@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0847: (2016-03-19 )
MTERILEVNDLHVSFDITAGEVQAVRGVDFYLNKGETLAIVGESGSGKSVTTKAITKLFQGDTGRIKKGEILFLGEDLAKKPENELIKLRGKDISMIFQDPMTSLNPTMQIGKQVMEPLIKHKNYSKAQAKKRALEILNLVGLPNAEKRFKAYPHQFSGGQRQRIVIATALACEPKVLIADEPTTALDVTMQAQILDLMKELQQKIDTAIIFITHDLGVVANIADRVAVMYGGQMVETGDVNEIFYDPKHPYTWGLLSSMPDLSTTNDTPLLAIPGAPPDLLHPPKGDAFARRSQYALDIDFKVEPPWFKVSPTHFVKSWLLDARAPKVELPELVKQRMKPMPNNYEKPLKVERVSFNEK
Atome Classification :
(31 SA)
.........10........20........30........40........50.......--.60........70........80........90........-----100----........--110-........120..-.-.....130..---......140....-...150.-......160.......170.......180.......190.......200.......210.......220.......230.......----240.......250.......260......----.270.......280.......290.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
E
R
I
L
E
V
N
D
L
H
V
S
F
D
I
TAG
E
V
Q
A
V
R
G
V
D
F
Y
LNKG
E
T
L
A
I
V
GESGSGKS
V
T
T
K
A
I
T
K
L
--FQGDTGRIKKG
E
I
L
F
LG
E
D
L
AKKPEN
E
L
I
K
LRGK
D
I
S
M
I
FQ-----DP-----MTSLN
P
T
M
--
Q
I
--
G
K
Q
V
M
E
P
L
I
-KHK-N-Y
S
K
A
Q
A
K
-
K
R
---
A
L
E
I
L
N
L
VGLP
N
A
-
E
K
R
F
K
AY-PHQFSGG
Q
R
Q
R
I
V
I
A
T
ALACE
P
K
V
L
I
ADEPTTA
L
D
V
T
M
Q
A
Q
I
L
D
L
M
K
E
L
Q
Q
KID
T
A
I
I
F
I
TH
D
L
G
V
V
A
N
I
A
D
R
V
A
V
MYG
G
Q
M
VETG----D
V
N
E
IFYDPKHPY
T
W
G
L
L
SSMPDLSTTND----T
P
L
L
AIPGAPPDLLHPPKG
D
A
F
A
RRS
Q
Y
A
L
D
I
D
F
KVEPP
W
F
KV
S
P
T
H
F
V
K
S
W
L
LDARAPKVE
L
P
E
L
V
K
Q
R
MKPMPNNYEKP
L
K
V
E
R
VSFNEK
1
PsiBlast_PDB
92.26
40%
-96
- C1 -
4FWI
3
?
B:
[4-321]
----
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
--
L
P
P
N
-
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
-----
A
A
-----
Q
Q
S
L
N
P
T
M
--
K
V
--
I
E
H
F
K
D
T
V
E
-
A
H
G
V
R
-
W
S
H
S
E
L
I
-
E
K
---
A
S
E
K
L
R
M
V
R
L
-
N
P
-
E
A
V
L
N
S
Y
-
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
----
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
---------------
P
I
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
------------------------------------
58
HHSearch
80.73
34%
-111
- C1 -
3TUI
1
METN_ECOLI
C:
[23-266]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
--
E
R
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
-----
H
F
-----
N
--
L
L
S
S
R
--
T
V
--
F
G
N
V
A
L
P
L
E
-
L
D
N
---
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
----
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
----
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
---------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.19
35%
-112
- C1 -
3TUZ
1
METN_ECOLI
C:
[41-275]
---------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-------
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
-----
H
-------
F
N
L
L
S
S
R
--
T
V
--
F
G
N
V
A
L
P
L
--
E
L
D
-
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
----
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
----
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
79.16
34%
-105
- C1 -
3C4J
4
?
B:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
79
Fugue
78.82
28%
-88
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-------
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
-----
H
F
-------
N
L
L
S
S
R
--
T
V
--
F
G
N
V
A
L
P
L
E
-
L
D
--
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
K
-
H
D
S
---
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
----
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
YQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
---
H
H
V
K
V
E
V
------
18
PsiBlast_PDB
78.58
35%
-106
- C1 -
4YMW
-
?
J:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.41
34%
-101
- C1 -
2OLK
1
?
A:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.35
34%
-97
- C1 -
2OLK
2
?
B:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.30
35%
-105
- C1 -
4YMV
1
?
J:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
78.29
34%
-101
- C1 -
2OLK
1
?
C:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
78.20
35%
-102
- C1 -
4YMU
2
?
A:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.20
35%
-104
- C1 -
4YMS
-
?
J:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.03
35%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[41-275]
---------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-------
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
-----
H
-------
F
N
L
L
S
S
R
--
T
V
--
F
G
N
V
A
L
P
L
--
E
L
D
-
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
----
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
----
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.96
34%
-99
- C1 -
2OUK
2
?
D:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.90
35%
-101
- C1 -
4YMU
2
?
J:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.87
35%
-101
- C1 -
4YMT
-
?
J:
[4-239]
-------
V
N
D
V
Y
K
N
F
----
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
--
L
E
E
P
T
----
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
-----
H
-------
F
N
L
F
P
H
L
--
T
A
--
I
E
N
I
T
L
A
P
V
-
K
V
K
-
K
-
M
N
K
K
E
A
E
-
E
L
---
A
V
D
L
L
A
K
V
G
L
L
D
K
-
K
D
Q
---
Y
-
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
----
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.80
36%
-104
- C1 -
4U00
3
?
A:
[3-241]
---
P
I
I
R
I
R
N
L
H
K
W
F
----
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
ED
F
Q
-------
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
V
G
M
V
F
Q
-----
Q
-------
F
N
L
F
P
H
M
--
T
V
--
L
E
N
V
T
L
A
P
M
-
R
V
R
-
R
-
W
P
R
E
K
A
E
-
K
K
---
A
L
E
L
L
E
R
V
G
I
L
D
Q
-
A
R
K
---
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
----
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
--------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.69
34%
-98
- C1 -
2OUK
1
?
C:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.52
34%
-102
- C1 -
2OUK
1
?
A:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.47
35%
-110
- C1 -
3TUI
1
METN_ECOLI
H:
[41-275]
---------------------
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-------
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
-----
H
-------
F
N
L
L
S
S
R
--
T
V
--
F
G
N
V
A
L
P
L
--
E
L
D
-
N
-
T
P
K
D
E
V
K
-
R
R
---
V
T
E
L
L
S
L
V
G
L
G
D
----
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
----
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.41
34%
-98
- C1 -
3C41
3
?
K:
[2-241]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
77.10
34%
-99
- C1 -
2OLK
1
?
D:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.35
34%
-98
- C1 -
3C4J
3
?
A:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.22
34%
-99
- C1 -
2OLJ
4
?
A:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
75.41
34%
-96
- C1 -
2OLJ
3
?
B:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.31
34%
-91
- C1 -
3C41
3
?
J:
[2-241]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.14
34%
-96
- C1 -
2Q0H
4
?
A:
[23-260]
---
Q
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
--
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
-----
R
-------
F
N
L
F
P
H
M
--
T
V
--
L
N
N
I
T
L
A
P
M
-
K
V
R
-
K
-
W
P
R
E
K
A
E
-
A
K
---
A
M
E
L
L
D
K
V
G
L
K
D
----
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
----
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
----------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.95
32%
-103
- C1 -
1VCI
1
?
A:
[23-251]
-------------------
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
--
E
E
P
T
E
G
R
I
Y
F
G
D
-----
R
D
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
------------------
H
M
--
T
V
--
Y
E
N
I
A
F
P
L
----
K
-
K
-
F
P
K
D
E
I
D
-
K
R
V
R
W
A
A
E
L
L
Q
I
-------
E
E
L
L
N
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
----
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
---------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.91
33%
-99
- C1 -
1L2T
4
Y796_METJA
B:
[18-223]
---------------------
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-------
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
------------
Q
F
N
L
I
P
L
L
--
T
A
--
L
E
N
V
E
L
P
L
I
F
K
Y
R
-
G
A
M
S
G
E
E
R
R
-
K
R
---
A
L
E
C
L
K
M
A
E
L
----
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.42
31%
-92
- C1 -
1G6H
3
LIVG_METJA
A:
[18-249]
-------------------
G
E
F
K
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
--
L
K
A
D
E
G
R
-----
V
Y
F
E
N
K
D
I
T
N
K
E
P
A
E
L
Y
H
Y
---
G
I
V
R
T
F
Q
-----
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
I
C
P
G
E
S
P
L
N
S
L
F
-
Y
K
K
-
W
-
I
P
K
E
E
E
M
V
E
K
---
A
F
K
I
L
E
F
L
K
L
S
H
L
-
Y
D
R
-
K
A
---
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
G
I
T
F
L
I
-
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
-------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
45.63
32%
-65
- C1 -
5DGX
1
?
A:
[21-241]
-------
I
K
D
L
S
F
A
F
----
G
E
H
K
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
--
Y
T
Q
-----
H
E
G
E
I
L
L
D
G
V
D
---
T
R
E
L
T
L
E
N
L
R
-
S
H
L
S
I
V
S
Q
NVHLF
D
D
-----
T
V
Y
N
N
I
A
F
--
G
-----
E
V
S
E
E
E
V
----------
I
D
A
L
-
K
R
---
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
-
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
K
S
C
T
T
--
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
----
K
H
Q
E
L
L
-----------------------------------------------------------------------------------------------------------------------