
V
A
-
D
P
N
-
F
V
G
H
L
P
-----
K
N
I
D
F
N
E
I
----
A
P
V
L
C
A
G
V
T
V
Y
-
K
G
L
K
--
V
T
--
D
T
K
P
G
D
-
W
V
V
I
S
G
I
G
G
L
G
H
M
A
V
Q
Y
A
R
-
A
M
G
L
N
V
A
A
V
D
I
D
D
R
K
L
D
L
A
R
R
L
G
A
T
V
T
V
N
A
K
T
V
A
D
P
A
A
Y
I
R
K
E
T
-
D
G
-
G
A
Q
G
V
L
-
V
T
A
V
S
P
K
A
F
E
Q
A
L
G
M
V
A
R
G
G
T
V
S
L
N
G
L
P
P
G
D
-
F
P
L
S
I
-
F
N
M
V
L
N
G
V
T
V
R
G
S
I
V
G
T
R
L
D
L
Q
E
S
L
D
F
A
A
D
G
K
V
K
A
T
I
-
Q
T
G
K
L
-------
E
D
I
N
A
I
F
D
D
M
R
-----
G
R
I
V
M
D
L
53
PsiBlast_CBE
79.68
40%
-96
- C1 -
3S2G
3
?
D:
[3-338]
M
K
A
A
V
V
--
R
A
F
G
-
A
P
-
L
T
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
---
G
D
W
P
V
--
K
-
P
---------
T
----
L
P
F
IP
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
R
V
K
E
G
D
R
V
G
V
--
P
W
L
Y
S
A
C
G
Y
C
E
H
C
L
Q
G
W
E
T
L
C
--
E
K
Q
Q
N
T
-
G
Y
-----
S
-----
V
N
G
-----------------
G
Y
G
E
Y
V
V
A
-
D
P
N
-
Y
V
G
L
L
P
-----
D
K
V
G
F
V
E
I
----
A
P
I
L
C
A
G
V
T
V
Y
-
K
G
L
K
--
V
T
--
D
T
R
P
G
Q
-
W
V
V
I
S
G
I
G
G
L
G
H
V
A
V
Q
Y
A
R
-
A
M
G
L
R
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
T
-
D
P
A
A
W
L
Q
K
---
E
I
G
G
A
H
G
V
L
-
V
T
A
V
S
P
K
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
D
-
F
G
T
P
I
-
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
A
T
V
-
S
T
A
K
L
-------
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
68
PsiBlast_CBE
79.63
40%
-94
- C1 -
3S2E
4
?
C:
[3-338]
M
K
A
A
V
V
--
R
A
F
G
-
A
P
-
L
T
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
---
G
D
W
P
V
--
K
-
P
---------
T
----
L
P
F
IP
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
R
V
K
E
G
D
R
V
G
V
--
P
W
L
Y
S
A
C
G
Y
C
E
H
C
L
Q
G
W
E
T
L
C
--
E
K
Q
Q
N
T
-
G
Y
-----
S
-----
V
N
G
-----------------
G
Y
G
E
Y
V
V
A
-
D
P
N
-
Y
V
G
L
L
P
-----
D
K
V
G
F
V
E
I
----
A
P
I
L
C
A
G
V
T
V
Y
-
K
G
L
K
--
V
T
--
D
T
R
P
G
Q
-
W
V
V
I
S
G
I
G
G
L
G
H
V
A
V
Q
Y
A
R
-
A
M
G
L
R
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
T
-
D
P
A
A
W
L
Q
K
---
E
I
G
G
A
H
G
V
L
-
V
T
A
V
S
P
K
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
D
-
F
G
T
P
I
-
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
A
T
V
-
S
T
A
K
L
-------
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
17
PsiBlast_PDB
64.76
34%
-83
- C1 -
1R37
5
ADH_SULSO
A:
[1-345]
M
R
A
V
R
L
--
V
E
-
I
-
G
K
P
L
S
L
Q
E
I
G
V
P
K
P
K
G
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
---
G
R
F
G
N
--
L
-
R
IVEDLGVKL
P
----
V
T
L
--
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
G
Y
S
K
G
D
L
V
A
V
N-
P
W
Q
G
E
--
G
N
C
Y
Y
C
R
I
G
E
E
H
L
C
--
D
S
P
R
W
L
-
G
I
-----
N
-----
F
D
G
-----------------
A
Y
A
E
Y
V
I
V
-
P
H
Y
-
K
Y
M
Y
K
L
-----
R
R
L
N
A
V
E
A
----
A
P
L
T
C
S
G
I
T
T
Y
-
R
A
V
R
--
K
A
--
S
L
D
P
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
Q
-
D
P
L
A
E
I
R
R
I
T
-
E
S
K
G
V
D
A
V
I
-
D
L
N
N
S
E
K
T
L
S
V
Y
P
K
A
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
D
-
L
H
Y
H
A
-
P
L
I
T
L
S
E
I
Q
F
V
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
P
M
I
T
K
T
M
K
L
-------
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
--
82
PsiBlast_CBE
63.65
34%
-84
- C1 -
1R37
6
ADH_SULSO
B:
[1-345]
M
R
A
V
R
L
--
V
E
-
I
-
G
K
P
L
S
L
Q
E
I
G
V
P
K
P
K
G
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
---
G
R
F
G
N
--
L
-
R
IVEDLGVKL
P
----
V
T
L
--
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
G
Y
S
K
G
D
L
V
A
V
N-
P
W
Q
G
E
--
G
N
C
Y
Y
C
R
I
G
E
E
H
L
C
--
D
S
P
R
W
L
-
G
I
-----
N
-----
F
D
G
-----------------
A
Y
A
E
Y
V
I
V
-
P
H
Y
-
K
Y
M
Y
K
L
-----
R
R
L
N
A
V
E
A
----
A
P
L
T
C
S
G
I
T
T
Y
-
R
A
V
R
--
K
A
--
S
L
D
P
T
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
Q
-
D
P
L
A
E
I
R
R
I
T
-
E
S
K
G
V
D
A
V
I
-
D
L
N
N
S
E
K
T
L
S
V
Y
P
K
A
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
D
-
L
H
Y
H
A
-
P
L
I
T
L
S
E
I
Q
F
V
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
P
M
I
T
K
T
M
K
L
-------
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
--
88
PsiBlast_CBE
63.25
32%
-99
- C1 -
1H2B
4
?
B:
[43-357]
------------------------------
D
V
I
V
R
I
A
G
A
G
V
C
H
T
D
L
H
L
V
Q
---
G
M
W
H
E
--
L
-
L
---------
Q
PKLP
Y
T
L
--
G
H
E
N
V
G
Y
I
E
E
V
A
E
G
V
E
G
L
E
K
G
D
P
V
-
I
--
L
H
P
A
V
T
D
G
T
C
L
A
C
R
A
G
E
D
M
H
C
--
E
N
L
E
F
P
-
G
L
-----
N
-----
I
D
G
-----------------
G
F
A
E
F
M
R
T
-
S
H
R
-
S
V
I
K
L
P
KDIS
R
E
K
L
--
V
E
M
----
A
P
L
A
D
A
G
I
T
A
Y
-
R
A
V
K
K
A
A
R
--
T
L
Y
P
G
A
-
Y
V
A
I
V
G
V
G
G
L
G
H
I
A
V
Q
L
L
K
V
M
T
P
A
T
V
I
A
L
D
V
K
E
E
K
L
K
L
A
E
R
L
G
A
D
H
V
V
D
A
R
R
--
D
P
V
K
Q
V
M
E
L
T
-
R
G
R
G
V
N
V
A
M
-
D
F
V
G
S
Q
A
T
V
D
Y
T
P
Y
L
L
G
R
M
G
R
L
I
I
V
G
Y
G
-
G
E
-
L
R
F
P
T
-
I
R
V
I
S
S
E
V
S
F
E
G
S
L
V
G
N
Y
V
E
L
H
E
L
V
T
L
A
L
Q
G
K
V
R
V
E
V
-
D
I
H
K
L
-------
D
E
I
N
D
V
L
E
R
L
E
K
G
E
V
L
G
R
A
V
L
--
107
HHSearch
61.73
31%
-89
- C1 -
3JV7
7
?
A:
[1-345]
M
K
A
V
Q
Y
--
T
E
-
I
G
S
E
-
P
V
V
V
D
I
P
T
P
T
P
G
P
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
D
---
M
P
A
A
Q
YA
Y
G
L
---------
P
----
L
T
L
--
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
G
F
G
V
G
D
A
V
A
V
--
Y
G
P
-
W
G
C
G
A
C
H
A
C
A
R
G
R
E
N
Y
C
--
T
R
A
A
D
L
-
G
I
TPPGL
G
-----
S
P
G
-----------------
S
M
A
E
Y
M
I
V
-
D
S
A
R
H
L
V
P
I
G
------
D
L
D
P
V
A
A
----
A
P
L
T
D
A
G
L
T
P
Y
-
H
A
I
S
--
R
V
LP
L
L
G
P
G
S
-
T
A
V
V
I
G
V
G
G
L
G
H
V
G
I
Q
I
L
R
A
V
S
A
A
R
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
G
A
G
--
A
A
-
D
A
I
R
E
L
T
G
G
Q
G
A
T
A
V
F
-
D
F
V
G
A
Q
S
T
I
D
T
A
Q
Q
V
V
A
V
D
G
H
I
S
V
V
G
I
H
A
G
A
H
A
K
V
G
F
-
F
M
I
P
F
-
G
A
S
V
V
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
I
H
T
-
E
T
F
T
L
-------
D
E
G
P
A
A
Y
R
R
L
R
E
G
S
I
R
G
R
G
V
V
V
P
93
PsiBlast_CBE
59.81
32%
-93
- C1 -
2XAA
5
?
D:
[25-343]
----------------------------
P
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
D
MPA
A
Q
Y
A
Y
--
G
-
L
---------
P
----
L
T
L
--
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
G
F
G
V
G
D
A
V
A
V
YG
P
W
---
G
C
G
A
C
H
A
C
A
R
G
R
E
N
Y
C
--
T
R
A
A
D
L
-
G
I
-----
T
PPGLG
S
P
G
-----------------
S
M
A
E
Y
M
I
V
D
S
A
R
-
H
L
V
P
I
G
-----
D
-
L
D
P
V
A
A
----
A
P
L
T
D
A
G
L
T
P
Y
-
H
A
I
S
R
V
L
P
--
L
L
G
P
G
S
-
T
A
V
V
I
G
V
G
G
L
G
H
V
G
I
Q
I
L
R
A
V
S
A
A
R
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
G
-
A
-
G
A
A
D
A
I
R
E
L
T
-
G
G
Q
G
A
T
A
V
F
-
D
F
V
G
A
Q
S
T
I
D
T
A
Q
Q
V
V
A
V
D
G
H
I
S
V
V
G
I
H
A
G
A
-
H
A
K
V
G
-
F
F
M
I
P
F
G
A
S
V
V
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
I
H
T
-
E
T
F
T
L
-------
D
E
G
P
A
A
Y
R
R
L
R
E
G
S
I
R
G
R
G
V
V
--
92
PsiBlast_CBE
59.33
32%
-92
- C1 -
3JV7
7
?
A:
[25-343]
----------------------------
P
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
D
MPA
A
Q
Y
A
Y
--
G
-
L
---------
P
----
L
T
L
--
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
G
F
G
V
G
D
A
V
A
V
YG
P
W
---
G
C
G
A
C
H
A
C
A
R
G
R
E
N
Y
C
--
T
R
A
A
D
L
-
G
I
-----
T
PPGLG
S
P
G
-----------------
S
M
A
E
Y
M
I
V
D
S
A
R
-
H
L
V
P
I
G
-----
D
-
L
D
P
V
A
A
----
A
P
L
T
D
A
G
L
T
P
Y
-
H
A
I
S
R
V
L
P
--
L
L
G
P
G
S
-
T
A
V
V
I
G
V
G
G
L
G
H
V
G
I
Q
I
L
R
A
V
S
A
A
R
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
G
-
A
-
G
A
A
D
A
I
R
E
L
T
-
G
G
Q
G
A
T
A
V
F
-
D
F
V
G
A
Q
S
T
I
D
T
A
Q
Q
V
V
A
V
D
G
H
I
S
V
V
G
I
H
A
G
A
-
H
A
K
V
G
-
F
F
M
I
P
F
G
A
S
V
V
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
I
H
T
-
E
T
F
T
L
-------
D
E
G
P
A
A
Y
R
R
L
R
E
G
S
I
R
G
R
G
V
V
--
94
PsiBlast_CBE
57.00
32%
-92
- C1 -
2XAA
5
?
C:
[25-343]
----------------------------
P
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
D
MPA
A
Q
Y
A
Y
--
G
-
L
---------
P
----
L
T
L
--
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
G
F
G
V
G
D
A
V
A
V
YG
P
W
---
G
C
G
A
C
H
A
C
A
R
G
R
E
N
Y
C
--
T
R
A
A
D
L
-
G
I
-----
T
PPGLG
S
P
G
-----------------
S
M
A
E
Y
M
I
V
D
S
A
R
-
H
L
V
P
I
G
-----
D
-
L
D
P
V
A
A
----
A
P
L
T
D
A
G
L
T
P
Y
-
H
A
I
S
R
V
L
P
--
L
L
G
P
G
S
-
T
A
V
V
I
G
V
G
G
L
G
H
V
G
I
Q
I
L
R
A
V
S
A
A
R
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
G
-
A
-
G
A
A
D
A
I
R
E
L
T
-
G
G
-
G
A
T
A
V
F
-
D
F
V
G
A
Q
S
T
I
D
T
A
Q
Q
V
V
A
V
D
G
H
I
S
V
V
G
I
H
A
G
A
-
H
A
K
V
G
-
F
F
M
I
P
F
G
A
S
V
V
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
I
H
T
-
E
T
F
T
L
-------
D
E
G
P
A
A
Y
R
R
L
R
E
G
S
I
R
G
R
G
V
V
--
102
PsiBlast_CBE
47.29
31%
-77
- C1 -
1HSO
5
ADH1A_HUMAN
A:
[10-365]
-
K
A
A
V
L
--
W
E
-
L
-
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
---
G
T
M
V
T
--
P
-
L
---------
P
----
V
I
L
--
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
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----------