@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0616: (2016-03-17 )
MAILEVKQLTKIYGTKKMAQEVLRDINMSIEEGEFIAIMGPSGSGKTTLLNVLSSIDYISQGSITLKGKKLEKLSNKELSDIRKHDIGFIFQEYNLLHTLTVKENIMLPLTVQKLDKEHMLNRYEKVAEALNILDISDKYPSELSGGQRQRTSAARAFITLPSIIFADEPTGALDSKSTQDLLKRLTRMNEAFKSTIIMVTHDPVAASYANRVVMLKDGQIFTELYQGDDDKHTFFKEIIRVQSVLGGVNYDL
Atome Classification :
(32 SA)
.........10..--......20.---.......30........40........50........60........70--.---------.......80........90.--.......100.....-.-.110..-.---....120-----........130-...-..----.-.140--...-------......150.......160.......170.......180.......-190.......200--------.-..-..-..210..-------.....220..-----....--..230.--......240.......250.----------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
I
L
E
V
K
Q
L
T
K
I
Y--G
T
K
K
M
A
Q
E
V
---
L
R
DINMSIEEG
E
F
I
A
I
MGPSGSG
K
T
T
L
L
N
V
L
S
S
I
D
YISQG
S
I
T
LK
G
K
K
L
--
E
---------
K
LSN
K
E
L
S
D
I
R
K
H
D
I
G
F
I
F
Q
--EYN
L
L
H
T
L
T
VKEN
I
M
-
L
-
P
L
T
V
Q
K-L---
D
K
E
H
M
L
------
N
R
Y
E
K
V
A
E
A
L
N
-ILD-IS----D-KY----
P
S
E-------LSGGQ
R
Q
R
T
S
A
A
R
A
F
I
TL
P
S
I
I
FADEPTGALDSK
S
T
Q
D
L
L
K
R
L
T
R
M
-
N
E
A
F
KS
T
I
I
M
V
TH--------D-P
V
-
A
A
-
S
YA
N
R
V
V
-------
M
LKDG
Q
I
-
F
T
-----
E
L
YQ--GDDD
K
H
--
T
F
F
K
E
I
I
R
V
Q
S
V
LGGVNYDL----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.43
38%
-96
- C1 -
1F3O
2
Y796_METJA
A:
[2-232]
---
I
K
L
K
N
V
T
K
T
Y
-----
K
M
G
E
E
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
---
G
A
M
S
G
E
------
E
R
R
K
R
A
L
E
C
L
K
-
M
A
E
-
L
E
----
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
E
R
E
-----
E
K
L
R
--
G
F
------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
86.10
33%
-99
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[3-249]
-
A
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
P
----
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
-------------
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
G
N
G
K
-
G
---
R
T
A
Q
E
R
------
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
E
-
L
A
----
G
-
R
Y
----
P
H
E
-------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
-
L
R
A
N
G
K
S
A
V
F
V
S
H
--------
D
R
E
E
-
A
L
-
Q
Y
A
D
R
I
A
-------
V
M
K
Q
G
R
I
-
L
Q
TASPH
E
L
Y
R
QP
A
D
L
D
A
A
--
L
F
I
G
E
G
I
V
F
P
A
A
L
-----------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.64
39%
-97
- C1 -
1L2T
4
Y796_METJA
B:
[1-232]
--
M
I
K
L
K
N
V
T
K
T
Y
-----
K
M
G
E
E
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
---
G
A
M
S
G
E
------
E
R
R
K
R
A
L
E
C
L
K
-
M
A
E
-
L
E
----
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
E
R
E
-----
E
K
L
R
--
G
F
------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.89
39%
-96
- C1 -
1L2T
4
Y796_METJA
A:
[1-230]
--
M
I
K
L
K
N
V
T
K
T
Y
-----
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
---
G
A
M
S
G
E
------
E
R
R
K
R
A
L
E
C
L
K
-
M
A
E
-
L
E
----
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
E
R
E
-----
E
K
L
R
----------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
84.63
33%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[3-254]
-
A
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
P
----
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
-------------
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
-
G
L
G
N
G
K
-
G
---
R
T
A
Q
E
R
------
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
E
-
L
A
----
G
-
R
Y
----
P
H
E
-------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
-
L
R
A
N
G
K
S
A
V
F
V
S
H
--------
D
R
E
E
-
A
L
-
Q
Y
A
D
R
I
A
-------
V
M
K
Q
G
R
I
-
L
Q
T
A
S
P
H
E
L
Y
R
QP
A
D
L
D
A
A
--
L
F
I
G
E
G
I
V
F
P
A
A
L
-----------------------------------------------------------------------------------------------------
117
Fugue
84.45
31%
-90
- C1 -
1OXS
23
?
C:
[1-352]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
--
V
V
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
--
A
---------
S
-
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
-
M
---
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
-
I
H
H
-
V
L
----
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
-
Q
S
R
L
G
V
T
L
L
V
V
S
H
--------
D
-
P
A
D
I
F
-
A
I
A
D
R
V
G
-------
V
L
V
K
G
K
L
-
V
Q
VGKPE
D
L
Y
D
--
N
P
V
S
I
Q
VA
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
GSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
108
HHSearch
83.53
37%
-93
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-222]
A
E
I
L
R
A
E
N
I
K
K
V
I
--
R
G
----
Y
E
I
---
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
--
D
---------
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
-
V
-
P
M
L
K
M
G
-
K
---
P
K
K
E
A
K
------
E
R
G
E
Y
L
L
S
E
L
G
-
L
G
D
-
K
L
----
S
-
R
K
----
P
Y
E
-------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
-
N
E
-
G
G
T
S
I
V
M
V
T
H
--------
E
-
R
E
-
L
A
-
E
L
T
H
R
T
L
-------
E
M
K
D
G
K
V
-
V
G
-----
E
I
T
-----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.66
38%
-100
- C1 -
3TIF
7
Y796_METJA
B:
[1-232]
--
M
V
K
L
K
N
V
T
K
T
Y
-----
K
M
G
E
E
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
---
G
A
M
S
G
E
------
E
R
R
K
R
A
L
E
C
L
K
-
M
A
E
-
L
E
----
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
E
R
E
-----
E
K
L
R
--
G
F
------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
81.93
32%
-98
- C1 -
2AWN
2
MALK_ECOLI
B:
[2-228]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.89
38%
-94
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
--
M
V
K
L
K
N
V
T
K
T
Y
-----
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
---
G
A
M
S
G
E
------
E
R
R
K
R
A
L
E
C
L
K
-
M
A
E
-
L
E
----
E
-
R
F
ANHK
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
E
R
E
-----
E
K
L
R
----------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
81.44
32%
-108
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-228]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
111
HHSearch
81.41
37%
-90
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
--
M
V
K
L
K
N
V
T
K
T
Y
--
K
M
G
E
E
I
I
Y
A
---
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
--
N
---------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
-
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
------
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
R
F
A
----
N
-
H
K
----
P
N
Q
-------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
--------
D
-
I
N
-
V
A
-
R
F
G
E
R
I
I
-------
Y
L
K
D
G
E
V
-
E
R
-----
E
E
K
L
--
R
-------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
81.33
34%
-98
- C1 -
1OXU
13
?
C:
[1-219]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
--
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
-
D
R
L
--
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
-
M
---
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
-
I
H
H
-
V
L
----
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
-
Q
S
R
L
G
V
T
L
L
V
V
S
H
--------
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
-------
V
L
V
K
G
K
L
----------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.23
32%
-104
- C1 -
4KI0
4
?
A:
[2-228]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.06
32%
-103
- C1 -
3PUW
5
MALK_ECOLI
B:
[2-238]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
81.05
34%
-98
- C1 -
1OXU
7
?
A:
[1-219]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
--
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
-
D
R
L
--
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
-
M
---
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
-
I
H
H
-
V
L
----
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
-
Q
S
R
L
G
V
T
L
L
V
V
S
H
--------
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
-------
V
L
V
K
G
K
L
----------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.94
32%
-107
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-228]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
80.72
32%
-89
- C1 -
1B0U
4
HISP_SALTY
A:
[7-255]
---
L
H
V
I
D
L
H
K
R
Y
--
G
----
G
H
E
V
---
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
--
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
L
G
-
L
---
S
K
H
D
A
R
------
E
R
A
L
K
Y
L
A
K
V
G
-
I
D
E
-
R
A
----
Q
G
K
Y
----
P
V
H
-------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
E
E
G
K
-
T
M
V
V
V
T
H
--------
E
M
G
F
-
A
R
-
H
V
S
S
H
V
I
-------
F
L
H
Q
G
K
I
-
E
E
-----
E
-----
G
D
P
E
Q
V
--
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
---------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
80.69
34%
-100
- C1 -
1OXU
6
?
B:
[1-219]
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
--
A
---
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
-
D
R
L
--
V
---------
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
-
F
-
P
L
T
N
M
K
-
M
---
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
-
I
H
H
-
V
L
----
N
-
H
F
----
P
R
E
-------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
-
Q
S
R
L
G
V
T
L
L
V
V
S
H
--------
D
-
P
A
-
D
I
F
A
I
A
D
R
V
G
-------
V
L
V
K
G
K
L
----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.42
32%
-105
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-228]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
E
V
V
V
S
-------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
---------
D
T
P
P
A
E
------
R
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
-
F
-
G
L
K
L
A
G
-
A
---
K
K
E
V
I
N
------
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
H
-
L
L
----
D
-
R
K
----
P
K
A
-------
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
-
H
K
R
L
G
R
T
M
I
Y
V
T
H
--------
D
-
Q
V
-
E
A
M
T
L
A
D
K
I
V
-------
V
L
D
A
G
R
V
-
A
Q
V
G
K
P
L
E
L
Y
H
--
Y
P
A
D
R
---------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
75.89
35%
-106
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-226]
---
I
K
V
E
N
V
S
F
I
Y
NE
G
T
P
-
Y
A
T
V
A
---
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
TD
K
---------
K
V
S
---
L
K
D
I
R
K
Q
-
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
-
F
-
G
P
S
N
L
G
-
L
---
S
E
E
E
V
---------
K
E
R
V
Y
E
A
M
E
-
I
V
G
-
I
S
KELA
D
-
K
S
----
P
F
E
-------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
-
H
D
K
Y
K
M
I
T
I
L
V
S
H
--------
N
M
E
D
-
I
A
-
R
I
A
D
K
I
I
-------
V
M
N
R
G
K
I
----------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
75.62
35%
-106
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-226]
---
I
K
V
E
N
V
S
F
I
Y
NE
G
T
P
-
Y
A
T
V
A
---
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
TD
K
---------
K
V
S
---
L
K
D
I
R
K
Q
-
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
-
F
-
G
P
S
N
L
G
-
L
---
S
E
E
E
V
---------
K
E
R
V
Y
E
A
M
E
-
I
V
G
-
I
S
KELA
D
-
K
S
----
P
F
E
-------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
-
H
D
K
Y
K
M
I
T
I
L
V
S
H
--------
N
M
E
D
-
I
A
-
R
I
A
D
K
I
I
-------
V
M
N
R
G
K
I
----------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
66.98
34%
-105
- C1 -
4YMU
2
?
J:
[15-217]
----------------------
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
---------
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
------
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
K
----
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
--
T
M
V
V
V
T
H
--------
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
-------
F
M
D
D
G
V
I
-
V
E
-----
E
-------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
66.89
33%
-93
* C1 *
2OLJ
4
?
A:
[22-246]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
----
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
---------
A
K
D
T
N
-
L
N
K
V
-
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
-
A
P
M
K
V
R
K
W
---
P
R
E
K
A
E
------
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
-
K
A
----
H
-
A
Y
----
P
D
S
-------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
--------
E
-
M
G
-
F
A
R
E
V
G
D
R
V
L
-------
F
M
D
G
G
Y
I
-
I
E
-----
E
G
K
P
--
E
D
L
-----------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.55
34%
-107
- C1 -
4YMV
1
?
A:
[15-217]
----------------------
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
---------
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
------
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
K
----
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
--
T
M
V
V
V
T
H
--------
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
-------
F
M
D
D
G
V
I
-
V
E
-----
E
-------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
66.02
34%
-107
- C1 -
4YMU
2
?
A:
[15-217]
----------------------
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
---------
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
------
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
K
----
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
--
T
M
V
V
V
T
H
--------
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
-------
F
M
D
D
G
V
I
-
V
E
-----
E
-------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.50
34%
-103
- C1 -
4YMV
1
?
J:
[15-217]
----------------------
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
---------
N
-
G
K
V
N
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
A
P
V
K
V
K
K
-
M
---
N
K
K
E
A
E
------
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
K
----
D
-
Q
Y
----
P
I
K
-------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
--
T
M
V
V
V
T
H
--------
E
M
G
F
-
A
R
-
E
V
G
D
R
V
I
-------
F
M
D
D
G
V
I
-
V
E
-----
E
-------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.62
33%
-90
- C1 -
2HYD
3
Y1866_STAAM
A:
[356-553]
-----------------------
I
---
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
-
Q
--
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
-
G
R
P
T
A
T
-----
D
E
E
--
V
------
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
----
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
K
--
D
R
T
T
L
I
V
A
H
--------
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
-------
V
I
E
N
G
H
I
----------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
56.11
33%
-91
- C1 -
2ONJ
4
Y1866_STAAM
B:
[356-553]
-----------------------
I
---
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
-
Q
--
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
-
G
R
P
T
A
T
-----
D
E
E
--
V
------
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
----
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
K
--
D
R
T
T
L
I
V
A
H
--------
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
-------
V
I
E
N
G
H
I
----------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.86
33%
-91
- C1 -
2HYD
3
Y1866_STAAM
B:
[356-553]
-----------------------
I
---
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
-
Q
--
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
-
G
R
P
T
A
T
-----
D
E
E
--
V
------
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
----
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
K
--
D
R
T
T
L
I
V
A
H
--------
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
-------
V
I
E
N
G
H
I
----------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.23
33%
-89
- C1 -
2ONJ
4
Y1866_STAAM
A:
[356-553]
-----------------------
I
---
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
--
K
---------
D
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
-
Q
--
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
-
G
R
P
T
A
T
-----
D
E
E
--
V
------
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
-
L
P
----
Q
-
G
Y
----
D
T
E
VGERGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
K
--
D
R
T
T
L
I
V
A
H
--------
R
-
L
S
-
T
I
-
T
H
A
D
K
I
V
-------
V
I
E
N
G
H
I
----------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
52.97
31%
-96
- C1 -
5DGX
1
?
A:
[21-252]
-----
I
K
D
L
S
F
A
F
--
G
E
H
K
----
V
---
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
E
G
E
I
L
L
D
G
V
D
T
--
R
---------
E
L
T
---
L
E
N
L
R
S
H
-
L
S
I
V
S
Q
--
N
V
H
L
F
D
D
-
T
V
Y
N
N
I
A
-
F
-
G
----
E
-
V
---
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
-
G
I
N
-
T
N
I---
G
-
N
N
----
G
S
K
-------
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
-------------
L
E
S
L
T
K
------
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
A
D
-
K
I
-
V
V
-
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
G
G
L
-
Y
T
-----
R
L
Y
Q
----------------------------------------------------------------------------------------------------------------------------