@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0742: (2016-03-18 )
MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQNTDASNKDVVSQAVNPSTPRMRAFSLAAVAADAPAAGTDITNQLTDVKVTIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVDNKENVTANITMPAYIDPENVTKTGNVTLTTGIGTNTASKTVLIDYEKYGQFHNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVVLPALTGNLIPNTKSNALIDAKNTDIKVYRVDNANDLSESYYVNPSDFEDVTNQVRISFPNANQYKVEFPTDDDQITTPYIVVVNGHIDPASTGDLALRSTFYGYDSNFIWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSESDSDSDSDSDSDSASDSDSGSDSDSSSDSDSDSTSDTGSDNDSDSDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEANTSLIWGLLASLGSLLLFRRKKENKDKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-...----..-----.--------.250.......260.....-----..270.....-----..280.......290--.......-.--.300........310.-.......320.......330.......340--......-.-.----.350.-----.....-.360.......370...-..-...380.......390.-----------------........400..-----...-..410.......420-------........430....-...440.......450...---.....460--.......470.......480.-.-.....490..----------------...------..500.........510.......520.......530.......540.......550.......560.......570------------------.-........580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNM
K
K
K
E
K
H
A
I
R
K
KSI
G
V
A
S
V
L
V
G
T
L
I
G
F
G
LLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNT
N
A
E
E
L
V
N
QTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQNTDAS
N
K
D
V
V
S
QAVNPSTP
R
M
R
A
F
S
L
A
A
V
AADAPAAGTDITNQ
L
T
D
V
K
V
T
-IDS----G
T
-----
T
--------VYPHQA
G
Y
V
K
L
N
YGFSVPN-----SAVKG
D
T
F
K
I
-----TVPKELNLNGVTS----TAKVPPI-M--AGD-Q
V
L
AN
G
V
ID-SD-G
N
V
I
Y
T
FTDYVDNKE
N
V
T
A
N
IT
M
P
A
Y
I
D
----
P
E
NVTK-T-G----
N
V
T
L
T
-----
T
GIGT-NTAS
K
T
V
L
I
D
Y
E
-KYGQ-FH-
N
L
S
I
K
G
TIDQIDKT--N-----------------N
T
Y
R
Q
T
I
Y
VNPSG-----D
N
V
-
V
L
P
ALTGNLIPNTK--------S
N
A
L
I
DAKNT
D
I
K
V
Y
-RVDNANDLSE
S
Y
YVN-
P
S
D
---
F
E
D
V
T
N
Q
V
--
R
I
SFPNA
N
Q
Y
K
V
EFPTDDDQI-T-T
P
Y
I
V
V
V
NGH----------------IDP------AST--GD
L
A
L
R
S
T
FYGYDS
N
F
I
W
R
SMSWDN
E
V
A
FNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSG--------------------S-DSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSESDSDSDSDSDSDSASDSDSGSDSDSSSDSDSDSTSDTGSDNDSDSDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEA
N
T
S
L
I
W
G
L
L
A
S
L
G
S
L
L
L
F
R
R
KKENKDKK
46
Fugue
97.94
87%
-89
- C9 -
1N67
3
CLFA_STAAE
A:
[28-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
-
I
D
S
----
G
T
-----
T
--------
V
Y
P
H
Q
A
G
Y
V
K
L
N
Y
G
F
S
V
P
N
-----
S
A
V
K
G
D
T
F
K
I
-----
T
V
P
K
E
L
N
L
N
G
V
T
S
----
T
A
K
V
P
P
I
-
M
--
A
G
D
-
Q
V
L
A
N
G
V
I
D
-
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
I
D
----
P
E
N
V
K
K
-
T
-
G
----
N
V
T
L
A
-----
T
G
I
G
S
-
T
T
A
N
K
T
V
L
V
D
Y
E
-
K
Y
G
K
-
F
Y
-
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
--
N
-----------------
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-----
D
N
V
-
I
A
P
V
L
T
G
N
L
K
P
N
T
D
--------
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
-
K
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
-
P
E
N
---
F
E
D
V
T
N
S
V
--
N
I
T
F
P
N
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
-
T
-
T
P
Y
I
V
V
V
N
G
H
----------------
I
D
P
------
N
S
K
--
G
D
L
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.63
87%
-90
- C9 -
1N67
3
CLFA_STAAE
A:
[28-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
-
I
D
S
----
G
T
-----
T
--------
V
Y
P
H
Q
A
G
Y
V
K
L
N
Y
G
F
S
V
P
N
-----
S
A
V
K
G
D
T
F
K
I
-----
T
V
P
K
E
L
N
L
N
G
V
T
S
----
T
A
K
V
P
P
I
-
M
--
A
G
D
-
Q
V
L
A
N
G
V
I
D
-
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
I
D
----
P
E
N
V
K
K
-
T
-
G
----
N
V
T
L
A
-----
T
G
I
G
S
-
T
T
A
N
K
T
V
L
V
D
Y
E
-
K
Y
G
K
-
F
Y
-
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
--
N
-----------------
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-----
D
N
V
-
I
A
P
V
L
T
G
N
L
K
P
N
T
D
--------
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
-
K
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
-
P
E
N
---
F
E
D
V
T
N
S
V
--
N
I
T
F
P
N
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
-
T
-
T
P
Y
I
V
V
V
N
G
H
----------------
I
D
P
------
N
S
K
--
G
D
L
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
96.79
87%
-86
- C9 -
1N67
3
CLFA_STAAE
A:
[28-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
-
I
D
S
----
G
T
-----
T
--------
V
Y
P
H
Q
A
G
Y
V
K
L
N
Y
G
F
S
V
P
N
-----
S
A
V
K
G
D
T
F
K
I
-----
T
V
P
K
E
L
N
L
N
G
V
T
S
----
T
A
-
K
V
P
P
I
M
--
A
G
D
-
Q
V
L
A
N
G
V
I
D
-
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
I
D
----
P
E
N
V
K
K
-
T
-
G
----
N
V
T
L
A
-----
T
G
I
G
S
-
T
T
A
N
K
T
V
L
V
D
Y
E
-
K
Y
G
K
-
F
Y
-
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
--
N
-----------------
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-----
D
N
V
-
I
A
P
V
L
T
G
N
L
K
P
N
T
D
--------
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
-
K
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
-
P
E
N
---
F
E
D
V
T
N
S
V
--
N
I
T
F
P
N
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
-
T
-
T
P
Y
I
V
V
V
N
G
H
----------------
I
D
P
------
N
S
K
--
G
D
L
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.57
86%
-99
- C9 -
2VR3
1
CLFA_STAA8
A:
[14-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
I
T
N
Q
L
T
N
V
T
V
G
-
I
D
S
----
G
T
-----
T
--------
V
Y
P
H
Q
A
G
Y
V
K
L
N
Y
G
F
S
V
P
N
-----
S
A
V
K
G
D
T
F
K
I
-----
T
V
P
K
E
L
N
L
N
G
V
T
S
----
T
A
K
V
P
P
I
-
M
--
A
----
V
L
A
N
G
V
I
D
-
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
C
D
V
K
A
T
L
T
M
P
A
Y
I
D
----
P
E
N
V
K
K
-
T
-
G
----
N
V
T
L
A
-----
T
G
I
G
S
-
T
T
A
N
K
T
V
L
V
D
Y
E
-
K
Y
G
K
-
F
Y
-
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
--
N
-----------------
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-----
D
N
V
-
I
A
P
V
L
T
G
N
L
K
P
N
T
D
--------
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
-
K
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
-
P
E
------
D
V
T
N
S
V
--
N
I
T
F
P
N
P
N
Q
Y
K
V
E
F
--
P
D
D
Q
I
-
T
-
T
P
Y
I
V
V
V
N
G
H
----------------
I
D
P
------
N
S
K
--
G
D
L
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
C
P
V
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
68.28
17%
-71
- C9 -
3IRP
5
X:
[3-379]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
G
R
N
V
N
H
L
V
F
A
N
T
S
Y
E
I
L
G
GGKK
Y
N
-----
Q
--------
V
F
M
T
M
D
G
K
L
K
I
K
I
D
Y
T
V
D
D
-----
S
V
V
E
G
D
Y
F
T
V
-----
D
F
G
K
Y
I
H
P
G
T
S
R
K
----
P
Y
R
V
N
N
I
H
D
--
A
N
G
-
R
T
I
A
I
G
S
Y
D
S
A
T
-
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
L
L
S
W
P
F
----
K
E
L
V
T
T
D
K
-
Q
----
S
V
P
V
G
-----
I
T
V
A
G
-
E
D
Y
T
Q
N
V
I
F
N
Y
G
-
N
R
T
V
-
P
V
-
I
S
D
I
-
N
Y
---
L
--
T
--
K
-----------------
D
F
A
E
F
T
T
Y
I
N
Q
N
R
-----
A
F
N
-
T
G
S
K
V
R
--
L
S
G
-----------
Q
G
F
K
F
T
-
S
P
D
E
I
E
V
Y
-
K
V
L
N
N
S
Q
F
R
D
S
F
S
P
D
-
Y
A
N
---
L
T
Q
V
R
-
N
P
--
K
I
I
I
N
S
D
G
S
A
T
V
D
L
G
----
D
I
-
G
T
L
G
Y
I
I
R
S
K
P
N
----------------
T
L
P
------
D
F
S
GI
G
V
L
K
S
E
Y
T
F
T
N
N
K
N
Q
R
--
D
T
R
A
H
A
S
S
I
Q
F
V
R
A
E
L
--------
A
G
F
G
G
F
G
G
Y
V
W
F
D
K
N
N
D
G
V
Q
N
D
S
N
A
A
A
A
GITVNLLDPTGIRLATTTTD
I
T
G
H
Y
N
F
D
N
L
T
N
G
N
Y
L
V
E
F
V
M
P
E
G
Y
I
P
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
63.43
16%
-9
* C9 *
3IRP
7
UAFA_STAS1
X:
[2-419]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
S
G
R
N
V
N
H
L
V
F
A
N
T
S
Y
-
E
I
L
----
G
G
GKKYN
Q
--------
V
F
M
T
M
D
G
K
L
K
I
K
I
D
Y
T
V
D
D
-----
S
V
V
E
G
D
Y
F
T
V
-----
D
F
G
K
Y
I
H
P
G
T
S
R
K
----
P
Y
R
V
N
N
I
-
H
--
D
A
N
G
R
T
I
A
I
G
S
Y
D
-
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
L
L
S
W
P
F
----
K
E
L
V
T
T
-
D
K
Q
----
S
V
P
V
G
-----
I
T
V
A
G
-
E
D
Y
T
Q
N
V
I
F
N
Y
G
-
N
R
T
V
-
P
V
-
I
S
D
I
N
Y
L
------
T
--
K
-----------------
D
F
A
E
F
T
T
Y
I
N
Q
N
R
-----
A
F
N
-
T
G
S
K
V
R
L
S
G
Q
G
F
K
F
--------
T
S
------
P
D
E
I
E
V
Y
-
K
V
L
N
N
S
Q
F
R
D
S
F
S
P
D
-
Y
A
N
---
L
T
Q
V
R
N
P
---
K
I
I
I
N
S
D
G
S
A
T
V
D
L
G
D
I
G
T
L
-----
G
Y
I
I
R
S
K
P
N
----------------
T
L
P
------
D
F
S
--
G
I
G
V
L
K
S
E
Y
T
F
T
N
N
K
N
Q
R
D
T
R
A
H
A
S
S
I
Q
F
V
R
A
E
L
A
G
F
G
G
F
G
G
Y
V
W
F
D
K
N
N
D
G
-----
V
Q
N
D
S
N
A
A
A
A
G
I
T
--------------------
V
-
N
L
L
D
P
T
G
I
R
L
A
T
T
T
T
D
I
T
G
H
Y
N
F
D
N
L
T
N
G
N
Y
L
V
E
F
V
M
P
E
G
Y
I
P
T
Q
A
N
S
T
V
D
D
K
D
S
D
V
V
F
E
N
G
R
Y
I
A
H
V
T
I
K
D
A
D
N
M
T
I
D
A
G
L
V
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.33
30%
-74
- C9 -
2RAL
-
SDRG_STAEP
A:
[315-592]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
V
D
D
-----
K
V
K
S
G
D
T
M
T
V
N
I
D
KN
T
V
P
S
D
L
-----
T
D
----
S
F
A
I
P
K
I
-
K
D
N
S
G
--
E
I
I
A
T
G
T
Y
D
N
T
N
-
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
C
N
I
K
A
H
L
K
L
T
S
Y
I
D
KSKV
P
N
N
N
T
K
-
L
------
D
V
E
Y
K
-----
T
A
L
---
S
S
V
N
K
T
I
T
V
E
Y
Q
-
K
P
N
E
-
N
R
-
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
--
N
-----------------
H
T
V
E
Q
T
I
Y
I
N
P
L
R
YSAKE
T
N
V
----
N
I
S
G
N
---
G
D
E
--------
G
S
T
I
I
D
-
D
S
T
I
I
K
V
Y
-
K
V
G
D
N
Q
N
L
P
D
S
N
R
I
Y
D
Y
S
E
---
Y
E
D
V
T
N
D
D
--
Y
A
Q
L
G
N
N
N
D
V
N
I
N
F
G
N
I
D
------
S
P
Y
I
I
K
V
I
S
K
----------------
Y
D
P
NKDDYT
T
I
Q
--
Q
T
V
T
M
Q
T
T
I
N
E
Y
T
G
E
F
--
R
T
A
S
Y
D
N
T
I
A
F
S
T
S
S
G
Q
G
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
63.08
31%
-73
- C9 -
1R17
2
SDRG_STAEP
B:
[60-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
V
D
D
-----
K
V
K
S
G
D
T
M
T
V
NIDKN
T
V
P
S
D
L
-----
T
D
----
S
F
A
I
P
K
I
-
K
DN
S
G
--
E
I
I
A
T
G
T
Y
D
N
T
N
-
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
E
N
I
K
A
H
L
K
L
T
S
Y
I
D
KSKV
P
N
N
N
T
K
-
L
------
D
V
E
Y
K
-----
T
A
L
---
S
S
V
N
K
T
I
T
V
E
Y
Q
-
K
P
N
E
-
N
R
-
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
--
N
-----------------
H
T
V
E
Q
T
I
Y
I
N
P
L
R
YSAKE
T
N
V
----
N
I
S
G
N
---
G
D
E
--------
G
S
T
I
I
D
-
D
S
T
I
I
K
V
Y
-
K
V
G
D
N
Q
N
L
P
D
S
N
R
I
Y
D
Y
S
E
---
Y
E
D
V
T
N
D
D
--
Y
A
Q
L
G
N
N
N
D
V
N
I
N
F
G
N
I
D
------
S
P
Y
I
I
K
V
I
S
K
----------------
Y
D
P
NKDDYT
T
I
Q
--
Q
T
V
T
M
Q
T
T
I
N
E
Y
T
G
E
F
--
R
T
A
S
Y
D
N
T
I
A
F
S
T
S
S
G
Q
G
Q
G
-
D
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.90
31%
-69
- C9 -
1R17
1
SDRG_STAEP
A:
[60-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
V
D
D
-----
K
V
K
S
G
D
T
M
T
V
N
I
DKN
T
V
P
S
D
L
-----
T
D
----
S
F
A
I
P
K
I
-
K
DN
S
G
--
E
I
I
A
T
G
T
Y
D
N
T
N
-
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
E
N
I
K
A
H
L
K
L
T
S
Y
I
D
KSKV
P
N
N
N
T
K
-
L
------
D
V
E
Y
K
-----
T
A
L
---
S
S
V
N
K
T
I
T
V
E
Y
Q
-
K
P
N
E
-
N
R
-
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
--
N
-----------------
H
T
V
E
Q
T
I
Y
I
N
P
L
R
YSAKE
T
N
V
----
N
I
S
G
N
---
G
D
E
--------
G
S
T
I
I
D
-
D
S
T
I
I
K
V
Y
-
K
V
G
D
N
Q
N
L
P
D
S
N
R
I
Y
D
Y
S
E
---
Y
E
D
V
T
N
D
D
--
Y
A
Q
L
G
N
N
N
D
V
N
I
N
F
G
N
I
D
------
S
P
Y
I
I
K
V
I
S
K
----------------
Y
D
P
NKDDYT
T
I
Q
--
Q
T
V
T
M
Q
T
T
I
N
E
Y
T
G
E
F
--
R
T
A
S
Y
D
N
T
I
A
F
S
T
S
S
G
Q
G
Q
G
-
D
L
P
--
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.85
28%
-90
- C9 -
4B5Z
-
FNBA_STAA8
A:
[10-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
V
T
S
-----
K
V
T
-
V
E
I
----
G
S
-----
I
E
G
HNNTNK
V
E
P
H
A
G
Q
R
A
V
L
K
Y
K
L
K
F
E
N
-----
G
L
H
Q
G
D
Y
F
D
F
-----
T
L
S
N
N
V
N
T
H
G
V
S
T
----
A
R
K
V
P
E
I
-
K
--
N
G
S
-
V
V
M
A
T
G
E
V
L
-
E
G
-
G
K
I
R
Y
T
F
T
N
D
I
E
D
K
V
D
V
T
A
E
L
E
I
N
L
F
I
D
----
P
K
T
V
Q
T
-
N
-
G
----
N
Q
T
I
T
-----
S
T
L
N
E
-
E
Q
T
S
K
E
L
D
V
K
Y
K
D
G
I
G
N
-
Y
Y
A
N
L
N
--
G
S
I
E
T
F
N
K
A
--
N
-----------------
N
R
F
S
H
V
A
F
I
K
P
N
N
-----
G
K
T
-
T
S
V
T
V
T
G
T
L
M
K
G
S
N
--------
Q
N
----
G
N
Q
P
K
V
R
I
F
E
Y
L
G
N
N
E
D
I
A
K
S
V
Y
A
N
-
T
T
D
TSK
F
K
E
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.64
28%
-90
- C- -
4B60
1
FNBA_STAA8
A:
[11-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
V
T
S
-----
K
V
T
-
V
E
I
----
G
S
-----
I
E
G
H
NNTNK
V
E
P
H
A
G
Q
R
A
V
L
K
Y
K
L
K
F
E
N
-----
G
L
H
Q
G
D
Y
F
D
F
-----
T
L
S
N
N
V
N
T
H
G
V
S
T
----
A
R
K
V
P
E
I
-
K
--
N
G
S
-
V
V
M
A
T
G
E
V
L
-
E
G
-
G
K
I
R
Y
T
F
T
N
D
I
E
D
K
V
D
V
T
A
E
L
E
I
N
L
F
I
D
----
P
K
T
V
Q
T
-
N
-
G
----
N
Q
T
I
T
-----
S
T
L
N
E
-
E
Q
T
S
K
E
L
D
V
K
Y
K
D
G
I
G
N
-
Y
Y
A
N
L
N
--
G
S
I
E
T
F
N
K
A
--
N
-----------------
N
R
F
S
H
V
A
F
I
K
P
N
N
-----
G
K
T
-
T
S
V
T
V
T
G
T
L
M
K
G
S
N
--------
Q
N
----
G
N
Q
P
K
V
R
I
F
E
Y
L
G
N
N
E
D
I
A
K
S
V
Y
A
N
-
T
T
D
TSK
F
K
E
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.89
31%
-83
- C9 -
1R19
-
SDRG_STAEP
A:
[315-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
V
D
D
-----
K
V
K
S
--
T
M
T
V
N
I
D
KN
T
V
P
S
D
L
-----
T
D
----
S
F
-
I
P
K
I
-
K
---
G
--
E
I
I
A
T
G
T
Y
D
N
T
N
-
K
Q
I
T
Y
T
-
T
D
Y
V
D
---
N
I
K
A
H
L
K
L
T
S
Y
I
D
KSKV
P
N
N
N
T
K
-
L
------
D
V
E
Y
K
-----
T
A
L
---
S
S
V
N
K
T
I
T
V
E
Y
Q
-
K
P
N
E
-
N
R
-
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
--
N
-----------------
H
T
V
E
Q
T
I
Y
I
N
P
L
R
YSAKE
T
N
V
----
N
I
S
G
N
---
G
D
E
--------
G
S
T
I
I
D
-
D
S
T
I
I
K
V
Y
-
K
V
G
D
N
Q
N
L
P
D
S
N
R
I
Y
D
Y
S
E
---
Y
E
D
V
T
N
D
D
--
Y
A
Q
L
G
--
N
D
V
N
I
N
F
G
N
I
D
------
S
P
Y
I
I
K
V
I
S
K
----------------
Y
D
P
------
T
I
Q
--
Q
T
V
T
M
Q
T
T
I
N
E
Y
T
G
E
F
--
R
T
A
S
Y
D
N
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.36
26%
-65
- C9 -
4F24
5
CLFB_STAAR
A:
[128-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
-
N
Y
S
S
P
I
A
G
I
D
------
K
-
P
N
-
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
SG
Q
-----------------
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
D
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
G
E
F
KD
K
I
S
Y
K
Y
D
N
V
A
S
I
N
F
----
G
D
I
-
N
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTGKNL
K
T
Q
V
I
Q
E
N
I
D
P
------
A
T
G
--
K
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.91
25%
-71
- C9 -
3AU0
2
CLFB_STAAN
A:
[105-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
----
T
Y
D
A
N
-----
I
N
I
A
D
-
E
M
F
N
N
K
I
T
Y
N
Y
S
--------------
S
P
I
A
G
I
D
K
P
--
N
G
A
N
I
S
S
Q
II
G
V
D
TASGQ
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
E
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
D
Q
F
KN
R
I
Y
Y
E
H
P
N
V
A
S
I
K
F
----
G
D
I
-
T
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTGKNL
K
T
Q
V
I
Q
E
N
V
D
P
------
V
T
N
--
R
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.50
26%
-73
- C9 -
4F1Z
2
CLFB_STAAR
A:
[128-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
-
N
Y
S
S
P
I
A
G
I
D
------
K
-
P
N
-
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
SG
Q
-----------------
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
D
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
G
E
F
KD
K
I
S
Y
K
Y
D
N
V
A
S
I
N
F
----
G
D
I
-
N
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTGK
N
L
K
T
Q
V
I
Q
E
N
I
D
P
------
A
T
G
--
K
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
R
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.14
26%
-68
- C9 -
4F20
3
CLFB_STAAR
A:
[128-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
-
N
Y
S
S
P
I
A
G
I
D
------
K
-
P
N
-
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
SG
Q
-----------------
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
D
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
G
E
F
KD
K
I
S
Y
K
Y
D
N
V
A
S
I
N
F
----
G
D
I
-
N
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTG
K
N
L
K
T
Q
V
I
Q
E
N
I
D
P
------
A
T
G
--
K
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.06
25%
-72
- C9 -
3AT0
1
CLFB_STAAN
A:
[104-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
----
T
Y
D
A
N
-----
I
N
I
A
D
-
E
M
F
N
N
K
I
T
Y
N
Y
S
-
S
-------------
P
I
A
G
I
D
K
P
--
N
G
A
N
I
S
S
Q
IIGVDTASGQ
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
E
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
D
Q
F
KN
R
I
Y
Y
E
H
P
N
V
A
S
I
K
F
----
G
D
I
-
T
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTGKNL
K
T
Q
V
I
Q
E
N
V
D
P
------
V
T
N
--
R
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.99
26%
-65
- C9 -
4F27
3
CLFB_STAAR
A:
[128-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
-
N
Y
S
S
P
I
A
G
I
D
------
K
-
P
N
-
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
SG
Q
-----------------
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
D
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
G
E
F
KD
K
I
S
Y
K
Y
D
N
V
A
S
I
N
F
----
G
D
I
-
N
-
K
T
Y
V
V
L
V
E
G
H
Y
D
NTGK
N
L
K
T
Q
V
I
Q
E
N
I
D
P
------
A
T
G
--
K
D
Y
S
I
---------------
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.69
27%
-80
- C9 -
3ASW
1
CLFB_STAAN
A:
[104-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
T
D
----
R
A
K
A
P
K
-
S
-
G
----
T
Y
D
A
N
-----
I
N
I
A
D
-
E
M
F
N
N
K
I
T
Y
N
Y
S
--------------
S
P
I
A
G
I
D
K
P
--
N
G
A
N
I
S
S
Q
IIGVDTASGQ
N
T
Y
K
Q
T
V
F
V
N
P
K
------------
Q
R
V
L
G
N
T
W
V
Y
I
K
GYQDKIEE
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
-
E
V
N
D
T
S
K
L
S
E
S
Y
Y
A
D
-
P
N
D
SN-
L
K
E
V
T
D
Q
F
KN
R
I
Y
Y
E
H
P
N
V
A
S
I
K
F
----
G
D
I
-
T
-
K
T
Y
V
V
L
V
E
G
H
----------------
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
50.99
15%
-74
- C10 -
3V10
-
?
A:
[32-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
T
N
E
A
I
F
T
Q
F
D
-
V
N
P
----
K
------
G
--------
L
I
N
N
P
S
Q
P
I
E
F
N
L
A
F
S
D
M
N
NG
Q
K
V
K
F
K
P
G
D
F
F
D
L
-----
T
L
P
S
N
D
E
V
S
L
R
S
L
RAMG
S
K
M
P
V
L
A
K-------
K
E
I
T
L
G
E
L
T
F
N
G
-
S
H
I
H
F
E
F
M
E
D
V
L
Q
L
E
N
V
T
G
T
I
N
L
K
S
V
Y
D
----
N
A
Y
R
G
E
D
D
-
K
----
I
A
E
L
P
-----
T
N
L
G
L
G
S
L
D
K
Q
M
I
T
I
S
Q
P
-
G
T
P
T
S
P
I
-
F
Y
W
K
T
G
T
F
S
--
T
E
V
--
H
-----------------
G
D
M
N
W
W
L
N
I
N
S
P
K
-----
E
A
V
Q
S
D
V
K
V
I
D
T
I
G
------------
E
G
H
K
L
V
D
--
G
S
I
M
V
D
-
V
E
A
N
G
---
E
L
K
H
I
-
S
-
A
E
A
---
F
N
K
E
Y
--
G
--
T
I
T
V
-
E
G
Q
V
L
T
V
M
I
P
K
--
E
K
A
A
K
-
T
T
F
T
V
T
Y
D
T
R
----------------
A
F
D
------
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------