@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0714: (2016-03-18 )
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDELTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-.........250...-....260.......270.......280.......290.......300.......310........320.......330.......340.......350...-..----..360.-----......370-----.......380.......----390.......400.......410.......420...--------....430...---....440.---......450----------.-----.......-.460.......470.......480.......490.......500....-...510.......520.......530.......540.......550-.......560.......570.......580..--.....590...---.--------.--..600..-.---.....610.......----.----620.......630.......640.......650......----.660......-------.670-------.----...-.-..680........690.......700.......710.......720--.......730.......740.......750.------------------------------------------------------------------------------------...----------------------------....760.......770.......780.......790.......800.--------------------------........810.......820.......830.......840.......850.......860.......870......-.880.......890..-.....900.......910.......920.......930.......940......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKEP
S
I
V
V
KGARAHN
L
K
D
I
D
I
ELPKN
K
L
I
V
M
TGLSGSGKS
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
GQMDKPDV
D
T
IEGLSP
A
I
S
IDQKTTSKNPR
S
T
V
A
T
V
T
E
I
Y
D
Y
I
R
L
L
Y
A
RVGKPYCPNH
N
I
E
I
E
S
Q
T
V
Q
Q
M
V
D
R
I
M
E
L
E
AR
T
K
I
Q
L
L
A
P
V
I
A
HRKG
S
H
E
K
L
I
E
D
IGKK
G
Y
V
R
L
R
ID
G
E
I
V
DVNDVPTLDKNKNH
T
I
E
V
V
V
D
R
L
V
V
KDG
I
E
T
R
L
A
D
S
I
E
T
A
L
ELSEG
Q
L
T
V
D
V
ID---GEDLKFSESHACPIC-GFSIGELE
P
R
M
FSFNSPFGACPTCDGLG
Q
K
L
T
V
D
V
D
L
V
VPDKDKTLNEGAIEPWIP-TSSD
F
Y
P
T
L
L
K
R
V
C
E
V
Y
KINMD
K
P
F
K
K
L
T
E
RQR
D
I
L
L
YGSGD
K
E
-
I
E
----
F
T
F
TQR-----QGGTR
K
R
T
M
-----
V
FEGVV
P
N
I
S
R
R
FHE
S
P
----
S
E
Y
T
R
E
M
M
S
K
Y
M
T
ELPCETCHGKRL
S
R
E
A
L
S
V
Y
VGG--------L
N
I
G
E
V
V
E
Y
S
---
I
S
Q
A
L
N
Y
Y
---KNIDL
S
E
------------
Q
-----
D
Q
A
I
A
N
Q
-
I
L
K
E
I
I
S
R
L
T
F
L
N
NVG
L
E
Y
L
T
LNRASGTLSGGE
A
Q
R
I
R
L
A
T
Q
I
G
S
RL
T
-
G
V
L
Y
V
LDEPSIGLHQRD
N
D
R
L
I
N
T
L
K
E
M
R
D
LG
N
T
L
I
V
V
EHDDD
T
M
R
-A
A
D
Y
L
V
DIGPGAGEHG
G
Q
IVSSGT
P
Q
K
V
M
K
D
K
--
K
S
LT
G
Q
YLSGK---K--------R--IDV-
P
E
Y-R---RPASD
R
K
-
I
S
I
R
GAR----S----NNLK
G
I
D
VDI
P
L
S
I
M
T
V
V
TGVSGS
G
K
S
S
L
V
N
E
V
L
Y
K
S
L
A
----
Q
K
I
N
K
S
KVKP-------G
L
Y
D
-------
K
----
I
E
G
-
I
-
D
Q
L
D
-
K
I
I
DIDQSPIGRTPRSNPATYT
G
V
F
D
D
I
R
D
V
F
AQTNE
A
K
I
R
--
G
Y
QK
G
R
F
S
F
NVKG
G
R
C
E
ACKGD
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------FLP----------------------------DVY
V
P
C
EVCDGKRYN
R
E
T
L
E
V
T
YKGK
N
I
A
D
I
L
E
M
T
V
E
E
A
T
Q
F
F
E
N
--
I
--------------------------
P
K
I
K
R
K
L
Q
T
L
V
D
VGL
G
Y
V
T
LG
Q
Q
ATTLSGG
E
A
Q
R
V
K
L
A
S
E
L
H
KRSTG
K
S
I
Y
I
L
DELTTGL
H
V
D
D
I
S
R
L
L
K
V
L
N
R
L
VE-NG
D
T
V
V
I
I
EHNL
D
V
I
K
-TA
D
Y
I
I
D
LGPEGGSGG
G
T
I
V
ATG
T
P
E
D
I
A
Q
T
K
S
SY
T
G
K
Y
L
K
E
V
L
E
RDKQNTEDK
1
PsiBlast_PDB
94.40
69%
-88
- C2 -
3UWX
3
?
A:
[24-966]
-----
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
---
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
-----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
----
F
R
Y
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
-----
A
F
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
---
D
G
L
E
L
T
E
------------
K
-----
E
A
Q
I
A
R
L
-
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
--
N
S
L
T
G
Q
Y
L
S
G
K
---
K
--------
F
--
I
P
I
-
P
A
E
-
R
---
R
R
P
D
G
R
W
-
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
----
Q
K
L
H
R
A
K
A
K
P
-------
G
E
H
R
-------
D
----
I
R
G
-
L
-
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
--
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
90
HHSearch
90.54
70%
-86
- C2 -
2R6F
5
?
A:
[21-963]
--
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
---
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
-----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
Y
F
----
R
Y
T
N
D
------
F
G
Q
V
R
E
Q
Y
I
-----
A
F
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
----
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
---
D
G
L
E
L
T
E
------------
K
-----
E
A
Q
I
A
R
L
-
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
--
N
S
L
T
G
Q
Y
L
S
G
K
---
K
--------
F
--
I
P
I
-
P
A
E
-
R
---
R
R
P
D
G
R
W
-
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
----
Q
K
L
H
R
A
K
A
K
P
-------
G
E
H
R
-------
D
----
I
R
G
-
L
-
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
--
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
---
2
PsiBlast_PDB
90.51
68%
-88
- C2 -
2R6F
5
?
A:
[24-966]
-----
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
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I
Q
S
Q
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I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
---
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
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V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
-----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
-
I
Y
----
F
R
Y
T
N
D
-----
F
G
Q
V
R
E
Q
Y
I
-----
A
F
E
G
V
I
P
N
V
E
R
R
Y
R
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T
S
----
S
D
Y
I
R
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Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
---
D
G
L
E
L
T
E
------------
K
-----
E
A
Q
I
A
R
L
-
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
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P
S
I
G
L
H
Q
R
D
N
D
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L
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L
K
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M
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L
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V
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L
-
A
A
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L
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G
A
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G
G
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V
V
A
A
G
T
P
E
E
V
M
N
D
P
--
N
S
L
T
G
Q
Y
L
S
G
K
---
K
--------
F
--
I
P
I
-
P
A
E
-
R
---
R
R
P
D
G
R
W
-
L
E
V
V
G
A
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
----
Q
K
L
H
R
A
K
A
K
P
-------
G
E
H
R
-------
D
----
I
R
G
-
L
-
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
--
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
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R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
3
PsiBlast_PDB
86.59
58%
-77
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[26-974]
-----
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
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V
Y
D
Y
L
R
L
L
Y
A
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A
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T
P
H
C
P
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A
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Q
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Q
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Q
V
L
A
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G
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L
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L
A
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V
V
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T
R
K
G
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F
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L
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A
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S
R
V
R
V
D
G
V
V
H
P
L
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D
P
P
K
L
K
K
Q
E
K
H
D
I
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V
V
V
D
R
L
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K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
-----
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
-----
D
F
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
----
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
D
F
L
---
N
A
L
T
L
G
P
------------
R
-----
E
Q
A
I
A
G
Q
-
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
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Q
I
G
S
G
L
V
-
G
V
L
Y
V
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D
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L
H
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D
N
R
R
L
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L
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L
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N
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L
I
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V
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H
D
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D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
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G
P
Y
D
E
L
L
R
N
K
--
D
S
I
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G
A
Y
L
S
G
R
---
E
--------
S
--
I
E
I
-
P
A
I
-
R
---
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
----
N
R
L
N
G
A
R
Q
V
P
-------
G
R
H
T
-------
R
----
V
T
G
-
L
-
D
Y
L
D
-
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
R
--
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
----------
23
PsiBlast_CBE
84.85
58%
-77
- C2 -
3ZQJ
3
UVRA_MYCTU
B:
[26-974]
-----
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
------------
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
-----------
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
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D
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D
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W
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K
L
P
A
K
A
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K
A
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L
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G
A
-
D
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Q
-
V
H
----
V
R
Y
R
N
R
-----
Y
G
R
T
R
S
Y
Y
A
-----
D
F
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
----
S
E
Q
M
K
E
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Y
E
G
F
M
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D
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P
C
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C
A
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T
L
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ESKGEHGA
K
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A
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C
E
L
S
---
I
A
D
C
A
D
F
L
---
N
A
L
T
L
G
P
------------
R
-----
E
Q
A
I
A
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Q
-
V
L
K
E
I
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S
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F
L
L
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L
E
Y
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--
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---
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--------
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--
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I
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R
---
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V
V
G
A
R
----
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----
H
N
L
R
G
I
D
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F
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L
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V
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V
T
G
V
S
G
S
G
K
S
T
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N
D
I
L
A
A
V
L
A
----
N
R
L
N
G
A
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Q
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P
-------
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R
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-------
R
----
V
T
G
-
L
-
D
Y
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D
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L
V
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S
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I
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P
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Y
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D
K
I
R
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A
A
T
T
E
A
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--
G
Y
Q
P
G
R
F
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F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
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G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
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A
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G
E
A
Q
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K
L
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L
Q
K
R
S
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V
Y
I
L
D
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T
T
G
L
H
F
D
D
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K
L
L
N
V
I
N
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L
V
D
-
K
G
N
T
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H
N
L
D
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-
T
S
D
W
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L
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G
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V
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E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
----------
21
PsiBlast_CBE
84.27
58%
-76
- C2 -
3ZQJ
2
UVRA_MYCTU
E:
[26-974]
-----
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
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L
I
V
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S
G
S
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K
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R
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L
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R
N
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Y
D
Y
L
R
L
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Y
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A
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P
H
C
P
------
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P
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V
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L
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P
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K
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D
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V
V
V
D
--------
K
R
R
L
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N
L
A
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I
V
V
L
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D
---
H
--------
L
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N
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D
D
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----
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----
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A
-KGEHGA--
K
S
I
A
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C
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S
---
I
A
D
C
A
D
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L
---
N
A
L
T
L
G
P
------------
R
-----
E
Q
A
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Q
-
V
L
K
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L
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---
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--------
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---
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V
G
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----
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----
H
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L
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I
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L
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V
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V
S
G
S
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K
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N
D
I
L
A
A
V
L
A
----
N
R
L
N
G
A
R
Q
V
P
-------
G
R
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-------
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----
V
T
G
-
L
-
D
Y
L
D
-
K
L
V
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V
D
Q
S
P
I
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P
A
T
Y
T
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F
D
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I
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A
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A
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--
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Y
Q
P
G
R
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V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
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A
P
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G
G
E
A
Q
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K
L
A
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L
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K
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T
V
Y
I
L
D
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T
T
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L
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L
L
N
V
I
N
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L
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-
K
G
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H
N
L
D
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I
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-
T
S
D
W
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I
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L
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G
G
A
G
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V
A
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D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
----------
22
PsiBlast_CBE
83.00
58%
-81
- C2 -
3ZQJ
3
UVRA_MYCTU
C:
[26-974]
-----
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
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G
S
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R
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V
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A
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A
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L
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N
R
N
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L
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L
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Q
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D
Q
V
L
A
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P
------
V
L
A
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V
V
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F
A
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L
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L
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V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
-----------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
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R
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F
S
F
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G
A
C
P
E
C
S
G
L
G
I
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K
E
V
D
P
E
L
V
V
P
---------
A
V
A
P
W
S
N
G
H
T
A
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Y
F
T
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M
M
A
G
L
G
E
A
L
G
------------
K
A
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K
A
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L
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G
A
-
D
E
Q
-
V
H
----
V
R
Y
R
N
R
-----
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Y
Y
A
-----
D
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----
S
E
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C
A
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L
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L
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K
S
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A
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---
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A
D
C
A
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---
N
A
L
T
L
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P
------------
R
-----
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-
V
L
K
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R
L
G
F
L
L
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L
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L
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L
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A
A
A
T
L
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-
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L
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---
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--------
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--
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----
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-------
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-------
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----
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--
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G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
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L
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D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
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A
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L
L
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K
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A
A
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A
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Y
T
G
K
F
L
A
E
V
V
----------
89
HHSearch
74.06
45%
-76
- C2 -
2VF7
4
?
A:
[12-841]
-
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
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V
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V
S
G
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D
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A
L
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Q
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G
T
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T
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L
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N
L
L
R
M
L
Y
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R
A
G
D
Y
P
P
G
-
Q
G
I
------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
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P
N
T
P
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G
A
C
P
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C
H
G
L
G
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A
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A
A
W
P
Q
-
A
W
---
G
G
Q
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Q
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D
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L
G
I
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D
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W
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L
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L
F
T
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V
-
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----
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A
E
T
Q
R
A
L
K
K
K
M
E
P
-----
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTE
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
---
L
A
R
V
S
E
L
L
---
R
P
Y
A
E
E
R
EPGHAERVKNRP
E
-----
Q
A
I
A
L
Q
R
-
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
---
R
--------
H
--
T
E
P
-
H
-
T
-
P
---
R
E
-
P
A
G
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
----
A
H
F
G
Q
------------------------G
S
A
R
L
G
G
-
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
26
PsiBlast_CBE
65.74
43%
-70
- C2 -
2VF7
4
?
B:
[142-841]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
PS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEE
R
E
P
G
H
A
E
------------
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
---
R
--------
H
--
T
E
P
-
H
T
P
-
R
---
E
P
A
G
--
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
--------------------G
S
A
----
R
----
L
G
G
D
L
-
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
24
PsiBlast_CBE
65.66
43%
-70
- C2 -
2VF8
9
?
B:
[142-841]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
PS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEE
R
E
P
G
H
A
E
------------
R
V
K
NR
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
---
R
--------
H
--
T
E
P
-
H
T
P
-
R
---
E
P
A
G
--
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
P
V
N
P
D
P
E
D
D
-------
E
D
P
A
DHTAG
S
A
R
----
L
G
G
D
L
-
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
4
PsiBlast_PDB
65.25
43%
-70
- C2 -
2VF7
4
?
A:
[142-841]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
PS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEE
R
E
P
G
H
A
E
------------
R
VKNRP
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
---
R
--------
H
--
T
E
P
-
H
T
P
-
R
---
E
P
A
G
--
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
--------------------G
S
A
----
R
----
L
G
G
D
L
-
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
25
PsiBlast_CBE
64.24
43%
-66
- C2 -
2VF7
5
?
C:
[142-841]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
Y
P
G
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
PS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEE
R
E
P
G
H
A
E
------------
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
---
R
--------
H
--
T
E
P
-
H
T
P
-
R
---
E
P
A
G
--
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
FG---------------------
S
A
-----
R
----
L
G
G
D
L
-
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
5
PsiBlast_PDB
63.46
43%
-69
- C2 -
2VF8
7
?
A:
[142-841]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
-
V
P
V
YPG
L
T
P
A
E
T
-----
Q
R
A
L
K
K
K
M
E
PS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
----
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEE
R
E
P
G
H
A
E
------------
R
VKNRP
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
--
E
S
Q
T
G
Q
Y
L
F
A
D
----------------
E
P
-
H
T
P
-
R
---
E
P
A
G
--
W
-
L
E
L
N
G
V
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
--------------------GS
A
----
R
----
L
G
G
D
L
-
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
--
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
----------
93
HHSearch
58.01
33%
-68
- C2 -
2VF7
3
?
A:
[13-502]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
-
V
Q
V
R
G
A
R
----
Q
----
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
----
R
R
Y
L
E
S
V
S
P
Y
ARRLFNQ
A
G
V
P
-------
D
----
V
D
A
-
I
-
D
G
L
P
-
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
G
QG
I
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
SMVPDPSLTIRERAVAAWPQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
GIDVDVPWRELP
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
--
Y
AEEREPGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
-
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
--------------
97
HHSearch
54.28
39%
-69
- C2 -
2R6F
3
?
A:
[628-954]
---
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
-------
A
K
P
G
E
H
R
D
I
R
G
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
-
I
E
M
H
-----------------------------
F
L
-------------------------------------------------------------------------------------------------
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
---
V
E
D
A
L
D
F
F
---
A
S
I
P
--------------------------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
--
E
S
H
T
G
R
Y
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
45.39
21%
-42
* C2 *
3J16
2
RLI1_YEAST
B:
[205-559]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
I
L
Q
L
E
N
V
-
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
---
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
G
-
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
--------
Q
--
F
R
I
-
A
D
A
T
E
DLQ
N
D
S
A
S
R
A
-
F
S
Y
P
S
L
K
K
T
QG
D
----
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
--------------------------
A
L
K
-------
P
----
D
E
G
-
Q
-
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
-------------------
A
P
K
F
P
--------------------------------
G
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
L
F
F
K
K
I
R
G
Q
---
F
L
N
-------------------------------
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
----
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
------------------------
7
PsiBlast_PDB
44.95
49%
-78
- C5 -
4DFC
-
UVRA_ECOLI
B:
[129-248]
----------------------------------------------------------------------------------------------------------------------------------
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
DPK
A
E
E
L
L
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
43.87
49%
-68
* C5 *
4DFC
-
UVRA_ECOLI
B:
[128-250]
---------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
DPK
A
E
E
L
L
F
S
A
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
43.35
25%
-44
- C2 -
1YQT
4
?
A:
[145-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
L
E
N
V
-
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
------
F
L
R
G
Y
L
K
D
E
---
N
VRFRP
Y
E
I
K
--
F
T
K
T
G
E
R
-
V
---
E
I
E
R
E
T
L
-
V
T
Y
P
R
L
V
K
D
YG
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
--------------------------
V
E
E
-------
P
----
T
E
G
-
K
--------
I
E
W
D
L
T
V
-
A
Y
K
P
-----------
Q
Y
I
K
A
D
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
Y
E
L
L
S
K
I
D
A
S
K
L
--------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
-------------------------------------------
94
HHSearch
42.96
24%
-47
- C2 -
3BK7
2
?
A:
[212-547]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
L
E
L
E
N
V
-
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
------
L
Q
G
Y
L
K
D
E
---
N
VRFRP
Y
--
E
I
R
F
T
K
L
S
E
R
-
V
---
D
V
E
R
E
T
L
-
V
E
Y
P
R
L
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
--------------------------
V
E
E
-------
P
----
T
E
G
-
K
--------
V
E
W
D
L
T
-
V
A
Y
K
P
-----------
Q
Y
I
K
A
E
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
Y
E
L
L
S
K
I
D
S
S
K
L
--------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
--------------------------------------------