@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0793: (2016-03-18 )
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNKQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERLGARLSTTDDGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING
Atome Classification :
(21 SA)
------------------------.........10........20.--.......30........40----....----.-----...-50.---...---....60........70........80........90........100......--.--..110---.----..---...---..-----120--.--------...-.-....130...-------------....140.......150.......160-.........-170....----.....180.......190.......200.......210.......220.......-230.......240.......250.---......260.--..--....270.---......280.......290.......300--.......310..----------.....320---------.----------..------------...-----------..330.......340.......350----.---..----....360.......-370........380.......390.......400.......410...-....420.......430...-..----.-..440.......450.....-..460.......470.......480...-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------
M
T
D
I
I
N
K
L
Q
A
F
ADANP
Q
S
I
A
V
R
--HT
T
D
E
L
T
Y
Q
Q
L
M
D
E
S
S
K
L
A
----
H
R
LQ----G-----SKK-
P
M
I
---
L
F
G---HM
S
P
Y
M
I
V
G
M
I
G
A
I
KAGCGYVPVDTSI
P
E
D
R
I
K
M
I
I
N
KVQ
P
E
F
V
F--NTTDE
S
--
F
--
E
SLE----G----
E
V
---
F
T
I
---
E
D-----I----K--------TSQ-D-
P
V
I
FDSQIKD-------------ND
T
V
Y
T
I
F
TSGSTGEPK
G
V
Q
I
E
Y
A
S
---
L
V
Q
F
T
E
W
M
L
-
E
--LNKS----G
N
K
Q
Q
W
L
NQAPFSF
D
L
S
V
M
A
I
Y
P
C
LASG
G
T
L
N
LV
D
K
NMIN
K
P
K
L
L
N
E
M
LTAT
P
I
N
-
I
W
VS
T
P
S
F
M
E
M
C
L
LLPTL
N
E
E
QYG---S
L
N
E
F
F
F
C
G
E
--I
L
--
P
H
R
A
A
K
A
L
---
V
S
RFPS
A
T
I
Y
NTYGPT
E
A
T
V
A
V
T
S
I
Q
I
T
Q
--
E
I
L
D
QYPTL
P
V
G
----------
V
E
R
LGAR----------L----------ST------------TDD-----------
G
E
L
V
I
EGQ
S
V
S
L
G
Y
LKNDQK
T
A
E
V
F----N---FD----DG
I
R
T
YHTGDKAKF-E-NG
Q
W
F
I
Q
G
R
I
D
F
Q
I
K
LNG
Y
R
M
E
L
E
E
I
E
T
Q
L
R
Q
S
E
F
V
K
E
A
I
V
V
P
V
Y-KND
K
V
I
H
L
I
GAIVPTT-EVT-D
N
----
A
-
E
M
T
K
N
I
K
N
D
L
K
S
R
L
P
E
Y
MIP-
R
K
F
E
W
M
E
QLPLTSNGKI
D
R
K
K
I
A
E
V
ING-------------------------------------------------------------------------------
6
PsiBlast_PDB
98.09
43%
-103
- C4 -
3FCE
1
DLTA_BACCR
A:
[3-498]
---------------------------
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
--
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
----
H
W
I
S
----
S
E
Y
PD-
D
R
S
-
P
I
M
---
V
Y
G
---
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
--
S
A
T
A
V
T
--
V
--
T
D
L
P
----
V
----
R
I
---
V
S
E
---
D
N
-----
L
----
K
D
I
F
F
T
H
KG
N
T
P
-
N
-
P
---
E
H
A
V
K
G
-------------
D
E
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
---
L
V
S
F
T
K
W
A
V
-
E
--
D
F
N
L
----
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
-
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
---
N
M
K
T
F
L
F
C
G
E
--
V
L
--
P
N
E
V
A
R
K
L
---
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
--
E
V
L
D
Q
Y
K
S
L
P
V
G
----------
Y
C
K
S
D
C
R
----------
L
L
I
M
K
EDG
T
I
A
P
D
------------
G
E
K
-----------
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
----
T
---
M
I
----
D
G
E
R
A
Y
K
T
G
D
A
G
Y
V
-
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
Y
L
L
A
V
V
V
P
G
E
-
H
S
F
-
E
K
----
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
-
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
-------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.68
45%
-101
- C4 -
3E7X
1
DLTA_BACSU
A:
[3-499]
---------------------------
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
--
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
I
Q
K
R
I
S
----
G
-----
E
K
K
S
P
I
L
---
V
Y
G
---
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
--
H
A
A
G
L
S
--
I
--
D
A
V
G
----
Q
----
Q
I
---
Q
T
V
S
A
E
E
L
-----
L
----
E
--------
N
E
G
-
G
-
S
V
S
Q
D
Q
W
V
K
E
-------------
H
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
---
L
Q
S
F
T
D
W
I
C
A
D
--
F
P
V
S
----
G
G
K
I
-
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
-
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
---
H
A
D
T
F
M
F
C
G
E
--
V
L
--
P
V
S
V
A
K
A
L
---
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
--
D
V
I
S
R
S
E
S
L
P
V
G
FAKPD
M
N
I
F
I
M
D
E
E
G
Q
P
----------
L
----------
P
E
------------
G
E
K
-----------
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
----
F
---
S
H
----
E
G
Q
W
A
Y
R
T
G
D
A
G
F
I
-
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
-
P
N
G
T
V
E
Y
L
I
A
A
I
V
P
E
E
H
E
F
E
-
K
E
----
F
-
Q
L
T
S
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
-
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
97.13
43%
-100
- C4 -
3DHV
2
DLTA_BACCR
A:
[3-498]
---------------------------
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
--
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
----
H
W
I
S
----
S
E
Y
PD-
D
R
S
-
P
I
M
---
V
Y
G
---
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
--
S
A
T
A
V
T
--
V
--
T
D
L
P
----
V
----
R
I
---
V
S
E
---
D
N
-----
L
----
K
D
I
F
F
T
H
KG
N
T
P
-
N
-
P
---
E
H
A
V
K
G
-------------
D
E
N
F
Y
I
I
Y
T
S
-----
P
K
G
V
Q
I
T
Y
N
C
---
L
V
S
F
T
K
W
A
V
-
E
--
D
F
N
L
----
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
-
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
---
N
M
K
T
F
L
F
C
G
E
--
V
L
--
P
N
E
V
A
R
K
L
---
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
--
E
V
L
D
Q
Y
K
S
L
P
V
G
----------
Y
C
K
S
D
C
R
----------
L
L
I
M
K
EDG
T
I
A
P
D
------------
G
E
K
-----------
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
----
T
---
M
I
----
D
G
E
R
A
Y
K
T
G
D
A
G
Y
V
-
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
Y
L
L
A
V
V
V
P
G
E
-
H
S
F
-
E
K
----
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
-
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
-------------------------------------------------------------------------------------
5
PsiBlast_PDB
96.92
43%
-103
- C4 -
3FCC
1
DLTA_BACCR
A:
[3-498]
---------------------------
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
--
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
----
H
W
I
S
----
S
E
Y
P
D-
D
R
S
-
P
I
M
---
V
Y
G
---
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
--
S
A
T
A
V
T
--
V
--
T
D
L
P
----
V
----
R
I
---
V
S
E
---
D
N
-----
L
----
K
D
I
F
F
T
H
KG
N
T
P
-
N
-
P
---
E
H
A
V
K
G
-------------
D
E
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
---
L
V
S
F
T
K
W
A
V
-
E
--
D
F
N
L
----
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
-
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
---
N
M
K
T
F
L
F
C
G
E
--
V
L
--
P
N
E
V
A
R
K
L
---
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
--
E
V
L
D
Q
Y
K
S
L
P
V
G
----------
Y
C
K
S
D
C
R
----------
L
L
I
M
K
EDGTIA
P
D
------------
G
E
K
-----------
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
----
T
---
M
I
----
D
G
E
R
A
Y
K
T
G
D
A
G
Y
V
-
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
Y
L
L
A
V
V
V
P
G
E
-
H
S
F
-
E
K
----
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
-
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.89
45%
-102
- C4 -
3E7W
2
DLTA_BACSU
A:
[3-499]
---------------------------
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
--
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
I
Q
K
R
I
S
----
G
-----
E
K
K
S
P
I
L
---
V
Y
G
---
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
--
H
A
A
G
L
S
--
I
--
D
A
V
G
----
Q
----
Q
I
---
Q
T
V
S
A
E
E
L
-----
L
----
E
--------
N
E
G
-
G
-
S
V
S
Q
D
Q
W
V
K
E
-------------
H
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
---
L
Q
S
F
T
D
W
I
C
A
D
--
F
P
V
S
----
G
G
K
I
-
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
-
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
---
H
A
D
T
F
M
F
C
G
E
--
V
L
--
P
V
S
V
A
K
A
L
---
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
--
D
V
I
S
R
S
E
S
L
P
V
G
FAKPD
M
N
I
F
I
M
D
E
E
G
Q
P
----------
L
----------
P
E
------------
G
E
K
-----------
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
----
F
---
S
H
----
E
G
Q
W
A
Y
R
T
G
D
A
G
F
I
-
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
-
P
N
G
T
V
E
Y
L
I
A
A
I
V
P
E
E
H
E
F
E
-
K
E
----
F
-
Q
L
T
S
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
-
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
-----------------------------------------------------------------------------------
41
HHSearch
95.91
46%
-95
- C4 -
3E7W
2
DLTA_BACSU
A:
[2-500]
--------------------------
K
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
--
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
----
A
A
I
Q
----
K
R
ISGE
K
K
S
-
P
I
L
---
V
Y
G
---
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
--
H
A
A
G
L
S
--
I
--
D
A
V
G
----
Q
QI--
Q
T
---
V
S
A
---
E
E
-----
L
----
L
--------
E
N
E
-
G
G
S
V
S
Q
D
Q
W
V
K
E
-------------
H
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
---
L
Q
S
F
T
D
W
I
C
-
A
--
D
F
P
V
----
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
-
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
---
H
A
D
T
F
M
F
C
G
E
--
V
L
--
P
V
S
V
A
K
A
L
---
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
--
D
V
I
S
R
S
E
S
L
P
V
G
----------
F
A
K
P
D
M
N
I
F
I
M
D
EEG
Q
P
L
----------
P
E
------------
G
E
K
-----------
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
----
F
---
S
H
----
E
G
Q
W
A
Y
R
T
G
D
A
G
F
I
-
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
-
P
N
G
T
V
E
Y
L
I
A
A
I
V
P
E
E
-
H
E
F
E
K
E
----
F
-
Q
L
T
S
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
-
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
----------------------------------------------------------------------------------
22
PsiBlast_CBE
94.73
38%
-97
- C4 -
3LGX
1
DLTA_STRP1
C:
[3-511]
------------------------
L
K
D
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
--
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
----
A
F
I
D
----
S
LALL-
A
K
S
-
P
V
L
---
V
F
G
---
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
E
I
A
K
P
S
L
I
I
---
A
I
E
E
F
--
P
--
L
T
I
E
----
G
ISLV
S
L
---
S
E
I
---
E
S
-----
A
----
K
--------
L
A
E
-
M
-
P
Y
E
R
T
H
S
V
K
G
-------------
D
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
---
L
L
S
F
T
N
W
M
I
-
E
DA
A
F
D
V
----
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
-
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
---
A
L
T
H
F
Y
F
D
G
E
--
E
L
--
T
V
S
T
A
R
K
L
---
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
--
E
M
V
D
N
Y
T
R
L
P
I
G
YPKPDSPTYI
I
D
E
D
G
K
E
----------
L
----------
S
S
------------
G
E
Q
-----------
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
----
F
---
T
F
----
K
G
Q
P
A
Y
H
T
G
D
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
N
K
E
H
K
V
Q
N
L
L
A
Y
I
V
V
K
D
-
G
V
K
-
E
R
FDRE
L
-
E
L
T
K
A
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
-
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
N
--------------------------------------------------------------------------------
23
PsiBlast_CBE
94.29
38%
-95
- C4 -
3LGX
1
DLTA_STRP1
B:
[3-511]
------------------------
L
K
D
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
--
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
----
A
F
I
D
----
S
L
ALL-
A
K
S
-
P
V
L
---
V
F
G
---
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
E
I
A
K
P
S
L
I
I
---
A
I
E
E
F
--
P
--
L
T
I
E
----
G
I
S
L
V
S
L
---
S
E
I
---
E
S
-----
A
----
K
--------
L
A
E
-
M
-
P
Y
E
R
T
H
S
V
K
G
-------------
D
D
N
Y
Y
I
I
F
T
S
---
G
Q
P
K
G
V
Q
I
S
H
D
N
---
L
L
S
F
T
N
W
M
I
-
E
DA
A
F
D
V
----
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
-
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
---
A
L
T
H
F
Y
F
D
G
E
--
E
L
--
T
V
S
T
A
R
K
L
---
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
--
E
M
V
D
N
Y
T
R
L
P
I
G
YPKPD
S
P
T
Y
I
I
D
E
D
G
K
E
----------
L
----------
S
S
------------
G
E
Q
-----------
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
----
F
---
T
F
----
K
G
Q
P
A
Y
H
T
G
D
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
N
K
E
H
K
V
Q
N
L
L
A
Y
I
V
V
K
D
-
G
V
K
-
E
R
F
DR
E
L
-
E
L
T
K
A
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
-
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
N
--------------------------------------------------------------------------------
4
PsiBlast_PDB
93.58
43%
-108
- C4 -
4PZP
-
DLTA_BACCR
A:
[3-498]
---------------------------
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
--
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
----
H
W
I
S
----
S
E
Y
P
D-
D
R
S
-
P
I
M
---
V
Y
G
---
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
--
S
A
T
A
V
T
--
V
--
T
D
L
P
----
V
----
R
I
---
V
S
E
---
D
N
-----
L
----
K
D
I
F
F
T
H
KG
N
T
P
-
N
-
P
---
E
H
A
V
K
G
-------------
D
E
N
F
Y
I
I
Y
T
-------
K
G
V
Q
I
T
Y
N
C
---
L
V
S
F
T
K
W
A
V
-
E
--
D
F
N
L
----
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
-
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
---
N
M
K
T
F
L
F
C
G
E
--
V
L
--
P
N
E
V
A
R
K
L
---
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
--
E
V
L
D
Q
Y
K
S
L
P
V
G
----------
Y
C
K
S
D
C
R
----------
L
L
I
M
K
EDGTIA
P
D
------------
G
E
K
-----------
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
-----
K
A
F
----
T
---
M
I
----
D
G
E
R
A
Y
K
T
G
D
A
G
Y
V
-
E
-
N
G
L
L
F
Y
N
G
-----------------
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
---------
L
L
A
V
V
V
P
G
E
-
H
S
F
-
E
K
----
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
-
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
-------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.50
38%
-97
- C4 -
3LGX
1
DLTA_STRP1
D:
[3-511]
------------------------
L
K
D
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
--
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
----
A
F
I
D
----
S
LALL-
A
K
S
-
P
V
L
---
V
F
G
---
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
E
I
A
K
P
S
L
I
I
---
A
I
E
E
F
--
P
--
L
T
I
E
----
G
ISLV
S
L
---
S
E
I
---
E
S
-----
A
----
K
--------
L
A
E
-
M
-
P
Y
E
R
T
H
S
V
K
G
-------------
D
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
---
L
L
S
F
T
N
W
M
I
-
E
DA
A
F
D
V
----
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
-
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
---
A
L
T
H
F
Y
F
D
G
E
--
E
L
--
T
V
S
T
A
R
K
L
---
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
--
E
M
V
D
N
Y
T
R
L
P
I
G
YPKPDSPTYI
I
D
E
D
G
K
E
----------
L
----------
S
S
------------
G
E
Q
-----------
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
----
F
---
T
F
----
K
G
Q
P
A
Y
H
T
G
D
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
N
K
E
H
K
V
Q
N
L
L
A
Y
I
V
V
K
D
-
G
V
K
-
E
R
FDRE
L
-
E
L
T
K
A
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
-
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
N
--------------------------------------------------------------------------------
8
PsiBlast_PDB
92.07
38%
-93
- C4 -
3LGX
1
DLTA_STRP1
A:
[3-511]
------------------------
L
K
D
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
--
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
----
A
F
I
D
----
S
L
ALL-
A
K
S
-
P
V
L
---
V
F
G
---
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
E
I
A
K
P
S
L
I
I
---
A
I
E
E
F
--
P
--
L
T
I
E
----
G
I
S
L
V
S
L
---
S
E
I
---
E
S
-----
A
----
K
--------
L
A
E
-
M
-
P
Y
E
R
T
H
S
V
K
G
-------------
D
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
---
L
L
S
F
T
N
W
M
I
-
E
DA
A
F
D
V
----
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
-
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
---
A
L
T
H
F
Y
F
D
G
E
--
E
L
--
T
V
S
T
A
R
K
L
---
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
--
E
M
V
D
N
Y
T
R
L
P
I
G
YPKPD
S
P
T
Y
I
I
D
E
D
G
K
E
----------
L
----------
S
S
------------
G
E
Q
-----------
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
----
F
---
T
F
----
K
G
Q
P
A
Y
H
T
G
D
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
N
K
E
H
K
V
Q
N
L
L
A
Y
I
V
V
K
D
-
G
V
K
-
E
R
F
DR
E
L
-
E
L
T
K
A
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
-
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
N
--------------------------------------------------------------------------------
14
PsiBlast_PDB
83.99
30%
-88
- C4 -
4D57
5
?
A:
[40-516]
-----------------------------------
V
E
R
T
P
E
A
V
A
V
L
--
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
----
H
Y
L
R
----
T
L
----
G
V
K
-
S
E
T
---
L
V
G
V
CV
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
--
T
Q
T
Q
W
S
NL
I
--
S
D
Y
Q
----
G
----
Q
V
---
I
C
L
---
D
S
Q
W
A
K
I
A
----
S
--------
Y
S
Q
-
E
-
N
L
V
--
N
T
V
N
P
-------------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
---
L
V
N
F
T
K
L
A
I
-
A
--
Q
Y
Q
I
----
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
-
V
W
S
L
P
T
A
Y
W
H
--
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
--
R
V
--
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
--
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
S
Q
LT
E
S
Q
R
N
R
T
E
I
P
I
G
-----------
K
S
L
G
E
N
----------
I
----------
S
V
Y
VLDETL
K
T
V
P
P
E
T
P
-----------
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQD-
P
---
F
S
----
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
-
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
--------
R
L
V
A
Y
L
V
P
H
----
S
-
T
E
----
E
-
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
-
A
T
F
V
V
L
-----------------------------------------------------------------------------------------------------
43
HHSearch
83.69
28%
-88
- C4 -
2VSQ
2
A:
[466-975]
---------------------------
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
--
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
----
R
R
L
Q
----
K
H
GAG-
K
G
S
-
V
V
A
---
L
Y
T
---
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
--
T
H
Q
E
M
K
--
E
QA
A
E
L
P
----
Y
T
G
--
T
T
---
L
F
I
---
D
D
-----
Q
----
T
--------
R
F
E
E
Q
-
A
S
D
P
A
T
A
I
D
P
-------------
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
---
I
Q
G
L
V
K
H
V
--
D
--
Y
M
A
F
----
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
-
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
G
---
E
D
W
M
K
---
G
L
R
C
I
L
F
G
G
E
--
R
A
--
S
V
P
H
V
R
K
A
---
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
---
L
P
D
S
I
S
S
L
P
I
G
----------
K
P
I
S
N
A
S
----------
V
Y
ILNEQSQLQ
P
F
------------
G
A
V
-----------
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
----
I
---
E
N
PFK-
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
-
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
-
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
-
Q
-----------
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
-
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
---------------------------------------------------------------------------------
57
HHSearch
83.39
27%
-85
- C4 -
1AMU
4
GRSA_ANEMI
A:
[40-526]
--------------------------
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
--
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
----
R
I
F
I
----
E
K
GIG-
K
D
T
-
L
V
G
---
I
M
M
---
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
--
T
Q
K
H
L
V
--
H
L
I
H
N
I
Q
----
F
N---
G
Q
V
E
I
F
E
E
---
D
T
-----
I
----
K
--------
I
-
R
-
E
-
G
T
N
L
H
V
P
S
K
S
-------------
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
---
I
S
N
L
K
V
F
F
E
-
N
--
S
L
N
V
----
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
-
V
I
T
L
P
P
T
Y
V
V
H
L
D
------
P
E
R
I
L
---
S
I
Q
T
L
I
T
A
G
S
--
A
T
--
S
P
S
L
V
N
K
W
---
K
E
K
---
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
T
K
--
E
--
T
I
G
H
S
V
P
I
G
----------
A
P
I
Q
N
T
Q
----------
I
Y
I
V
D
ENLQLK
S
V
------------
G
E
A
-----------
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
----
V
---
D
N
PFV-
P
G
E
K
L
Y
K
T
G
D
Q
A
R
W
-
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
-
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
S
E
K
-
H
-----------
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
-
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
----------------------------------------------------------------------------------
10
PsiBlast_PDB
83.32
30%
-86
- C4 -
4D4G
4
?
A:
[40-514]
-----------------------------------
V
E
R
T
P
E
A
V
A
V
L
--
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
----
H
Y
L
R
----
T
L
----
G
V
K
-
S
E
T
---
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
--
T
Q
T
Q
W
S
NL
I
--
S
D
Y
Q
----
G
----
Q
V
---
I
C
L
---
D
S
Q
W
A
K
I
A
----
S
--------
Y
S
Q
-
E
-
N
L
V
--
N
T
V
N
P
-------------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
---
L
V
N
F
T
K
L
A
I
-
A
--
Q
Y
Q
I
----
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
-
V
W
S
L
P
T
A
Y
W
H
--
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
--
R
V
--
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
--
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
S
Q
LT
E
S
Q
R
N
R
T
E
I
P
I
G
-----------
K
S
L
G
E
N
----------
I
----------
S
V
Y
VLDETLKTVPP
E
T
P
-----------
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQD-
P
---
F
S
----
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
-
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
--------
R
L
V
A
Y
L
V
P
H
----
S
-
T
E
----
E
-
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
-
A
T
F
V
-------------------------------------------------------------------------------------------------------
60
Fugue
83.22
27%
-99
- C4 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
GTH
E
E
E
Q
Y
L
F
A
V
N
NT
K
A
E
Y
PRDKT
I
H
Q
L
F
E
E
Q
V
S
K
R
---
P
N
N
V
A
I
V
CE--
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
----
R
I
F
I
----
E
K
GIG-
K
D
T
-
L
V
G
---
I
M
M
---
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
--
I
--
H
N
I
------QFN
G
Q
V
---
E
I
F
---
E
E
-----
D
-------------------------
T
I
K
I
REGTNLHVPSKST-
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
---
I
S
N
L
K
V
F
F
E
-
N
S-
L
N
-
V
----
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
-
V
I
T
L
P
P
T
Y
V
V
H
L
----
D
P
E
R
I
--
L
---
S
I
Q
T
L
I
T
A
G
S
--
A
T
--
S
P
S
L
V
N
K
W
---
K
E
K
V
---
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
T
K
--
E
--
T
I
G
H
S
V
P
I
G
----------
A
P
I
Q
N
T
Q
----------
I
----------
Y
I
------------
V
D
E
NLQLKSVGEA-
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
----
V
DNP
F
V
----
P
G
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
-
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
-
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
S
E
---
K
H
-
I
P
--------
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S-
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F------------------------------------------------------------------------------
61
Fugue
82.11
23%
-81
- C4 -
4DG9
1
?
A:
[18-604]
----------------NSLLDLYA
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
--
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
----
D
Y
L
L
----
E
H
Y
PQ-
P
G
V
-
C
L
G
---
V
Y
G
---
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
--
D
C
S
T
T
P
--
T
--
P
A
N
G
----
L
----
P
C
---
V
P
V
---
R
H
-----
L
----
P
--------
A
A
P
-
A
-
S
V
A
-
R
P
C
F
A
A
-------------
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
---
I
T
R
L
C
L
G
Q
S
-
F
--
L
A
-
F
----
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
L
D
-
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
-
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
---
D
P
D
C
L
G
---
G
L
R
Q
L
L
T
G
G
D
--
I
L
--
S
V
P
H
V
R
R
A
---
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
--
D
D
L
E
E
-
D
D
I
P
I
G
----------
K
A
I
A
G
T
A
----------
V
----------
L
L
------------
L
D
E
HGQEIAEPD
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
----
V
---
E
L
P
Y
RG
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
-
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
-
R
N
G
V
K
Q
L
L
C
A
W
T
G
K
A
D
-
A
----------------
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
-
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
E
L
DP
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
ADFFLCGGN
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
GAGANLGLADLQANSR
L
D
Q
F
S
R
L
L
R
S
H
GLAPERLLE
13
PsiBlast_PDB
81.86
30%
-88
- C4 -
4D56
5
?
A:
[40-516]
-----------------------------------
V
E
R
T
P
E
A
V
A
V
L
--
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
----
H
Y
L
R
----
T
L
----
G
V
K
-
S
E
T
---
L
V
G
V
CV
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
--
T
Q
T
Q
W
S
NL
I
--
S
D
Y
Q
----
G
----
Q
V
---
I
C
L
---
D
S
Q
W
A
K
I
A
----
S
--------
Y
S
Q
-
E
-
N
L
V
--
N
T
V
N
P
-------------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
---
L
V
N
F
T
K
L
A
I
-
A
--
Q
Y
Q
I
----
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
-
V
W
S
L
P
T
A
Y
W
H
--
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
--
R
V
--
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
--
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
S
Q
LT
E
S
Q
R
N
R
T
E
I
P
I
G
-----------
K
S
L
G
E
N
----------
I
----------
S
V
Y
VLDETL
K
T
V
P
P
E
T
P
-----------
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQD-
P
---
F
S
----
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
-
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
--------
R
L
V
A
Y
L
V
P
H
----
S
-
T
E
----
E
-
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
-
A
T
F
V
V
L
-----------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.74
29%
-73
- C4 -
2VSQ
2
A:
[475-969]
------------------------------------
N
A
N
P
D
A
P
A
L
T
--
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
----
R
R
L
Q
K
H
GA
G
-----
K
G
S
-
V
V
A
---
L
Y
T
---
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
--
T
H
Q
E
M
K
--
E
--
Q
A
A
E
LPYT
G
----
T
T
---
L
F
I
---
D
D
-----
Q
TRFE
E
--------
Q
A
S
-
D
-
P
A
---
T
A
I
D
P
-------------
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
D
Y
M
-------
A
F
----
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
-
V
M
F
A
T
T
A
L
F
N
---
L
L
T
D
A
G
E
D
W
M
K
---
G
L
R
C
I
L
F
G
G
E
RA
S
V
--
P
H
-
V
R
K
A
L
---
R
I
M
G
P
G
K
L
I
-
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
-
H
V
V
H
--
D
L
P
D
S
I
S
S
L
P
I
G
----------
K
P
I
S
N
A
S
----------
V
----------
Y
I
------------
L
N
E
QSQLQPFGAV-
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
IEN-
P
---
F
K
----
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
-
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
-
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
-
Q
L
S
-----------
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
-
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
---------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.50
23%
-86
- C4 -
4DG9
1
?
A:
[29-519]
---------------------------
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
--
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
---
Y
L
L
E
----
H
-----
Y
P
Q
-
P
G
V
C
L
G
V
Y
G
---
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
--
D
C
S
T
T
P
--
T
--
P
A
N
G
----
L
----
P
C
---
V
P
V
---
R
H
-----
L
----
P
--------
A
A
P
-
A
-
S
V
A
R
P
C
F
A
A
D
-------------
Q
-
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
---
I
T
R
L
C
--------
L
G
Q
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
L
D
-
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
----
L
V
D
L
D
P
D
C
L
G
---
G
L
R
Q
L
L
T
G
G
D
--
I
L
S
V
P
H
-
V
R
R
A
L
---
L
-
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
--
D
D
L
E
E
-
D
D
I
P
I
G
----------
K
A
I
A
G
T
A
----------
V
----------
L
L
------------
L
D
E
HGQEIAEPD
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
---
R
G
----
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
-
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
-
V
R
-
E
R
N
G
V
K
Q
L
L
C
A
W
T
G
K
A
-
D
A
S
-
P
Q
----
A
----------
L
L
R
Q
L
P
T
W
Q
R
P
-
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.48
30%
-88
- C4 -
4D4I
4
?
A:
[40-515]
-----------------------------------
V
E
R
T
P
E
A
V
A
V
L
--
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
----
H
Y
L
R
----
T
L
----
G
V
K
-
S
E
T
---
L
V
G
V
CV
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
--
T
Q
T
Q
W
S
NL
I
--
S
D
Y
Q
----
G
----
Q
V
---
I
C
L
---
D
S
Q
W
A
K
I
A
----
S
--------
Y
S
Q
-
E
-
N
L
V
--
N
T
V
N
P
-------------
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
---
L
V
N
F
T
K
L
A
I
-
A
--
Q
Y
Q
I
----
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
-
V
W
S
L
P
T
A
Y
W
H
--
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
--
R
V
--
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
--
L
I
N
V
Y
G
P
T
E
G
T
I
A
V
S
L
C
R
L
S
Q
LT
E
S
Q
R
N
R
T
E
I
P
I
G
-----------
K
S
L
G
E
N
----------
I
----------
S
V
Y
VLDETL
K
T
V
P
P
E
T
P
-----------
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQD-
P
---
F
S
----
P
S
E
R
L
Y
K
T
G
D
L
G
R
Y
L
A
-
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
--------
R
L
V
A
Y
L
V
P
H
----
S
-
T
E
----
E
-
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
-
A
T
F
V
V
------------------------------------------------------------------------------------------------------