@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0728: (2016-03-18 )
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
Atome Classification :
(55 SA)
........-.-10........20.......-.30........40........50.-.-......60...----.....-----------70........80........90...-...-..-100.--......110.......120------.--------.....----------...130.-------.....---.140---.......150.......160......-.---170-........180.......190.......200.......210...--.--...220.......230.-.-.....---240...-------....250...---..---.---.260--..---......270.......280-.-..-...-..290------.......300.......310.......320.......330...----....340-...--.-..--...350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
K
K
I
V
S
D-L-DLKG
K
T
V
L
V
R
ADFNVPLKD-GEITND
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
EQG
G
-
K
-
I
V
L
F
S
H
LGKVK----EESDK-----------A
K
L
T
L
R
P
V
A
E
D
L
S
K
KLDK
E
V
V
F
V
PE-TR
G
-
E
K
-
L
E
A
A
--
I
K
DLKEG
D
V
L
L
V
ENTRY--------E--------DLDGK----------KESKND
P
-------
E
L
G
K
Y
---
W
A
S
L
---
G
D
V
F
V
NDAFG
T
A
H
R
E
H
ASNVGI
S
T
H
L
-
E
---
T
-
A
-
A
G
F
L
MDK
E
I
K
F
I
G
G
VVNDPHK
P
V
V
A
I
LGGAKV
S
D
K
I
N
V
I
K
N
L
V
N
--
I
--
A
D
K
I
I
IGG
G
M
A
Y
T
F
L
KA-Q-
G
K
E
I
G
---
I
S
L
L
E
E-------D
K
I
D
F
A
K
D
L
L
---
E
K---H---G
D
K
---
I
V
---
L
PV
D
T
K
V
A
K
EFSND
A
K
I
-
T
-
V
-
V
P-SDS-IPADQ------EGMDIGP
N
T
V
K
L
F
A
D
ELEG
A
H
T
V
V
WNGPM
G
V
F
E
F
S
N
FA
Q
G
T
I
G
----
V
C
K
A
I
---
A
NL--K-
D
A
--
I
T
I
I
GGGDS
A
A
A
A
I
S
LGFENDF
T
H
ISTGGGA
S
L
E
YLEGKELPGIKAINNK
1
PsiBlast_PDB
95.71
100%
-94
- C9 -
4DG5
-
PGK_STAAR
A:
[2-396]
-
A
K
K
I
V
S
D
-
L
-
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
E
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
L
F
S
H
L
G
K
V
K
----
E
E
S
D
K
-----------
A
K
L
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
P
E
-
T
R
G
-
E
K
-
L
E
A
A
--
I
K
D
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
--------
E
--------
D
L
D
G
K
----------
K
E
S
K
N
D
P
-------
E
L
G
K
Y
---
W
A
S
L
---
G
D
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
S
T
H
L
-
E
---
T
-
A
-
A
G
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
V
N
--
I
--
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
K
A
-
Q
-
G
K
E
I
G
---
I
S
L
L
E
E
-------
D
K
I
D
F
A
K
D
L
L
---
E
K
---
H
---
G
D
K
---
I
V
---
L
P
V
D
T
K
V
A
K
E
F
S
N
D
A
K
I
-
T
-
V
-
V
P
-
S
D
S
-
I
P
A
D
Q
------
E
G
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
----
V
C
K
A
I
---
A
N
L
--
K
-
D
A
--
I
T
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
66
HHSearch
83.60
52%
-87
- C9 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
-
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
K
----
G
K
V
V
------------
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
-
A
V
G
-
D
E
-
V
K
A
A
--
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
--------
P
G
E
E
--------------
K
N
D
P
-------
E
L
A
K
A
---
F
A
E
L
---
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
-
V
-
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
E
--
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
---
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
---
E
K
---
A
K
E
K
G
V
R
---
F
Y
---
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
T
-
K
-
V
-
V
P
-
I
D
A
-
I
P
A
D
W
------
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
----
I
A
E
A
L
---
A
E
---
A
L
D
T
--
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
2
PsiBlast_PDB
83.58
57%
-86
- C9 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
K
----
G
E
P
S
------------
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
-
V
V
G
-
D
E
-
V
K
K
A
--
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
--------
P
--------------
G
E
T
K
N
D
P
-------
E
L
A
K
F
---
W
A
S
L
---
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
-
V
-
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
E
--
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
---
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
---
E
K
---
A
---
K
E
K
G
V
E
I
V
---
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
-
K
-
V
-
V
R
I
D
D
G
-
I
P
E
G
W
------
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
----
V
A
L
A
I
---
A
A
L
T
E
K
-
G
A
--
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
72
HHSearch
83.40
58%
-86
- C9 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
K
----
G
E
P
S
------------
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
-
V
V
G
-
D
E
-
V
K
K
A
--
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
--------
P
G
E
T
--------------
K
N
D
P
-------
E
L
A
K
F
---
W
A
S
L
---
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
-
V
-
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
E
--
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
---
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
---
E
K
---
A
K
E
K
G
V
E
---
I
V
---
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
-
K
-
V
V
R
I
-
D
D
G
-
I
P
E
G
W
------
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
----
V
A
L
A
I
---
A
A
L
T
E
K
-
G
A
--
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
3
PsiBlast_PDB
83.37
51%
-85
- C9 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
-
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
K
----
G
K
V
V
E
------------
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
-
A
V
G
-
D
E
-
V
K
A
A
--
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
------------
P
----------
G
E
E
K
N
D
P
-------
E
L
A
K
A
---
F
A
E
L
---
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
-
V
-
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
E
--
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
---
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
---
E
K
A
K
E
K
---
G
V
R
---
F
Y
---
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
T
-
K
-
V
-
V
P
-
I
D
A
-
I
P
A
D
W
------
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
----
I
A
E
A
L
---
A
E
A
--
L
-
D
T
--
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
21
PsiBlast_CBE
82.45
48%
-85
- C9 -
1V6S
3
PGK_THET8
B:
[2-390]
---
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
------
G
P
D
-----------
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
-
P
P
G
S
E
E
-
A
R
R
E
--
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
-
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
---
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
GRA
E
A
---
L
---
G
V
R
---
V
Y
---
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
----
V
G
Q
A
I
---
A
A
L
--
E
-
G
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
4
PsiBlast_PDB
81.78
48%
-86
- C9 -
1V6S
3
PGK_THET8
A:
[2-390]
---
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
------
G
P
D
-----------
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
-
P
P
G
S
E
E
-
A
R
R
E
--
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
-
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
---
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
---
L
---
G
V
R
---
V
Y
---
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
----
V
G
Q
A
I
---
A
A
L
--
E
-
G
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
68
HHSearch
81.63
47%
-85
* C9 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
-
I
-
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
K
----
E
I
S
-------------
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
-
V
I
G
-
E
D
-
A
K
T
K
--
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
--------
K
G
E
T
--------------
K
N
D
E
-------
N
L
A
K
E
---
L
A
S
M
---
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
-
D
EKH
K
-
G
-
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
P
--
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
D
I
G
---
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
---
T
K
---
G
K
N
L
G
V
K
---
I
Y
---
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
M
-
K
-
F
-
V
P
-
A
Q
E
-
I
P
N
G
W
------
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
----
M
S
H
Y
I
---
S
E
---
G
-
H
A
--
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
70
HHSearch
80.51
49%
-82
- C9 -
1V6S
3
PGK_THET8
A:
[1-389]
--
M
R
T
L
L
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
----
G
P
D
-------------
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
F
-
P
P
G
-
S
E
E
A
R
R
E
--
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
--------
P
G
E
E
--------------
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
-
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
---
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
---
G
R
---
A
E
A
L
G
V
R
---
V
Y
---
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
----
V
G
Q
A
I
---
A
A
---
L
E
G
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
--
44
PsiBlast_CBE
80.33
44%
-91
- C9 -
3OZ7
2
PGK_PLAF7
A:
[10-417]
-----
I
S
D
-
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
L
I
S
H
C
G
R
-
P
----
D
G
L
R
N
-----------
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
N
D
-
C
V
G
-
K
E
-
V
E
D
K
--
I
N
A
A
K
E
N
S
V
I
L
L
E
N
L
R
F
--------
H
IEEEG
K
G
V
D
A
N
G
N
----------
K
V
K
A
N
K
E
-------
D
V
E
K
F
Q
N
D
L
T
K
L
---
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
-
K
-----
A
-
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
L
D
--
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
L
N
-
N
M
K
I
G
---
T
S
L
F
D
E
-------
A
G
S
K
I
V
G
E
I
M
---
E
K
---
A
---
K
A
K
N
V
Q
I
F
---
L
P
V
D
F
K
I
A
D
N
F
D
N
N
A
N
T
-
K
-
F
-
V
T
D
E
E
G
-
I
P
D
N
W
------
M
G
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
----
C
L
N
L
V
---
V
E
V
T
K
K
-
G
A
--
I
T
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
-
7
PsiBlast_PDB
80.31
46%
-91
- C9 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
-
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
N
----
G
E
R
N
E
------------
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
G
-
P
E
-
V
E
A
A
--
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
HIEEEG
S
-
R
--------
K
V
D
G
Q
----------
K
V
K
A
S
K
E
-------
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
L
P
--
Q
---
R
-
A
-
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
D
--
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
---
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
A
K
A
K
---
G
V
E
---
V
V
---
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
T
K
T
-
V
-
T
D
-
K
E
G
-
I
P
A
G
W
------
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
----
L
L
D
E
V
---
V
K
S
--
S
-
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
5
PsiBlast_PDB
80.13
48%
-84
- C9 -
2IE8
-
?
A:
[6-390]
-------
D
-
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
------
G
P
D
-----------
P
R
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
-
P
P
G
S
E
E
-
A
R
R
E
--
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
----------
G
E
E
K
N
D
P
-------
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
-
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
P
--
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
---
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
---
L
---
G
V
R
---
V
Y
---
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
T
-
R
-
V
-
F
P
-
A
R
A
-
I
P
V
P
Y
------
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
----
V
G
Q
A
I
---
A
A
L
--
E
-
G
A
--
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
43
PsiBlast_CBE
79.78
44%
-92
- C9 -
3OZ7
2
PGK_PLAF7
B:
[10-417]
-----
I
S
D
-
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
L
I
S
H
C
G
R
-
P
----
D
G
L
R
N
-----------
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
N
D
-
C
V
G
-
K
E
-
V
E
D
K
--
I
N
A
A
K
E
N
S
V
I
L
L
E
N
L
R
F
--------
H
IEEEG
K
G
V
D
A
N
G
N
----------
K
V
K
A
N
K
E
-------
D
V
E
K
F
Q
N
D
L
T
K
L
---
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
-
K
-----
A
-
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
L
D
--
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
L
N
-
N
M
K
I
G
---
T
S
L
F
D
E
-------
A
G
S
K
I
V
G
E
I
M
---
E
K
---
A
---
K
A
K
N
V
Q
I
F
---
L
P
V
D
F
K
I
A
D
N
F
D
N
N
A
N
T
-
K
-
F
-
V
T
D
E
E
G
-
I
P
D
N
W
------
M
G
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
----
C
L
N
L
V
---
V
E
V
T
K
K
-
G
A
--
I
T
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
-
11
PsiBlast_PDB
79.61
44%
-85
- C9 -
2PAA
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
I
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
G
-
P
E
-
V
E
Q
A
--
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
S
S
G
K
----------
K
I
S
A
D
P
A
-------
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
D
--
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
---
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
---
N
---
G
V
K
---
I
V
---
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
-
G
-
Q
-
A
T
-
I
E
S
G
I
P
S
G
W
------
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
---
S
N
-----
G
C
--
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
10
PsiBlast_PDB
79.61
44%
-82
- C9 -
2P9T
1
PGK2_MOUSE
A:
[4-415]
-
A
K
L
T
L
D
K
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
I
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
G
-
P
E
-
V
E
Q
A
--
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
S
S
G
K
----------
K
I
S
A
D
P
A
-------
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
D
--
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
---
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
---
N
---
G
V
K
---
I
V
---
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
-
G
-
Q
-
A
T
-
I
E
S
G
I
P
S
G
W
------
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
---
S
N
-----
G
C
--
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
20
PsiBlast_PDB
79.56
44%
-85
- C9 -
2XE6
1
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
23
PsiBlast_CBE
78.69
44%
-81
- C9 -
13PK
5
PGKC_TRYBB
C:
[2-415]
--
K
K
S
I
N
E
-
C
-
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
K
GIPM
A
Q
A
G
K
IRSTGGVPGFQ
Q
K
A
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
-
C
------
L
N
A
A
DV
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
--------
K
E
E
G
S
----------
K
K
A
K
D
R
E
-------
A
M
A
K
I
---
L
A
S
Y
---
G
D
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
---
G
-
A
-
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
Q
--
R
--
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
Y
S
I
G
---
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
---
K
K
---
A
---
E
D
R
KVQ
V
I
---
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
P
-
L
-
I
-
T
E
-
D
Q
N
-
I
P
E
G
H
------
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
----
I
A
K
A
M
GRG
T
H
E
--
H
-
G
L
--
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
75
HHSearch
78.55
47%
-86
- C9 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
-
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
N
----
G
E
R
N
------------
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
G
-
P
E
-
V
E
A
A
--
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
--------
I
E
E
E
G
S
R
K
V
DGQKVK
A
S
K
E
D
V
Q
-------
K
F
R
H
E
---
L
S
S
L
---
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
-
P
---
Q
R
A
-
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
D
--
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
E
I
G
---
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
---
A
K
A
K
G
V
E
---
V
V
---
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
T
-
K
T
V
-
T
D
-
K
E
G
-
I
P
A
G
W
------
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
----
L
L
D
E
V
---
V
K
S
S
A
A
-
G
N
--
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
22
PsiBlast_CBE
78.48
44%
-81
- C9 -
13PK
5
PGKC_TRYBB
D:
[2-415]
--
K
K
S
I
N
E
-
C
-
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
K
GIPM
A
Q
A
G
K
IRSTGGVPGFQ
Q
K
A
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
-
C
------
L
N
A
A
DV
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
--------
K
E
E
G
S
----------
K
K
A
K
D
R
E
-------
A
M
A
K
I
---
L
A
S
Y
---
G
D
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
---
G
-
A
-
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
Q
--
R
--
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
Y
S
I
G
---
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
---
K
K
---
A
---
E
D
R
KVQ
V
I
---
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
P
-
L
-
I
-
T
E
-
D
Q
N
-
I
P
E
G
H
------
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
----
I
A
K
A
M
GRG
T
H
E
--
H
-
G
L
--
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
47
PsiBlast_CBE
78.23
43%
-83
- C9 -
4O33
2
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
42
PsiBlast_CBE
78.15
44%
-87
- C9 -
2ZGV
1
PGK1_HUMAN
A:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
35
PsiBlast_CBE
78.13
44%
-84
- C9 -
3C3C
3
PGK1_HUMAN
A:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
31
PsiBlast_CBE
78.03
44%
-83
- C9 -
2YBE
5
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-----------------------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
27
PsiBlast_CBE
78.01
43%
-84
- C9 -
4NG4
2
PGK_COXBU
B:
[17-400]
-----
M
S
N
-
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
E
----
E
G
K
F
E
-----------
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
I
N
D
W
L
K
G
-
V
A
-
V
E
P
---------
G
Q
A
I
L
C
E
N
V
R
F
--------------------
N
K
----------
G
E
N
E
N
N
T
-------
E
L
A
K
R
---
M
A
E
L
---
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
---
L
-
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
D
--
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
---
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
---
A
---
A
E
K
---
N
V
S
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
A
-
T
-
V
-
K
N
-
I
D
A
-
V
T
S
N
E
------
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
----
L
A
Q
A
V
---
A
K
---
S
-
T
A
--
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
32
PsiBlast_CBE
77.95
44%
-83
- C9 -
2XE8
2
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
33
PsiBlast_CBE
77.89
44%
-82
- C9 -
2XE7
2
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
36
PsiBlast_CBE
77.88
44%
-87
- C9 -
3C3B
2
PGK1_HUMAN
B:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
------
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
19
PsiBlast_PDB
77.87
44%
-87
- C9 -
2X15
3
PGK1_HUMAN
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-------------------------
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
51
PsiBlast_CBE
77.83
43%
-81
- C9 -
1HDI
3
PGK1_PIG
A:
[8-412]
---------
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
S
P
M
P
-----------
D
K
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
D
-
C
V
G
-
P
A
-
V
E
K
A
--
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
A
A
G
E
P
A
-------
K
I
K
A
F
---
R
A
S
L
S
A
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
---
K
-
A
-
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
---
S
K
A
A
A
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
I
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
67
HHSearch
77.80
45%
-82
- C9 -
2WZB
5
PGK1_HUMAN
A:
[3-415]
S
N
K
L
T
L
D
K
-
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
--------
V
E
E
E
G
KG---------
E
P
A
K
I
E
-------
A
F
R
A
S
---
L
S
K
L
---
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
-
P
---
Q
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
---
A
E
K
N
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
---
V
K
A
T
S
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
45
PsiBlast_CBE
77.73
43%
-84
- C9 -
1KF0
3
PGK1_PIG
A:
[11-415]
---------
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
S
P
M
P
-----------
D
K
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
K
T
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
H
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
14
PsiBlast_PDB
77.65
44%
-87
- C9 -
1VJD
2
PGK1_PIG
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
I
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
S
----------
K
V
K
A
D
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
25
PsiBlast_CBE
77.53
44%
-84
- C9 -
2PAA
1
PGK2_MOUSE
B:
[4-415]
-
A
K
L
T
L
D
K
-
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
I
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
G
-
P
E
-
V
E
Q
A
--
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
HVEEEGKG
K
--------
D
S
S
G
K
----------
K
I
S
A
D
P
A
-------
K
V
E
A
F
---
R
A
S
L
SKL
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
D
--
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
---
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
EKA
E
K
---
N
---
G
V
K
---
I
V
---
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
-
G
-
Q
-
A
T
-
I
E
S
G
I
P
S
G
W
------
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
LMDE
V
V
K
A
T
---
S
N
-----
G
C
--
V
T
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
13
PsiBlast_PDB
77.50
44%
-85
- C9 -
1VJC
1
PGK1_PIG
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
I
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
S
----------
K
V
K
A
D
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
K
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
41
PsiBlast_CBE
77.21
44%
-88
- C9 -
3C39
1
PGK1_HUMAN
A:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-------------------------
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
29
PsiBlast_CBE
77.19
44%
-84
- C9 -
4AXX
5
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
--------------------------
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
12
PsiBlast_PDB
77.10
43%
-79
- C9 -
2Y3I
5
PGK1_HUMAN
A:
[3-416]
M
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
8
PsiBlast_PDB
77.09
44%
-82
- C9 -
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
-
V
-
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
T
----
E
G
E
Y
D
-----------
S
Q
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
------
L
D
G
V
----
D
V
K
A
G
E
I
V
M
C
E
N
V
R
F
--------
N
----------
S
G
E
----------
K
K
S
T
D
D
---------
L
S
K
K
---
I
A
S
L
---
G
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
-
P
---
V
-
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
D
--
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
D
V
G
---
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
---
A
K
---
A
K
A
L
G
V
N
---
I
P
---
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
A
-
I
-
I
-
K
K
-
V
S
D
-
V
V
A
D
E
------
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
----
L
S
L
A
I
---
A
Q
---
S
-
H
A
--
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
26
PsiBlast_CBE
77.08
43%
-86
- C9 -
4NG4
2
PGK_COXBU
C:
[17-400]
-----
M
S
N
-
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
E
----
E
G
K
F
E
-----------
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
I
N
D
W
L
K
G
-
V
A
-
V
E
P
---------
G
Q
A
I
L
C
E
N
V
R
F
--------------------
N
K
----------
G
E
N
E
N
N
T
-------
E
L
A
K
R
---
M
A
E
L
---
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
---
L
-
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
D
--
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
---
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
---
A
---
A
E
K
---
N
V
S
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
A
-
T
-
V
-
K
N
-
I
D
A
-
V
T
S
N
E
------
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
----
L
A
Q
A
V
---
A
K
---
S
-
T
A
--
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
18
PsiBlast_PDB
77.06
44%
-85
- C9 -
2X13
3
PGK1_HUMAN
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-------------------------
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
50
PsiBlast_CBE
76.95
43%
-84
- C9 -
4O3F
2
PGK1_MOUSE
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
N
A
--
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
D
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
40
PsiBlast_CBE
76.86
44%
-88
- C9 -
3C39
1
PGK1_HUMAN
B:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
---------
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
28
PsiBlast_CBE
76.62
43%
-79
- C9 -
2Y3I
5
PGK1_HUMAN
D:
[3-416]
M
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
SKL
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
SKA
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
VK-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
30
PsiBlast_CBE
76.50
44%
-85
- C9 -
3ZOZ
5
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG----------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
17
PsiBlast_PDB
76.48
44%
-85
- C9 -
2WZC
5
PGK1_HUMAN
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG----------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
34
PsiBlast_CBE
76.47
44%
-85
- C9 -
3C3C
1
PGK1_HUMAN
B:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
------
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
38
PsiBlast_CBE
76.45
44%
-86
- C9 -
3C3A
3
PGK1_HUMAN
B:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
39
PsiBlast_CBE
76.34
44%
-84
- C9 -
3C3A
1
PGK1_HUMAN
A:
[15-419]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
----------
K
V
K
A
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
16
PsiBlast_PDB
76.21
44%
-88
- C9 -
2WZB
5
PGK1_HUMAN
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG----------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
49
PsiBlast_CBE
75.82
43%
-85
- C9 -
2WZD
5
PGK1_HUMAN
A:
[12-416]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG----------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
48
PsiBlast_CBE
75.10
43%
-85
- C9 -
2X14
3
PGK1_HUMAN
A:
[11-415]
---------
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
----
G
V
P
M
P
-----------
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
G
-
P
E
-
V
E
K
A
--
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG----------------------------
E
P
A
-------
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
L
P
--
Q
---
K
-
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
D
--
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
---
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
---
N
---
G
V
K
---
I
T
---
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
-
A
S
G
-
I
P
A
G
W
------
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
----
L
M
D
E
V
V
K
-
A
T
S
--
R
-
G
C
--
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
54
PsiBlast_CBE
73.85
36%
-84
- C9 -
2CUN
5
PGK_PYRHO
B:
[4-399]
-----
L
E
D
-
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
----
S
E
D
--------------
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
G
-
R
Y
-
A
R
E
K
--
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
--------------------
S
A
----------
E
E
V
K
N
K
P
IEECEKT
F
L
V
K
K
---
L
S
K
V
---
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
-
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
RE
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
RKN
V
E
F
M
K
K
KGLL---
D
Y
V
K
H
A
E
E
I
L
---
D
E
---
F
---
Y
P
Y
---
I
R
---
T
P
V
D
------
F
A
V
D
Y
K
G
-
E
-
R
-
V
E
-
I
D
L
-
L
S
E
N
R
GLLHQY
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
----
V
F
K
A
I
---
A
D
---
S
-
P
A
--
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
55
PsiBlast_CBE
73.73
36%
-86
- C9 -
2CUN
5
PGK_PYRHO
A:
[4-399]
-----
L
E
D
-
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
----
S
E
D
--------------
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
G
-
R
Y
-
A
R
E
K
--
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
--------------------
S
A
----------
E
E
V
K
N
K
P
I
E
E
C
E
K
T
F
L
V
K
K
---
L
S
K
V
---
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
-
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL---
D
Y
V
K
H
A
E
E
I
L
---
D
E
---
F
---
Y
P
Y
---
I
R
---
T
P
V
D
------
F
A
V
D
Y
K
G
-
E
-
R
-
V
E
-
I
D
L
-
L
S
E
N
R
G
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
----
V
F
K
A
I
---
A
D
---
S
-
P
A
--
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
71
HHSearch
72.47
37%
-68
- C9 -
2CUN
5
PGK_PYRHO
A:
[1-401]
--
M
F
R
L
E
D
-
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
----
S
E
D
--------------
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
G
-
R
Y
-
A
R
E
K
--
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
--------
S
--------
A
E
E
V
K
N
K
P
-------
I
E
E
C
E
K
T
-------
F
L
V
K
K
---
L
S
K
V
---
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
-
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
--
R
ER
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
---
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
---
D
E
---
F
---
Y
P
Y
---
I
R
---
T
P
V
D
F
A
V
D
Y
K
G
E
R
V
-
E
I
-
D
L
L
-
S
E
-
N
R
G
-
L
L
H
Q
Y
------
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
----
V
F
K
A
I
---
A
D
---
S
-
P
A
--
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
46
PsiBlast_CBE
47.13
45%
20
- C9 -
3PGK
3
PGK_YEAST
A:
[7-415]
-
S
K
L
S
V
Q
D
-
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
R
P
N
----
G
E
R
N
E
------------
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
G
-
P
E
-
V
E
A
A
--
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
HIEEEGS-
R
--------
K
V
D
G
Q
----------
K
V
K
A
S
K
E
-------
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
L
P
--
Q
---
R
-
A
-
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
D
--
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
---
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
---
E
K
A
K
A
K
---
G
V
E
---
V
V
---
L
P
V
D
F
I
I
A
D
A
F
S
A
S
A
N
T
K
T
-
V
-
T
D
-
K
E
G
-
I
P
A
G
W
------
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
----
L
L
D
E
V
---
V
K
S
--
S
-
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K