@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0677: (2016-03-17 )
MIKFKNVTKRYGKHVAVDNISFNINEGEFFVLIGPSGCGKTTTLKMINRLIHLSEGYIYFKDKPISDYPVYEMRWDIGYVLQQIALFPHMTIKENIAQVPQMKKWKEKDIDKRVDELLDMVGLEPEKYKNRKPDELSGGQRQRVGVIRALAADPPVILMDEPFSALDPISREKLQDDLIELQTKIKKTIIFVTHDIQEAMKLGDKICLLNEGHIEQIDTPEGFKNNPQSEFVKQFMGSHLEDDAPCVEENAIIRDLDIMKPIDEVTSMSAYPIVYDNQPIEVLYQHLSESERVIVMQEDSVGQYVIDRKDIFKYLSQKKEVAQHD
Atome Classification :
(44 SA)
.........10-.-..-----.....20........30........40........50........60--....----.-------------.----..70--........80.--.......90........100...-.....110.......120.--......130.......140.......150.......160.......170.......180....---...190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIK
F
K
N
V
T
K
RY-G-K
H
-----
V
A
V
D
N
I
S
F
N
INE
G
E
F
F
V
L
IGPSGCGK
T
T
T
L
K
M
I
N
R
L
I
HLSE
G
Y
I
Y
FK--DKPI----S-------------D----YP
V
Y
--
E
M
RW
D
I
G
Y
V
L
Q
--
Q
I
A
LFPH
M
T
I
K
E
N
I
A
Q
V
P
-
Q
M
K
K
-
W
K
E
K
D
I
D
K
R
V
D
E
L
L
D
M
VGL--
E
P
E
K
YKNRKPDELSGGQ
R
Q
R
V
G
V
I
R
A
LAADP
P
V
I
L
MDEPFSALDP
I
S
R
E
K
L
Q
D
D
L
I
E
L
Q
T
K
IK---
K
T
I
I
F
V
TH
D
I
Q
E
A
M
KLG
D
K
I
C
L
LNEGHIEQIDTPEGFKNN
P
Q
S
E
F
V
K
Q
F
M
G
SHLEDDAPCVEEN
A
I
I
RD
L
D
IMK
P
I
D
E
V
TSMSA
Y
P
I
V
YDNQ
P
I
E
V
L
Y
Q
H
LSES
E
R
V
I
V
M
QEDSVG
Q
Y
V
I
D
R
K
D
I
F
K
Y
L
S
Q
K
K
E
V
AQHD
109
HHSearch
87.08
46%
-114
- C1 -
1V43
-
?
A:
[12-251]
E
V
K
L
E
N
L
T
K
R
F
-
G
-
N
F
-----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
--
D
R
D
V
----
T
-------------
Y
----
L
P
P
----
K
D
R
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
---
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
--
E
E
--
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
---------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.00
45%
-106
- C1 -
1VCI
1
?
A:
[13-251]
-
V
K
L
E
N
L
T
K
R
F
-
G
-
N
F
-----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
--
D
R
D
V
----
T
-------------
Y
----
L
P
P
K
--
D
R
--
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
---
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
--
L
--
Q
I
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
---------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.23
45%
-108
- C1 -
1V43
-
?
A:
[13-251]
-
V
K
L
E
N
L
T
K
R
F
-
G
-
N
F
-----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
--
D
R
D
V
----
T
-------------
Y
----
L
P
P
K
--
D
R
--
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
---
K
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
--
L
--
Q
I
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
---
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
---------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.17
43%
-102
- C1 -
2D62
7
?
A:
[7-245]
-
V
K
L
I
N
I
W
K
R
F
-
G
-
D
V
-----
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
--
D
N
L
V
----
A
-------------
D
PEKG
V
F
V
P
--
P
K
E
R
D
V
A
M
V
F
Q
--
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
P
L
-
K
L
R
K
-
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
--
T
--
E
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
---
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.20
39%
-104
- C1 -
3PUZ
2
MALK_ECOLI
B:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.69
39%
-99
- C1 -
3PUY
3
MALK_ECOLI
A:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.65
39%
-100
- C1 -
3PUV
5
MALK_ECOLI
A:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
108
HHSearch
79.61
41%
-102
- C1 -
1Z47
1
?
A:
[15-249]
-
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
A
-----
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
K
R
V
----
T
-------------
D
----
L
P
P
----
Q
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
-
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
--
E
S
--
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.59
39%
-99
- C1 -
3PUX
5
MALK_ECOLI
A:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.78
39%
-95
- C1 -
4KI0
3
?
B:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.74
39%
-95
- C1 -
3PUW
5
MALK_ECOLI
B:
[4-246]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
81
PsiBlast_CBE
78.41
34%
-98
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-240]
-
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
-----
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
FSKN
T
-------------
N
----
L
P
V
R
--
E
R
R
--
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
-
G
N
G
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
--
S
--
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
----------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.38
41%
-110
- C1 -
4TQU
-
?
S:
[5-237]
-
V
S
I
Q
N
V
V
K
R
Y
-
D
-
K
T
-----
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
--
G
R
V
I
----
N
-------------
D
----
L
A
P
K
--
D
--
R
D
V
A
M
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
L
-
R
L
K
R
-
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
--
Q
P
--
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
---
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
---------------------------------------------------------------------------------------
40
PsiBlast_CBE
78.34
41%
-100
- C1 -
1Z47
1
?
B:
[15-247]
-
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
-----
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
K
R
V
----
T
-------------
D
----
L
P
----
P
Q
K
R
N
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
-
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
--
E
--
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
----------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.04
39%
-96
- C1 -
3PUX
5
MALK_ECOLI
B:
[4-246]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.04
39%
-99
- C1 -
3PUY
3
MALK_ECOLI
B:
[4-246]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.01
39%
-94
- C1 -
3RLF
3
MALK_ECOLI
B:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.97
39%
-96
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-236]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
82
PsiBlast_CBE
77.88
34%
-98
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-245]
-
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
-----
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
FSKN
T
-------------
N
----
L
P
V
R
--
E
R
R
--
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
-
G
N
G
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
--
S
--
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
----------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.72
39%
-94
- C1 -
3PUV
5
MALK_ECOLI
B:
[4-246]
-
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
V
-----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
--
E
K
R
M
----
N
-------------
D
----
T
P
P
A
--
E
R
--
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
-
K
L
A
G
-
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
--
L
--
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
---
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
---------------------------------------------------------------------------------------
113
HHSearch
74.26
33%
-97
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-246]
A
L
H
I
G
H
L
S
K
S
F
-
Q
-
N
T
-----
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
--
G
K
T
I
----
F
-------------
S
KN--
T
N
L
P
--
V
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
-
G
N
G
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
--
S
E
--
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
---------------------------------------------------------------------------------------
89
PsiBlast_CBE
69.53
33%
-95
- C1 -
1B0U
4
HISP_SALTY
A:
[11-258]
-----
D
L
H
K
R
Y
-
G
-
G
H
-----
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
--
G
Q
N
I
----
N
L
V
R
D
KDGQLKVAD
K
----
N
Q
L
R
--
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
--
D
-
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
----
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
------------------------------------------------------------------------------------
61
PsiBlast_CBE
66.52
36%
-88
- C1 -
3C4J
4
?
B:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
79
PsiBlast_CBE
66.37
34%
-91
- C1 -
4YMU
2
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
-----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
----
N
-------------
N
----
G
K
V
N
IN
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.96
36%
-79
- C1 -
2OLK
1
?
D:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
78
PsiBlast_CBE
64.70
34%
-93
- C1 -
4YMV
1
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
-----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
----
N
-------------
N
----
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-------------------------------------------------------------------------------------
80
PsiBlast_CBE
64.65
34%
-92
- C1 -
4YMU
2
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
-----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
----
N
-------------
N
----
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-------------------------------------------------------------------------------------
77
PsiBlast_CBE
64.60
34%
-91
- C1 -
4YMV
1
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
-
G
-
S
L
-----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
V
K
I
----
N
-------------
N
----
G
K
V
N
IN
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-------------------------------------------------------------------------------------
74
PsiBlast_CBE
64.44
36%
-83
- C1 -
2OLJ
4
?
A:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.20
35%
-98
- C1 -
4U00
3
?
A:
[4-238]
I
I
R
I
R
N
L
H
K
W
F
-
G
-
P
L
-----
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
--
G
L
S
V
----
K
-------------
D
D---
R
A
L
R
--
E
I
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
LD
Q
A
R
K
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-----------------------------------------------------------------------------------------
59
PsiBlast_CBE
63.72
36%
-85
- C1 -
3C41
3
?
K:
[3-238]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
62
PsiBlast_CBE
63.71
36%
-77
- C1 -
3C4J
3
?
A:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
70
PsiBlast_CBE
62.87
36%
-85
- C1 -
2OLK
1
?
C:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.56
34%
-97
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-232]
-
I
K
V
E
N
V
S
F
I
Y
-
N
-
E
G
TPYAT
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
--
G
I
D
I
----
T
-------------
D
----
K
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G
-
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
--
S
K
E
-
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
---
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
---------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.53
34%
-98
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-232]
-
I
K
V
E
N
V
S
F
I
Y
-
N
-
E
G
TPYAT
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
--
G
I
D
I
----
T
-------------
D
----
K
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G
-
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
--
S
K
E
-
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
---
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
---------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.92
36%
-81
- C1 -
2OLK
2
?
B:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
60
PsiBlast_CBE
60.56
36%
-78
- C1 -
3C41
3
?
J:
[3-238]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
72
PsiBlast_CBE
60.53
36%
-84
- C1 -
2OLK
1
?
A:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
73
PsiBlast_CBE
60.21
36%
-80
- C1 -
2OLJ
3
?
B:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.07
36%
-76
- C1 -
2Q0H
4
?
A:
[24-259]
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
L
-----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
L
K
A
----
K
-------------
D
----
T
N
L
N
--
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
---
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-----------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.05
31%
-97
- C1 -
4QC2
2
?
B:
[4-221]
-
L
T
A
K
N
L
A
K
A
Y
-
K
-
G
R
-----
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
--
D
D
D
I
----
S
-------------
L
----
L
P
L
H
A-
R
A
R
R
G
I
G
Y
L
P
Q
--
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
H
I
--
E
--
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
-
R
I
I
E
H
L
R
D
S
G
---
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
---------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
54.34
31%
-103
- C1 -
4P32
2
LPTB_ECOLI
B:
[3-220]
-
L
T
A
K
N
L
A
K
A
Y
-
K
-
G
R
-----
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
--
D
D
D
I
----
S
-------------
L
----
L
P
L
H
A-
R
A
R
R
G
I
G
Y
L
P
Q
--
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
H
I
--
E
--
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
-
R
I
I
E
H
L
R
D
S
G
---
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
---------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
54.25
31%
-99
- C1 -
4QC2
2
?
A:
[4-221]
-
L
T
A
K
N
L
A
K
A
Y
-
K
-
G
R
-----
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
--
D
D
D
I
----
S
-------------
L
----
L
P
L
H
A
-
R
A
R
R
G
I
G
Y
L
P
Q
--
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
H
I
--
E
--
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
-
R
I
I
E
H
L
R
D
S
G
---
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
---------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
52.72
31%
-104
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-220]
-
L
T
A
K
N
L
A
K
A
Y
-
K
-
G
R
-----
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
--
D
D
D
I
----
S
-------------
L
----
L
P
L
H
A
-
R
A
R
R
G
I
G
Y
L
P
Q
--
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
H
I
--
E
--
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
-
R
I
I
E
H
L
R
D
S
G
---
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
---------------------------------------------------------------------------------------------------------