@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0654: (2016-03-17 )
MIYTVTFNPSIDYVIFTNDFKIDGLNRATATYKFAGGKGINVSRVLKTLDVESTALGFAGGFPGKFIIDTLNNSAIQSNFIEVDEDTRINVKLKTGQETEINAPGPHITSTQFEQLLQQIKNTTSEDIVIVAGSVPSSIPSDAYAQIAQITAQTGAKLVVDAEKELAESVLPFHPLFIKPNKDELEVMFNTTVNSDTDVIKYGRLLVDKGAQSVIVSLGGDGAIYIDKEISIKAVNPQGKVVNTVGSGDSTVAGMVAGIASGLTIEKAFQQAVACGTATAFDEDLATRDAIEKIKSQVTISVLDGE
Atome Classification :
(24 SA)
.........10......-.-.20........30........40........50........60.-.......70........80...-.....---.90.-..---.---....100.......110--..-------..-..----.---.---.120...-..-...130.......140.......150.......160....---...170-.--.-...-...180.......190..-.--....200.-.....-.---210........220..--.....230.......240.......250.......260.......270.......280.--.--.....--290.......300....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
Y
T
V
TFNPSI
D
Y
V
I
F
T-N-
D
F
K
IDGLNR
A
T
A
T
Y
K
FAGGKGI
N
V
S
R
V
L
K
T
LDVESTALGFAGGF-PG
K
F
I
I
DTLNNSAIQSN
F
-
I
EV-DED
T
R
---
I
N
V
K
-
L
K---T---GQETEINAPGPHI
T
S
----
T
Q
-------
F
E
-
Q
L
----
L
---
Q
---
Q
I
-KNTT-SE-
D
I
V
I
V
AGSVPSSIP
S
D
A
Y
A
Q
I
A
Q
I
T
A
QTG
A
K
L
V
VD
A
E
K
E
L
---
A
E
SVL--P--F-H
P
L
-
F
IKPNKD
E
L
E
V
M
F
NTTVN-S--D
T
D
V
I
K
Y
G
-
R
L
L
VD-K---G-A
Q
S
V
I
V
S
LGGD
G
A
I
--
Y
I
DK
E
I
S
I
K
A
VNPQG
K
V
V
N
TVGSGD
S
T
V
A
G
M
V
A
G
I
ASG
L
T
I
E
K
A
F
Q
Q
A
V
ACGTATAF
D
E
--
D
--L
A
T
R
D
--
A
I
E
K
I
K
S
Q
V
T
I
S
VLDGE
1
PsiBlast_PDB
98.75
99%
-98
- C1 -
2JG5
-
?
A:
[1-306]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
-
N
-
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
-
I
E
V
-
D
E
D
T
R
---
I
N
V
K
-
L
K
---
T
---
G
Q
E
T
E
I
N
A
P
G
P
H
I
T
S
----
T
Q
-------
F
E
-
Q
L
----
L
---
Q
---
Q
I
-
K
N
T
T
-
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
--
P
--
Y
-
H
P
L
-
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
-
S
--
D
A
D
V
I
K
Y
G
-
R
L
L
V
D
-
K
---
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
--
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
--
D
--
L
A
T
R
D
--
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
G
E
36
HHSearch
97.96
99%
-97
- C1 -
2JG5
-
?
A:
[1-306]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
-
N
-
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
-
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
-
I
E
V
-
D
E
D
T
R
---
I
N
V
K
-
L
K
---
T
---
G
Q
E
T
E
I
N
A
P
G
P
H
I
T
S
----
T
Q
-------
F
E
-
Q
L
----
L
---
Q
---
Q
I
-
K
N
-
T
T
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
-----
P
Y
H
P
L
-
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
-
S
--
D
A
D
V
I
K
Y
G
-
R
L
L
V
D
-
K
---
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
--
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
--
D
--
L
A
T
R
D
--
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
G
E
41
HHSearch
80.91
43%
-89
- C1 -
2ABQ
3
?
A:
[1-299]
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
-
E
-
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
-
I
E
V
-
E
G
D
T
R
---
I
N
V
K
-
I
K
---
G
---
K
Q
E
T
E
L
N
G
T
A
P
L
I
K
K
----
E
H
-------
V
Q
-
A
L
----
L
E
Q
L
T
---
E
L
-
E
K
----
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
--
A
--
A
-
K
P
S
-
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
-
S
--
I
E
D
A
I
P
H
V
-
Q
R
L
I
G
-
E
---
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
--
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
--
G
--
F
C
T
R
E
--
E
V
E
R
L
Q
Q
Q
L
Q
-------
2
PsiBlast_PDB
80.69
42%
-88
- C1 -
2ABQ
3
?
A:
[2-302]
-
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
-
E
-
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
-
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
-
I
E
V
-
E
G
D
T
R
---
I
N
V
K
-
I
K
---
G
---
K
Q
E
T
E
L
N
G
T
A
P
L
I
K
K
----
E
H
-------
V
Q
-
A
L
----
L
---
E
---
Q
L
-
T
E
L
E
-
K
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
--
A
--
A
-
K
P
S
-
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
-
S
--
I
E
D
A
I
P
H
V
-
Q
R
L
I
G
-
E
---
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
--
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
--
G
--
F
C
T
R
E
--
E
V
E
R
L
Q
Q
Q
L
Q
R
T
I
----
10
PsiBlast_PDB
76.16
33%
-91
- C1 -
2Q5R
-
LACC_STAAC
A:
[2-285]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
I
L
H
---
E
---
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
----
Q
E
A
A
G
F
I
K
H
F
E
-
Q
L
----
L
---
E
---
K
V
---------
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
L
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
--------------------------------
9
PsiBlast_PDB
75.47
33%
-90
- C1 -
2JGV
-
LACC_STAA8
A:
[22-305]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
I
L
H
---
E
---
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
----
Q
E
A
A
G
F
I
K
H
F
E
-
Q
L
----
L
---
E
---
K
V
---------
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
L
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
--------------------------------
37
HHSearch
74.45
28%
-87
- C1 -
3IE7
3
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
G
-
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
N
L
-
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
-
L
V
E
A
G
T
S
T
R
---
E
C
F
V
-
V
L
---
S
DDT
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
T
N
K
-
D
N
-------
L
L
K
Q
I
----
A
---
K
---
K
V
-
K
K
----
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
--
E
--
M
-
G
V
D
-
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
------
S
L
E
E
N
I
-
R
T
L
A
E
-----
K
-
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
--
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
--
D
S
S
S
F
D
L
E
--
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
13
PsiBlast_PDB
74.03
32%
-87
- C1 -
2JG1
2
LACC_STAA8
A:
[22-305]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
I
L
H
---
E
---
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
----
Q
E
-------
A
A
-
G
F
----
I
---
K
---
H
F
-
E
Q
M
M
-
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
L
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
--------------------------------
16
PsiBlast_PDB
74.02
30%
-85
- C1 -
3HIC
1
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
-
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
-
G
T
S
T
R
E
C
F
V
V
L
S
-
D
D
---
T
---
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
----
T
N
-------
K
D
-
N
L
----
L
---
K
---
Q
I
A
K
K
V
K
-
K
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
--
E
--
M
-
G
V
D
-
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
-
S
--
L
E
E
N
I
----
R
T
L
A
E
-
K
-----
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
--
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
--------
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
5
PsiBlast_PDB
73.29
30%
-85
- C1 -
3N1C
2
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
--
D
T
Q
K
I
------------
6
PsiBlast_PDB
73.24
30%
-81
- C1 -
3UMO
7
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
--
D
T
Q
K
I
------------
8
PsiBlast_PDB
73.13
30%
-83
- C1 -
3UQD
6
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
--
D
T
Q
K
I
------------
14
PsiBlast_PDB
72.99
30%
-80
- C1 -
3Q1Y
2
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
-
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
-
G
T
S
T
R
E
C
F
V
V
L
S
-
D
D
---
T
---
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
----
T
N
-------
K
D
-
N
L
----
L
---
K
---
Q
I
A
K
K
V
K
-
K
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
--
E
--
M
-
G
V
D
-
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
-
S
--
L
E
E
N
I
----
R
T
L
A
E
-
K
-----
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
--
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
A
V
M
Q
Q
--
D
--
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
4
PsiBlast_PDB
72.88
30%
-82
- C1 -
3CQD
7
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
-------
L
C
S
H
D
--
D
T
Q
K
I
------------
17
PsiBlast_PDB
72.84
30%
-81
- C1 -
3IE7
3
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
-
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
-
G
T
S
T
R
E
C
F
V
V
L
S
-
D
D
---
T
---
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
----
T
N
-------
K
D
-
N
L
----
L
---
K
---
Q
I
A
K
K
V
K
-
K
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
--
E
--
M
-
G
V
D
-
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
-
S
--
L
E
E
N
I
----
R
T
L
A
E
-
K
-----
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
--
C
A
H
N
G
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
--
D
--
S
S
S
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
7
PsiBlast_PDB
72.65
30%
-81
- C1 -
3UMP
7
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
--
D
T
Q
K
I
------------
18
PsiBlast_PDB
72.54
30%
-88
- C1 -
3JUL
2
?
A:
[3-310]
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
-
R
G
E
L
E
K
R
K
T
N
R
V
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
K
N
E
A
L
G
I
A
G
S
D
-
N
L
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
A
-
G
T
S
T
R
E
C
F
V
V
L
S
-
D
D
---
T
---
N
G
S
T
M
I
P
E
A
G
F
T
V
S
Q
----
T
N
-------
K
D
-
N
L
----
L
---
K
---
Q
I
A
K
K
V
K
-
K
E
-
D
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
Y
---
L
N
L
A
V
--
E
--
M
-
G
V
D
-
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
-
S
--
L
E
E
N
I
----
R
T
L
A
E
-
K
-----
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
--
C
A
H
N
G
K
L
Y
Q
V
I
P
P
-------
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
N
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
--------
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--
3
PsiBlast_PDB
72.53
30%
-77
- C1 -
3UQE
4
PFKB_ECOLI
A:
[4-303]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
D
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
-
K
D
W
T
R
---
Q
N
L
H
-
V
H
V
EA
S
---
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
---
Q
V
-
L
E
I
E
-
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
-
S
---
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
--
R
--
L
C
S
H
D
--
D
T
Q
K
I
------------
39
HHSearch
71.81
31%
-76
* C1 *
2F02
1
LACC_ENTFA
A:
[3-312]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
-
D
-
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
-
T
S
I
-
K
E
E
T
R
---
D
S
I
A
-
I
L
---
H
E--
G
N
Q
T
E
I
L
E
A
G
P
T
V
S
P
----
E
E
-------
I
S
-
N
F
L
E
N
F
D
---
Q
---
L
I
-
K
Q
----
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
--
Q
GP
W
-
K
P
Y
-
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
-
E
NP
L
A
A
V
Q
T
A
L
-
T
K
P
M
F
-
A
---
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
--
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
--
M
TG
H
V
D
V
E
--
N
V
K
K
H
L
M
N
I
Q
V
V
E
----
22
PsiBlast_CBE
70.93
34%
-88
- C1 -
2JGV
1
LACC_STAA8
B:
[22-284]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
I
L
H
---
E
---
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
----
Q
E
A
A
G
F
I
K
H
F
E
-
Q
L
----
L
---
E
---
K
V
---------
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
L
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
-----------------------------------------------------
38
HHSearch
70.48
31%
-78
- C1 -
2JG1
2
LACC_STAA8
A:
[21-329]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
-
I
L
---
H
E--
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
-------
I
K
-
H
F
----
E
---
Q
---
M
M
-
E
K
----
V
-
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
N
P
-----
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
--
L
E
S
L
K
Q
A
V
-
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
--
Q
TG
Y
V
N
L
N
--
N
Y
D
D
L
F
N
Q
I
E
V
L
E
----
21
PsiBlast_CBE
70.28
34%
-84
- C1 -
2JGV
1
LACC_STAA8
D:
[22-284]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
-
T
-
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
-
Y
N
I
-
K
G
E
T
R
---
N
C
I
A
I
L
H
---
E
---
G
Q
Q
T
E
I
L
E
Q
G
P
E
I
D
N
----
Q
E
AAGFIKH
F
E
-
Q
L
----
L
---
E
---
K
V
---------
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
EN
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
-
E
--
S
L
E
S
L
K
Q
A
V
S
Q
P
L
F
-
E
---
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
--
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
-----------------------------------------------------
40
HHSearch
67.47
30%
-67
- C1 -
3UMO
7
PFKB_ECOLI
A:
[3-308]
R
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
-
P
-
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
-
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
-
V
E
A
K
D
W
T
R
Q
---
N
L
H
V
-
H
V
---
E
AS-
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
-------
F
R
-
Q
L
----
E
---
E
Q
V
L
E
I
-
E
S
----
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
L
S
-
A
A
L
A
I
-----
G
-
N
I
E
-
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
-
Q
--
P
D
D
V
R
K
A
A
-
Q
E
I
V
N
S
G
---
K
-
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
--
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
--
G
TR
L
C
S
H
D
--
D
T
Q
K
I
Y
A
Y
L
S
-------
12
PsiBlast_PDB
67.00
34%
-84
- C1 -
2F02
1
LACC_ENTFA
A:
[3-268]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
-
D
-
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
-
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
-
T
S
I
-
K
E
E
T
R
---
D
S
I
A
I
L
H
---
E
---
G
N
Q
T
E
I
L
E
A
G
P
T
V
S
P
----
E
E
-------
I
S
-
N
F
----
L
---
E
---
N
F
-
D
Q
L
I
-
K
Q
A
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
Q
G
P
--
W
-
K
P
Y
-
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
--
S
--
E
N
P
L
A
A
V
Q
-
T
A
L
T
K
-
P
MFA
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
--
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
----------------------------------------------------