@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0823: (2016-03-19 )
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEDNIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
Atome Classification :
(20 SA)
----------------------------------------------.........10----------........20..-----.-----...---..30..-----....--.---.40........50-...--------------.------------------..-...60........70--------...---------......80........90........100..-------------------.....-------..110.......120.......130.......140.......150.......160---..--.-.-....170.......180.......190-.........200.......210.....--..-220........230.......240........250.....-..260.......270.......280.......290------.----------.-----.......300.......310.......320.......330-----..------....---.-.---340--------........350.......---------360------.--------...---------....--.--370.......380.......390.......400.......410.......420.......430.......440.--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------M
T
H
I
Q
L
D
F
S
K
T
----------
L
E
F
F
G
E
H
E
L
K
Q
Q
-----
Q
-----
E
I
V
---
K
S
I
H
K
T
-----
I
HEG--T---GAGSD
F
L
G
W
VDL--PVD--------------Y------------------
D
K
-
E
E
F
S
R
I
V
E
A
S
K
R
IK---------ENS---------
D
V
L
V
V
I
GIGG
S
Y
L
G
A
R
A
A
I
E
M
L
T
S
SFR--NS-------------------NEY
P
E
-------
I
V
F
VGNHL
S
S
T
Y
T
K
E
L
V
D
Y
L
ADKD
F
S
V
N
V
I
SKSGTTTE
P
A
V
A
F
R
L
F
K
Q
L
V
E
E
RY----
G
K
--
E
-
E
-
A
Q
K
R
I
F
ATTDKEK
G
A
L
K
Q
L
ATNEG
Y
---
E
T
F
I
V
PDDVGG
R
Y
S
V
L
T
AVGL
L
P
IATA--G
I
-
N
-
I
E
A
M
M
IG
A
A
K
A
R
E
E
L
S
S
D
KL-EDN
I
A
Y
Q
Y
A
T
I
R
N
I
L
YA-KGY
T
T
E
M
L
I
NYEP
S
M
Q
Y
F
N
E
W
W
K
Q
L
FGESEGKD--------F----------K-----GIYPSSANY
T
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
F
L
F
E
T
V
V
KVNHP
K
Y
------
D
I
------
T
I
EK---D-S---DD---------LD
G
L
N
Y
L
AGK
T
I
D
EVNTK---------A--------F--------
E
G
T
---------
L
L
A
H--T--DGGVP
N
M
V
V
NIPQLDEETF
G
Y
V
V
Y
F
F
E
L
A
C
A
MS
G
Y
Q
LGVNPFNQP
G
V
E
A
Y
K
Q
N
M
F
A
L
LGKP
G
F
E
D
L
K
K
E
L
E
ERL--------------
29
HHSearch
99.19
99%
-97
- C4 -
3FF1
3
G6PI_STAAC
A:
[5-446]
-----------------------------------------------
T
H
I
Q
L
D
F
S
K
T
----------
L
E
F
F
G
E
H
E
L
K
Q
Q
-----
Q
-----
E
I
V
---
K
S
I
H
K
T
-----
I
H
E
G
--
T
---
G
A
G
S
D
F
L
G
W
V
D
L
--
P
V
D
--------------
Y
------------------
D
K
-
E
E
F
S
R
I
V
E
A
S
K
R
I
K
---------
E
N
S
---------
D
V
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
T
S
S
F
R
--
N
S
-------------------
N
E
Y
P
E
-------
I
V
F
V
G
N
H
L
S
S
T
Y
T
K
E
L
V
D
Y
L
A
D
K
D
F
S
V
N
V
I
S
K
S
G
T
T
T
E
P
A
V
A
F
R
L
F
K
Q
L
V
E
E
R
Y
----
G
K
--
E
-
E
-
A
Q
K
R
I
F
A
T
T
D
K
E
K
G
A
L
K
Q
L
A
T
N
E
G
Y
---
E
T
F
I
V
P
D
D
V
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
T
A
--
G
I
-
N
-
I
E
A
M
M
I
G
A
A
K
A
R
E
E
L
-
S
S
D
K
L
E
E
N
I
A
Y
Q
Y
A
T
I
R
N
I
L
Y
A
-
K
G
Y
T
T
E
M
L
I
N
Y
E
P
S
M
Q
Y
F
N
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
F
----------
K
-----
G
I
Y
P
S
S
A
N
Y
T
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
F
L
F
E
T
V
V
K
V
N
H
P
K
Y
------
D
I
------
T
I
E
K
---
D
-
S
---
D
D
---------
L
D
G
L
N
Y
L
A
G
K
T
I
D
E
V
N
T
K
---------
A
--------
F
--------
E
G
T
---------
L
L
A
H
--
T
--
D
G
G
V
P
N
M
V
V
N
I
P
Q
L
D
E
E
T
F
G
Y
V
V
Y
F
F
E
L
A
C
A
M
S
G
Y
Q
L
G
V
N
P
F
N
Q
P
G
V
E
A
Y
K
Q
N
M
F
A
L
L
G
K
P
G
F
E
D
L
K
K
E
L
E
E
R
L
--------------
1
PsiBlast_PDB
99.12
97%
-98
- C4 -
3FF1
3
G6PI_STAAC
A:
[5-446]
-----------------------------------------------
T
H
I
Q
L
D
F
S
K
T
----------
L
E
F
F
G
E
H
E
L
K
Q
Q
-----
Q
-----
E
I
V
---
K
S
I
H
K
T
-----
I
H
E
G
--
T
---
G
A
G
S
D
F
L
G
W
V
D
L
--
P
V
D
--------------
Y
------------------
D
K
-
E
E
F
S
R
I
V
E
A
S
K
R
I
K
---------
E
N
S
---------
D
V
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
T
S
S
F
R
--
N
S
-------------------
N
E
Y
P
E
-------
I
V
F
V
G
N
H
L
S
S
T
Y
T
K
E
L
V
D
Y
L
A
D
K
D
F
S
V
N
V
I
S
K
S
G
T
T
T
E
P
A
V
A
F
R
L
F
K
Q
L
V
E
E
R
Y
----
G
K
--
E
-
E
-
A
Q
K
R
I
F
A
T
T
D
K
E
K
G
A
L
K
Q
L
A
T
N
E
G
Y
---
E
T
F
I
V
P
D
D
V
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
T
A
--
G
I
-
N
-
I
E
A
M
M
I
G
A
A
K
A
R
E
E
L
S
S
D
K
L
-
E
E
N
I
A
Y
Q
Y
A
T
I
R
N
I
L
Y
A
-
K
G
Y
T
T
E
M
L
I
N
Y
E
P
S
M
Q
Y
F
N
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
F
----------
K
-----
G
I
Y
P
S
S
A
N
Y
T
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
F
L
F
E
T
V
V
K
V
N
H
P
K
Y
------
D
I
------
T
I
E
K
---
D
-
S
---
D
D
---------
L
D
G
L
N
Y
L
A
G
K
T
I
D
E
V
N
T
K
---------
A
--------
F
--------
E
G
T
---------
L
L
A
H
--
T
--
D
G
G
V
P
N
M
V
V
N
I
P
Q
L
D
E
E
T
F
G
Y
V
V
Y
F
F
E
L
A
C
A
M
S
G
Y
Q
L
G
V
N
P
F
N
Q
P
G
V
E
A
Y
K
Q
N
M
F
A
L
L
G
K
P
G
F
E
D
L
K
K
E
L
E
E
R
L
--------------
2
PsiBlast_PDB
91.29
68%
-94
- C4 -
3IFS
1
G6PI_BACAN
A:
[6-452]
-----------------------------------------------
T
H
V
T
F
D
Y
S
K
A
----------
L
S
F
I
G
E
H
E
I
T
Y
L
-----
R
-----
D
A
V
---
K
V
T
H
H
A
-----
I
H
E
K
--
T
---
G
A
G
N
D
F
L
G
W
V
D
L
--
P
L
Q
--------------
Y
------------------
D
K
-
E
E
F
A
R
I
Q
K
C
A
E
K
I
K
---------
N
D
S
---------
D
I
L
L
V
V
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
M
L
N
H
S
F
Y
--
N
T
LSKEQ--------------
R
K
T
P
Q
-------
V
L
F
V
G
Q
N
I
S
S
T
Y
M
K
D
L
M
D
V
L
E
G
K
D
F
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
L
A
F
R
I
F
R
K
L
L
E
E
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
A
T
T
D
K
A
R
G
A
L
K
T
L
A
D
N
E
G
Y
---
E
T
F
V
I
P
D
D
V
G
G
R
F
S
V
L
T
P
V
G
L
L
P
I
A
V
S
--
G
L
-
N
-
I
E
E
M
M
K
G
A
A
A
G
R
D
D
F
G
T
S
E
L
-
E
E
N
P
A
Y
Q
Y
A
V
V
R
N
A
L
Y
N
-
K
G
K
T
I
E
M
L
I
N
Y
E
P
A
L
Q
Y
F
A
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
I
F
P
S
S
A
N
F
S
T
D
L
H
S
L
G
Q
Y
V
Q
E
G
R
R
D
L
F
E
T
V
L
K
V
G
K
S
T
H
------
E
L
------
T
I
E
S
---
E
-
E
---
N
D
---------
L
D
G
L
N
Y
L
A
G
E
T
V
D
F
V
N
T
K
---------
A
--------
Y
--------
E
G
T
---------
L
L
A
H
--
S
--
D
G
G
V
P
N
L
I
V
N
I
P
E
L
N
E
Y
T
F
G
Y
L
V
Y
F
F
E
K
A
C
A
M
S
G
Y
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
E
L
K
A
E
L
E
E
R
L
--------------
6
PsiBlast_PDB
89.02
63%
-91
- C4 -
2PGI
-
G6PIB_GEOSE
A:
[3-443]
-------------------------------------------------
I
S
F
D
Y
S
N
A
----------
L
P
F
M
Q
E
N
E
L
D
Y
L
-----
S
-----
E
F
V
---
K
A
A
H
H
M
-----
L
H
E
R
--
K
---
G
P
G
S
D
F
L
G
W
V
D
W
--
P
I
R
--------------
Y
------------------
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
H
S
---------
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
--
N
Q
M------------------
N
D
T
T
Q
-------
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
---
E
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
V
A
--
G
L
-
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
-
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
I
E
T
V
L
H
V
K
K
P
Q
I
------
E
L
------
T
I
Q
E
---
D
-
P
---
E
N
---------
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
---------
A
--------
F
--------
Q
G
T
---------
L
L
A
H
--
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
--------------
3
PsiBlast_PDB
89.02
63%
-91
- C4 -
1B0Z
-
G6PIB_GEOSE
A:
[3-443]
-------------------------------------------------
I
S
F
D
Y
S
N
A
----------
L
P
F
M
Q
E
N
E
L
D
Y
L
-----
S
-----
E
F
V
---
K
A
A
H
H
M
-----
L
H
E
R
--
K
---
G
P
G
S
D
F
L
G
W
V
D
W
--
P
I
R
--------------
Y
------------------
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
H
S
---------
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
--
N
Q
M------------------
N
D
T
T
Q
-------
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
---
E
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
V
A
--
G
L
-
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
-
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
I
E
T
V
L
H
V
K
K
P
Q
I
------
E
L
------
T
I
Q
E
---
D
-
P
---
E
N
---------
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
---------
A
--------
F
--------
Q
G
T
---------
L
L
A
H
--
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
--------------
4
PsiBlast_PDB
88.94
63%
-91
- C4 -
1C7Q
1
G6PIB_GEOSE
A:
[3-443]
-------------------------------------------------
I
S
F
D
Y
S
N
A
----------
L
P
F
M
Q
E
N
E
L
D
Y
L
-----
S
-----
E
F
V
---
K
A
A
H
H
M
-----
L
H
E
R
--
K
---
G
P
G
S
D
F
L
G
W
V
D
W
--
P
I
R
--------------
Y
------------------
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
H
S
---------
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
--
N
Q
M------------------
N
D
T
T
Q
-------
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
---
E
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
V
A
--
G
L
-
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
-
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
I
E
T
V
L
H
V
K
K
P
Q
I
------
E
L
------
T
I
Q
E
---
D
-
P
---
E
N
---------
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
---------
A
--------
F
--------
Q
G
T
---------
L
L
A
H
--
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
--------------
5
PsiBlast_PDB
88.01
63%
-96
- C4 -
1C7R
1
G6PIB_GEOSE
A:
[3-443]
-------------------------------------------------
I
S
F
D
Y
S
N
A
----------
L
P
F
M
Q
E
N
E
L
D
Y
L
-----
S
-----
E
F
V
---
K
A
A
H
H
M
-----
L
H
E
R
--
K
---
G
P
G
S
D
F
L
G
W
V
D
W
--
P
I
R
--------------
Y
------------------
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
H
S
---------
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
------------------------------
T
Q
-------
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
---
E
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
V
A
--
G
L
-
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
N
N
P
D
L
-
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
I
E
T
V
L
H
V
K
K
P
Q
I
------
E
L
------
T
I
Q
E
---
D
-
P
---
E
N
---------
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
---------
A
--------
F
--------
Q
G
T
---------
L
L
A
H
--
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
R
L
--------------
28
HHSearch
87.43
63%
-89
- C4 -
1B0Z
-
G6PIB_GEOSE
A:
[2-441]
------------------------------------------------
A
I
S
F
D
Y
S
N
A
----------
L
P
F
M
Q
E
N
E
L
D
Y
L
-----
S
-----
E
F
V
---
K
A
A
H
H
M
-----
L
H
E
R
--
K
---
G
P
G
S
D
F
L
G
W
V
D
W
--
P
I
R
--------------
Y
------------------
D
K
-
N
E
F
S
R
I
K
Q
A
A
E
R
I
R
---------
N
H
S
---------
D
A
L
V
V
I
G
I
G
G
S
Y
L
G
A
R
A
A
I
E
A
L
S
H
T
F
H
--
N
Q
M------------------
N
D
T
T
Q
-------
I
Y
F
A
G
Q
N
I
S
S
T
Y
I
S
H
L
L
D
V
L
E
G
K
D
L
S
I
N
V
I
S
K
S
G
T
T
T
E
P
A
I
A
F
R
I
F
R
D
Y
M
E
K
K
Y
----
G
K
--
E
-
E
-
A
R
K
R
I
Y
V
T
T
D
R
T
K
G
A
L
K
K
L
A
D
Q
E
G
Y
---
E
T
F
V
I
P
D
N
I
G
G
R
Y
S
V
L
T
A
V
G
L
L
P
I
A
V
A
--
G
L
-
N
-
I
D
R
M
M
E
G
A
A
S
A
Y
H
K
Y
-
N
N
P
D
L
L
T
N
E
S
Y
Q
Y
A
A
V
R
N
I
L
Y
R
-
K
G
K
A
I
E
L
L
V
N
Y
E
P
S
L
H
Y
V
S
E
W
W
K
Q
L
F
G
E
S
E
G
K
D
--------
Q
----------
K
-----
G
L
F
P
A
S
V
D
F
T
T
D
L
H
S
M
G
Q
Y
V
Q
E
G
R
R
N
L
I
E
T
V
L
H
V
K
K
P
Q
I
------
E
L
------
T
I
Q
E
---
D
-
P
---
E
N
---------
I
D
G
L
N
F
L
A
G
K
T
L
D
E
V
N
K
K
---------
A
--------
F
--------
Q
G
T
---------
L
L
A
H
--
V
--
D
G
G
V
P
N
L
I
V
E
L
D
E
M
N
E
Y
T
F
G
E
M
V
Y
F
F
E
K
A
C
G
I
S
G
H
L
L
G
V
N
P
F
D
Q
P
G
V
E
A
Y
K
K
N
M
F
A
L
L
G
K
P
G
F
E
D
E
K
A
A
L
M
K
----------------
27
HHSearch
73.80
33%
-78
- C4 -
2Q8N
6
G6PI_THEMA
A:
[14-456]
------------------------------------------------
S
L
K
F
D
F
S
N
L
FEPNI-----
S
G
G
L
T
D
E
D
V
K
S
V
-----
E
-----
E
K
V
---
T
S
A
V
R
N
-----
F
V
E
-----------
N
T
P
D
F
A
K
L
--
D
R
S
-------------------------------------
W
I
D
S
V
K
S
L
E
D
W
I
I
----------
N
F
---------
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
L
H
Y
S
L
R
P
L
N
W
--
N
E
MTREER-------------
N
G
Y
A
R
-------
V
F
V
V
-
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
E
A
-
Y
----
G
L
----
D
-
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
---
R
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
L
S
A
M
A
E
--
G
I
-
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
-
M
K
E
N
I
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
R
--------
Y
NLKGEEVF--
T
-----
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
V
I
T
F
L
R
V
E
N
F
D
R
------
E
I
------
V
I
P
E
---
T
-
G
--------------
R
A
E
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
---------
E
--------
Q
--------
T
G
T
---------
E
E
A
L
--
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
T
Y
E
I
K
E
R
S
K
K
---------------
33
HHSearch
71.16
28%
-78
- C4 -
1ZZG
-
G6PI_THET8
A:
[1-415]
------------------------------------------------
M
L
R
L
D
T
R
F
L
----------
P
-
G
F
P
-
E
A
L
S
R
H
-----
G
-----
P
L
L
---
E
E
A
R
R
R
-----
L
L
A
K
--
R
---
G
E
P
G
S
M
L
G
W
M
D
L
--
P
E
D
--------------
T
---------------------
E
T
L
R
E
V
R
R
Y
R
E
A
N
P
----------
W
V
---------
E
D
F
V
L
I
G
I
G
G
S
A
L
G
P
K
A
L
E
A
A
F
N
E
S
---------------------------
G
V
R
-------
F
H
Y
L
-
D
H
V
E
P
E
P
I
L
R
L
L
R
T
L
D
P
R
K
T
L
V
N
A
V
S
K
S
G
S
T
A
E
T
L
A
G
L
A
V
F
L
K
W
L
K
A
H
L
----
G
E
----
D
-
W
R
R
H
L
V
V
T
T
D
P
K
E
G
P
L
R
A
F
A
E
R
E
G
L
---
K
A
F
A
I
P
K
E
V
G
G
R
F
S
A
L
S
P
V
G
L
L
P
L
A
F
A
--
G
A
-
D
-
L
D
A
L
L
M
G
A
R
K
A
N
E
T
A
-
L
A
P
L
-
E
E
S
L
P
L
K
T
A
L
L
L
H
L
H
---
R
H
L
P
V
H
V
F
M
V
Y
S
E
R
L
S
H
L
P
S
W
F
V
Q
L
H
D
E
S
L
G
K
V
--------
D
RQG
Q
R
-----
V
-----
G
T
T
A
V
P
A
L
G
P
K
D
Q
H
A
Q
V
Q
L
F
R
E
G
P
L
D
K
L
L
A
L
V
I
P
E
A
P
L
E
------
D
V
------
E
I
P
E
---
V
-----
E
G
---------
L
E
A
A
S
Y
L
F
G
K
T
L
F
Q
L
L
K
A
---------
E
--------
A
--------
E
A
T
---------
Y
E
A
L
--
A
--
E
A
G
Q
R
V
Y
A
L
F
L
P
E
V
S
P
Y
A
V
G
W
L
M
Q
H
L
M
W
Q
T
A
F
L
G
E
L
W
E
V
N
A
F
D
Q
P
G
V
E
L
G
K
V
L
T
R
K
R
L
A
G
----------------------------
8
PsiBlast_PDB
68.33
28%
-68
- C4 -
1ZZG
-
G6PI_THET8
A:
[2-406]
-------------------------------------------------
L
R
L
D
-
T
R
F
----------
L
P
G
F
P
E
-
A
L
S
R
H
-----
G
-----
P
L
L
---
E
E
A
R
R
R
-----
L
L
A
K
--
R
---
G
E
P
G
S
M
L
G
W
M
D
L
--
P
E
D
--------------
T
------------------
E
T
L
R
E
V
R
R
Y
R
E
A
N
P
W
V
E
---------
D
-------------
F
V
L
I
G
I
G
G
S
A
L
G
P
K
A
----
L
E
A
A
F
N
--
E
S
-------------------
G
V
R
F
H
-------
Y
L
---
D
H
V
E
P
E
P
I
L
R
L
L
R
T
L
D
P
R
K
T
L
V
N
A
V
S
K
S
G
S
T
A
E
T
L
A
G
L
A
V
F
L
K
W
L
K
A
H
L
----
G
---
E
-
D
-
W
R
R
H
L
V
V
T
T
D
P
K
E
G
P
L
R
A
F
A
E
R
E
G
L
---
K
A
F
A
I
P
K
E
V
G
G
R
F
S
A
L
S
P
V
G
L
L
P
L
A
F
A
--
G
A
-
D
-
L
D
A
L
L
M
G
A
R
K
A
N
E
T
-
A
L
A
P
L
-
E
E
S
L
P
L
K
--
T
A
L
L
L
H
L
H
-
R
H
L
P
V
H
V
F
M
V
Y
S
E
R
L
S
H
L
P
S
W
F
V
Q
L
H
D
E
S
L
G
K
V
--------
D
----------
R
QG
Q
R
V
G
T
T
A
V
P
A
L
G
P
K
D
Q
H
A
Q
V
Q
L
F
R
E
G
P
L
D
K
L
L
A
L
V
I
P
E
A
P
L
E
------
D
V
------
E
I
-
P
---
E
-
V
---
E
G
---------
L
E
A
A
S
Y
L
F
G
K
T
L
F
Q
L
L
K
A
---------
E
--------
A
--------
E
A
T
---------
Y
E
A
L
--
A
--
E
A
G
Q
R
V
Y
A
L
F
L
P
E
V
S
P
Y
A
V
G
W
L
M
Q
H
L
M
W
Q
T
A
F
L
G
E
L
W
E
V
N
A
F
D
Q
P
G
V
E
L
G
K
-------------------------------------
38
HHSearch
66.81
22%
-69
- C4 -
2CXN
3
G6PI_MOUSE
A:
[50-532]
------------------------------------------------
H
I
L
V
D
Y
S
K
N
----------
L
--
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
-----
R
G
V
---
E
A
A
R
D
N
-----
M
F
S
G
--
S
KIN
Y
T
E
D
R
A
V
L
H
V
A
L
--
R
N
R
SNT
P
I
K
V
DGKDV
M
P
E
------------------
V
N
-
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
GDWKGYTG
K
S
I
---------
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
------------------------
G
G
P
R
-------
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
----
K
D
--
P
S
A
-
V
A
K
H
F
V
A
L
S
T
-
N
T
A
K
V
K
E
F
G
I
D
-
P
Q
---
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
--
G
F
-
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
-
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
--------
I
TKSGARVDHQ
T
-----
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
------
P
I
------
R
K
G
L
H
H
K
I
-
L
L
A
N
F
L
---------
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
---------
L
--------
Q
A
A
GKS
P
E
D
L
E
K
---------
L
L
P
H
--
K
VF
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
------------------------
30
HHSearch
66.71
23%
-72
- C4 -
3QKI
-
?
A:
[45-554]
------------------------------------------------
N
F
Y
M
D
L
S
R
Q
----------
R
--
Y
S
E
K
T
L
N
K
L
V
E
Y
A
E
E
-----
V
E
L
---
K
K
K
V
E
K
-----
T
F
M
G
--
E
KVN
M
T
E
N
R
S
V
L
H
T
A
L
--
R
I
P
--------------
I
EKINTH
K
I
I
I
DNKN
V
L
E
D
V
H
-
G
V
L
K
K
I
E
K
Y
S
D
D
I
R
N
GVIKTCKN
T
K
F
---------
K
N
V
I
C
I
G
I
G
G
S
Y
L
G
T
E
F
V
Y
E
A
M
K
Y
Y
Y
Y
--
N
M
ELNKNEKDQVNNFNNNYDQ
D
N
V
F
N
-------
V
R
F
L
-
A
N
V
D
P
N
D
V
N
R
A
I
Q
N
L
D
Q
Y
D
T
L
V
I
I
I
S
K
T
F
T
T
A
E
T
M
L
N
A
R
S
I
K
K
W
L
S
L
K
I
----
K
D
D
-
E
-
N
-
L
S
K
H
M
V
A
V
S
T
N
-
L
----
K
L
T
D
E
F
G
I
SRD
N
V
F
E
F
W
D
W
V
G
G
R
F
S
V
T
S
S
V
G
I
L
P
L
S
I
A
FG
Y
K
-
N
-
M
R
N
F
L
N
G
C
H
D
M
D
E
H
F
-
L
H
A
D
L
K
E
N
I
P
V
L
L
A
L
T
S
F
Y
N
S
H
F
F
D
Y
K
N
V
A
I
L
P
Y
F
Q
N
L
L
K
F
S
A
H
I
Q
Q
L
S
M
E
S
N
G
K
S
--------
V
DRNNQPIHYN
T
-----
C
Q
V
Y
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
Q
V
-
I
P
V
E
L
I
G
F
K
H
S
H
F
------
P
I
------
K
F
D
K
---
E
V
V
---
S
N
H
D
E
L
M
T
N
F
F
A
Q
A
D
A
L
A
I
G
K
T
Y
E
Q
V
K
E
E
---------
N
EKNK----
M
--------
S
P
E
---------
L
L
T
H
--
K
VF
N
G
N
R
P
S
T
L
L
L
F
D
E
L
N
F
Y
T
C
G
L
L
L
S
L
Y
E
S
R
I
V
A
E
G
F
L
L
N
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
E
V
R
N
Y
F
N
D
T
------------------------
7
PsiBlast_PDB
66.06
34%
-75
- C4 -
2Q8N
6
G6PI_THEMA
A:
[77-453]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
---------
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
----
L
H
Y
S
L
R
PL
N
W
-------------------
N
E
M
T
R
EERNG
Y
A
R
V
F
V
V
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
E
A
-
Y
----
G
L
--
D
---
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
---
R
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
L
S
A
M
A
E
--
G
I
-
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
M
K
E
N
I
-
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
R
YNLKGEEV
F
----------
T
-----
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
V
I
T
F
L
R
V
E
N
F
D
R
------
E
I
------
V
I
P
E
---
T
-
G
---
R
-----------
A
E
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
---------
E
--------
Q
--------
T
G
T
---------
E
E
A
L
--
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
---
T
Y
E
I
K
E
R
---------------
21
PsiBlast_CBE
65.87
34%
-74
- C4 -
2Q8N
4
G6PI_THEMA
C:
[77-453]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
---------
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
----
L
H
Y
S
L
R
PL
N
W
-------------------
N
E
M
T
R
EERNGYA
R
V
F
V
V
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
E
A
-
Y
----
G
L
--
D
---
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
---
R
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
L
S
A
M
A
E
--
G
I
-
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
M
K
E
N
I
-
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
R
YNLKGEEV
F
----------
T
-----
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
V
I
T
F
L
R
V
E
N
F
D
R
------
E
I
------
V
I
P
E
---
T
-
G
---
R
-----------
A
E
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
---------
E
--------
Q
--------
T
G
T
---------
E
E
A
L
--
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
---
T
Y
E
I
K
E
R
---------------
22
PsiBlast_CBE
65.86
34%
-75
- C4 -
2Q8N
6
G6PI_THEMA
B:
[77-453]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
---------
D
T
V
V
V
L
G
I
G
G
S
G
L
G
N
L
A
----
L
H
Y
S
L
R
PL
N
W
-------------------
N
E
M
T
R
EERNG
Y
A
R
V
F
V
V
D
N
V
D
P
D
L
M
S
S
V
L
D
R
I
D
P
K
T
T
L
F
N
V
I
S
K
S
G
S
T
A
E
V
M
A
T
Y
S
I
A
R
G
I
L
E
A
-
Y
----
G
L
--
D
---
P
R
E
H
M
L
I
T
T
D
P
E
K
G
F
L
R
K
L
V
K
E
E
G
F
---
R
S
L
E
V
P
P
G
V
G
G
R
F
S
V
L
T
P
V
G
L
L
S
A
M
A
E
--
G
I
-
D
-
I
D
E
L
H
E
G
A
K
D
A
F
E
K
S
M
K
E
N
I
-
L
E
N
P
A
A
M
I
A
L
T
H
Y
L
Y
L
N
-
K
G
K
S
I
S
V
M
M
A
Y
S
N
R
M
I
Y
L
V
D
W
Y
R
Q
L
W
A
E
S
L
G
K
R
YNLKGEEV
F
----------
T
-----
G
Q
T
P
V
K
A
L
G
A
T
D
Q
H
S
Q
I
Q
L
Y
N
E
G
P
N
D
K
V
I
T
F
L
R
V
E
N
F
D
R
------
E
I
------
V
I
P
E
---
T
-
G
---
R
-----------
A
E
L
S
Y
L
A
R
K
K
L
S
E
L
L
L
A
---------
E
--------
Q
--------
T
G
T
---------
E
E
A
L
--
R
--
E
N
N
R
P
N
M
R
V
T
F
D
G
L
T
P
Y
N
V
G
Q
F
F
A
Y
Y
E
A
A
T
A
F
M
G
Y
L
L
E
I
N
P
F
D
Q
P
G
V
E
L
G
K
K
I
T
F
A
L
M
G
R
E
G
Y
---
T
Y
E
I
K
E
R
---------------
37
HHSearch
65.24
21%
-69
* C4 *
2O2C
3
G6PI_TRYBB
A:
[98-584]
------------------------------------------------
F
L
F
L
D
Y
S
K
S
----------
H
--
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
-----
R
G
I
---
R
Q
F
V
Q
S
-----
V
F
R
G
--
E
RVN
T
T
E
N
R
P
V
L
H
I
A
L
--
R
N
R
SNR
P
I
Y
V
DGKDV
M
P
A
------------------
V
N
-
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
GEWKGHTG
K
A
I
---------
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
K
P
F
S
Q
------------------------
R
D
L
S
-------
L
H
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
R
A
L
L
D
Y
L
R
S
R
G
I
D
EK
G
-
S
-
V
A
K
H
F
V
A
L
S
T
-
N
N
Q
K
V
K
E
F
G
I
D
E
-
E
---
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
L
P
I
M
I
S
I
--
G
Y
E
N
-
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
-
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
--------
V
TRSGKTVSTL
T
-----
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
Q
S
Q
N
------
K
I
GD
H
H
K
I
F
M
S
N
---
F
------
F
---------
A
Q
T
E
A
L
M
I
G
K
S
P
S
E
V
R
R
E
---------
L
--------
E
--------
A
A
G
ERS
A
E
K
I
N
A
L
L
P
H
--
K
TF
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
P
G
------------------------
35
HHSearch
64.51
21%
-72
- C4 -
2WU8
2
G6PI_MYCTU
A:
[44-521]
------------------------------------------------
D
L
Y
I
D
Y
S
K
H
----------
R
--
V
T
R
E
T
L
A
L
L
-----
I
D
L
A
R
T
A
H
L
---
E
E
R
R
D
Q
-----
M
F
A
G
--
V
HIN
T
S
E
D
R
A
V
L
H
T
A
L
R
L
P
R
D
A
E
L
V
V
DGQD
V
V
T
--
D
------------------
V
H
-
A
V
L
D
A
M
G
A
F
T
D
R
L
R
S
GEWTGATG
K
R
I
---------
S
T
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
Y
Q
A
L
R
H
Y
A
D
------------------------
A
G
I
S
-------
A
R
F
V
-
S
N
V
D
P
A
D
L
I
A
T
L
A
D
L
D
P
A
T
T
L
F
I
V
A
S
K
T
F
S
T
L
E
T
L
T
N
A
T
A
A
R
R
W
L
T
D
A
L
----
G
D
--
A
-
A
-
V
S
R
H
F
V
A
V
S
T
N
-
K
R
L
V
D
D
F
G
I
N
-
T
D
---
N
M
F
G
F
W
D
W
V
G
G
R
Y
S
V
D
S
A
I
G
L
S
L
M
T
V
I
--
G
R
-
D
A
F
A
D
F
L
A
G
F
H
I
I
D
R
H
F
-
A
T
A
P
L
E
S
N
A
P
V
L
L
G
L
I
G
L
W
Y
S
N
F
F
G
A
Q
S
R
T
V
L
P
Y
S
N
D
L
S
R
F
P
A
Y
L
Q
Q
L
T
M
E
S
N
G
K
S
--------
T
RADGSPVSAD
T
-----
G
E
I
F
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
L
H
Q
G
T
R
L
V
P
A
D
F
I
G
F
A
Q
P
L
D
------
D
L
------
P
T
A
E
---
G
-
T
G--
S
M
H
D
L
L
M
S
N
F
F
A
Q
T
Q
V
L
A
F
G
K
T
A
E
E
I
A
A
D
---------
G
--------
T
--------
P
A
H
---------
V
V
A
H
--
K
VM
P
G
N
R
P
S
T
S
I
L
A
S
R
L
T
P
S
V
L
G
Q
L
I
A
L
Y
E
H
Q
V
F
T
E
G
V
V
W
G
I
D
S
F
D
Q
W
G
V
E
L
G
K
T
Q
A
K
A
L
L
P
V
I
T
G
A
------------------------
53
Fugue
64.35
20%
-59
- C4 -
1DQR
2
G6PI_RABIT
A:
[1-555]
AALTRN
P
Q
F
Q
K
L
Q
Q
W
H
R
E
HGSELN
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TN
H
G
H
I
L
L
D
Y
S
K
N
LVT
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
-----
R
-----
E
S
M
F
N
G
E
K
I
N
S
T
ED
R
A
V
L
H
V
A
L
R
N
---
R
S
N
T
P
I
V
V
D
G
K
D
--
V
M
P
--------------
E
------------------
V
N
-
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
---------
S
G
D
WKGYTGKTI
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
--
G
G
----------------------
P
R
-------
V
W
F
V
S
N
-
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
----
K
D
--
P
-
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
----
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
A
L
H
V
--
G
F
D
N
-
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
-
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
--------
I
TKSGARVDHQ
T
-----
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
PIRKG
L
H
H
------
K
I
L
L
---
A
-
N
---
F
L
---------
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
---------
L
Q
A
A
GKS
P
E
D
--------
L
M
K
---------
L
L
P
H
KV
F
--
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
P
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
EAK
32
HHSearch
63.96
21%
-71
- C4 -
3HJB
10
G6PI_VIBCH
A:
[73-552]
------------------------------------------------
D
I
L
V
D
Y
S
K
N
----------
L
--
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
-----
T
D
L
---
Q
S
A
I
T
A
-----
M
F
K
G
--
E
AIN
Q
T
E
D
R
A
V
L
H
T
A
L
--
R
N
R
--------------
S
NS
P
V
L
V
NGEDV
M
P
A
----
V
N
-
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
GEWKGFTG
K
A
I
---------
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
Y
K
-------------------------
N
H
L
T
-------
V
H
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
F
L
K
A
A
----
G
D
--
E
-
A
H
V
A
K
H
F
A
A
L
S
T
-
N
G
K
A
V
A
E
F
G
I
D
-
T
D
---
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
L
S
I
I
L
S
I
--
G
Y
-
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
-
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
--------
V
DRNGNPVTYQ
T
-----
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
S
H
N
------
L
V
GD
H
H
Q
K
L
M
S
N
---
F
------
F
---------
A
Q
T
E
A
L
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
K
A
GKS
A
A
E
--------
I
--------
A
A
L
---------
V
P
F
K
--
V
F-
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
S
------------------------