@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0915: (2016-03-20 )
MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEAKNAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPSLVTKDVVKEGAVIIDVGNTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS
Atome Classification :
(27 SA)
.........10........20.....--.-.--.--30-........40........50........60........70........80........90........100--.--......110.......120.......130-.--.--.--.-...140.......150.......160.......170.......180.......190...--......200.......210.......220.......230...------..---..------..240.......250.......260.......270...-....280....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVAKIL
D
G
K
Q
I
A
K
D
Y
R
Q
G
L
Q
D
Q
V
E
A
L
--
K
-E--K--GF-T
P
K
L
S
V
I
L
V
GNDGA
S
Q
S
Y
V
R
S
K
K
K
A
A
E
K
I
G
M
I
S
E
I
V
H
LEETA
T
E
E
E
V
L
N
E
L
N
RLNNDDSV
S
G
I
L
V
QVPLPK--Q--
V
S
E
Q
K
I
L
E
AINPEKDVDGFHPI
N
I
G
K
L
Y
I-D--E--Q--T-FVPCT
P
L
G
I
M
E
I
L
K
HADI
D
L
EAK
N
A
V
V
IGRSHIV
G
Q
P
V
S
K
L
L
L
QKNA
S
V
T
I
L
HS--R
S
K
--
D
M
A
S
Y
L
K
D
A
D
V
I
V
S
AVGKP
S
L
V
T
K
D
V
VKEG
A
V
I
I
DVG--NTP------DE---NG------KLKGDV
D
Y
D
A
V
K
E
I
A
G
AITPVPGGVG
P
L
T
I
T
M
VLN
N
T
L
-
L
A
E
K
M
R
RGIDS-
42
HHSearch
95.48
48%
-95
* C5 *
3P2O
2
FOLD_CAMJE
A:
[2-284]
N
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
--
K
-
S
--
K
--
G
I
-
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
P
D
--
H
--
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
N
L
-
G
--
L
E-
S
--
G
-
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
I
--
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
--
I
N
R
------
L
E
---
S
G
------
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
-
K
S
A
K
N
R
L
-----
21
PsiBlast_CBE
94.94
49%
-104
- C5 -
3L07
4
FOLD_FRATT
B:
[6-285]
----
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
--
K
-
H
--
H
T-
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
D
--
K
--
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I-
N
H
V
------
D
-----
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
R
-----
2
PsiBlast_PDB
94.90
48%
-98
- C5 -
3P2O
2
FOLD_CAMJE
A:
[6-283]
----
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
--
K
-
S
--
K
--
G
I
-
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
P
D
--
H
--
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
N
L
-
G
L-
E
--
S
--
G
-
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
I
--
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
--
I
N
R
------
L
E
---
S
G
------
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
-
K
S
A
K
N
R
------
1
PsiBlast_PDB
94.04
49%
-104
- C5 -
3L07
4
FOLD_FRATT
A:
[6-284]
----
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
--
K
-
H
--
H
T-
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
D
--
K
--
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I-
N
H
V
------
D
-----
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
------
30
PsiBlast_CBE
92.72
40%
-101
- C5 -
4CJX
2
?
B:
[25-309]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
ER
R
-
Y
--
K
--
G
R
-
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
P
P
--
H
--
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
H
I
-
R
--
E
--
R
NP
A
-
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
S
--
A
T
P
LC
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
--
T
T
P
------
V
A
---
D
P
SKVPGY
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
-------------
25
PsiBlast_CBE
92.47
44%
-95
- C5 -
4A26
1
?
B:
[6-298]
--
A
Q
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
--
R
-
E
L
Y
G
--
G
R
-
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
P
K
--
H
--
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
H
Y
-
K
GR
E
--
P
--
P
-
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
E
N
A
T
V
T
I
V
H
S
GT
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
--
T
T
P
V
PDPS------
G
Y
------
R
L
V
G
D
V
C
F
E
E
A
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
-
E
A
F
K
A
A
L
G
----
5
PsiBlast_PDB
92.38
46%
-102
- C5 -
4B4V
4
?
A:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
44
HHSearch
92.34
48%
-95
- C5 -
3L07
4
FOLD_FRATT
A:
[3-284]
-
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
--
K
-
H
H
-
T
--
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
-
R
--
D
K-
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
--
I
N
H
------
V
D
----
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
-
Q
C
A
Q
E
L
N
-----
22
PsiBlast_CBE
92.02
46%
-102
- C5 -
4B4W
3
?
B:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
13
PsiBlast_PDB
91.74
40%
-98
- C5 -
4CJX
4
?
A:
[25-309]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
R
-
Y
--
K
--
G
R
-
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
P
P
--
H
--
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
H
I
-
R
--
E
--
R
NP
A
-
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
S
--
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
--
T
T
P
------
V
A
---
D
P
SKVPG
Y
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
-------------
23
PsiBlast_CBE
91.52
46%
-103
- C5 -
4B4V
3
?
B:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
3
PsiBlast_PDB
91.15
46%
-94
- C5 -
1B0A
-
FOLD_ECOLI
A:
[2-278]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
--
I
-
A
--
A
--
G
L
R
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
P
A
--
G
--
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
-
R
--
A
--
P
--
R
-
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
R
--
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
--
I
N
R
------
L
E
---
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
-
Q
A
----------
6
PsiBlast_PDB
90.83
46%
-98
- C5 -
4B4W
4
?
A:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
4
PsiBlast_PDB
90.71
46%
-97
- C5 -
4B4U
9
?
A:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
8
PsiBlast_PDB
90.53
44%
-97
- C5 -
4A26
1
?
A:
[6-300]
--
A
Q
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
--
R
-
E
L
Y
G
--
G
R
-
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
P
K
--
H
--
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
H
Y
-
K
GR
E
--
P
--
P
-
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
E
N
A
T
V
T
I
V
H
S
GT
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
--
T
T
P
V
PDPSR
K
D
---
G
Y
------
R
L
V
G
D
V
C
F
E
E
A
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
-
E
A
F
K
A
A
L
G
V
S
--
24
PsiBlast_CBE
90.15
46%
-101
- C5 -
4B4U
7
?
B:
[22-297]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
--
K
-
A
--
K
T-
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
-
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
--
F
H
P
------
R
D
---
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
-
E
A
----------
29
PsiBlast_CBE
90.04
43%
-94
- C5 -
1A4I
1
C1TC_HUMAN
B:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
V
P
------
D
D
KKP
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
46
HHSearch
89.72
45%
-88
- C5 -
1B0A
-
FOLD_ECOLI
A:
[2-283]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
--
I
A
A
--
G
--
L
R
-
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
P
A
--
G
--
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
-
R
--
A
--
P
--
R
-
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
R
--
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
--
I
N
R
------
L
E
---
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
-
Q
A
C
V
E
Y
H
-----
32
Fugue
89.54
44%
-88
- C5 -
1B0A
-
FOLD_ECOLI
A:
[2-288]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
--
I
-
A
--
A
G-
L
R
-
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
P
A
---G-
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
-
R
--
A
--
P
---R
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
R
--
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
--
I
N
R
------
L
E
---
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
-
Q
A
C
V
E
Y
H
D
P
Q
D
E
27
PsiBlast_CBE
89.34
43%
-97
- C5 -
1DIB
1
C1TC_HUMAN
B:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
V
P
------
D
D
KKP
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
28
PsiBlast_CBE
89.28
43%
-95
- C5 -
1DIA
1
C1TC_HUMAN
B:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
V
P
------
D
D
KKP
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
9
PsiBlast_PDB
89.23
43%
-100
- C5 -
1DIA
2
C1TC_HUMAN
A:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
---------------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
26
PsiBlast_CBE
89.01
43%
-96
- C5 -
1DIG
2
C1TC_HUMAN
B:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
V
P
------
D
D
KKP
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
45
HHSearch
88.87
43%
-93
- C5 -
1A4I
1
C1TC_HUMAN
A:
[2-296]
A
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
Q
V
P
--
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
EN
S
--
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
--
I
N
Y
-------------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
R
F
L
E
----
12
PsiBlast_PDB
88.41
43%
-96
- C5 -
1A4I
1
C1TC_HUMAN
A:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
V
P
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
---------------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
10
PsiBlast_PDB
88.11
43%
-97
- C5 -
1DIB
2
C1TC_HUMAN
A:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
---------------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------
11
PsiBlast_PDB
87.54
43%
-100
- C5 -
1DIG
2
C1TC_HUMAN
A:
[4-292]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
--
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
-
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
IN
Y
---------------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
-
E
S
A
K
--------