@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0599: (2016-03-17 )
MKRENPLFFLFKKLSWPVGLIVAAITISSLGSLSGLLVPLFTGRIVDKFSVSHINWNLIALFGGIFVINALLSGLGLYLLSKIGEKIIYAIRSVLWEHIIQLKMPFFDKNESGQLMSRLTDDTKVINEFISQKLPNLLPSIVTLVGSLIMLFILDWKMTLLTFITIPIFVLIMIPLGRIMQKISTSTQSEIANFSGLLGRVLTEMRLVKISNTERLELDNAHKNLNEIYKLGLKQAKIAAVVQPISGIVMLLTIAIILGFGALEIATGAITAGTLIAMIFYVIQLSMPLINLSTLVTDYKKAVGASSRIYEIMQEPIEPTEALEDSENVLIDDGVLSFEHVDFKYDVKKILDDVSFQIPQGQVSAFVGPSGSGKSTIFNLIERMYEIESGDIKYGLESVYDIPLSKWRRKIGYVMQSNSMMSGTIRDNILYGINRHVSDEELINYAKLANCHDFIMQFDEGYDTLVGERGLKLSGGQRQRIDIARSFVKNPDILLLDEATANLDSESELKIQEALETLMEGRTTIVIAHRLSTIKKAGQIIFLDKGQVTGKGTHSELMASHAKYKNFVVSQKLTD
Atome Classification :
(65 SA)
.........10........20.........30........40.---......-.50..------..-----.--...60.----..---....-.70........80........90........100.......110.......120.......130.......140.......150.......160.......170........180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.------......320---....---.....330-.----......340...--.-.---.---.---350.......360.......370.......380......---.390.......400...--..-..410.......420.......430..--..--...440.......450.......460.......470.......480.......490.......500.......510.......--520.........530.......540.......550.......560.........570...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKREN
P
L
F
F
L
F
K
K
LSW
P
V
G
L
-
I
V
A
A
I
T
I
S
S
L
G
S
L
S
G
L
L
V
P
LFT---G
R
I
V
D
K
-
F
S
VSH------I
N
-----
W
--
N
L
I
A
L
F
----
G
G
---
I
F
V
I
-
N
A
L
L
S
G
L
G
L
Y
L
L
S
K
I
G
E
K
I
I
Y
A
I
R
S
V
L
W
E
H
I
I
Q
LKMPFFDKNES
G
Q
L
M
S
R
LTD
D
T
K
V
I
N
E
F
I
S
Q
K
L
P
N
L
L
P
S
I
V
T
L
V
G
S
L
I
M
L
F
I
L
D
W
K
M
T
L
L
T
F
I
T
I
P
I
F
V
L
-
I
M
I
P
L
G
R
I
M
Q
K
IST
S
T
Q
S
E
I
A
N
F
S
G
L
L
G
R
V
L
T
E
M
R
L
V
K
ISNT
E
R
L
EL
D
N
A
H
K
N
L
N
E
I
Y
K
LGL
K
Q
A
K
I
A
A
V
V
Q
P
I
S
G
I
V
M
L
L
T
I
A
I
I
L
GF
G
A
L
E
IATGA
I
T
A
G
T
L
I
A
M
I
F
Y
V
I
Q
LSM
P
L
I
N
L
S
T
L
V
T
D
Y
K
K
AVGA
S
S
R
I
Y
E
I
M
------QEPIE
P
T
-----
E
ALE---DSE
N
V
L
ID-D----GV
L
S
F
E
HVD
F
K
Y
--
D
-
V
---
K
---
K
---
I
L
D
D
VSFQIPQG
Q
V
S
A
F
VGPSGS
G
K
S
T
I
F
N
L
I
E
R
M
Y
EIE---SGD
I
K
Y
G
L
E
S
V
YDI
P
L
S
--
K
W
-
R
R
KI
G
Y
V
MQSNSMMSGTI
R
D
N
I
L
Y
G
IN--RH--V
S
D
E
E
L
I
N
Y
A
K
L
A
N
C
H
D
F
I
M
Q
FDE
G
Y
D
T
L
V
GERGLKLSGGQ
R
Q
R
I
D
I
A
R
S
F
VKNP
D
I
L
L
LDEATANLD
S
E
S
E
L
K
I
Q
E
A
L
E
T
L
M--E--G
R
T
T
I
V
I
A
H
R
L
S
T
I
K
KA
G
Q
I
I
F
L
DKGQVTGKG
T
H
S
E
L
M
A
S
--
H
A
K
Y
K
N
F
V
V
SQKLTD
10
PsiBlast_PDB
87.72
33%
-101
- C2 -
4Q4A
1
Y288_THEMA
B:
[47-590]
-----------------------------
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
---
G
K
T
I
D
V
-
V
F
V
P
R
-------
R
-----
F
--
D
L
L
P
R
Y
M
L
I
L
G
T
---
I
Y
A
L
-
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L----
E
E
E
K
D
D
P
-----
D
A
V
E
---
L
R
E
V
-----
R
----
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
---
K
---
K
P--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
--
S
L
-
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
----
5
PsiBlast_PDB
87.11
33%
-102
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[19-570]
-----------
R
R
L
A
A
A
V
G
F
-
L
----
T
M
S
S
V
I
S
M
S
---
A
P
F
F
L
---
G
K
I
I
D
V
I
Y
T
N
P
T
------
V
D
-----
Y
S
D
N
L
T
R
L
C
----
L
G
L
S
A
V
F
L
C
-
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
------
E
R
--
E
P
K
-------
L
P
---
F
N
E
G
V
I
L
N
-
E
KSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
---
R
---
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
--
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
------------------
115
HHSearch
87.03
32%
-100
- C2 -
3WMG
5
?
A:
[30-598]
----------------------
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
---
G
R
M
F
Q
V
-
F
T
K
S
K
S
Q
I
E
G
-
E
T
-----
W
--
K
Y
S
V
G
F
----
V
G
---
I
G
V
F
-
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
-
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
------
D
R
V
P
Q
Y
R
-----
R
P
D
P
G
A
E
V
V
T
Q
P
L
V
L
-
K
----
Q
G
I
V
F
E
N
V
H
F
R
Y
--
P
-
T
RMN
V
---
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
--
A
L
-
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
R
--
D
---
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-
11
PsiBlast_PDB
86.96
33%
-99
- C2 -
4Q4H
-
Y288_THEMA
B:
[47-590]
-----------------------------
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
---
G
K
T
I
D
V
-
V
F
V
P
R
-------
R
-----
F
--
D
L
L
P
R
Y
M
L
I
L
G
T
---
I
Y
A
L
-
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
----
E
E
E
K
D
D
P
-----
D
A
V
E
---
L
R
E
V
-----
R
----
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
---
K
---
K
P--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
--
S
L
-
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
----
9
PsiBlast_PDB
86.75
33%
-104
- C2 -
3QF4
1
Y288_THEMA
B:
[47-590]
-----------------------------
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
---
G
K
T
I
D
V
-
V
F
V
P
R
-------
R
-----
F
--
D
L
L
P
R
Y
M
L
I
L
G
T
---
I
Y
A
L
-
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L----
E
E
E
K
D
D
P
-----
D
A
V
E
---
L
R
E
V
-----
R
----
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
---
K
---
K
P--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
--
S
L
-
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
----
114
HHSearch
86.53
32%
-98
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[12-572]
------------
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
---
G
K
I
I
D
V
-
I
Y
T
N
P
TVDY
S
D
N
L
-----
T
--
R
L
C
L
G
L
----
S
A
---
V
F
L
C
-
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
------
E
R
E
P
K
L
P
-----
F
N
E
G
---
V
I
L
N
E
K
S
F
-
Q
----
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
RPE
V
---
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
--
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
--
D
P
SS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P----------------
6
PsiBlast_PDB
86.26
33%
-100
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[19-570]
-----------
R
R
L
A
A
A
V
G
F
-
L
----
T
M
S
S
V
I
S
M
S
---
A
P
F
F
L
---
G
K
I
I
D
V
I
Y
T
N
P
T
------
V
D
-----
Y
S
D
N
L
T
R
L
C
----
L
G
L
S
A
V
F
L
C
-
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
------
E
R
--
E
P
K
-------
L
P
---
F
N
E
G
V
I
L
N
-
E
KSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
---
R
---
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
--
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
------------------
32
PsiBlast_CBE
86.14
33%
-101
- C2 -
4M1M
3
MDR1A_MOUSE
A:
[140-679]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
17
PsiBlast_PDB
85.76
32%
-102
- C2 -
3WMF
-
?
A:
[38-581]
---------------------------------
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
-
F
T
K
S
K
------
S
Q
I
E
G
E
T
W
--
K
Y
S
V
G
F
----
V
G
---
I
G
V
F
-
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
-
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
-
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
RVPQY
R
R
P
D
P
G
A
-----
E
V
V
-----
T
Q
P
L
V
L
K
-
Q
----
G
I
V
-
F
E
N
V
H
F
R
Y
--
P
-
T
---
R
MNV
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
--
A
L
-
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
--
R
D
--
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
------------------
8
PsiBlast_PDB
85.10
33%
-100
- C2 -
4Q4J
-
Y288_THEMA
B:
[47-590]
-----------------------------
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
---
G
K
T
I
D
V
-
V
F
V
P
R
-------
R
-----
F
--
D
L
L
P
R
Y
M
L
I
L
G
T
---
I
Y
A
L
-
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L----
E
E
E
K
D
D
P
-----
D
A
V
E
---
L
R
E
V
-----
R
----
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
---
K
---
K
P--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
--
S
L
-
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
--
P
G
--
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
----
7
PsiBlast_PDB
84.89
33%
-102
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[52-598]
---------------------
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
---
G
K
I
I
D
V
I
Y
T
N
P
T
------
V
D
-----
Y
S
D
N
L
T
R
L
C
----
L
G
L
S
A
V
F
L
C
-
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
------
E
R
--
E
P
K
-------
L
P
---
F
N
E
G
V
I
L
N
-
E
KSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
---
R
---
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
--
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------
31
PsiBlast_CBE
84.87
33%
-98
- C2 -
4M1M
3
MDR1A_MOUSE
B:
[140-686]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
21
PsiBlast_CBE
84.76
36%
-93
- C2 -
2ONJ
4
Y1866_STAAM
B:
[65-578]
----------------------------------------------------------------------------
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
------
D
E
D
Y
D
I
K
-----
N
G
V
----
G
A
Q
P
I
E
I
K
-
Q
----
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
---
N
---
E
AP-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
--
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
--
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--
23
PsiBlast_CBE
84.63
33%
-99
- C2 -
4M2T
2
MDR1A_MOUSE
B:
[140-686]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
25
PsiBlast_CBE
84.53
33%
-99
- C2 -
4M2S
1
MDR1A_MOUSE
B:
[140-686]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
24
PsiBlast_CBE
84.07
33%
-101
- C2 -
4M2T
2
MDR1A_MOUSE
A:
[140-679]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
2
PsiBlast_PDB
83.99
36%
-92
- C2 -
2ONJ
4
Y1866_STAAM
A:
[65-578]
----------------------------------------------------------------------------
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
------
D
E
D
Y
D
I
K
-----
N
G
V
----
G
A
Q
P
I
E
I
K
-
Q
----
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
---
N
---
E
AP-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
--
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
--
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--
26
PsiBlast_CBE
83.97
33%
-102
- C2 -
4M2S
1
MDR1A_MOUSE
A:
[140-679]
-----------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
-
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
--
K
P
S
IDSFS
K
S
G
H
---
K
P
D
N
I
----
Q
----
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
---
R
---
K
EVQ
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
--
Y
L
-
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
-
R
--
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----
19
PsiBlast_PDB
83.89
32%
-103
- C2 -
3WME
-
?
A:
[38-581]
---------------------------------
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
-
F
T
K
S
K
------
S
Q
I
E
G
E
T
W
--
K
Y
S
V
G
F
----
V
G
---
I
G
V
F
-
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
-
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
-
A
G
A
A
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
RVPQY
R
R
P
D
P
G
A
-----
E
V
V
-----
T
Q
P
L
V
L
K
-
Q
----
G
I
V
-
F
E
N
V
H
F
R
Y
--
P
-
T
---
R
MNV
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
--
A
L
-
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
--
R
D
--
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
------------------
18
PsiBlast_PDB
83.85
32%
-101
- C2 -
3WMG
3
?
A:
[38-581]
---------------------------------
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
-
F
T
K
S
K
------
S
Q
I
E
G
E
T
W
--
K
Y
S
V
G
F
----
V
G
---
I
G
V
F
-
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
-
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
-
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
RVPQY
R
R
P
D
P
G
A
-----
E
V
V
-----
T
Q
P
L
V
L
K
-
Q
----
G
I
V
-
F
E
N
V
H
F
R
Y
--
P
-
T
---
R
MNV
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
--
A
L
-
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
--
R
D
--
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
------------------
4
PsiBlast_PDB
83.64
33%
-99
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[19-567]
-----------
R
R
L
A
A
A
V
G
F
-
L
----
T
M
S
S
V
I
S
M
S
---
A
P
F
F
L
---
G
K
I
I
D
V
I
Y
T
N
P
T
------
V
D
-----
Y
S
D
N
L
T
R
L
C
----
L
G
L
S
A
V
F
L
C
-
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
-
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
------
E
R
--
E
P
K
-------
L
P
---
F
N
E
G
V
I
L
N
-
E
KSFQ
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
---
R
---
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
--
W
L
-
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
DP
S
S
--
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------
22
PsiBlast_CBE
83.38
36%
-92
- C2 -
2HYD
3
Y1866_STAAM
B:
[65-578]
----------------------------------------------------------------------------
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
------
D
E
D
Y
D
I
K
-----
N
G
V
----
G
A
Q
P
I
E
I
K
-
Q
----
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
---
N
---
E
AP-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
--
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
--
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--
1
PsiBlast_PDB
83.38
36%
-90
- C2 -
2HYD
3
Y1866_STAAM
A:
[65-578]
----------------------------------------------------------------------------
I
A
L
F
---------
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
-
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
------
D
E
D
Y
D
I
K
-----
N
G
V
----
G
A
Q
P
I
E
I
K
-
Q
----
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
---
N
---
E
AP-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
--
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
--
P
T
--
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--
37
PsiBlast_CBE
74.83
32%
-85
- C2 -
4S0F
2
?
B:
[214-717]
-----------------------------------------------------------------------------
A
G
F
----
A
V
---
I
F
L
L
-
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
-
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
------
E
L
A
T
E
K
------
E
L
R
E
---
D
S
D
D
F
V
I
S
L
K
----
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
-
L
---
R
---
K
P--
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
--
L
I
-
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
--
E
N
--
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
-----------
38
PsiBlast_CBE
74.71
32%
-84
- C2 -
4S0F
2
?
A:
[214-717]
-----------------------------------------------------------------------------
A
G
F
----
A
V
---
I
F
L
L
-
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
-
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
------
E
L
A
T
E
K
------
E
L
R
E
---
D
S
D
D
F
V
I
S
L
K
----
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
-
L
---
R
---
K
P--
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
--
L
I
-
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
--
E
N
--
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
-----------
40
PsiBlast_CBE
66.84
51%
-88
- C2 -
1MV5
3
LMRA_LACLA
C:
[1-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
S
A
R
H
V
D
F
A
Y
--
D
D
S
---
E
---
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
--
N
W
-
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
-
V
S
E
Q
L
T
-
41
PsiBlast_CBE
65.73
51%
-82
- C2 -
1MV5
2
LMRA_LACLA
B:
[1-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
S
A
R
H
V
D
F
A
Y
--
D
D
S
---
E
---
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
--
N
W
-
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
-
V
S
E
Q
L
T
-
42
PsiBlast_CBE
64.40
51%
-85
- C2 -
1MV5
3
LMRA_LACLA
A:
[1-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
S
A
R
H
V
D
F
A
Y
--
D
D
S
---
E
---
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
--
N
W
-
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
-
V
S
E
Q
L
T
-
121
HHSearch
63.61
52%
-82
- C2 -
1MV5
3
LMRA_LACLA
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
--
D
-
D
S--
E
---
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
--
N
W
-
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
----
50
PsiBlast_CBE
63.47
45%
-84
- C2 -
3NH9
3
A:
[52-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
A-
D
-
G
---
R
---
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
--
S
L
-
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
--
A
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
--------
48
PsiBlast_CBE
62.58
45%
-85
- C2 -
3NHB
3
A:
[52-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
A-
D
-----
R
---
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
--
S
L
-
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
--
A
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
--------
124
HHSearch
62.45
44%
-90
- C2 -
2FF7
1
A:
[6-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
I
T
F
R
N
I
R
F
R
Y
--
K
-
P
DS-
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
--
W
L
-
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
--
G
---
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
----
49
PsiBlast_CBE
62.07
45%
-80
- C2 -
3NHA
4
A:
[52-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
A-
D
-----
R
---
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
--
S
L
-
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
--
V
T
--
A
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
G
V
Y
A
D
M
--------
78
PsiBlast_CBE
61.09
35%
-86
- C2 -
4K8O
4
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
76
PsiBlast_CBE
60.64
35%
-87
- C2 -
2IXE
3
D:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
--
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
39
PsiBlast_CBE
60.60
51%
-88
- C2 -
1MV5
3
D:
[1-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
S
A
R
H
V
D
F
A
Y
--
D
D
S
---
E
---
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
--
N
W
-
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
--
G
D
--
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
P
L
Y
A
K
Y
-
V
S
E
Q
L
T
-
72
PsiBlast_CBE
60.13
36%
-85
- C2 -
2IXF
4
D:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
73
PsiBlast_CBE
59.96
36%
-83
- C2 -
2IXF
4
TAP1_RAT
C:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
77
PsiBlast_CBE
59.86
35%
-82
- C2 -
2IXE
4
TAP1_RAT
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
56
PsiBlast_CBE
59.74
46%
-84
- C2 -
2FFB
1
A:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
79
PsiBlast_CBE
59.37
35%
-84
- C2 -
2IXG
2
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
74
PsiBlast_CBE
59.37
36%
-85
- C2 -
2IXF
4
TAP1_RAT
B:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
44
PsiBlast_CBE
59.30
47%
-87
- C2 -
2FF7
1
A:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
75
PsiBlast_CBE
59.16
36%
-85
- C2 -
2IXF
5
TAP1_RAT
A:
[15-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
---
H
PNV
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
-------
119
HHSearch
59.08
35%
-77
- C2 -
2IXE
4
TAP1_RAT
A:
[12-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
-
K
----
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
HPN
V
---
Q
---
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
--
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
--
R
T
--
P
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
--
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
R
S
M
V
E
A
-----
65
PsiBlast_CBE
58.90
46%
-87
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[2-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
67
PsiBlast_CBE
58.60
42%
-83
- C2 -
5DGX
1
?
A:
[16-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
G
N
V
T
I
K
D
L
S
F
A
F
--
G
-
E
---
H
---
K
---
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
--
N
L
-
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
-----
E
--
V
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
--
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
G
L
Y
-----------
64
PsiBlast_CBE
58.44
46%
-90
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[2-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
47
PsiBlast_CBE
58.32
47%
-89
- C2 -
2PMK
1
A:
[4-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
61
PsiBlast_CBE
57.99
46%
-81
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
62
PsiBlast_CBE
57.95
46%
-87
- C2 -
2FFA
2
A:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
80
PsiBlast_CBE
57.92
32%
-74
- C2 -
1JJ7
2
A:
[12-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
G
L
V
Q
F
Q
D
V
S
F
A
Y
--
P
-
N
---
R
---
P
DVL
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
--
Y
L
-
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
--
Q
K
--
P
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
--
E
RY
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
G
C
Y
-----------
59
PsiBlast_CBE
57.86
46%
-84
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
66
PsiBlast_CBE
57.69
46%
-88
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[2-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
63
PsiBlast_CBE
57.39
46%
-84
- C2 -
1XEF
3
D:
[2-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
54
PsiBlast_CBE
57.05
46%
-82
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
53
PsiBlast_CBE
56.96
46%
-78
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
58
PsiBlast_CBE
56.94
46%
-89
- C2 -
2FGJ
2
D:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
52
PsiBlast_CBE
56.70
46%
-84
- C2 -
2FGK
2
D:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
57
PsiBlast_CBE
56.31
46%
-89
- C2 -
3B5J
1
A:
[4-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
60
PsiBlast_CBE
56.08
46%
-80
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
DP
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
55
PsiBlast_CBE
56.00
46%
-80
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[8-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
KP
D
-
S
---
P
---
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
--
P
G
--
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
------------------
81
PsiBlast_CBE
54.58
34%
-74
- C2 -
3VX4
3
?
D:
[28-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
F
L
D
------
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
G--
R
---
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
--
A
L
-
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
--
E
G
--
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
--------
118
HHSearch
51.68
34%
-72
- C2 -
3VX4
3
?
A:
[29-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
-
D
----
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
G--
R
---
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
--
A
L
-
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
--
E
G
--
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
-
D
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
--
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
F
N
------
82
PsiBlast_CBE
51.62
34%
-72
- C2 -
3VX4
3
?
A:
[29-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
------
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
G--
R
---
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
--
A
L
-
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
--
E
G
--
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
Y
N
L
--------