@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0776: (2016-03-18 )
MAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPMQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSAIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF
Atome Classification :
(20 SA)
.........10........20........30........40........50....--....60........70........80........90........100.......110....-...120.......130.......140.......150.-....--.-..160.......170.......180.......190...--.----.----..200.......210.......220.......230........240....-...250.....-..260......-..270.......280.......290.......300------------.-........310.......320.......330.-.--......340....-...-350......-.360.......370-----..---....-----..-----380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEHSF
D
V
N
E
V
I
K
DFPILDQKVNG
K
R
L
A
Y
L
DSTATSQ
T
P
M
Q
V
L
N
V
L
E
D
Y
Y
K
R
YNS--
N
V
H
R
G
V
H
T
L
G
S
L
ATDG
Y
E
N
A
R
E
T
V
R
R
F
I
N
A
K
Y
F
E
E
I
I
FTRGT
T
A
S
I
N
L
V
A
HSYGDANVEEG-
D
E
I
V
V
T
E
M
E
HHANIV
P
W
Q
Q
L
A
K
RKNA
T
L
K
F
I
P
MT-AD-GEL
N
--
I
-
E
D
I
K
Q
T
INDK
T
K
I
V
A
I
A
H
I
S
N
V
L
G
T
I
N
D
V
K
T
I
A
E
I
A
H
Q--H----G----
A
I
I
S
VDGAQAAP
H
M
K
L
D
M
Q
E
MNADFYSFSG
H
K
ML-GPT
G
I
G
V
LF
G
K
R
E
L
L
-
Q
KM
E
P
I
EFG
G
D
-
M
I
D
F
-
V
S
KYDA-TWADLPTKFEAG
T
P
L
I
A
Q
A
I
G
L
A
E
A
I
R
Y
L
E
R
IG--------------
F
-
D
A
I
H
K
Y
E
Q
E
L
T
I
Y
A
Y
EQMSAIE
G
I
E
I
YGP-PK-D--R
R
A
G
V
I
T
F
NLQDV-HPH-DVATAVDTE-
G
V
A
V
RAG
H
H
C
A
Q
P
------
L
M
---
K
W
LN-----VS-----ST
A
R
A
S
F
Y
I
Y
N
T
K
E
D
I
D
Q
L
I
N
A
L
K
Q
T
K
E
F
FSYEF
21
PsiBlast_CBE
96.05
46%
-103
- C1 -
4W91
1
?
I:
[19-422]
-----
Y
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
--
N
V
H
---
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
-
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
-
D
N
-
G
V
F
H
--
I
-
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
--
R
----
G
----
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
-
E
K
M
R
P
F
Q
G
G
G
E
-
M
I
E
E
-
V
T
E
E
N
V
-
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
--------------
R
-
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
-----
D
--
K
G
A
-
I
I
S
F
A
L
E
G
I
-
H
A
H
-
D
V
S
M
V
I
D
R
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
------
L
L
---
K
R
F
G
-----
V
T
-----
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
G
---
24
PsiBlast_CBE
92.61
46%
-98
- C1 -
4W91
1
?
D:
[19-422]
-----
Y
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
--
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
-
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
-
D
N
-
G
V
F
H
--
I
-
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
--
R
----
G
----
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
-
E
K
M
R
P
F
Q
G
G
G
E
-
M
I
E
E
-
V
T
E
E
N
V
-
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
--------------
R
-
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
-
A
P
-
D
--
K
G
A
-
I
I
S
F
A
L
E
G
I
-
H
A
H
-
D
V
S
M
V
I
D
R
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
------
L
L
---
K
R
F
G
-----
V
T
-----
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
G
---
4
PsiBlast_PDB
92.54
49%
-93
- C1 -
4Q76
-
CNIF1_ARATH
A:
[21-426]
--------
H
R
V
R
K
D
F
R
I
L
H
Q
E
V
N
G
S
K
L
V
Y
L
D
S
A
A
T
S
Q
K
P
A
A
V
L
D
A
L
Q
N
Y
Y
E
F
Y
N
S
--
N
V
H
R
G
I
H
Y
L
S
A
K
A
T
D
E
F
E
L
A
R
K
K
V
A
R
F
I
N
A
S
D
S
R
E
I
V
F
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
L
S
N
L
K
P
G
-
D
E
V
I
L
T
V
A
E
H
H
S
C
I
V
P
W
Q
I
V
S
Q
K
T
G
A
V
L
K
F
V
T
L
N
-
E
D
-
E
V
P
D
--
I
-
N
K
L
R
E
L
I
S
P
K
T
K
L
V
A
V
H
H
V
S
N
V
L
A
S
S
L
P
I
E
E
I
V
V
W
A
H
D
--
V
----
G
----
A
K
V
L
V
D
A
C
Q
S
V
P
H
M
V
V
D
V
Q
K
L
N
A
D
F
L
V
A
S
S
H
K
M
C
-
G
P
T
G
I
G
F
L
Y
G
K
S
D
L
L
-
H
S
M
P
P
F
L
G
G
G
E
-
M
I
S
D
-
V
F
L
D
H
S
-
T
Y
A
E
P
P
S
R
F
E
A
G
T
P
A
I
G
E
A
I
A
L
G
A
A
V
D
Y
L
S
G
I
G
--------------
M
-
P
K
I
H
E
Y
E
V
E
I
G
K
Y
L
Y
E
K
L
S
S
L
P
D
V
R
I
Y
G
P
R
P
S
-
E
S
V
H
R
G
A
L
C
S
F
N
V
E
G
L
-
H
P
T
-
D
L
A
T
F
L
D
Q
Q
H
G
V
A
I
R
S
G
H
H
S
A
Q
P
------
L
H
---
R
Y
L
G
-----
V
N
-----
A
S
A
R
A
S
L
Y
F
Y
N
T
K
D
D
V
D
A
F
I
V
A
L
A
D
T
V
S
F
F
N
---
22
PsiBlast_CBE
92.49
46%
-100
- C1 -
4W91
1
?
H:
[19-422]
-----
Y
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
--
N
V
H
----
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
-
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
-
D
N
-
G
V
F
H
--
I
-
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
--
R
----
G
----
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
-
E
K
M
R
P
F
Q
G
G
G
E
-
M
I
E
E
-
V
T
E
E
N
V
-
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
--------------
R
-
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
-
A
P
-
D
--
K
G
A
-
I
I
S
F
A
L
E
G
I
-
H
A
H
-
D
V
S
M
V
I
D
R
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
------
L
L
---
K
R
F
G
-----
V
T
-----
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
G
---
23
PsiBlast_CBE
92.25
46%
-99
- C1 -
4W91
1
?
E:
[19-422]
-----
Y
D
V
E
A
I
R
R
D
F
P
I
L
S
R
Q
V
H
G
K
T
L
V
Y
L
D
N
G
A
S
A
Q
K
P
Q
S
V
I
D
A
V
T
H
A
Y
A
N
E
Y
A
--
N
V
H
R
G
L
H
F
L
S
N
A
A
T
D
A
Y
E
K
S
R
E
T
V
R
R
F
L
N
A
G
S
V
D
E
I
V
F
T
K
N
A
T
E
A
I
N
T
V
A
Y
G
Y
G
M
P
F
I
G
E
G
-
D
E
I
L
L
S
I
M
E
H
H
S
N
I
V
P
W
H
F
I
R
E
R
Q
G
A
K
L
V
F
T
P
V
D
-
D
N
-
G
V
F
H
--
I
-
E
E
F
E
K
R
L
S
E
R
T
K
L
V
A
I
T
H
M
S
N
T
L
G
T
V
V
P
I
K
K
I
V
E
L
A
H
A
--
R
----
G
----
I
P
V
L
V
D
G
S
Q
G
A
V
H
L
P
V
D
V
Q
D
L
G
C
D
W
Y
V
F
T
G
H
-
V
Y
-
G
P
S
G
I
G
V
L
Y
G
R
A
Q
M
L
-
E
K
M
R
P
F
Q
G
G
G
E
-
M
I
E
E
-
V
T
E
E
N
V
-
T
Y
N
H
P
P
H
R
F
E
A
G
T
P
P
I
V
Q
A
I
G
L
G
A
A
L
E
Y
M
E
K
I
G
--------------
R
-
H
A
I
L
A
H
E
A
D
L
R
D
Y
A
H
E
R
L
G
R
I
N
S
L
R
I
F
G
N
-
A
P
-
D
--
K
G
A
-
I
I
S
F
A
L
E
G
I
-
H
A
H
-
D
V
S
M
V
I
D
R
A
-
G
V
A
V
R
A
G
T
H
C
A
Q
P
------
L
L
---
K
R
F
G
-----
V
T
-----
S
T
C
R
A
S
F
A
L
Y
N
T
R
A
E
V
D
A
L
A
E
A
L
E
K
A
R
K
F
F
G
---
1
PsiBlast_PDB
91.91
47%
-99
- C1 -
1JF9
1
SUFS_ECOLI
A:
[5-407]
-----
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
--
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
-
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
-
P
D
-
G
T
L
Q
--
L
-
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
--
H
----
G
----
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
-
Q
E
M
P
P
W
E
G
G
G
S
-
M
I
A
T
-
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
--------------
L
-
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
P
----
Q
--
N
R
L
G
V
I
A
F
N
L
G
K
H
-
H
A
Y
-
D
V
G
S
F
L
D
N
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
------
L
M
---
A
Y
Y
N
-----
V
P
-----
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
I
H
R
L
L
----
27
PsiBlast_CBE
91.34
49%
-93
- C1 -
1T3I
4
CSD_SYNY3
B:
[13-414]
----------
V
R
Q
D
F
P
I
L
N
Q
E
I
N
G
H
P
L
V
Y
L
D
N
A
A
T
S
Q
K
P
R
A
V
L
E
K
L
M
H
Y
Y
E
N
D
N
A
--
N
V
---
A
H
Q
L
S
V
R
A
T
D
A
Y
E
A
V
R
N
K
V
A
K
F
I
N
A
R
S
P
R
E
I
V
Y
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
M
N
N
L
K
A
G
-
D
E
I
I
T
T
V
M
E
H
H
S
N
L
V
P
W
Q
M
V
A
A
K
T
G
A
V
L
K
F
V
Q
L
D
-
E
Q
-
E
S
F
D
--
L
-
E
H
F
K
T
L
L
S
E
K
T
K
L
V
T
V
V
H
I
S
N
T
L
G
C
V
N
P
A
E
E
I
A
Q
L
A
H
Q
--
A
----
G
----
A
K
V
L
V
D
A
C
Q
S
A
P
H
Y
P
L
D
V
Q
L
I
D
C
D
W
L
V
A
S
G
H
K
M
C
-
A
P
T
G
I
G
F
L
Y
G
K
E
E
I
L
-
E
A
M
P
P
F
F
G
G
G
E
-
M
I
A
E
-
V
F
F
D
H
F
-
T
T
G
E
L
P
H
K
F
E
A
G
T
P
A
I
A
E
A
I
A
L
G
A
A
V
D
Y
L
T
D
L
G
--------------
M
-
E
N
I
H
N
Y
E
V
E
L
T
H
Y
L
W
Q
G
L
G
Q
I
P
Q
L
R
L
Y
G
P
N
P
K
H
G
--
D
R
A
A
L
A
S
F
N
V
A
G
L
-
H
A
S
-
D
V
A
T
M
V
D
Q
D
-
G
I
A
I
R
S
G
H
H
C
T
Q
P
------
L
H
---
R
L
F
D
-----
A
S
-----
G
S
A
R
A
S
L
Y
F
Y
N
T
K
E
E
I
D
L
F
L
Q
S
L
Q
A
T
I
R
F
F
S
---
2
PsiBlast_PDB
87.86
47%
-97
- C1 -
1I29
2
SUFS_ECOLI
A:
[3-405]
-----
F
S
V
D
K
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
--
A
V
H
R
G
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
-
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
-
P
D
-
G
T
L
Q
--
L
-
E
T
L
P
T
L
F
D
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
--
H
----
G
----
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
-
Q
E
M
P
P
W
E
G
G
G
S
-
M
I
A
T
-
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
--------------
L
-
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
P
----
Q
--
N
R
L
G
V
I
A
F
N
L
G
K
H
-
H
A
Y
-
D
V
G
S
F
L
D
N
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
------
L
M
---
A
Y
Y
N
-----
V
P
-----
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
I
H
R
L
L
----
5
PsiBlast_PDB
87.36
47%
-95
- C1 -
1C0N
2
SUFS_ECOLI
A:
[3-405]
-----
F
S
V
D
A
V
R
A
D
F
P
V
L
S
R
E
V
N
G
L
P
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
Y
A
--
A
V
H
A
G
A
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
L
V
A
N
S
W
G
N
S
N
V
R
A
G
-
D
N
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
L
N
-
P
D
-
G
T
L
Q
--
L
-
E
T
L
P
T
L
F
D
A
A
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
H
Q
--
H
----
G
----
A
K
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
I
L
Y
V
K
E
A
L
L
-
Q
E
M
P
P
W
E
G
G
G
S
-
M
I
A
T
-
V
S
L
S
E
G
T
T
W
T
K
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
--------------
L
-
N
N
I
A
E
Y
E
Q
N
L
M
H
Y
A
L
S
Q
L
E
S
V
P
D
L
T
L
Y
G
P
----
Q
--
A
R
L
G
V
I
A
F
N
L
G
A
H
-
H
A
Y
-
D
V
G
S
F
L
D
N
Y
-
G
I
A
V
R
T
G
H
H
C
A
M
P
------
L
M
---
A
Y
Y
N
-----
V
P
-----
A
M
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
I
H
R
L
L
----
7
PsiBlast_PDB
75.83
39%
-91
- C1 -
4LW4
2
CSDA_ECOLI
A:
[25-402]
----------------------------
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--------
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
-
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
-
A
Q
-
R
L
P
D
--
V
-
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
--
A
----
G
----
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
-
E
A
M
S
P
W
L
G
G
G
K
-
M
V
H
E
-
V
S
F
D
G
F
-
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
-
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
----
R
-
C
--
Q
D
S
S
L
L
A
F
D
F
A
G
V
-
H
H
S
-
D
M
V
T
L
L
A
E
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
------
L
L
---
A
E
L
G
-----
V
T
-----
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
29
PsiBlast_CBE
74.58
39%
-89
- C1 -
4LW2
3
CSDA_ECOLI
C:
[25-402]
----------------------------
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
-
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
-
A
Q
-
R
L
P
D
--
V
-
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
--
A
----
G
----
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
-
E
A
M
S
P
W
L
G
G
G
K
-
M
V
H
E
-
V
S
F
D
G
F
-
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
-
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
----
R
-
C
--
Q
D
S
S
L
L
A
F
D
F
A
G
V
-
H
H
S
-
D
M
V
T
L
L
A
E
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
------
L
L
---
A
E
L
G
-----
V
T
-----
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
28
PsiBlast_CBE
74.47
39%
-87
- C1 -
4LW4
2
CSDA_ECOLI
B:
[25-402]
----------------------------
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
-
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
-
A
Q
-
R
L
P
D
--
V
-
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
--
A
----
G
----
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
-
E
A
M
S
P
W
L
G
G
G
K
-
M
V
H
E
-
V
S
F
D
G
F
-
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
-
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
----
R
-
C
--
Q
D
S
S
L
L
A
F
D
F
A
G
V
-
H
H
S
-
D
M
V
T
L
L
A
E
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
------
L
L
---
A
E
L
G
-----
V
T
-----
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
6
PsiBlast_PDB
74.28
39%
-88
- C1 -
4LW2
2
CSDA_ECOLI
A:
[25-402]
----------------------------
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
-
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
-
A
Q
-
R
L
P
D
--
V
-
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
--
A
----
G
----
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
-
E
A
M
S
P
W
L
G
G
G
K
-
M
V
H
E
-
V
S
F
D
G
F
-
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
-
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
----
R
-
C
--
Q
D
S
S
L
L
A
F
D
F
A
G
V
-
H
H
S
-
D
M
V
T
L
L
A
E
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
------
L
L
---
A
E
L
G
-----
V
T
-----
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
30
PsiBlast_CBE
73.94
39%
-88
- C1 -
4LW2
3
CSDA_ECOLI
B:
[25-402]
----------------------------
Y
L
D
S
A
A
T
A
L
K
P
E
A
V
V
E
A
T
Q
Q
F
Y
S
L
S
A
G
--
N
V
H
R
S
Q
F
A
E
A
Q
R
L
T
A
R
Y
E
A
A
R
E
K
V
A
Q
L
L
N
A
P
D
D
K
T
I
V
W
T
R
G
T
T
E
S
I
N
M
V
A
Q
C
Y
A
R
P
R
L
Q
P
G
-
D
E
I
I
V
S
V
A
E
H
H
A
N
L
V
P
W
L
M
V
A
Q
Q
T
G
A
K
V
V
K
L
P
L
N
-
A
Q
-
R
L
P
D
--
V
-
D
L
L
P
E
L
I
T
P
R
S
R
I
L
A
L
G
Q
M
S
N
V
T
G
G
C
P
D
L
A
R
A
I
T
F
A
H
S
--
A
----
G
----
M
V
V
M
V
D
G
A
Q
G
A
V
H
F
P
A
D
V
Q
Q
L
D
I
D
F
Y
A
F
S
G
H
K
L
Y
-
G
P
T
G
I
G
V
L
Y
G
K
S
E
L
L
-
E
A
M
S
P
W
L
G
G
G
K
-
M
V
H
E
-
V
S
F
D
G
F
-
T
T
Q
S
A
P
W
K
L
E
A
G
T
P
N
V
A
G
V
I
G
L
S
A
A
L
E
W
L
A
D
Y
D
--------------
I
-
N
Q
A
E
S
W
S
R
S
L
A
T
L
A
E
D
A
L
A
K
R
P
G
F
R
S
F
----
R
-
C
--
Q
D
S
S
L
L
A
F
D
F
A
G
V
-
H
H
S
-
D
M
V
T
L
L
A
E
Y
-
G
I
A
L
R
A
G
Q
H
C
A
Q
P
------
L
L
---
A
E
L
G
-----
V
T
-----
G
T
L
R
A
S
F
A
P
Y
N
T
K
S
D
V
D
A
L
V
N
A
V
D
R
A
L
E
L
L
----
46
HHSearch
61.12
23%
-80
- C1 -
3CAI
-
Y3778_MYCTU
A:
[3-397]
-----
Y
D
V
A
R
V
R
G
L
H
P
S
L
G
-----
D
G
W
V
H
F
D
A
P
A
G
M
L
I
P
D
S
V
A
T
T
V
S
T
A
F
R
R
S
G
A
--
S
T
V
G
-
A
H
P
S
A
R
R
S
A
A
V
L
D
A
A
R
E
A
V
A
D
L
V
N
A
D
-
P
G
G
V
V
L
G
A
D
R
A
V
L
L
S
L
L
A
E
A
S
S
S
-
R
A
G
L
G
-
Y
E
V
I
V
S
R
L
D
D
E
A
N
I
A
P
W
L
R
A
A
H
R
Y
G
A
K
V
K
W
A
E
V
D
I
E
T
-
G
E
L
P
--
T
-
W
Q
W
E
S
L
I
S
K
S
T
R
L
V
A
V
N
S
A
S
G
T
L
G
G
V
T
D
L
R
A
M
T
K
L
V
H
D
--
V
----
G
----
A
L
V
V
V
D
H
S
A
A
A
P
Y
R
L
L
D
I
R
E
T
D
A
D
V
V
T
V
N
A
H
A
W
G
-
G
P
P
-
I
G
A
M
V
F
R
D
P
S
V
M
N
S
F
G
S
V
----
S
----------
T
N
-
P
Y
A
T
G
P
A
R
L
E
I
G
V
H
Q
F
G
L
L
A
G
V
V
A
S
I
E
Y
L
A
A
L
D
ESARGS
R
R
E
R
L
A
V
S
M
-
Q
S
A
D
A
Y
L
N
R
V
F
D
Y
L
M
V
S
L
R
S
L
P
L
V
M
L
I
G
R
-
P
E
-
A
---
Q
I
P
V
V
S
F
A
V
H
K
V
-
P
A
D
-
R
V
V
Q
R
L
A
D
N
-
G
I
L
A
I
A
N
T
G
S
R
V
--------
L
---
D
V
L
G
VND--
V
G
-----
G
A
V
T
V
G
L
A
H
Y
S
T
M
A
E
V
D
Q
L
V
R
A
L
A
S
L
--------
11
PsiBlast_PDB
59.19
23%
-83
- C1 -
3LVJ
2
ISCS_ECO57
A:
[25-395]
----------------------------
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
FG
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
-
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
Y
Q
K
K
G
-
K
H
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
P
Q
-
R
N
-
G
I
I
D
--
L
-
K
E
L
E
A
A
M
R
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
--
R
----
G
----
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
-
G
P
K
G
I
G
A
L
Y
V
R
R
K
P
R
-
V
R
I
E
A
Q
M
H
G
G
G
-
H
----------------
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
--------------
A
-
T
E
M
E
R
L
-
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
E
V
Y
L
N
G
D
-
L
E
-
H
--
G
A
P
N
I
L
N
V
S
F
N
Y
V
-
E
G
E
-
S
L
I
M
A
L
--
K
-
D
L
A
V
S
S
G
------SLEPS
Y
V
L
---
R
A
L
G
-----
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
--------
31
Fugue
58.05
21%
-85
- C1 -
1ELU
4
?
A:
[10-390]
-------------
Q
F
P
G
L
------
A
N
K
T
Y
F
N
F
G
G
Q
G
I
L
P
T
V
A
L
E
A
I
T
A
M
Y
G
Y
L
Q
E
--
N
G
P
F
S
-
I
A
A
N
Q
H
I
Q
Q
L
I
A
Q
L
R
Q
A
L
A
E
T
F
N
V
D
-
P
N
T
I
T
I
T
D
N
V
T
T
G
C
D
I
V
L
W
G
L
---
D
W
H
Q
G
-
D
E
I
L
L
T
D
C
E
H
P
G
I
I
A
I
V
Q
A
I
A
A
R
F
G
I
T
Y
R
F
F
P
V
A
-
A
T
-
L
N
Q
G
D
A
A
-
A
V
L
A
N
H
L
G
P
K
T
R
L
V
I
L
S
H
L
L
W
N
T
G
Q
V
L
P
L
A
E
I
M
A
V
C
R
R
--
H
----
Q
GNYP
V
R
V
L
V
D
G
A
Q
S
A
G
S
L
P
L
D
F
S
R
L
E
V
D
Y
Y
A
F
T
G
H
K
W
F
A
G
P
A
G
V
G
G
L
Y
I
H
G
D
C
L
-
G
E
I
N
P
T
Y
V
G
W
R
S
I
T
Y
G
-
A
K
G
E
P
T
-
G
W
A
E
G
G
K
R
F
E
V
A
T
S
A
Y
P
Q
Y
A
G
L
L
A
A
L
Q
L
H
Q
R
Q
G
T-------------
A
-
E
E
R
Y
Q
A
I
C
Q
R
S
E
F
L
W
R
G
L
N
Q
L
P
H
V
H
C
L
A
T
-
S
A
-
P
--
Q
-
A
G
L
V
S
F
T
V
D
S
P
-
L
G
H
R
A
I
V
Q
K
L
E
E
Q
-
R
I
Y
L
--------------------
R
T
I
A
-----
D
P
-----
D
C
I
R
A
C
C
H
Y
I
T
D
E
E
E
I
N
H
L
L
A
R
L
A
D
F
G
P
------
44
HHSearch
57.83
22%
-90
- C1 -
1EG5
3
?
A:
[2-376]
--------------------------
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
Y
G
--
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
-
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
-
T
F
E
K
R
K
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
-
L
S
M
K
G
F
K
V
K
Y
V
P
V
D
-
S
R
-
G
V
V
K
--
L
-
E
E
L
E
K
L
V
D
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
K
----
E
----
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
-
G
P
K
G
V
G
I
T
Y
I
R
K
G
V
P
---
I
R
P
L
I
H
G
G
G
-----------------
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
-
E
--------------
L
-
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
-
G
A
H
I
I
T
P
-
L
E
-
I
--
S
L
P
N
T
L
S
V
S
F
P
N
I
-
R
G
S
-
T
L
Q
N
L
L
S
G
Y
-
G
I
Y
V
S
T
---------------H
V
L
D
A
M
G
VD
R
R
I
A
Q
-----
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
----
12
PsiBlast_PDB
56.96
23%
-84
- C1 -
3LVK
1
ISCS_ECO57
A:
[25-395]
----------------------------
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
FG
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
-
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
Y
Q
K
K
G
-
K
H
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
P
Q
-
R
N
-
G
I
I
D
--
L
-
K
E
L
E
A
A
M
R
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
--
R
----
G
----
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
-
G
P
K
G
I
G
A
L
Y
V
R
R
K
P
R
-
V
R
I
E
A
Q
M
H
G
G
G
-
H
----------------
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
--------------
A
-
T
E
M
E
R
L
-
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
E
V
Y
L
N
G
D
-
L
E
-
H
--
G
A
P
N
I
L
N
V
S
F
N
Y
V
-
E
G
E
-
S
L
I
M
A
L
--
K
-
D
L
A
V
S
S
G
S
A
C
---LEPS
Y
-
V
L
---
R
A
L
G
-----
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
--------
42
HHSearch
56.91
21%
-86
- C1 -
1ELU
4
?
A:
[10-388]
-------------
Q
F
P
G
L
A
------
N
K
T
Y
F
N
F
G
G
Q
G
I
L
P
T
V
A
L
E
A
I
T
A
M
Y
G
Y
L
Q
E
--
N
G
-
P
F
S
I
A
A
N
Q
H
I
Q
Q
L
I
A
Q
L
R
Q
A
L
A
E
T
F
N
V
D
-
P
N
T
I
T
I
T
D
N
V
T
T
G
C
D
I
V
L
W
G
L
D
---
W
H
Q
G
-
D
E
I
L
L
T
D
C
E
H
P
G
I
I
A
I
V
Q
A
I
A
A
R
F
G
I
T
Y
R
F
F
P
V
A
-
A
T
L
N
Q
G
D
--
A
A
A
V
L
A
N
H
L
G
P
K
T
R
L
V
I
L
S
H
L
L
W
N
T
G
Q
V
L
P
L
A
E
I
M
A
V
C
R
R
--
H
QGNY
P
----
V
R
V
L
V
D
G
A
Q
S
A
G
S
L
P
L
D
F
S
R
L
E
V
D
Y
Y
A
F
T
G
H
K
W
F
A
G
P
A
G
V
G
G
L
Y
I
H
G
D
C
L
-
G
E
I
N
P
T
Y
V
G
W
R
-
S
I
T
Y
G
A
K
G
E
P
T
-
G
W
A
E
G
G
K
R
F
E
V
A
T
S
A
Y
P
Q
Y
A
G
L
L
A
A
L
Q
L
H
Q
R
Q
G
--------------
T
A
E
E
R
Y
Q
A
I
C
Q
R
S
E
F
L
W
R
G
L
N
Q
L
P
H
V
H
C
L
A
T
-
S
A
----
P
Q
A
G
L
V
S
F
T
V
D
S
P
L
G
H
R
-
A
I
V
Q
K
L
E
E
Q
-
R
I
Y
L
R
T
I
A
-------------------------
D
P
-----
D
C
I
R
A
C
C
H
Y
I
T
D
E
E
E
I
N
H
L
L
A
R
L
A
D
F
--------