@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0791: (2016-03-18 )
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAEILAQSPNLKVIANMAVGYDNIDVESATANNVVVTNTPNVLTETTAELGFTLMLAIARRIVEAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKAFARRLQGFNTNILYHNRSRHKDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQIVDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQLCINNIEAVMTNQVPHTPVN
Atome Classification :
(22 SA)
.........10........20-........-.30........40........50........60.-...-....70........80........90........100.......110.......120.......130----....----...140.......150.......160.......170........180.-......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
K
I
V
VSRKI
P
D
K
F
Y
Q
Q
L
S
K--LG
D
V
V
M
W
Q
-
K
SLVPM
P
K
D
Q
F
V
T
A
L
RDA
D
A
C
F
I
T
L
S
EQI
D
A
E
I
L-AQS-PN
L
K
V
I
A
N
M
A
VGYDN
I
D
VESATAN
N
V
V
V
TNTP
N
V
L
T
E
T
T
A
E
L
G
F
T
L
M
L
A
I
A
R
R
I
V
E
A
E
K
Y
V
E
A
D
A
WQ----SWG
P
----
Y
LLSG
K
D
V
F
NSTIGIYGM
G
D
I
G
K
A
F
A
R
R
LQGFNT
N
-
I
L
YHNRSRHKDA-EADF
N
A
T
Y
V
S
F
E
T
L
LAES
D
F
I
I
C
TAPLTKETHHKF
N
A
E
A
F
E
Q
MKN
D
A
I
F
I
NIGRG
Q
I
V
D
E
T
A
L
I
DALDN
K
E
I
L
A
CG
L
D
V
LANEPIDHTHPLMGRD
N
V
L
I
TPHIGSASVTT
R
D
N
M
I
Q
L
C
I
N
N
I
E
A
V
M
TNQVPHTPVN
61
HHSearch
96.63
43%
-123
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[2-322]
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
K
-
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
----
K
R
G
V
AWHP
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
-
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
26
PsiBlast_CBE
95.61
42%
-123
- C1 -
2DBR
3
GYAR_PYRHO
B:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
22
PsiBlast_CBE
95.41
42%
-123
- C1 -
2DBR
3
GYAR_PYRHO
F:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
3
PsiBlast_PDB
95.39
41%
-123
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
K
-
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
23
PsiBlast_CBE
95.31
42%
-121
- C1 -
2DBR
3
GYAR_PYRHO
E:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
24
PsiBlast_CBE
95.02
42%
-124
- C1 -
2DBR
3
GYAR_PYRHO
D:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
1
PsiBlast_PDB
94.78
42%
-125
- C1 -
2DBR
3
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
27
PsiBlast_CBE
94.55
39%
-137
- C1 -
2WWR
1
GRHPR_HUMAN
C:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
9
PsiBlast_PDB
94.28
38%
-131
- C1 -
2CUK
-
?
A:
[1-310]
-
M
R
V
L
V
T
R
T
L
P
G
K
A
L
D
R
L
R
E
--
R
G
L
E
V
E
V
H
-
R
G
L
F
-
L
P
K
A
E
L
L
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
-
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
----
A
W
H
P
----
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
Y
H
A
R
T
------
P
K
P
L
P
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
-
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
H
P
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
-
21
PsiBlast_CBE
94.13
42%
-123
- C1 -
2DBZ
3
GYAR_PYRHO
B:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
25
PsiBlast_CBE
93.70
42%
-125
- C1 -
2DBR
4
GYAR_PYRHO
C:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
KRGV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
71
HHSearch
93.24
39%
-128
* C1 *
2CUK
-
?
A:
[1-311]
-
M
R
V
L
V
T
R
T
L
P
G
K
A
L
D
R
L
R
E
R
-
G
L
E
V
E
V
H
R
-
G
L
--
F
L
P
K
A
E
L
L
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
-
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
----
A
W
H
P
----
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
Y
H
A
R
T
P
K
P
L
P
------
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
H
P
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
V
5
PsiBlast_PDB
93.24
39%
-136
- C1 -
2WWR
1
GRHPR_HUMAN
A:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
31
PsiBlast_CBE
93.02
39%
-134
- C1 -
2GCG
3
GRHPR_HUMAN
B:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
2
PsiBlast_PDB
92.97
42%
-121
- C1 -
2DBZ
3
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
V
W
G
-
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
-
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
-
E
R
E
L
N
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
-
Y
N
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
32
PsiBlast_CBE
92.81
38%
-126
- C1 -
2CUK
1
?
C:
[1-310]
-
M
R
V
L
V
T
R
T
L
P
G
K
A
L
D
R
L
R
E
--
R
G
L
E
V
E
V
H
-
R
G
L
F
-
L
P
K
A
E
L
L
K
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
-
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
----
A
W
H
P
----
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
Y
H
A
R
T
------
P
K
P
L
P
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
-
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
H
P
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
-
28
PsiBlast_CBE
92.46
39%
-133
- C1 -
2WWR
1
GRHPR_HUMAN
B:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
4
PsiBlast_PDB
92.34
39%
-132
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
29
PsiBlast_CBE
92.19
39%
-129
- C1 -
2GCG
6
GRHPR_HUMAN
D:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
30
PsiBlast_CBE
91.54
39%
-128
- C1 -
2GCG
5
GRHPR_HUMAN
C:
[8-322]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
--
A
A
D
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
-
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
-------
58
HHSearch
89.87
37%
-122
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-329]
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
AA
D
C
E
V
E
Q
W
D
-
S
D
-
E
P
I
P
A
K
E
L
E
R
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
-
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
----
S
W
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
-
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
P
M
P
S
E
L
K
12
PsiBlast_PDB
78.67
37%
-116
- C1 -
3BAZ
1
HPPR_PLESU
A:
[78-332]
------------------------------------------------------------
D
A
E
L
I
-
D
A
L
-
P
K
L
E
I
V
S
S
F
S
V
G
L
D
K
V
D
L
I
K
C
E
E
K
G
V
R
V
T
N
T
P
D
V
L
T
D
D
V
A
D
L
A
I
G
L
I
L
A
V
L
R
R
I
C
E
C
D
K
Y
V
R
R
G
A
W
K
-----
F
G
D
----
F
K
L
T
T
K
-
F
S
G
K
R
V
G
I
I
G
L
G
R
I
G
L
A
V
A
E
R
A
E
A
F
D
C
P
-
I
S
Y
F
S
R
S
K
K
P
N
T
-
N
Y
T
Y
---
Y
G
S
V
V
E
L
A
S
N
S
D
I
L
V
V
A
C
P
L
T
P
E
T
T
H
I
I
N
R
E
V
I
D
A
L
G
P
K
G
V
L
I
N
I
G
R
G
P
H
V
D
E
P
E
L
V
S
A
L
V
E
G
R
L
G
G
A
G
L
D
V
F
E
R
E
P
-
E
V
P
E
K
L
F
G
L
E
N
V
V
L
L
P
H
V
G
S
G
T
V
E
T
R
K
V
M
A
D
L
V
V
G
N
L
E
A
H
F
S
G
K
P
L
L
T
P
V
-