@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0675: (2016-03-17 )
MEAYKIEHLNKSYADKTIFDNLDLSISEGEKIGLVGINGTGKSTLLKVIGGIDDDFTANVMHPNQYRIRYSSQKQDLNEDMTVFDAVLSSDTTTLRIIKQYEQAVQAYADDQSDKLFKRMIDAQDAMDQHDAWDYNAEIKTILSKLGIHDTTKYIKELSGGQQKRVVLAKTLIEQPDLLLLDEPTNHLDFESISWLINYVKQYPHTVLFVTHDRYFLNEVSTRIIELNRGKLASYPGNYESYIEMRAEREVTLQKQQQKQRALYKEELAWMRAGAKARTTKQQARINRFNDLENEVNQQYKDDKGELNLAYSRLGKQVFELEDLSKAINDKVLFEHLTEIIQKGERIGVVGPNGAGKTTLLNILSGEDQQFEGKLKTGQTVKVAYFKQTDETLDRDIRMIDYLREESEVAKEKDGTSVSITQLLERFLFPSATHGKKVYKLSGGEQKRLYLLRLLVHQPNVLLLDEPTNDLDTETLTILEDYIHTFGGTVITVSHDRYFLNKVAQSYWFIHDGQMEKIIGTFEDYESYKKSLDKNKSTLKQQSKSYTTVRKKNGLSYKEKLEYEQLMKRIEQAEVRMEEIDVLMIEASADYGKIKELNEEKEQLEIQYDLDITRWSELEEIKEQQ
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10...-.-------.-.-..----20...----..-...30........40........50..-------..-....--.60...--------------..---.-.--.70....-..-.---.--80....--....90........100.......110..--....-.120.......130.......140.......150.-.-..-.....160.......170....--...180.......190--........200.----..---....210.......220.....------..230.......240.......250.......260.......270.......280.......290.......300--........310-......--.320.......-330.........340.......350.......360.......370-------------------.........380-------.-----------........390.-.------------------------------------------------------------------------.--.....400.....----------------------------------------------------------------------.------.410-------------------------.........420.......430.-......440.......450.......---460.......470..----.....480....----.----..490.......500.......510-----.--.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------ME
A
Y
K
I
E
HL
N
K
SYA-D-------K-T-IF----DNL
D
L
----SI-SEG
E
K
I
G
L
V
G
INGT
G
K
S
T
L
L
K
V
I
G-GI-------DD-DFTA--NVMHPN--------------
Q
Y
---
R
-
I
--
R
YSSQKQ-DL-N---E--
D
M
T
V
F
D
--
A
V
LSSD
T
T
T
L
R
I
I
K
Q
Y
E
Q
A
V
Q
A
YADD
Q
S
D
--
K
L
F
K
-
R
M
I
D
A
Q
D
AMDQHDAWDYN
A
E
I
K
T
I
L
S
K
LGI
H
D
--
T
-
T
-
K
Y
-
I
K
E
LSGGQ
Q
K
R
V
V
L
A
K
T
L
IEQP--
D
L
L
L
LDEPTNHL
D
F
E
---
S
I
S
W
L
I
N
Y
V
K
QY----P
H
---
T
V
L
F
V
TH
D
R
Y
F
L
N
E
V
S
T
R
I
I
E
L------NRGKLASYPG
N
Y
E
S
Y
I
E
M
R
A
ER
E
V
T
L
Q
K
Q
Q
Q
K
Q
R
A
L
Y
K
E
E
L
A
W
M
RAGAKART
T
K
Q
Q
A
R
INRF
N
D
L
E
N
E
V
N
Q
Q
YK---DDKGE
L
N
L
A
Y
S
-
R
L
G
K
Q
V
--
F
E
L
E
D
L
S
K
AI
N
-
D
--
K
V
L
F
E
H
L
T
E
I
I
QKG
E
R
I
G
V
VGPNGAGK
T
T
L
L
N
ILSGED
Q
Q
---------------------FEGKLKTG
Q
T
---------
V
-----------
K
V
A
Y
F
KQT
D
E
-
T
-
L
------------------------------------------------------------------------
D
--
R
D
I
R
M
I
D
Y
L
R
E
E
S
----------------------------------------------------------------------
E
------
V
A---------------------------KEKDGTS
V
S
I
T
Q
L
L
E
R
FLFPSAT-HG
K
K
V
Y
K
LSGGE
Q
K
R
L
Y
L
L
R
L
L
VHQP---
N
V
L
L
L
DEPTNDLD
T
E
----
T
L
T
I
L
E
D
Y
I
H
TF----G----
G
T
V
I
T
V
SH
D
R
Y
F
L
N
K
V
A
Q
S
Y
W
F
IH------D--G
Q
M
E
K
I
I
G
T
F
E
D
Y
E
S
Y
K
K
S
LDK
N
K
S
T
L
K
Q
Q
SKSY
T
T
V
RKKNGL
S
Y
K
E
KL
E
Y
E
Q
L
M
K
R
I
E
Q
A
E
V
R
M
E
EI
D
V
L
M
I
EASADYG
K
I
K
E
L
N
EEK
E
Q
L
E
I
Q
YDLDIT
R
W
S
E
L
E
E
I
K
EQQ
2
PsiBlast_PDB
91.48
37%
-70
- C1 -
4FIN
13
ETTA_ECOLI
A:
[19-535]
-----------------------------------------------------------------------------------------
R
-
H
-
I
L
----
K
N
I
S
L
----
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
-
G
I
-------
D
K
-
D
I
E
G
--
E
A
R
P
Q
P
--------------
D
I
---
K
-
I
--
G
Y
L
P
Q
E
P
-
Q
L
-
N
---
P
--
E
H
T
V
R
E
--
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
-
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
-
D
-
A
K
-
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
R
F
E
E
L
-
N
S
T
E
Y
Q
K
R
---
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
--
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
T
---------
V
-----------
K
L
A
S
V
D
Q
F
R
D
-
S
-
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
G
L
----------------------------------------------------------------------
D
------
I
M
---------------------------
K
I
G
N
-
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
----
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
-----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.87
37%
-53
- C1 -
3J5S
-
ETTA_ECOLI
D:
[12-541]
---------------------------------------------------------------------
Y
T
M
H
R
V
G
K
V
V
P
-
P
-------
K
-
R
H
I
L
----
K
N
I
S
L
----
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
-
G
I
-------
D
K
-
D
I
E
G
--
E
A
R
P
Q
P
--------------
D
I
---
K
-
I
--
G
Y
L
P
Q
E
P
-
Q
L
-
N
---
P
--
E
H
T
V
R
E
--
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
P
D
A
D
FD
K
L
A
A
-
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
-
D
-
A
K
-
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
E
L
-
N
S
T
E
Y
Q
K
R
---
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
--
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
T
---------
V
-----------
K
L
A
S
V
D
Q
F
R
D
-
S
-
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
G
L
----------------------------------------------------------------------
D
------
I
M
---------------------------
K
I
G
N
-
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
----
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
-----------------------------------------------------------------------------------------------
35
HHSearch
78.38
28%
-74
- C- -
2IW3
7
EF3A_YEAST
A:
[440-979]
-------------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
-
N
G
-------
Q
V
---
D
G
--
F
P
T
-
Q
E
--------------
E
C
---
R
-
T
--
V
Y
V
E
H
D
I
-
D
G
T
H
---
S
--
D
T
S
V
L
D
--
F
V
F
E
S
G
V
--------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
-
M
I
A
-
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
-----
Y
E
E
L
S
----------------------
N
T
-----
D
L
E
--
F
K
-
F
P
E
---
P
--
G
Y
L
E
-
G
V
K
-
T
K
Q
K
A
I
--
V
K
V
T
N
M
E
F
Q
Y
P
-
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
H
A
F
-
A
H
I
------------------------------------------------------------------------
E
SH
L
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
R
P
L
T
R
K
-
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
----
S
L
G
A
L
S
K
A
L
K
E
F
----
E
----
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
------
D
--
G
R
M
T
P
S
-----------------------------------------------------------------------------------------------------------
39
HHSearch
66.11
21%
-58
- C1 -
3OZX
5
?
A:
[4-464]
-------------------------------------------------------------------------
E
V
I
H
R
Y
K
-
V
N------
G
-
F
-
K
L
----
F
G
L
P
T
-----
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
-
G
E
-------
I
I
-
P
N
F
G
--
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
K
---
E
-
I
--
Y
N
Y
F
K
E
L
-
Y
S
-----
N
--
E
L
K
I
V
H
--
K
I
Q
Y
V
E
Y
A
-
S
K
---------------------
F
L
K
---
G
T
V
N
E
I
---
L
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
--
L
W
N
-
K
D
-
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
---
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
-----------
G
I
N
N
F
L
K
---
G
Y
L
P
----
A
E
----
N
M
K
I
R
P
-
D
E
I
K
--
F
M
-
L
K
------------------
L
K
T
K
--
M
K
W
T
K
I
I
K
K
L
G
-
D
---
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
V
T
P
E
K
----------
Q
-----------
I
L
S
Y
K
P
Q
R
I
F
---
P
------------------------------------------------------------------------
N
--
Y
D
G
T
V
Q
Q
Y
L
E
N
A
S
----------------------------------------------------------------------
K
------
D
A
---------------------------
L
-
S
T
S
S
W
-
F
F
E
E
V
T
K
R
L
N
L
H
-
R
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
----
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
----
A
V
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
------
G
--
E
P
E
--------------------------------------------------------------------------------------------------------------
38
HHSearch
63.40
24%
-50
- C1 -
1YQT
4
?
A:
[25-480]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
-
V
N------
A
-
F
-
V
L
----
Y
R
L
P
-----
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
-
G
Q
-------
L
I
-
P
N
L
C
GD
N
D
S
W
D
G
--------------
V
I
---
R
-
A
F
R
G
N
E
L
Q
N
Y
F
E
K
-
L
---
K
--
N
G
E
I
R
P
--
V
V
K
P
Q
Y
V
D
L
I
P
----------
K
A
---------
V
K
G
-
K
V
I
------
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
--
V
L
E
-
R
E
-
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
---
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
--------
G
I
N
E
F
L
R
---
G
Y
L
K
D
----------
E
N
V
-
R
F
R
P
Y
E
--
I
K
-
F
T
K
----
T
G
E
R
V
----
E
-
I
E
R
E
T
L
--
V
T
Y
P
R
L
V
K
D
Y
G
-
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
----------------------
T
V
A
Y
K
P
Q
Y
I
K
-
A
--------------------------------------------------------------------------
D
--
Y
E
G
T
V
Y
E
L
L
S
K
I
D
----------------------------------------------------------------------
A
------
S
K
-----------------------------
L
N
S
N
F
-
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
--
E
P
G
--------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.44
25%
-46
- C1 -
3BK7
2
?
A:
[114-539]
-------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
-
G
Q
LIPNLCE
D
N
-
D
S
W
D
--
N
V
I
R
----------------
A
F
---
R
-------------
G
-
N
---
E
--
L
Q
N
Y
F
E
--
R
L
K
N
G
E
I
R
P
V
-
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
K
V
R
--
E
L
L
K
-
K
V
----
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
------------
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
V
I
H
V
------
V
Y
G
E
----
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
----
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
E
R
V
----
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
S
F
K
L
-------------
E
V
E
P
G
E
------------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
L
T
---------
V
A
Y
---------
K
P
Q
Y
I
K
A
E
Y
E
G
T
-
V
------------------------------------------------------------------------
Y
--
E
L
L
S
K
I
D
S
S
K
L
N
S
----------------------------------------------------------------------
N
------
F
Y
---------------------------
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-----------
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
NE
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
---------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
61.14
23%
-48
- C1 -
3BK7
4
?
A:
[83-547]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
-
A
F
----
V
L
Y
R
L
----
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
-
G
Q
-------
L
I
-
P
N
L
C
--
E
D
N
D
S
W
--------------
D
----
N
-
V
--
I
R
A
F
R
G
N
-
E
L
-
Q
---
N
--
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
------
P
Q
Y
V
D
L
L
--------
P
--
K
A
V
K
---
G
K
V
R
E
L
---
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
--
V
L
D
-
R
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
---
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
--------
G
I
N
E
F
L
Q
G
---
Y
L
K
----
D
E
----
N
V
R
F
R
P
-
Y
E
I
R
--
F
T
-
K
L
S
--------
E
--
R
V
D
-
V
E
R
E
T
L
--
V
E
Y
P
R
L
V
K
D
Y
G
-
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
-----------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
-
A
--------------------------------------------------------------------------
E
--
Y
E
G
T
V
Y
E
L
L
S
K
I
D
----------------------------------------------------------------------
S
------
S
K
-----------------------------
L
N
S
N
F
-
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
------
G
-------------------------------------------------------------------------------------------------------------------
49
HHSearch
60.35
23%
-65
- C1 -
1V43
-
?
A:
[8-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
M
V
E
--
V
K
L
E
N
L
T
K
R
F
G
-
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
---------------------
T
E
G
R
I
Y
F
G
D
R
DVTYLPPKD
R
-----------
N
I
S
M
V
F
Q
-----------------------------------------------------------------------------------
H
M
T
V
Y
E
N
I
A
F
P
L
------------------------------------------------------------------------------
K
KF-------------------------
P
K
D
E
I
D
K
-
R
V
R
W
A
A
E
L
L
Q
I
E
-
E
L
-
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
---
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
----
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
----
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
------
R
--
G
Q
L
L
-
Q
I
G
S
P
T
E
V
Y
L
R
-------------------------------------------------------------------------------------------------
56
HHSearch
60.32
27%
-70
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
--
V
Q
L
Q
N
V
T
K
A
W
G
-
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
---------------------
T
S
G
D
L
F
I
G
E
K
RMNDTPPAE
R
-----------
G
V
G
M
V
F
Q
S
Y
A
---
L
------------------------------------------------------------------------
Y
--
P
H
L
S
V
A
E
N
M
S
F
G
L
----------------------------------------------------------------------
K
------
L
A
GA-------------------------
K
K
E
V
I
N
Q
-
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
-
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
---
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
----
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
----
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
--
G
R
V
A
-
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
-----------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.84
25%
-38
- C1 -
3J15
2
?
B:
[100-525]
-------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
-
G
Q
LIPNLCE
D
N
-
D
S
W
D
--
N
V
I
R
----------------
A
F
---
R
-------------
G
-
N
---
E
--
L
Q
N
Y
F
E
--
R
L
K
N
G
E
I
R
P
V
-
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
K
V
R
--
E
L
L
K
-
K
V
----
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
------------
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
V
I
H
V
------
V
Y
G
E
----
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
----
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
E
R
V
----
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
S
F
K
L
-------------
E
V
E
P
G
E
------------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
L
T
---------
V
A
Y
---------
K
P
Q
Y
I
K
A
E
Y
E
G
T
-
V
------------------------------------------------------------------------
Y
--
E
L
L
S
K
I
D
S
S
K
L
N
S
----------------------------------------------------------------------
N
------
F
Y
---------------------------
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-----------
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
---------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
59.48
20%
-45
- C1 -
3J16
2
RLI1_YEAST
B:
[81-559]
------------------------------------------------------------------------
A
H
V
T
H
R
Y
S
-
A
-------
N
S
F
-
K
L
----
H
R
L
P
-----
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
-
G
K
-------
Q
K
-
P
N
L
G
--
R
F
D
D
P
P
--------------
E
W
Q
--
E
I
I
--
K
Y
F
R
G
-
S
-
E
L
-
Q
---
N
Y
F
T
K
M
L
E
D
--
D
I
K
A
I
I
K
P
Q
Y
-
V
D
-
N
I
P
R
A
---
I
----------
K
G
-
P
V
Q
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
--
V
L
K
-
R
D
-
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
Y
--
G
V
V
T
L
P
A
S
V
R
E
-----------
G
I
N
I
F
L
D
G
H
-------
I
P
A
E
N
L
--
R
F
R
T
E
A
L
Q
F
R
---
I
A
-
D
A
T
------
E
D
L
---
Q
N
-
D
S
A
S
R
A
--
F
S
Y
P
S
L
K
K
T
Q
G
----
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
--
K
---------
L
-----------
N
V
S
M
K
P
Q
K
I
A
-
P
-
K
---------------------------------------------------------------------------
F
P
G
T
V
R
Q
L
F
F
K
K
I
----------------------------------------------------------------------
R
------
G
Q
---------------------------
F
--
L
N
P
Q
-
F
Q
T
D
V
V
K
P
L
R
I
D
-
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
----
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
----
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------
G
I
P
S
K
N
A
-
H
A
R
A
P
E
S
L
L
T
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.07
26%
-35
- C1 -
1YQT
4
?
A:
[44-435]
-------------------------------------------------------------------------------------------------------------
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
-
G
-----------
Q
L
I
P
--
N
L
C
G
D
N
--------------
D
S
W
D
G
V
-
I
--
R
A
F
R
G
------
N
---
E
--
L
Q
N
Y
F
E
--
K
L
K
N
G
E
I
R
P
V
-
V
K
P
Q
Y
V
D
L
I
P
K
A
V
K
G
K
V
I
--
E
L
L
K
-
K
A
-------------
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
--
V
-
L
E
R
E
-
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
----
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
I
I
H
V
------
V
Y
G
E
----
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
----
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
K
F
T
K
T
G
E
R
V
----
E
I
E
R
E
T
L
--------------
V
T
Y
P
-
R
L
V
K
D
Y
GS
F
R
L
E
V
E
P
G
E
I
----------------
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
T
---------
V
A
Y
---------
K
P
Q
Y
I
K
A
D
Y
E
G
T
-
V
------------------------------------------------------------------------
Y
--
E
L
L
S
K
I
D
A
S
K
L
N
S
----------------------------------------------------------------------
N
------
F
Y
---------------------------
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-----------
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
59.04
23%
-51
- C1 -
2R6F
3
?
A:
[487-944]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
G
L
D
Y
L-
T
L
S
-
R
S
-
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
---
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
N
---
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
--------------
L
T
G
---
Q
Y
L
S
----
G
-----
K
K
----
F
------
I
P
-
I
P
A
-----------
E
R
R
-
R
P
D
G
R
W
--
L
E
V
V
G
A
R
--------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
I
D
I
D
Q
S
---------
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
D
I
R
D
-
V
-
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
--
L
D
M
T
V
E
D
A
L
D
F
F
A
----------------------------------------------------------------------
S
-------------------------------------
I
P
K
I
K
-
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
----
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
----
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
PEGGDR
G
--
G
Q
I
V
-
A
V
G
T
P
E
E
V
A
E
V
K
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.23
27%
-48
- C1 -
2IW3
6
EF3A_YEAST
A:
[444-743]
-----------------------------------------------------------------------------
A
Y
G
-
A
-------
K
-
I
-
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
-------
V
D
-
G
F
--------
P
T
--------------
Q
E
---
E
-
C
--
R
T
V
Y
V
E
H
-
D
I
-
D
GTH
S
--
D
T
S
V
L
D
--
F
V
F
E
S
G
V
G
T
K
E
A
I
K
--------------
D
--
K
L
I
E
----------------------------
F
G
F
T
D
E
M
I
-
A
-
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
-
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
-
G
V
K
---
T
K
Q
K
A
-
I
V
K
V
T
N
M
E
F
Q
Y
P
G
T
S
K
---
P
Q
I
T
D
I
N
F
Q
C
S
--------------
L
S
S
----------------------
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
58.16
29%
-73
- C1 -
1Z47
1
?
A:
[13-234]
-------------------------------------------------------------------
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-------
A
-
R
-
S
V
----
R
G
V
S
F
----
Q
I
-
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
-
G
L
-------
E
R
-
P
T
K
G
--
D
V
W
I
G
G
KRVTDLPPQ-----
K
R
---
N
-
V
--
G
L
V
F
Q
N
Y
-
A
L
-
F
---
Q
--
H
M
T
V
Y
D
--
N
V
S
F
G
L
R
E
K
R
V
-------------------------------------
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
--
Y
A
N
-
R
F
-
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
--
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
---
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
57.66
27%
-56
- C1 -
1Z47
1
?
A:
[11-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
--
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
---------------------
T
K
G
D
V
W
I
G
G
K
RVTDLPPQK
R
-----------
N
V
G
L
V
F
Q
N
Y
A
---
L
------------------------------------------------------------------------
F
--
Q
H
M
T
V
Y
D
N
V
S
F
G
L
----------------------------------------------------------------------
R
------
E
K
RV-------------------------
P
K
D
E
M
D
A
-
R
V
R
E
L
L
R
F
M
R
L
E
-
S
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
----
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
----
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
------
E
--
G
N
V
E
-
Q
F
G
T
P
E
E
V
Y
E
K
P
------------------------------------------------------------------------------------------------
28
Fugue
57.26
18%
-30
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CP
F
D
A
I
Q
I
I
N
L
P
T
N
L
E
-
A
-------
H
-
V
-
T
H
RYSA
N
S
F
K
L
H
R
L
P
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
-
G
K
-------
Q
K
P
N
L
G
R
--
F
D
D
P
P
E
--------------
W
Q
---
E
-
I
--
I
K
Y
F
R
G
S
-
E
L
-
Q
---
N
--
Y
F
T
K
M
L
--
E
----
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
P
V
Q
--
K
V
G
E
-
L
L
K
L
R
--------
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
--
V
-
L
-
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
----------------
V
P
S
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
------
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
---
N
D
S
A
S
R
A
F
S
Y
P
-
S
L
K
K
T
Q
--------------
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
K
L
N
---------
V
-----------
S
M
K
P
Q
K
I
A
P
K
-
F
-
P
------------------------------------------------------------------------
G
--
T
-------
V
R
Q
L
F
----------------------------------------------------------------------
F
------
K
K
---------------------------
I
R
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
----
K
----
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------
G
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
--------------------------------------------------
3
PsiBlast_PDB
56.62
27%
-43
- C1 -
2IWH
8
EF3A_YEAST
A:
[444-743]
-----------------------------------------------------------------------------
A
Y
G
-
A
-------
K
-
I
-
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
-------
V
D
-
G
F
--------
P
T
--------------
Q
E
---
E
-
C
--
R
T
V
Y
V
E
H
-
D
I
-
D
GTH
S
--
D
T
S
V
L
D
--
F
V
F
E
S
G
V
G
T
K
E
A
I
K
--------------
D
--
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
-------------------------------
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
-
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
-
G
V
K
---
T
K
Q
K
A
-
I
V
K
V
T
N
M
E
F
Q
Y
P
G
T
S
K
---
P
Q
I
T
D
I
N
F
Q
C
S
--------------
L
S
S
----------------------
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.34
24%
-63
- C1 -
2YYZ
3
?
A:
[2-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
--
I
R
V
V
N
L
K
K
Y
F
G
-
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
---------------------
T
S
G
E
I
Y
F
D
D
V
LVNDIPPKY
R
-----------
E
V
G
M
V
F
Q
N
Y
A
---
L
------------------------------------------------------------------------
Y
--
P
H
M
T
V
F
E
N
I
A
F
P
L
----------------------------------------------------------------------
R
------
A
R
RI-------------------------
S
K
D
E
V
E
K
-
R
V
V
E
I
A
R
K
L
L
I
D
-
N
L
-
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
---
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
----
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
----
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
------
Q
--
G
K
L
V
-
Q
Y
G
T
P
D
E
V
Y
D
S
P
------------------------------------------------------------------------------------------------
44
HHSearch
56.21
24%
-47
- C1 -
1OXX
25
?
K:
[1-310]
------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK-----
V
-
V
-
A
L
----
D
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
-
G
L
-------
D
V
-
P
S
T
G
--
E
L
Y
F
D
D
RLVASNGKLIVPPE
D
R
---
K
-
I
--
G
M
V
F
Q
T
W
-
A
L
-
Y
---
P
--
N
L
T
A
F
E
--
N
I
A
F
P
L
T
N
M
K
-------------------------------------
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
--
V
L
N
-
H
F
-
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
--
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
---
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
K
G
K
L
V
Q
V
-
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
---------
A
S
L
I
G
E
I
N
E
L
------------
E
G
K
V
---
T
N
E
G
--
V
V
-
I
G
------
S
L
R
F
P
-
V
S
V
-
S
S
D
R
A
I
--
I
G
I
R
P
E
D
V
K
L
S
----
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------