@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0731: (2016-03-18 )
MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
Atome Classification :
(61 SA)
.........10........20........30----------........40-........50........60........70........80-.........90........100.......110.......120.......130...---....140---.---..-----......150.......160.......170.......180.......190--......-..--.--200.-..--......210.......220.......230......-.240.......250-.--.--.-.....-260---.......--.---270...-....280........290.......300.......310.......-320...-.....330.......340.......350.......360.......370..-.....380.......390.......400.......410.......420.......430..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
I
I
T
D
V
Y
A
R
E
V
L
DSRGN
P
T
V
E
V
E
V
L
TESGA----------FGRALVPSGA-STGEH
E
A
V
E
LRDGDKS
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
II--E
G
E
F
S
V
L
D
QVSI
D
K
M
M
I
A
L
DGTPNKGKLGA
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---LGGFN-----G---KQ-----LP
V
P
M
M
N
IVNGGSHSDA
P
I
A
F
Q
E
F
M
I
LPV
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
----
L
K
S
I
L
S
-KR--G--L--E-TA--VGDEGGFAPKFEG
T
E
D
A
V
E
T
I
I
Q
A
I
E
AAGYKPGE
E
-
V
F
L
G
F
DCAS
S
E
F
Y
--E--N--G-VYDYS-KF----EGEHGAK--R---
T
A
A
E
Q
V
-
D
Y
L
E
Q
-
L
V
D
KY
P
I
I
T
IEDGMDEND
W
D
G
W
K
Q
L
T
E
R
IGD
R
V
Q
LVGD
D
-
L
-
F
VT
N
-
T
E
I
L
A
K
G
I
E
NGIG
N
S
I
L
I
K
VNQIG
T
L
T
E
T
F
D
A
I
E
M
A
Q
KAG
Y
T
A
V
V
SHRSG-ETED
T
T
I
A
D
I
A
V
ATNAG
Q
I
KTGSLS
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
YDG
I
K
S
F
YNLDK-
23
PsiBlast_CBE
97.28
81%
-79
- C1 -
3ZLF
2
ENO_STRP6
C:
[21-454]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
K
--
25
PsiBlast_CBE
97.00
81%
-79
- C1 -
3ZLG
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
27
PsiBlast_CBE
96.86
81%
-79
- C1 -
3ZLG
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
22
PsiBlast_CBE
96.57
81%
-77
- C1 -
3ZLF
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
26
PsiBlast_CBE
96.43
81%
-78
- C1 -
3ZLG
2
ENO_STRP6
C:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
2
PsiBlast_PDB
96.30
81%
-82
- C1 -
3ZLH
-
ENO_STRP6
A:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
-----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
24
PsiBlast_CBE
96.23
81%
-78
- C1 -
3ZLF
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
V
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
3
PsiBlast_PDB
95.09
80%
-81
- C1 -
4EWJ
-
?
A:
[1-433]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
V
I
A
D
A
I
I
--
G
--
F
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
S
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
A
R
--
G
--
L
--
V
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
I
E
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D----
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
I
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
D
Y
L
A
R
G
I
K
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
V
Y
K
G
L
N
S
F
Y
N
L
---
29
PsiBlast_CBE
91.56
74%
-79
- C1 -
1IYX
5
ENO_ENTHR
B:
[2-429]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
-
S
R
--
G
--
L
--
A
-
T
S
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
DK
E
--
K
--
G
-
V
Y
V
L
A
-
D
S
G---
E
G
E
------
K
---
T
T
D
E
M
I
-
K
F
Y
E
E
-
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
L
---
28
PsiBlast_CBE
91.44
73%
-79
- C1 -
4A3R
3
ENO_BACSU
D:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
-----
S
---
K
T
-----
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
-
A
K
--
G
--
L
--
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
--
G
-
K
Y
H
L
S
--------
G
E
-
G
V
V
--
K
---
T
S
A
E
M
V
-
D
W
Y
E
E
-
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
5
PsiBlast_PDB
91.19
74%
-81
- C1 -
1IYX
6
ENO_ENTHR
A:
[2-429]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
-
S
R
--
G
--
L
--
A
-
T
S
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
DK
E
--
K
--
G
-
V
Y
V
L
A
-
D
S
G---
E
G
E
------
K
---
T
T
D
E
M
I
-
K
F
Y
E
E
-
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
L
---
4
PsiBlast_PDB
91.14
73%
-79
- C1 -
4A3R
-
ENO_BACSU
A:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
-----
S
---
K
T
-----
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
-
A
K
--
G
--
L
--
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
--
G
-
K
Y
H
L
S
--------
G
E
-
G
V
V
--
K
---
T
S
A
E
M
V
-
D
W
Y
E
E
-
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
21
PsiBlast_CBE
87.30
81%
-37
- C- -
1W6T
2
ENO_STRPN
B:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
-
S
R
--
G
--
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
I
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
K
--
101
HHSearch
86.73
82%
-35
- C- -
1W6T
2
ENO_STRPN
A:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
-
S
R
--
G
--
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
D
--
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
I
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
K
--
1
PsiBlast_PDB
86.38
81%
-36
- C- -
1W6T
2
ENO_STRPN
A:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
G
F
N
-----
T
---
K
V
-----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
-
S
R
--
G
--
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
D----
R
--
K
-
V
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
--
R
---
T
S
A
E
Q
I
-
D
Y
L
E
E
-
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
-
F
V
T
N
-
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
K
--
8
PsiBlast_PDB
86.11
60%
-76
- C1 -
4Z1Y
1
ENO_CHLAA
A:
[4-424]
--
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
G
V
Y
-----
A
---
H
V
-----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
--
G
--
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
-----
D
--
G
-
K
Y
H
L
K
-
R
--------
E
G
R
S
--
L
---
S
S
A
E
M
V
-
D
Y
W
V
D
-
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
-
L
V
T
N
-
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
105
HHSearch
85.73
58%
-73
- C1 -
2FYM
2
ENO_ECOLI
A:
[1-429]
-
S
K
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
-
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
A
E
L
N
GTPG-
K
---
Y
S
-----
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
-
A
K
--
G
--
M
--
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
-
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
--
G
-
K
Y
V
L
A
-
G
E
-------
G
N
K
A
--
F
---
T
S
E
E
F
T
-
H
F
L
E
E
-
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
-
F
-
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
----
44
PsiBlast_CBE
85.43
58%
-80
- C1 -
3UJ2
3
?
E:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
-
E
I
L
--
S
G
-
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
R
-----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
--
A
-
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
--
G
-
E
Y
I
L
P
-
K
C
----
K
----
R
K
--
F
---
A
S
E
E
L
V
-
A
H
W
K
S
-
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
41
PsiBlast_CBE
85.35
58%
-81
- C1 -
3UJ2
6
?
H:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
-
E
I
L
--
S
G
-
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
R
-----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
--
A
-
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
--
G
-
E
Y
I
L
P
-
K
C
----
K
----
R
K
--
F
---
A
S
E
E
L
V
-
A
H
W
K
S
-
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
42
PsiBlast_CBE
85.30
58%
-78
- C1 -
3UJ2
6
?
G:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
-
E
I
L
--
S
G
-
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
R
-----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
--
A
-
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
--
G
-
E
Y
I
L
P
-
K
C
----
K
----
R
K
--
F
---
A
S
E
E
L
V
-
A
H
W
K
S
-
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
-
F
V
T
N
-
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
7
PsiBlast_PDB
85.23
60%
-75
- C1 -
4Z17
3
ENO_CHLAA
A:
[4-424]
--
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
G
V
Y
-----
A
---
H
V
-----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
--
G
--
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
--
G
-
K
Y
H
L
K
-
R
--------
E
G
R
S
--
L
---
S
S
A
E
M
V
-
D
Y
W
V
D
-
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
-
L
V
T
N
-
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
67
PsiBlast_CBE
83.84
50%
-73
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
66
PsiBlast_CBE
83.54
50%
-72
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
32
PsiBlast_CBE
83.34
60%
-76
- C1 -
4Z17
3
ENO_CHLAA
B:
[4-424]
--
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
G
V
Y
-----
A
---
H
V
-----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
--
G
--
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
--
G
-
K
Y
H
L
K
-
R
--------
E
G
R
S
--
L
---
S
S
A
E
M
V
-
D
Y
W
V
D
-
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
-
L
V
T
N
-
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
60
PsiBlast_CBE
83.12
50%
-73
- C1 -
1ONE
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
58
PsiBlast_CBE
83.04
50%
-72
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
80
PsiBlast_CBE
82.77
50%
-72
- C1 -
1P43
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
65
PsiBlast_CBE
82.76
50%
-70
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
64
PsiBlast_CBE
82.71
50%
-71
- C1 -
1EBG
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
72
PsiBlast_CBE
82.68
50%
-71
- C1 -
1ELS
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
57
PsiBlast_CBE
82.37
50%
-73
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
59
PsiBlast_CBE
82.30
50%
-72
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSPYV
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
70
PsiBlast_CBE
82.14
50%
-72
- C1 -
2AL2
5
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
--
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
D
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
D
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
78
PsiBlast_CBE
82.08
50%
-70
- C1 -
1P48
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
106
HHSearch
82.00
51%
-67
* C1 *
2AL1
3
ENO1_YEAST
A:
[1-429]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
KSKTS
P
---
Y
V
-----
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
Y-
G
A-
S
--
A
-
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
-
F
K
NP--
N
S
D
K
S
K
W
--
L
---
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
--------
99
PsiBlast_CBE
81.97
50%
-70
- C1 -
2AL2
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
A
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
77
PsiBlast_CBE
81.75
50%
-68
- C1 -
1P48
3
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSPYV
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
63
PsiBlast_CBE
81.70
50%
-69
- C1 -
1EBG
3
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSPYV
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
55
PsiBlast_CBE
81.66
50%
-73
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSPYV
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
56
PsiBlast_CBE
81.40
50%
-70
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
123
Fugue
81.28
51%
-66
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
--
A
-
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
--
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
---G
K
Y
D
L
D
-
F
K
----
N
P
N
S
D
K
S
KW
L
---
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
L
79
PsiBlast_CBE
81.14
50%
-70
- C1 -
1P43
3
ENO1_YEAST
B:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
K
TSPYV
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
--
G
--
A
-
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
--
G
-
K
Y
D
L
D
--
F
----
K
N
P
N
S
D
K
--
S
KWL
T
G
P
Q
L
A
-
D
L
Y
H
S
-
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
-
T
V
T
N
-
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
-
83
PsiBlast_CBE
80.95
49%
-73
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
94
PsiBlast_CBE
80.27
49%
-72
- C1 -
1TE6
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
75
PsiBlast_CBE
80.25
49%
-72
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
90
PsiBlast_CBE
79.95
49%
-72
- C1 -
2AKZ
6
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
92
PsiBlast_CBE
79.78
49%
-72
- C1 -
2AKM
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
85
PsiBlast_CBE
79.71
49%
-72
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
84
PsiBlast_CBE
79.68
49%
-73
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
81
PsiBlast_CBE
79.43
49%
-73
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
73
PsiBlast_CBE
79.36
49%
-71
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
87
PsiBlast_CBE
79.19
49%
-71
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
86
PsiBlast_CBE
78.93
49%
-69
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
DLI--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
82
PsiBlast_CBE
78.93
49%
-71
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
76
PsiBlast_CBE
78.91
49%
-71
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
110
HHSearch
78.48
49%
-67
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-439]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
-
D
-----------
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
-----
G
HK
E
M
T
-----
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
-
A
K
--
Y
GQ
D
--
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
--
Y
T
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
EE
T
--
K
-
K
Y
D
L
G
-
K
K
IPAD
K
K
D
P
S
L
V
--
K
---
D
V
D
G
L
I
-
A
E
Y
V
D
-
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
-
L
-
L
V
T
N
-
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
-
W
R
N
S
---
74
PsiBlast_CBE
78.43
49%
-70
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
109
HHSearch
78.39
49%
-69
- C1 -
2AKZ
6
ENOG_HUMAN
A:
[1-431]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
GNS--
D
---
L
I
-----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
--
Y
--
G
KD
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
--
T
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
S---
P
T
D
P
S
R
Y
--
I
---
T
G
D
Q
L
G
-
A
L
Y
Q
D
-
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
-
V
-
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
S
---
88
PsiBlast_CBE
78.30
49%
-71
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
--
S
S
G
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
I
--
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y
--
G
--
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
--
G
-
K
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
--
Y
---
I
T
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
111
HHSearch
74.14
46%
-69
- C1 -
2PTZ
5
?
A:
[3-429]
H
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
GTK--
E
---
L
R
-----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
-
Q
D
--------
A
-
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
--
R
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
--
D
--
E
KK
Q
-
Q
Y
N
L
T
-
F
K
----
S
P
-
E
P
T
W
--
V
---
T
A
E
Q
L
R
-
E
T
Y
C
K
-
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
-
L
T
V
-
T
N
-
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
-
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
---------
19
PsiBlast_PDB
37.94
50%
29
- C1 -
1PDZ
2
ENO_HOMGA
A:
[5-430]
---
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
--
K
S
G
L
K
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
N
Y
D
-----
E
---
V
I
-----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
----
L
K
A
V
I
K
-
A
R
F-
G
--
L
--
D
A
T
A
--
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
G
K
I
E
-
I
--
G
M
D
V
A
A
S
E
F
Y
K-
Q
--
N
--
N
-
I
Y
D
L
D
F
K
T
----
A
N
N
D
G
S
Q
--
K
---
I
S
G
D
Q
L
R
D
M
Y
M
E
-
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
D
D
-
L
-
T
V
T
N
-
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
-
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
-
K
N
F
------