@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0658: (2016-03-17 )
MLNEIQILNNGYPMPSVGLGVYKISDEDMTKVVNAAIDAGYRAFDTAYFYDNEASLGRALKDNGVDREDLFITTKLWNDYQGYEKTFEYFNKSIENLQTDYLDLFLIHWPCEADGLFLETYKAMEELYEQGKVKAIGVCNFNVHHLEKLMAQSSIKPMVNQIEVHPYFNQQELQEFCDRHDIKVTAWMPLMRNRGLLDNPVIVKIAEKYHKTPAQVVLRWHLAHNRIIIPKSQTPKRIQENIDILDFNLELTEVAEIDALDRNARQGKNPDDVKIGDLK
Atome Classification :
(99 SA)
.......--..-10........20.....-...30-....---....40........50........----60---.----.----.-----.-.....70........80......--..90........100.......110----------------.------------------.-----------.-----------.-----------------..-------..-------------.-------------120.......130.......140.......150.--...--...160.......170.......180.......190-------..------.--.--------.----------..---------..200.......210.......220.......230.......240.......250-.........260-..-.---...---.270.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
N
E
I
Q
I
--LN-NGYPMPSVG
L
G
V
Y
KI
S
D
-
E
D
M
T
K
-
V
V
N
A
---
A
I
DAGY
R
A
F
D
T
A
Y
F
YDNE
A
S
LG
R
A
----
L
----K----D----N-----G-VDRE
D
L
F
I
T
T
KLWNDYQ
G
Y
E
K
T
F
--
E
Y
F
N
K
S
I
E
N
L
Q
T
D
Y
L
D
L
F
L
I
HWP------------------C------------------E-----------A-----------D-----------------G
L
-------
F
L
-------------
E
-------------
T
Y
K
A
M
E
E
L
Y
EQGK
V
K
A
I
G
V
CNF
N
V
H
H
L
E
K
L
M
A
Q
S--SI
K
--
P
M
V
N
Q
I
E
VHPYF
N
Q
Q
E
L
Q
E
F
C
D
RHD
I
K
V
T
A
W
M
P
L
---------
M
R------N--R--------G----------LL---------DN
P
V
I
V
K
I
A
E
K
YHK
T
P
A
Q
V
V
L
R
W
HLAH
N
R
I
I
I
PKSQ
T
P
K
R
I
Q
ENI
D
I
L
DFNL
E
---
L
T
E
V
A
E
I
D
ALDR-NA-R---QGK---NPDDVKIGDLK
3
PsiBlast_PDB
94.77
48%
-98
- C7 -
4FZI
1
PGFS_TRYCC
A:
[18-283]
---------
L
H
-
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
-
A
V
R
W
---
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
----
I
----
R
----
E
----
S
-----
G
-
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
--
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
K
-----------
K
--------------------------
F
V
-------------
D
-------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
---------
G
S
------
G
--
E
EA------
G
----------
I
L
---------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
K
-
R
---
I
G
A
---
D
P
D
N
-------
8
PsiBlast_PDB
94.27
51%
-97
- C7 -
3F7J
8
GR_BACSU
A:
[11-274]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
-
S
V
K
A
---
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
----
I
----
K
----
E
----
S
-----
G
-
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
--
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
Y
K
-------------
D
-------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
-
R
---
V
G
P
---
N
P
D
E
L
------
22
PsiBlast_CBE
94.10
49%
-100
- C7 -
4F40
10
PGFS_LEIMA
B:
[15-287]
---------
L
S
-
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
E
V
T
E
N
A
V
K
W
---
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
----
L
----
R
----
A
----
S
-----
G
-
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
--
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
------------------
G
-----------
K
-----------
D
-----------------
I
L
SKEGKK-
Y
L
-------------
D
-------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
---------
G
----------
K
-------------------
L
L
---------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
-
R
---
Y
G
P
---
D
P
D
E
A
Q
-----
7
PsiBlast_PDB
93.75
51%
-94
- C7 -
3D3F
1
GR_BACSU
A:
[10-273]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
-
S
V
K
A
---
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
----
I
----
K
----
E
----
S
-----
G
-
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
--
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
Y
K
-------------
D
-------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
-
R
---
V
G
P
---
N
P
D
E
L
------
29
PsiBlast_CBE
93.21
51%
-97
- C7 -
3F7J
7
GR_BACSU
B:
[11-274]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
-
S
V
K
A
---
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
----
I
----
K
----
E
----
S
-----
G
-
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
--
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
Y
K
-------------
D
-------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
-
R
---
V
G
P
---
N
P
D
E
L
------
110
HHSearch
92.99
51%
-95
- C7 -
3F7J
8
GR_BACSU
A:
[8-274]
----
T
V
K
--
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
-
S
V
K
A
---
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
----
I
----
K
----
E
----
S
-----
G
-
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
--
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
------------------------------
K
-------
Y
K
-------------
D
-------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
--------
L
----------
L
D
----------
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
-
R
---
V
G
P
---
N
P
D
E
L
------
28
PsiBlast_CBE
92.95
51%
-99
- C7 -
3D3F
1
GR_BACSU
B:
[10-273]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
-
S
V
K
A
---
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
----
I
----
K
----
E
----
S
-----
G
-
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
--
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
Y
K
-------------
D
-------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
---
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
-
R
---
V
G
P
---
N
P
D
E
L
------
4
PsiBlast_PDB
92.72
48%
-99
- C7 -
4GIE
2
PGFS_TRYCC
A:
[18-283]
---------
L
H
-
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
-
A
V
R
W
---
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
----
I
----
R
----
E
----
S
-----
G
-
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
--
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
K
-----------
K
--------------------------
F
V
-------------
D
-------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
---------
G
S
------
G
--
E
EA------
G
----------
I
L
---------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
K
-
R
---
I
G
A
---
D
P
D
N
-------
21
PsiBlast_CBE
92.57
49%
-95
- C7 -
4G5D
1
PGFS_LEIMA
B:
[15-287]
---------
L
S
-
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
E
V
T
E
N
A
V
K
W
---
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
----
L
----
R
----
A
----
S
-----
G
-
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
--
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
------------------
G
-----------
K
-----------
D
-----------------
I
L
S
K
EGKK-
Y
L
-------------
D
-------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
---------
G
Q
------
G
--
K
-------------------
L
L
---------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
-
R
---
Y
G
P
---
D
P
D
E
A
Q
-----
1
PsiBlast_PDB
92.39
49%
-98
- C7 -
4F40
11
PGFS_LEIMA
A:
[15-287]
---------
L
S
-
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
E
V
T
E
N
A
V
K
W
---
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
----
L
----
R
----
A
----
S
-----
G
-
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
--
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
------------------
G
-----------
K
-----------
D
-----------------
I
L
S
K
EGKK-
Y
L
-------------
D
-------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
---------
G
----------
K
-------------------
L
L
---------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
-
R
---
Y
G
P
---
D
P
D
E
A
Q
-----
2
PsiBlast_PDB
92.05
49%
-97
- C7 -
4G5D
1
PGFS_LEIMA
A:
[15-287]
---------
L
S
-
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
-
G
E
V
T
E
N
A
V
K
W
---
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
----
L
----
R
----
A
----
S
-----
G
-
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
--
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
------------------
G
-----------
K
-----------
D
-----------------
I
L
S
K
EGKK-
Y
L
-------------
D
-------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
---------
G
Q
------
G
--
K
-------------------
L
L
---------
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
---
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
-
R
---
Y
G
P
---
D
P
D
E
A
Q
-----
39
PsiBlast_CBE
92.03
47%
-99
- C7 -
3B3D
1
YTBE_BACSU
B:
[45-311]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
Q
V
E
E
G
S
E
L
V
N
-
A
V
K
T
---
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
----
I
----
R
----
E
----
G
I
E
E
A
-
G
-
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
--
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
------------------
E
-----------------------------------------
G
K
-------
Y
K
-------------
E
-------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
L
-
R
---
V
G
P
---
D
P
D
N
-------
35
PsiBlast_CBE
91.97
46%
-99
- C7 -
4Q3M
1
?
D:
[6-272]
---------
L
N
-
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
-
N
D
A
Y
N
-
A
V
K
A
---
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
----
I
----
K
----
D
----
S
-----
N
-
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
--
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
------------------
G
-----------
Y
-----------
D
-----------------
N
A
--------
L
-------------
S
-------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
---------
M
S
------
H
QI
K
--------
D
----------
L
L
---------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
---
E
E
D
M
K
S
I
R
S
V
N
T
-
G
K
-
K
---
I
F
T
---
E
F
D
N
V
------
23
PsiBlast_CBE
91.86
48%
-99
- C7 -
4FZI
2
PGFS_TRYCC
B:
[18-283]
---------
L
H
-
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
-
A
V
R
W
---
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
----
I
----
R
----
E
----
S
-----
G
-
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
--
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
K
-----------
K
--------------------------
F
V
-------------
D
-------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
---------
G
S
-----------------------------
I
L
---------
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
---
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
K
-
R
---
I
G
A
---
D
P
D
N
-------
38
PsiBlast_CBE
91.53
47%
-96
- C7 -
3B3D
1
YTBE_BACSU
C:
[45-311]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
Q
V
E
E
G
S
E
L
V
N
-
A
V
K
T
---
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
----
I
----
R
----
E
----
G
IEEA-
G
-
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
--
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
------------------
E
-----------------------------------------
G
K
-------
Y
K
-------------
E
-------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
L
-
R
---
V
G
P
---
D
P
D
N
-------
36
PsiBlast_CBE
91.25
46%
-100
- C7 -
4Q3M
1
?
C:
[6-272]
---------
L
N
-
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
-
N
D
A
Y
N
-
A
V
K
A
---
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
----
I
----
K
----
D
----
S
-----
N
-
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
--
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
------------------
G
-----------
Y
-----------
D
-----------------
N
A
--------
L
-------------
S
-------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
---------
M
S
------
H
Q
I
K
--------
D
----------
L
L
---------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
---
E
E
D
M
K
S
I
R
S
V
N
T
-
G
K
-
K
---
I
F
T
---
E
F
D
N
V
------
34
PsiBlast_CBE
91.19
46%
-96
- C7 -
4Q3M
1
?
E:
[6-272]
---------
L
N
-
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
-
N
D
A
Y
N
-
A
V
K
A
---
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
----
I
----
K
----
D
----
S
-----
N
-
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
--
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
------------------
G
-----------
Y
-----------
D
-----------------
N
A
--------
L
-------------
S
-------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
---------
M
S
------
H
QI
K
--------
D
----------
L
L
---------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
---
E
E
D
M
K
S
I
R
S
V
N
T
-
G
K
-
K
---
I
F
T
---
E
F
D
N
V
------
6
PsiBlast_PDB
90.93
45%
-97
- C7 -
1MZR
4
DKGA_ECOLI
A:
[30-292]
---------
L
Q
-
D
G
N
V
M
P
Q
L
G
L
G
V
W
Q
A
S
N
-
E
E
V
I
T
-
A
I
Q
K
---
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
----
L
----
K
----
N
----
A
-----
S
-
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
--
D
H
K
R
P
R
--
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
------------------
V
------------------
P
-----------
A
-----------
I
-----------------
D
H
-------
Y
V
-------------
E
-------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
--
G
V
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
---------
A
Q
G-----
G
--
K
--------
G
----------
V
F
---------
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
---
K
D
E
L
G
E
I
A
K
L
D
Q
-
G
K
-
R
---
L
G
P
---
D
P
D
--------
13
PsiBlast_PDB
90.68
47%
-98
- C7 -
3B3D
1
YTBE_BACSU
A:
[45-311]
---------
L
H
-
N
G
V
E
M
P
W
F
G
L
G
V
F
Q
V
E
E
G
S
E
L
V
N
-
A
V
K
T
---
A
I
V
H
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
----
I
----
R
----
E
----
G
I
E
E
A
-
G
-
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
--
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
------------------
E
-----------------------------------------
G
K
-------
Y
K
-------------
E
-------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
L
---------
M
Q
------
G
--
Q
-------------------
L
L
---------
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
---
Q
D
D
M
N
R
I
D
A
L
N
E
-
N
L
-
R
---
V
G
P
---
D
P
D
N
-------
37
PsiBlast_CBE
90.21
46%
-99
- C7 -
4Q3M
1
?
B:
[6-272]
---------
L
N
-
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
--
K
-
N
D
A
Y
N
-
A
V
K
A
---
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
----
I
----
K
----
D
----
S
-----
N
-
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
--
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
------------------
K
------------------
G
-----------
Y
-----------
D
-----------------
N
A
--------
L
-------------
S
-------------
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
--
K
I
P
--
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
---------
M
S
------
H
Q
I
K
--------
D
----------
L
L
---------
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
---
E
E
D
M
K
S
I
R
S
V
N
T
-
G
K
-
K
---
I
F
T
---
E
F
D
N
V
------
120
HHSearch
89.64
44%
-94
- C7 -
1MZR
4
DKGA_ECOLI
A:
[25-294]
--
P
T
V
I
K
--
L
Q
-
D
G
N
V
M
P
Q
L
G
L
G
V
W
Q
A
S
N
-
E
E
V
I
T
-
A
I
Q
K
---
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
----
L
----
K
----
N
----
A
-----
S
-
V
N
R
E
E
L
F
I
T
T
K
L
W
N
--
D
D
H
K
R
P
R
--
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
------------------
V
------------------
P
A----------
I
-----------
D
------------------
H
-------
Y
V
-------------
E
-------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
--
G
V
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
---------
A
Q
------
G
--
G
--------
K
----------
G
V
F--------
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
---
K
D
E
L
G
E
I
A
K
L
D
Q
-
G
K
-
R
---
L
G
P
---
D
P
D
Q
F
------
20
PsiBlast_PDB
88.67
44%
-101
- C7 -
1VP5
1
?
A:
[20-291]
---------
L
N
-
N
G
V
E
M
P
I
L
G
Y
G
V
F
Q
I
P
P
-
E
K
T
E
E
-
C
V
Y
E
---
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
----
I
----
K
R
A
I
-
D
----
E
-----
G
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
--
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
------------------------------------------------------------
G
D
-------
V
H
-------------
C
-------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
--
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
---------
A
E
------
G
--
R
K-------
N
----------
I
F
---------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
E
-
G
Q
-
S
AFF
S
H
R
---
D
P
E
V
V
K
-----
42
PsiBlast_CBE
88.14
44%
-100
- C7 -
1VP5
1
?
B:
[20-291]
---------
L
N
-
N
G
V
E
M
P
I
L
G
Y
G
V
F
Q
I
P
P
-
E
K
T
E
E
-
C
V
Y
E
---
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
----
I
----
K
RAI-
D
----
E
-----
G
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
--
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
------------------------------------------------------------
G
D
-------
V
H
-------------
C
-------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
--
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
---------
A
E
------
G
--
R
K-------
N
----------
I
F
---------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
E
-
G
Q
-
S
AFF
S
H
R
---
D
P
E
V
V
K
-----
31
PsiBlast_CBE
88.00
44%
-98
- C7 -
3WBW
3
?
B:
[19-281]
---------
F
H
-
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
-
D
E
T
A
E
-
V
V
K
E
---
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
----
L
----
E
----
D
----
H
----------
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
--
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
A
-----------
Q
-----------------
G
Q
-------
Y
V
-------------
E
-------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
---------
G
K
------
G
--
R
-------------------
V
L
---------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
-
R
---
M
G
A
---
D
P
N
T
A
K
-----
24
PsiBlast_CBE
87.86
48%
-103
- C7 -
3O0K
3
?
D:
[31-283]
---------
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
-
A
V
S
E
---
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
----
I
----
N
----
G
----
S
-----
G
-
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
S
-----------
K
-----------------
D
L
-------
F
M
-------------
E
-------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
---------
G
----------
K
-------------------
L
L
---------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
D
--------------------------
5
PsiBlast_PDB
87.44
48%
-102
- C7 -
3O0K
4
?
A:
[31-283]
---------
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
-
A
V
S
E
---
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
----
I
----
N
----
G
----
S
-----
G
-
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
S
-----------
K
-----------------
D
L
-------
F
M
-------------
E
-------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
---------
G
Q
------
G
----------------------
L
L
---------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
D
--------------------------
26
PsiBlast_CBE
87.30
48%
-104
- C7 -
3O0K
4
?
B:
[31-283]
---------
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
-
A
V
S
E
---
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
----
I
----
N
----
G
----
S
-----
G
-
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
S
-----------
K
-----------------
D
L
-------
F
M
-------------
E
-------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
---------
G
------------------------------
L
L
---------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
D
--------------------------
25
PsiBlast_CBE
87.22
48%
-105
- C7 -
3O0K
3
?
C:
[31-283]
---------
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
-
A
V
S
E
---
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
----
I
----
N
----
G
----
S
-----
G
-
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
S
-----------
K
-----------------
D
L
-------
F
M
-------------
E
-------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
---------
G
------------------------------
L
L
---------
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
D
--------------------------
103
HHSearch
86.94
48%
-100
- C7 -
3O0K
4
?
A:
[24-282]
M
T
V
P
T
V
K
--
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
-
A
V
S
E
---
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
----
I
----
N
----
G
----
S
-----
G
-
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
S----------
K
-----------
D
------------------
L
-------
F
M
-------------
E
-------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
---------
G
Q
------
G
-----------
L
----------
L
E
----------
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
---
G
T
D
H
D
A
I
T
K
L
---------------------------
9
PsiBlast_PDB
86.81
44%
-99
- C7 -
3WBW
2
?
A:
[19-281]
---------
F
H
-
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
-
D
E
T
A
E
-
V
V
K
E
---
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
----
L
----
E
----
D
----
H
----------
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
--
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
A
-----------
Q
-----------------
G
Q
-------
Y
V
-------------
E
-------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
---------
G
K
------
G
--
R
-------------------
V
L
---------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
-
R
---
M
G
A
---
D
P
N
T
A
K
-----
61
PsiBlast_CBE
86.78
39%
-111
- C7 -
3H7U
2
AKRC9_ARATH
A:
[24-306]
---
A
I
T
F
F
K
L
N
-
T
G
A
K
F
P
S
V
G
L
G
T
W
Q
A
S
P
-
G
L
V
G
D
-
A
V
A
A
---
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
----
L
----
K
K
L
F
E
D
----
R
-----
V
-
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
--
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
------------------
R
I
K
K
G-------
S
-----------
V
-----------------
G
I
-------
K
P
-------------
E
NLLPVD
I
P
S
----
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
---------
G
S
PGTTWL
K
--
S
--------
D
----------
V
L
---------
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
-----------------------------
104
HHSearch
86.67
46%
-91
- C7 -
1VBJ
2
PGFS_TRYBB
A:
[9-278]
---
T
Q
S
L
--
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
E
A
E
T
-
A
T
M
W
---
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
----
I
----
A
----
S
----
C
-----
G
-
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
------------------------------
K
-------
F
I
-------------
D
-------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
---------
G
Q
------
G
--
H
--------
L
----------
V
E
----------
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
H
-
R
---
Y
G
P
---
D
P
E
V
F
M
-----
32
PsiBlast_CBE
86.55
44%
-95
- C7 -
3WBY
1
?
B:
[19-281]
---------
F
H
-
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
-
D
E
T
A
E
-
V
V
K
E
---
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
----
L
----
E
----
D
----
H
----------
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
--
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
A
-----------
Q
-----------------
G
Q
-------
Y
V
-------------
E
-------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
---------
G
K
------
G
--
R
-------------------
V
L
---------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
-
R
---
M
G
A
---
D
P
N
T
A
K
-----
108
HHSearch
86.43
45%
-93
- C7 -
3WBW
2
?
A:
[12-281]
-
E
A
Q
T
V
I
--
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
-
D
E
T
A
E
-
V
V
K
E
---
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
----
L
----
E
----
D
--------------
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
--
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
A----------
Q
-----------
G
------------------
Q
-------
Y
V
-------------
E
-------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
---------
G
K
------
G
--
R
--------
V
----------
L
S
----------
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
-
K
D
G
R
---
M
G
A
---
D
P
N
T
A
K
-----
60
PsiBlast_CBE
86.37
41%
-106
- C7 -
1FRB
2
ALD2_MOUSE
A:
[6-306]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
P
-
N
Q
V
K
E
-
A
V
K
A
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
A
Y
C
N
E
N
E
V
G
E
A
----
I
Q
E
K
I
K
----
E
----
K
-----
A
-
V
Q
R
E
D
L
F
I
V
S
K
L
W
P
T
--
C
F
E
K
K
L
L
K
E
A
F
Q
K
T
L
T
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
QGLQPGKEL
F
P
K
D
DQG
R
I
L
------------------
T
-----------
S
-----------
K
-----------------
T
T
-------
F
L
-------------
E
-------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
S
V
T
A
Y
S
P
L
GSPDRPSAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
E
K
T
S
A
Q
V
L
I
R
F
H
I
Q
R
N
V
V
V
I
P
K
S
V
T
P
S
R
I
Q
E
N
I
Q
V
F
D
F
Q
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
---
A
C
L
---
L
P
E
T
V
N
M
----
14
PsiBlast_PDB
86.16
46%
-88
- C7 -
1VBJ
2
PGFS_TRYBB
A:
[14-275]
---------
L
S
-
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
-
G
N
E
A
E
-
T
A
T
M
W
--
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
----
I
----
A
----
S
----
C
-----
G
-
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
F
I
-------------
D
-------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
---------
G
Q
------
G
--
H
-------------------
L
V
---------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
H
-
R
---
Y
G
P
---
D
P
E
--------
52
PsiBlast_CBE
86.06
37%
-106
- C7 -
4GAC
2
AK1A1_MOUSE
B:
[6-303]
------
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
H
---
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
----
L
----
K
----
E
----
S
VGSGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
E
RGDNPFPK-------------------------------
G
T
VRYDSTH
Y
K
-------------
E
-------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G-----------------------------PDEPV-----
L
L
---------
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
W
-
R
--------------------
19
PsiBlast_PDB
86.02
39%
-94
- C7 -
1A80
1
DKGA_CORSC
A:
[6-276]
------
V
--
L
N
-
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
-
A
D
T
Q
R
-
A
V
E
E
---
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
----
I
----
A
----
A
----
S
-----
G
-
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
--
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
------------------
T
------------------
P
-----------
A
-----------
A
-----------------
D
N
-------
Y
V
-------------
H
-------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
--
G
V
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
---------
G
Q
------
G
--
K
Y-------
D
----------
L
F
---------
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
---
D
T
E
I
A
A
I
D
A
M
D
P
-
G
D
-
G
---
S
G
R
VSA
H
P
D
E
V
------
118
HHSearch
85.89
40%
-97
- C7 -
3H7U
2
AKRC9_ARATH
A:
[26-308]
---
T
F
F
K
--
L
N
-
T
G
A
K
F
P
S
V
G
L
G
T
W
Q
A
S
P
-
G
L
V
G
D
-
A
V
A
A
---
A
V
K
I
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
----
L
----
K
----
K
----
L
F
E
D
R-
V
-
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
--
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
------------------
R
I
----------
K
-----------
K
GSVGIKPENLLP-----
V
D
-------
I
P
-------------
S
-------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
L
---------
G
S
------
P
--
G
--------
T
----------
T
W
LKSDVL---
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
---
D
Y
M
F
A
K
F
A
E
I
E
Q
-
A
-----------------------
57
PsiBlast_CBE
85.68
36%
-99
- C7 -
3CV7
5
AK1A1_PIG
A:
[1-300]
M
A
A
S
C
V
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
Y
---
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
----
L
----
Q
----
E
----
T
VGPGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
ERGDNP
F
P
K
N
A
-----------
D
-----------------
G
T
I
R
Y
D
ATH
Y
K
-------------
D
-------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G--------
S
S
------
D
--
R
--------
A
WRDPNEPV--
L
L
---------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
L
-
R
--------------------
11
PsiBlast_PDB
85.55
44%
-92
- C7 -
3WBY
2
?
A:
[19-281]
---------
F
H
-
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
-
D
E
T
A
E
-
V
V
K
E
---
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
----
L
----
E
----
D
----
H
----------
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
--
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
------------------
P
-----------
A
-----------
Q
-----------------
G
Q
-------
Y
V
-------------
E
-------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
---------
G
K
------
G
--
R
-------------------
V
L
---------
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
---
A
D
D
M
Q
A
I
E
Q
M
D
R
K
D
G
-
R
---
M
G
A
---
D
P
N
T
A
K
-----
55
PsiBlast_CBE
85.52
36%
-101
- C7 -
3H4G
3
AK1A1_PIG
A:
[1-301]
M
A
A
S
C
V
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
Y
---
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
----
L
----
Q
----
E
----
T
VGPGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
E
RGDNP
F
P
K
N
A
-----------
D
-----------------
G
T
IRYDATH
Y
K
-------------
D
-------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G--------
S
S
------
D
--
R
--------
A
WRDPNEPV--
L
L
---------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
L
-
R
--------------------
40
PsiBlast_CBE
85.49
46%
-87
- C7 -
1VBJ
2
PGFS_TRYBB
B:
[14-275]
---------
L
S
-
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
-
G
N
E
A
E
-
T
A
T
M
W
--
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
----
I
----
A
----
S
----
C
-----
G
-
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
--
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
K
-----------
D
-----------
K
--------------------------
F
I
-------------
D
-------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
---------
G
Q
------
G
--
H
-------------------
L
V
---------
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
---
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
H
-
R
---
Y
G
P
---
D
P
E
--------
53
PsiBlast_CBE
85.22
37%
-98
- C7 -
4GAC
2
AK1A1_MOUSE
A:
[6-296]
------
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
H
---
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
----
L
----
K
----
E
----
S
VGSGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
ERGDNPFPKN
A
-----------
D
-----------------
G
T
V
R
Y
D
STH
Y
K
-------------
E
-------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G--------
S
S
------
D
--
R
--------
A
WRHPDEPV--
L
L
---------
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
W
-
R
--------------------
16
PsiBlast_PDB
85.15
38%
-98
- C7 -
2WZM
1
Y2407_MYCS2
A:
[16-277]
---------
L
N
-
D
D
N
T
L
P
V
V
G
I
G
V
G
E
L
S
D
-
S
E
A
E
R
-
S
V
S
A
---
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
----
I
----
A
----
A
----
S
-----
G
-
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
--
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
G
-----------
D
-----------
T
-----------------
S
K
-------
Y
V
-------------
D
-------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
--
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
---------
G
V
------
G
--
R
-------------------
L
L
---------
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
---
A
D
E
M
E
T
L
N
G
L
D
D
-
G
T
-
R
---
F
R
P
---
D
P
---------
98
PsiBlast_CBE
85.12
39%
-105
- C7 -
3LEP
4
ALDR_HUMAN
A:
[6-297]
------
L
--
L
N
-
N
G
A
K
M
P
I
L
G
L
G
T
W
K
S
P
P
-
G
Q
V
T
E
-
A
V
K
V
---
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
I
Q
E
K
L
----
R
----
E
----
Q
-----
V
-
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
--
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
C
GFKPGKEF
F
P
L
D
ESGNVV
P
-----------
S
-----------
D
-----------------
T
N
-------
I
L
-------------
D
-------------
T
W
A
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
N
H
L
Q
V
E
M
I
L
N
K
P
--
G
L
K
YK
P
A
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
K
V
F
D
F
E
L
S
---
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
W
-
R
--------------------
41
PsiBlast_CBE
85.11
38%
-98
- C7 -
2WZM
1
Y2407_MYCS2
B:
[16-277]
---------
L
N
-
D
D
N
T
L
P
V
V
G
I
G
V
G
E
L
S
D
-
S
E
A
E
R
-
S
V
S
A
---
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
----
I
----
A
----
A
----
S
-----
G
-
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
--
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
G
-----------
D
-----------
T
-----------------
S
K
-------
Y
V
-------------
D
-------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
--
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
---------
G
V
------
G
--
R
-------------------
L
L
---------
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
---
A
D
E
M
E
T
L
N
G
L
D
D
-
G
T
-
R
---
F
R
P
---
D
P
---------
63
PsiBlast_CBE
85.08
40%
-107
- C7 -
3QKZ
1
ALD1_RAT
B:
[7-297]
---------
L
R
-
T
K
A
K
M
P
L
V
G
L
G
T
W
K
S
P
P
-
G
Q
V
K
E
-
A
V
K
A
---
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
----
I
QEKI
K
----
E
----
K
-----
A
-
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
--
F
E
K
S
L
MK
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
QGLQAGKEFLPKDSQGKV
L
------------------
M
-----------
S
-----------
K
-----------------
S
T
-------
F
L
-------------
D
-------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
GSPDRPYAK
P
E
------
D
--
P
--------
V
----------
V
L
---------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
N
V
A
V
I
P
K
S
V
T
L
S
R
I
K
E
N
I
Q
V
F
D
F
Q
L
S
---
E
E
D
M
A
A
I
L
S
L
N
R
-
N
W
-
R
--------------------
109
HHSearch
85.06
45%
-97
* C7 *
1VP5
1
?
A:
[17-278]
-----
K
V
--
T
L
N
N
G
V
E
M
P
I
L
G
Y
G
V
F
Q
I
P
P
-
E
K
T
E
E
-
C
V
Y
E
---
A
I
K
V
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
----
I
----
K
----
R
----
A
I
D
E
G-
I
-
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
--
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
------------------
G
------------------------------------------
D
-------
V
H
-------------
C
-------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
--
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
F
---------
A
E
------
G
--
R
--------
K
----------
N
I
F--------
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
---
Q
E
D
M
E
K
I
A
T
L
D
E
-
G
Q
----------------------
43
PsiBlast_CBE
84.86
39%
-90
- C7 -
1M9H
2
DKGA_CORSC
A:
[7-277]
------
V
--
L
N
-
D
G
N
S
I
P
Q
L
G
Y
G
V
Y
K
V
P
P
-
A
D
T
Q
R
-
A
V
E
E
---
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
----
I
----
A
----
A
----
S
-----
G
-
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
--
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
------------------
T
------------------
P
-----------
A
-----------
A
-----------------
D
N
-------
Y
V
-------------
H
-------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
--
G
V
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
---------
G
Q
------
G
--
K
Y-------
D
----------
L
F
---------
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
G
S
V
R
R
E
H
L
E
E
N
L
D
V
F
D
F
D
L
T
---
D
T
E
I
A
A
I
D
A
M
D
P
-
G
D
-
G
---
S
G
R
VSG
H
P
D
E
V
------
56
PsiBlast_CBE
84.83
36%
-99
- C7 -
3FX4
5
AK1A1_PIG
A:
[1-297]
M
A
A
S
C
V
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
Y
---
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
----
L
----
Q
----
E
----
T
VGPGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
ERGDNP
F
P
K
N
A
-----------
D
-----------------
G
T
I
R
Y
D
ATH
Y
K
-------------
D
-------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G--------
S
S
------
D
--
R
--------
A
WRDPNEPV--
L
L
---------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
L
-
R
--------------------
48
PsiBlast_CBE
84.63
39%
-103
- C7 -
4GQG
1
AK1BA_HUMAN
A:
[9-299]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
50
PsiBlast_CBE
84.59
39%
-103
- C7 -
1ZUA
2
AK1BA_HUMAN
X:
[8-298]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
IQEK-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
69
PsiBlast_CBE
84.33
40%
-110
- C7 -
3O3R
1
ALD1_RAT
B:
[7-297]
---------
L
R
-
T
K
A
K
M
P
L
V
G
L
G
T
W
K
S
P
P
-
G
Q
V
K
E
-
A
V
K
A
---
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
----
I
QEKI
K
----
E
----
K
-----
A
-
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
--
F
E
K
S
L
MK
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
QGLQAGKEFLPKDSQGKV
L
------------------
M
-----------
S
-----------
K
-----------------
S
T
-------
F
L
-------------
D
-------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
GSPDRPYAK
P
E
------
D
--
P
--------
V
----------
V
L
---------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
N
V
A
V
I
P
K
S
V
T
L
S
H
I
K
E
N
I
Q
V
F
D
F
Q
L
S
---
E
E
D
M
A
A
I
L
S
L
N
R
-
N
W
-
R
--------------------
47
PsiBlast_CBE
84.31
39%
-104
- C7 -
4JII
3
AK1BA_HUMAN
X:
[9-299]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
IQEK-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
44
PsiBlast_CBE
84.26
39%
-103
- C7 -
4GAB
3
AK1BA_HUMAN
A:
[7-297]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
112
HHSearch
84.05
42%
-90
- C7 -
1US0
4
ALDR_HUMAN
A:
[1-301]
--
M
A
S
R
I
--
L
L
N
N
G
A
K
M
P
I
L
G
L
G
T
W
K
S
P
P
-
G
Q
V
T
E
-
A
V
K
V
---
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
V
A
----
I
----
Q
----
E
K
L
R
E
Q
-----
V
-
V
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
--
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
T
------------------
G
F----------
K
-----------
P
GKEF
F
P
L
D
ESGNVVPSD
T
N
-------
I
L
-------------
D
-------------
T
W
A
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
N
H
L
Q
V
E
M
I
L
N
K
P
GL
K
Y
K
--
P
A
V
N
Q
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
---------
G
S
------
P
--
D
--------
R
----------
P
W
AKPEDPSLL
E
D
P
R
I
K
A
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
K
V
F
D
F
E
L
S
---
S
Q
D
M
T
T
L
L
S
Y
N
R
-
N
W
-
R
---
V
C
A
---
L
----------
46
PsiBlast_CBE
84.02
39%
-103
- C7 -
4JIH
2
AK1BA_HUMAN
A:
[9-299]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
70
PsiBlast_CBE
83.86
40%
-105
- C7 -
3O3R
1
ALD1_RAT
A:
[7-297]
---------
L
R
-
T
K
A
K
M
P
L
V
G
L
G
T
W
K
S
P
P
-
G
Q
V
K
E
-
A
V
K
A
---
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
----
I
Q
E
K
I
K
----
E
----
K
-----
A
-
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
--
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
QGLQAGKEF
L
P
K
D
SQG
K
V
L
------------------
M
-----------
S
-----------
K
-----------------
S
T
-------
F
L
-------------
D
-------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
GSPDRPYAK
P
E
------
D
--
P
--------
V
----------
V
L
---------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
N
V
A
V
I
P
K
S
V
T
L
S
H
I
K
E
N
I
Q
V
F
D
F
Q
L
S
---
E
E
D
M
A
A
I
L
S
L
N
R
-
N
W
-
R
--------------------
101
HHSearch
83.66
37%
-92
- C7 -
2WZM
1
Y2407_MYCS2
A:
[10-279]
-
A
I
P
T
V
T
--
L
N
-
D
D
N
T
L
P
V
V
G
I
G
V
G
E
L
S
D
-
S
E
A
E
R
-
S
V
S
A
---
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
----
I
----
A
----
A
----
S
-----
G
-
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
--
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
------------------
G
------------------
G
D----------
T
-----------
S
------------------
K
-------
Y
V
-------------
D
-------------
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
--
Y
F
T
--
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
---------
G
V
------
G
--
R
--------
L
----------
L
D
----------
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
---
A
D
E
M
E
T
L
N
G
L
D
D
-
G
T
-
R
---
F
R
P
---
D
P
A
T
-------
59
PsiBlast_CBE
83.58
36%
-94
- C7 -
1HQT
1
AK1A1_PIG
A:
[3-298]
-
A
A
S
C
V
L
--
L
H
-
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
-
G
Q
V
K
A
-
A
I
K
Y
---
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
F
G
N
E
L
E
I
G
E
A
----
L
----
Q
----
E
----
T
VGPGK
A
-
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
--
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
------------------
A
F
ERGDNP
F
P
K
N
A
-----------
D
-----------------
G
T
IR
Y
D
A
T
H
Y
K
-------------
D
-------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G--------
S
S
------
D
--
R
--------
A
W
R
D
P
N
E
PV--
L
L
---------
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
---
P
E
E
M
K
Q
L
D
A
L
N
K
-
N
L
-
R
--------------------
45
PsiBlast_CBE
83.42
39%
-102
- C7 -
4GA8
2
AK1BA_HUMAN
A:
[7-297]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
49
PsiBlast_CBE
83.17
39%
-103
- C7 -
4GQ0
2
AK1BA_HUMAN (first)
A:
[9-299]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
64
PsiBlast_CBE
83.09
40%
-105
- C7 -
3QKZ
1
ALD1_RAT
A:
[7-297]
---------
L
R
-
T
K
A
K
M
P
L
V
G
L
G
T
W
K
S
P
P
-
G
Q
V
K
E
-
A
V
K
A
---
A
I
D
A
G
Y
R
H
F
D
C
A
Y
V
Y
Q
N
E
S
E
V
G
E
A
----
I
Q
E
K
I
K
----
E
----
K
-----
A
-
V
R
R
E
D
L
F
I
V
S
K
L
W
S
T
F
--
F
E
K
S
L
M
K
E
A
F
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
Q
G
L
Q
AGKEF
L
P
K
D
SQGK
V
L
------------------
M
-----------
S
-----------
K
-----------------
S
T
-------
F
L
-------------
D
-------------
A
W
E
G
M
E
E
L
V
D
Q
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
L
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
A
V
I
A
Y
S
P
L
GSPDRPYAK
P
E
------
D
--
P
--------
V
----------
V
L
---------
E
I
P
K
I
K
E
I
A
A
K
H
K
K
T
I
A
Q
V
L
I
R
F
H
V
Q
R
N
V
A
V
I
P
K
S
V
T
L
S
R
I
K
E
N
I
Q
V
F
D
F
Q
L
S
---
E
E
D
M
A
A
I
L
S
L
N
R
-
N
W
-
R
--------------------
77
PsiBlast_CBE
83.05
35%
-97
- C7 -
1XJB
5
AK1C2_HUMAN
A:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
51
PsiBlast_CBE
82.75
39%
-100
- C7 -
4I5X
2
AK1BA_HUMAN
A:
[9-299]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
K
S
P
L
-
G
K
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
----
I
----
Q
----
E
----
K
I
Q
E
K-
A
-
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
--
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDLFPKDDKG
N
A
I
------------------
G
-----------
G
-----------
K
-----------------
A
T
-------
F
L
-------------
D
-------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
--
G
L
K
YK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
GSPDRPWAK
P
E
------
D
--
P
--------
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
---
D
E
E
M
A
T
I
L
S
F
N
R
-
N
W
-
R
--------------------
93
PsiBlast_CBE
82.38
35%
-95
- C7 -
4JQ3
4
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
K
P
G
EEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
71
PsiBlast_CBE
82.33
39%
-100
- C7 -
1C9W
1
ALD2_CRIGR
A:
[6-306]
---------
L
S
-
T
K
A
K
M
P
I
V
G
L
G
T
W
Q
S
P
P
-
G
Q
V
K
E
-
A
V
K
V
---
A
I
D
A
G
Y
R
H
I
D
C
A
Y
A
Y
Y
N
E
H
E
V
G
E
A
----
I
Q
E
K
I
K
----
E
----
K
-----
A
-
V
R
R
E
D
L
F
I
V
S
K
L
W
P
T
C
F
E
R
K
L
L
K
--
E
A
F
Q
K
T
L
T
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
Q
G
L
Q
P
G
KEL
F
P
K
D
DQG
N
V
L
------------------
T
-----------
S
-----------
K
-----------------
I
T
-------
F
L
-------------
D
-------------
A
W
E
V
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
N
H
F
Q
I
E
R
I
L
N
K
P
--
G
L
K
HK
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
E
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
L
---------
G
S
P-----
N
--
R
PWAKPEDP
S
----------
L
L
---------
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
S
A
Q
V
L
I
R
F
H
I
Q
R
N
V
V
V
I
P
K
S
V
T
P
A
R
I
H
E
N
F
Q
V
F
D
F
Q
L
S
---
D
Q
E
M
A
T
I
L
G
F
N
R
-
N
W
-
R
---
A
C
L
---
L
P
E
T
V
N
M
----
86
PsiBlast_CBE
82.06
35%
-99
- C7 -
4JTQ
9
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
119
HHSearch
81.98
36%
-92
- C7 -
2BGS
4
ALDR_HORVU
A:
[37-317]
---
Q
D
H
F
--
V
L
K
S
G
H
A
M
P
A
V
G
L
G
T
W
R
A
G
S
-
D
T
A
H
S
-
V
R
T
A
---
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
V
E
K
E
V
G
K
G
----
L
----
K
----
A
----
A
M
E
A
--
G
-
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
--
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
------------------
F
------------------
R
L
----------
K
-----------
D
GAHMPPEAGE
V
L
E
----
F
D
-------
M
E
-------------
G
-------------
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
S
A
--
K
I
P
--
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
L
---------
G
S
------
S
--
E
--------
K
----------
N
L
A--------
H
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
F
G
W
E
I
P
---
E
E
D
F
K
V
L
C
S
I
K
D
-
E
K
-
R
--------------------
91
PsiBlast_CBE
81.98
35%
-98
- C7 -
4JQ4
5
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
97
PsiBlast_CBE
81.83
35%
-96
- C7 -
4JQ1
4
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
100
PsiBlast_CBE
81.64
37%
-94
- C7 -
2VDG
6
ALDR_HORVU
A:
[41-303]
------
V
--
L
K
-
S
G
H
A
M
P
A
V
G
L
G
T
W
R
A
G
S
-
D
T
A
H
S
-
V
R
T
A
---
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
V
E
K
E
V
G
K
G
----
L
----
K
A
A
M
-
E
----
A
-----
G
-
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
--
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
------------------
F
------------------
R
L
----------
K
-----------
D
-----------------
G
A
-------
H
M
-------------
P
PEAGE
V
L
E
F
D
M
E
G
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
S
A
--
K
I
P
--
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
L
---------
G
S
------
S
E-
K
--------
N
----------
L
A
---------
H
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
--
F
G
W
E
---
I
P
E
----------------------------------
85
PsiBlast_CBE
81.63
35%
-97
- C7 -
4JTR
5
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
78
PsiBlast_CBE
81.52
35%
-99
- C7 -
2HDJ
7
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
VKL
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
SKIA
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
FDTVDLC------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
87
PsiBlast_CBE
81.48
35%
-97
- C7 -
4JTQ
4
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
K
P
G
EEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
84
PsiBlast_CBE
81.41
35%
-98
- C7 -
4JTR
7
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
76
PsiBlast_CBE
81.25
35%
-95
- C7 -
1XJB
5
AK1C2_HUMAN
B:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
75
PsiBlast_CBE
81.14
35%
-97
- C7 -
4L1W
4
AK1C2_HUMAN
A:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
73
PsiBlast_CBE
81.12
35%
-98
- C7 -
4L1X
4
AK1C2_HUMAN
A:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
89
PsiBlast_CBE
81.08
35%
-97
- C7 -
4JQA
5
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
88
PsiBlast_CBE
80.94
35%
-98
- C7 -
4JQA
7
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
79
PsiBlast_CBE
80.82
35%
-94
- C7 -
2HDJ
5
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
K
P
G
EEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
72
PsiBlast_CBE
80.82
35%
-96
- C7 -
4L1X
3
AK1C2_HUMAN
B:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
VKL
A
I
E
A
G
F
H
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
SKIA
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
FDTVDLC------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
81
PsiBlast_CBE
80.74
35%
-97
- C7 -
1J96
3
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
K
PGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
95
PsiBlast_CBE
80.72
35%
-98
- C7 -
4JQ2
5
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
74
PsiBlast_CBE
80.72
35%
-97
- C7 -
4L1W
3
AK1C2_HUMAN
B:
[12-306]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
VKL
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
SKIA
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
FDTVDLC------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
65
PsiBlast_CBE
80.71
35%
-95
- C7 -
3NTY
3
AK1C1_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
68
PsiBlast_CBE
80.62
35%
-98
- C7 -
3GUG
3
AK1C1_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
94
PsiBlast_CBE
80.23
35%
-97
- C7 -
4JQ2
7
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
67
PsiBlast_CBE
80.15
35%
-97
- C7 -
1MRQ
3
AK1C1_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
92
PsiBlast_CBE
80.12
35%
-96
- C7 -
4JQ3
8
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
82
PsiBlast_CBE
80.02
35%
-92
- C7 -
1IHI
2
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
VKL
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
SKIA
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
FDTVDLC------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
80
PsiBlast_CBE
79.98
35%
-97
- C7 -
1J96
3
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
K
PGEEVIP----------------------
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
66
PsiBlast_CBE
79.94
35%
-98
- C7 -
3C3U
3
AK1C1_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
T
K
L
A
I
E
A
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
90
PsiBlast_CBE
79.92
35%
-96
- C7 -
4JQ4
7
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
------------PWVDPNSPV-
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
83
PsiBlast_CBE
79.92
35%
-93
- C7 -
1IHI
2
AK1C2_HUMAN
A:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
V
K
L
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
S
K
I
A
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEV
I
P
K
D
E
N
-----------------
G
K
-------
I
L
F
D
T
V
D
L
C
------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
96
PsiBlast_CBE
79.79
35%
-95
- C7 -
4JQ1
5
AK1C2_HUMAN
B:
[10-304]
---------
L
N
-
D
G
H
F
M
P
V
L
G
F
G
T
Y
A
P
A
E
-
V
P
K
S
K
-
A
L
E
A
VKL
A
I
E
A
G
F
H
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
L
A
----
I
----
R
SKIA
D
----
G
-----
S
-
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
--
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
------------------
S
-----------
V
KPGEEVIPKDE
N
-----------------
G
K
-------
I
L
FDTVDLC------
A
-------------
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
H
R
L
L
E
M
I
L
N
K
P
--
G
L
K
YK
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
L
---------
G
S
------
H
--
R
--------
E
EPWVDPNSPV
L
L
---------
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
---
S
E
E
M
K
A
I
D
G
L
N
R
-
N
V
-
R
--------------------
62
PsiBlast_CBE
79.24
38%
-108
- C7 -
3H7R
13
AKRC8_ARATH
A:
[30-290]
---------
L
N
-
T
G
A
K
L
P
C
V
G
L
G
T
Y
A
M
-----
V
A
T
-
A
I
E
Q
---
A
I
K
I
G
Y
R
H
I
D
C
A
S
I
Y
G
N
E
K
E
I
G
G
V
----
L
----
K
K
L
I
G
D
----
G
-----
F
-
V
K
R
E
E
L
F
I
T
S
K
L
W
S
N
D
H
L
P
E
D
V
P
--
K
A
L
E
K
T
L
Q
D
L
Q
I
D
Y
V
D
L
Y
L
I
H
W
P
------------------
A
------------------
S
-----------
L
-----------
K
-----------------
K
E
-------
S
L
MPTPEMLTKPD
I
T
S
-------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
S
K
K
L
T
D
L
L
N
V
A
--
R
V
T
--
P
A
V
N
Q
V
E
C
H
P
V
W
Q
Q
Q
G
L
H
E
L
C
K
S
K
G
V
H
L
S
G
Y
S
P
L
G--------
S
Q
------
S
--
K
--------
G
EVR
L
K
-----
V
L
---------
Q
N
P
I
V
T
E
V
A
E
K
L
G
K
T
T
A
Q
V
A
L
R
W
G
L
Q
T
G
H
S
V
L
P
K
S
S
S
G
A
R
L
K
E
N
L
D
V
F
D
W
S
I
-----------------------------------------