@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0843: (2016-03-19 )
MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINDNTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
Atome Classification :
(51 SA)
.........10........20........30.....-----...40........50-------..----------...-------...60........--------------------70........80........90.-...-...-.-.100--.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--.--......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.....-..--330.......340.......350.......360.......370...--....380-.......-390--........400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQN
K
R
V
V
I
T
GMGALSPIG
N
D
V
K
T
T
W
E
N
A
L
KGVNG
I
-----
D
K
I
TRIDTEP
Y
S
V
H
L
-------AG----------ELK-------NFNIEDHI
D
K
K
E
A
--------------------
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
VKD
A
-
Q
-
L
DI-NDN-T-A
D
R
I
--
G
V
W
I
GSGIGG
M
E
T
F
E
I
A
H
K
Q
L
M
D
KGPRRVS
P
F
F
V
P
M
LIPDMAT
G
Q
V
S
I
D
LGAKGPNG
A
T
V
T
A
C
ATGT
N
S
I
G
E
A
F
K
I
V
QRGDA
D
A
M
I
TGGTEAP
I
T
H
M
A
IAGFSASRALS-T--N--D
D
I
E
T
A
C
R
P
F
Q
EGRD
G
F
V
MGEG
A
G
I
L
V
I
ES
L
E
S
A
QARG
A
N
I
Y
A
E
I
V
GYGTTGD
A
Y
H
I
TAPAPEGEGG
S
R
A
M
Q
A
A
MDDAGIEPK
D
V
Q
Y
L
NAHGTSTPVG
D
L
N
E
V
K
A
I
K
N
T
F
G
E
A
A
-
K
H
--LKVSSTKSM
T
G
H
L
LGATG
G
I
E
A
I
F
S
A
LSIKDSKVA
P
T
I
H
AVTPDPE--CDLDIVP-NEAQD
L
D
-
I
T
---
Y
A
MSNSLGFGGH
N
A
V
L
V
F
K
KFEA
117
HHSearch
99.23
100%
-72
- C4 -
2GQD
-
FABF_STAAC (first)
A:
[4-414]
---
N
K
R
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
-----
D
K
I
T
R
I
D
T
E
P
Y
S
V
H
L
-------
A
G
----------
E
L
K
-------
N
F
N
I
E
D
H
I
D
K
K
E
A
--------------------
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
-
Q
-
L
D
I
-
N
E
N
-
T
-
A
D
R
I
--
G
V
W
I
G
S
G
I
G
G
M
E
T
F
E
I
A
H
K
Q
L
M
D
K
G
P
R
R
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
G
Q
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
-
T
--
N
--
D
D
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
I
T
A
P
A
P
E
G
E
G
G
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
F
G
E
A
A
-
K
H
--
L
K
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
D
P
E
--
C
D
L
D
I
V
P
-
N
E
A
Q
D
L
D
-
I
T
---
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
A
1
PsiBlast_PDB
99.03
99%
-72
- C4 -
2GQD
-
FABF_STAAC (first)
A:
[4-414]
---
N
K
R
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
-----
D
K
I
T
R
I
D
T
E
P
Y
S
V
H
L
-------
A
G
----------
E
L
K
-------
N
F
N
I
E
D
H
I
D
K
K
E
A
--------------------
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
-
Q
-
L
D
I
-
N
E
N
-
T
-
A
D
R
I
--
G
V
W
I
G
S
G
I
G
G
M
E
T
F
E
I
A
H
K
Q
L
M
D
K
G
P
R
R
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
G
Q
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
-
T
--
N
--
D
D
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
I
T
A
P
A
P
E
G
E
G
G
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
F
G
E
A
A
-
K
H
--
L
K
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
D
P
E
--
C
D
L
D
I
V
P
-
N
E
A
Q
D
L
D
-
I
T
---
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
A
2
PsiBlast_PDB
89.93
68%
-70
- C4 -
4LS5
5
FABF_BACSU
A:
[17-426]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
5
PsiBlast_PDB
89.75
68%
-69
- C4 -
4LS6
4
FABF_BACSU
A:
[17-426]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
24
PsiBlast_CBE
89.27
68%
-69
- C4 -
4LS6
6
FABF_BACSU
B:
[17-425]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
4
PsiBlast_PDB
89.04
68%
-69
- C4 -
4LS8
9
FABF_BACSU
A:
[17-426]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
23
PsiBlast_CBE
89.01
68%
-69
- C4 -
4LS5
4
FABF_BACSU
B:
[17-425]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
22
PsiBlast_CBE
88.91
68%
-68
- C4 -
4LS7
6
FABF_BACSU
B:
[17-425]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
21
PsiBlast_CBE
88.75
68%
-69
- C4 -
4LS8
5
FABF_BACSU
B:
[17-426]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
3
PsiBlast_PDB
88.02
68%
-68
- C4 -
4LS7
6
FABF_BACSU
A:
[17-426]
----
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
-----
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
-------
A
A
----------
E
L
K
-------
D
F
N
V
E
D
Y
M
D
K
K
E
A
--------------------
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
-
D
-
L
N
I
-
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
--
N
--
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
E
H
A
-
H
K
--
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
--
C
D
L
D
Y
V
P
-
D
E
A
R
R
Q
E
-
L
N
---
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
29
PsiBlast_CBE
85.49
51%
-69
- C4 -
4B7V
1
?
B:
[26-434]
----
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
-----
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
-------
G
G
----------
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
A
--------------------
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
-
L
E
V
-
T
D
A
-
N
-
R
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
L
V
A
-
H
E
A
K
P
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
--
11
PsiBlast_PDB
85.49
51%
-67
- C4 -
4B7V
1
?
A:
[24-434]
--
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
-----
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
-------
G
G
----------
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
A
--------------------
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
-
L
E
V
-
T
D
A
-
N
-
R
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
L
V
A
-
H
E
A
K
P
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
--
7
PsiBlast_PDB
85.36
55%
-66
- C4 -
1E5M
-
FABF_SYNY3
A:
[6-416]
---
K
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
-----
G
P
I
T
R
F
D
A
S
D
Q
A
C
R
F
-------
G
G
----------
E
V
K
-------
D
F
D
A
T
Q
F
L
D
R
K
E
A
--------------------
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
-
K
-
L
V
I
-
N
E
L
-
N
-
A
D
E
I
--
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
F
R
--
N
--
D
D
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
N
H
A
-
Y
N
--
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
P
E
--
C
D
L
D
Y
V
P
-
G
Q
S
R
A
L
I
-
V
D
---
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
Q
-
12
PsiBlast_PDB
85.13
51%
-67
- C4 -
4JPF
3
?
A:
[25-434]
---
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
-----
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
-------
G
G
----------
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
A
--------------------
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
-
L
E
V
-
T
D
A
-
N
-
R
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
L
V
A
-
H
E
A
K
P
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
--
115
HHSearch
84.80
55%
-66
- C4 -
1E5M
-
FABF_SYNY3
A:
[6-415]
---
K
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
-----
G
P
I
T
R
F
D
A
S
D
Q
A
C
R
F
-------
G
G
----------
E
V
K
-------
D
F
D
A
T
Q
F
L
D
R
K
E
A
--------------------
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
-
K
-
L
V
I
-
N
E
L
-
N
-
A
D
E
I
--
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
-
F
--
R
N-
D
D
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
N
H
A
-
Y
N
--
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
P
E
--
C
D
L
D
Y
V
P
-
G
Q
S
R
A
L
I
-
V
D
---
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
--
14
PsiBlast_PDB
84.34
51%
-64
- C4 -
4JB6
1
?
A:
[2-412]
--
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
-----
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
-------
G
G
----------
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
A
--------------------
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
-
L
E
V
-
T
D
A
-
N
-
R
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
Q
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
L
V
A
-
H
E
A
K
P
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
--
31
PsiBlast_CBE
84.27
51%
-65
- C4 -
4JB6
1
?
B:
[2-412]
--
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
-----
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
-------
G
G
----------
S
V
K
-------
G
F
N
V
E
E
Y
L
S
A
K
E
A
--------------------
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
-
G
-
L
E
V
-
T
D
A
-
N
-
R
E
R
I
--
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
Q
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
E
H
A
-
H
A
--
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
L
V
A
-
H
E
A
K
P
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
--
26
PsiBlast_CBE
83.85
52%
-69
- C4 -
4JRM
1
FABF_VIBCH
A:
[7-417]
----
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
-----
V
N
I
E
H
F
D
T
T
N
F
S
T
R
F
-------
A
G
----------
L
V
K
-------
G
F
D
C
E
Q
Y
M
S
K
K
D
A
--------------------
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
-
G
-
L
E
V
-
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
-
T
R-
N
--
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
D
A
G
V
T
G
E
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E
A
G
T
K
Q
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
--
L
G
V
D
L
V
P
-
H
V
A
R
K
V
E
S
M
E
---
Y
A
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
--
8
PsiBlast_PDB
83.79
52%
-69
- C4 -
4JRH
2
FABF_VIBCH
A:
[7-417]
----
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
-----
V
N
I
E
H
F
D
T
T
N
F
S
T
R
F
-------
A
G
----------
L
V
K
-------
G
F
D
C
E
Q
Y
M
S
K
K
D
A
--------------------
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
-
G
-
L
E
V
-
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
-
T
R-
N
--
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
D
A
G
V
T
G
E
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E
A
G
T
K
Q
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
--
L
G
V
D
L
V
P
-
H
V
A
R
K
V
E
S
M
E
---
Y
A
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
--
28
PsiBlast_CBE
83.73
53%
-66
- C4 -
4QAV
2
?
B:
[3-414]
--
Q
-
R
R
V
V
I
T
G
L
G
Q
V
S
P
V
G
N
T
V
A
E
A
W
D
T
L
L
A
G
K
S
G
I
-----
G
A
I
T
R
F
D
A
S
D
I
N
S
R
V
-------
A
G
----------
E
V
R
-------
G
F
D
I
G
Q
Y
I
S
A
K
E
A
--------------------
R
R
M
D
V
F
I
H
Y
G
I
A
A
A
L
Q
A
I
A
D
S
-
G
-
L
D
D
-
V
E
N
-
L
D
K
D
R
I
--
G
V
N
I
G
S
G
I
G
G
L
P
S
I
E
V
T
G
K
A
V
I
E
G
G
A
R
K
I
N
P
F
F
I
P
G
S
L
I
N
L
I
S
G
H
V
T
I
L
K
G
Y
R
G
P
S
Y
G
M
V
S
A
C
T
T
G
A
H
A
I
G
N
S
A
R
L
I
K
Y
G
D
A
D
I
M
V
A
G
G
A
E
G
A
I
S
T
L
G
V
G
G
F
A
A
M
K
A
L
S
-
T
R-
N
--
D
D
P
A
T
A
S
R
P
W
D
K
G
R
D
G
F
V
I
G
E
G
A
G
I
L
V
L
E
E
L
E
H
A
K
K
R
G
A
K
I
Y
A
E
I
V
G
F
G
M
S
S
D
A
Y
H
I
T
A
P
N
E
E
G
P
--
A
L
A
V
T
R
A
L
K
D
A
G
I
N
P
E
D
V
D
Y
V
N
A
H
G
T
S
T
P
L
G
D
A
N
E
T
K
A
L
K
R
A
F
G
E
H
A
-
Y
K
--
T
V
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
V
E
A
V
Y
S
I
L
A
I
H
D
G
K
I
P
P
T
I
N
I
F
E
Q
D
V
E
AG
C
D
L
D
Y
C
A
-
N
E
A
R
D
A
E
-
I
D
---
V
A
I
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
K
R
F
K
-
34
PsiBlast_CBE
83.55
51%
-66
- C4 -
3G11
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
16
PsiBlast_PDB
83.53
51%
-67
- C4 -
1B3N
1
FABF_ECOLI
A:
[3-412]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
33
PsiBlast_CBE
82.65
51%
-66
- C4 -
3HO9
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
32
PsiBlast_CBE
82.61
51%
-66
- C4 -
3I8P
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
20
PsiBlast_PDB
82.51
51%
-66
- C4 -
3HO2
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
19
PsiBlast_PDB
81.88
51%
-65
- C4 -
3HNZ
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
18
PsiBlast_PDB
81.79
51%
-63
- C4 -
2GFY
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
A
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
35
PsiBlast_CBE
81.78
51%
-66
- C4 -
3G0Y
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
36
PsiBlast_CBE
81.58
51%
-64
- C4 -
2GFX
1
FABF_ECOLI
A:
[18-427]
----
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
-----
S
L
I
D
H
F
D
T
S
A
Y
A
T
K
F
-------
A
G
----------
L
V
K
-------
D
F
N
C
E
D
I
I
S
R
K
E
Q
--------------------
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
-
G
-
L
E
I
-
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
-
T
R-
N
--
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
E
A
S
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
A
A
-
S
R
--
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
--
C
D
L
D
F
V
P
-
H
E
A
R
Q
V
S
G
M
E
---
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
--
47
PsiBlast_CBE
80.92
48%
-65
- C4 -
3KZU
2
?
A:
[10-428]
----
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
-----
R
R
V
T
E
F
E
V
D
D
L
A
C
Q
I
-------
A
C
----------
R
I
P
VGDGTNG
T
F
N
P
D
L
H
M
D
P
K
E
Q
--------------------
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
-
W
H
P
E
N
D
E
-
D
-
Q
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
-
T
ER
N
--
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
--
T
R
I
D
L
V
P
-
H
K
P
R
E
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
T
A
119
HHSearch
80.35
49%
-66
- C4 -
3KZU
2
?
A:
[9-428]
---
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
-----
R
R
V
T
E
F
E
V
D
D
L
A
C
Q
I
ACRIPVG
D
G
----------
T
N
G
-------
T
F
N
P
D
L
H
M
D
P
K
E
Q
--------------------
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
-
W
H
P
-
E
N
D
E
D
-
Q
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
-
T
--
E
RN
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
M
-
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
--
T
R
I
D
L
V
P
-
H
K
P
R
E
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
T
A
46
PsiBlast_CBE
80.01
48%
-65
- C4 -
3KZU
4
?
B:
[10-428]
----
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
-----
R
R
V
T
E
F
E
V
D
D
L
A
C
Q
I
-------
A
C
----------
R
I
P
VGDGTNG
T
F
N
P
D
L
H
M
D
P
K
E
Q
--------------------
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
-
G
-
W
H
P
E
N
D
E
-
D
-
Q
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
-
T
ER
N
--
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
E
A
A
-
A
K
--
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
--
T
R
I
D
L
V
P
-
H
K
P
R
E
R
K
-
I
D
---
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
T
A
37
PsiBlast_CBE
79.92
47%
-64
- C4 -
4JGA
2
?
B:
[15-432]
---
N
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
-----
K
T
I
T
E
F
D
T
S
K
L
A
C
K
I
-------
A
G
LIDNSEKDGF
K
L
E
-------
N
F
T
Q
A
D
D
I
N
R
--
L
--------------------
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
G
W
-
L
P
D
-
D
E
K
-
S
-
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
-
T
KY
N
--
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
D
A
T
I
T
P
D
M
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
E
A
N
-
P
K
--
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
D
E
--
V
N
I
D
L
V
A
-
L
K
A
K
K
T
K
-
I
D
---
Y
V
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
----
38
PsiBlast_CBE
79.43
47%
-65
- C4 -
4JGA
3
?
A:
[15-432]
---
N
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
-----
K
T
I
T
E
F
D
T
S
K
L
A
C
K
I
-------
A
G
LIDNSEKDGF
K
L
E
-------
N
F
T
Q
A
D
D
I
N
R
--
L
--------------------
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
G
W
-
L
P
D
-
D
E
K
-
S
-
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
-
T
KY
N
--
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
D
A
T
I
T
P
D
M
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
E
A
N
-
P
K
--
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
D
E
--
V
N
I
D
L
V
A
-
L
K
A
K
K
T
K
-
I
D
---
Y
V
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
----
48
PsiBlast_CBE
77.61
44%
-60
- C4 -
2IWZ
3
OXSM_HUMAN
B:
[20-434]
---
H
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
-----
V
S
L
V
G
E
E
Y
K
S
I
P
C
S
V
-------
A
A
----------
Y
V
P
RGSDEG-
Q
F
N
E
Q
N
F
V
S
K
S
D
I
--------------------
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
-
G
-
W
H
--
P
Q
S
-
E
-
A
D
Q
V
AT
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
-
T
--
N
--
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
D
A
G
V
Q
P
E
E
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
D
H
A
-
Y
A
--
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
P
E
--
F
D
L
N
Y
V
P
-
L
K
A
Q
E
W
K
-
T
E
KRF
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
------
49
PsiBlast_CBE
77.05
44%
-61
- C4 -
2IWZ
3
OXSM_HUMAN
A:
[20-434]
---
H
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
-----
V
S
L
V
G
E
E
Y
K
S
I
P
C
S
V
-------
A
A
----------
Y
V
P
RGSDEG-
Q
F
N
E
Q
N
F
V
S
K
S
D
I
--------------------
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
-
G
-
W
H
--
P
Q
S
-
E
-
A
D
Q
V
A
T
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
-
T
--
N
--
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
D
A
G
V
Q
P
E
E
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
D
H
A
-
Y
A
--
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
P
E
--
F
D
L
N
Y
V
P
-
L
K
A
Q
E
W
K
-
T
E
K
R
F
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
------
55
PsiBlast_CBE
74.18
44%
-54
- C4 -
2IX4
3
KASM_ARATH
A:
[1-428]
----
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
-----
R
G
L
T
L
D
D
L
K
M
K
S
F
D
E
-------
E
T
----------
K
L
Y
-------
T
F
---
D
Q
L
S
S
K
V
A
A
F
V
PYGSNPGEFDEALWLNS
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
-
E
W
L
P
T
-
E
E
E
-
E
-
K
E
R
T
--
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
-
T
KF
N
--
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
H
A
-
T
S
GT
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
--
F
D
K
R
F
M
P
L
T
T
S
K
K
M
L
-
V
R
---
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
-----
54
PsiBlast_CBE
74.05
44%
-55
- C4 -
2IX4
3
KASM_ARATH
B:
[1-428]
----
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
-----
R
G
L
T
L
D
D
L
K
M
K
S
F
D
E
-------
E
T
----------
K
L
Y
-------
T
F
---
D
Q
L
S
S
K
V
A
AFVPYGSNPGEFDEALWLNS
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
-
E
W
L
P
T
-
E
E
E
-
E
-
K
E
R
T
--
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
-
T
KF
N
--
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
Q
S
G
L
C
P
N
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
H
A
-
T
S
GT
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
--
F
D
K
R
F
M
P
L
T
T
S
K
K
M
L
-
V
R
---
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
-----
62
PsiBlast_CBE
68.00
38%
-55
- C4 -
2WGD
5
FAB1_MYCTU
A:
[25-416]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
59
PsiBlast_CBE
67.05
38%
-55
- C4 -
4C6V
3
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
61
PsiBlast_CBE
66.82
38%
-54
- C4 -
2WGE
10
FAB1_MYCTU
A:
[25-416]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
67
PsiBlast_CBE
66.63
37%
-52
- C4 -
4C73
13
?
B:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
60
PsiBlast_CBE
66.60
38%
-53
- C4 -
4C6U
6
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
71
PsiBlast_CBE
66.54
37%
-53
- C4 -
4C71
9
?
B:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
74
PsiBlast_CBE
65.97
37%
-51
- C4 -
4C70
9
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
73
PsiBlast_CBE
65.95
37%
-51
- C4 -
4C70
8
?
B:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
75
PsiBlast_CBE
65.89
37%
-52
- C4 -
4C6Z
9
?
B:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
69
PsiBlast_CBE
65.81
37%
-51
- C4 -
4C72
14
?
B:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
70
PsiBlast_CBE
65.73
37%
-51
- C4 -
4C72
17
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
68
PsiBlast_CBE
65.30
37%
-53
- C4 -
4C73
19
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
76
PsiBlast_CBE
65.12
37%
-51
- C4 -
4C6Z
9
?
A:
[48-439]
-----------------
I
S
P
D
I
E
S
T
W
K
G
L
L
A
G
E
S
G
I
HALED
E
F
V
T
K
W
D
---
L
A
V
K
I
-------
G
G
----------
H
L
K
-------
D
-
P
V
D
S
H
M
G
R
L
D
M
--------------------
R
R
M
S
Y
V
Q
R
M
G
K
L
L
G
G
Q
L
W
E
S
A
-
G
-
S
P
E
-
V
D
----
P
D
R
F
--
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
Q
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
A
F
S
M
M
R
A
M
S
-
T
R-
N
--
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
P
A
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
D
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
Q
A
------
A
V
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
E
--
I
D
L
D
V
V
A
-
G
E
P
R
Y
G
D
-
Y
R
---
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--