@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0990: (2016-03-20 )
MTKKDVIKLLEQIATYMELKGENTFKISAYRKAAQSLELDERPLDEISDVTELKGIGKGVAEVINDYRETGESQYLQQLQEEVPEGLIPLLKIQGLGSKKIAKLYKELNIVDKASLQVACENGKVSELSGFAKKTEQNILEAVKQLGAKKDRYPIDQMRRLNQEIIDYIDTLNYIDQYSSAGSFRRFKEMSKDLDFIISTDNPKAVQQQLLNIPNKVKEVAVGNTKVSLELAYDDETIGVDFRLIEPRAFYHTLQHFTGSKEHNIRIRQLAKARDEKVSEYGIEQADGTLIQYDSEAKIYEHFNVNFIPPAMREDGSEFDKDLSNIITLDDINGDIHMHTTYSDGAFSIRDMVEANIAKGYKFMVITDHSQSLRVANGLQVERLLRQNEEIKALDKEYSEIDIYSGTEMDILPDGSLDYDDEILAQLDYVIGAIHQSFNQSEEQIMERLANACRNPYVRHIAHPTGRIIGRRDGYKPNIEQLMALAEETNTVLEINANPHRLDLNAEIVRKYPNVKLTINTDAHHTNHLDFMNYGVATAQKGFVTKDRVINALSREAFKDFIENNIKLKK
Atome Classification :
(20 SA)
.........10........20........30........--40.......-----.-----50........60........70........-80........90-........100.......110...-....120.......130.......140.......150.......160.......170.......180.......190......--------.200.-------.....---.210.......220..-----...---...230...---..----..240.......250.......260.-......270.......280----......-----------..290.......300.......310..----....----.320--.----........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500..-..-...510.--.......--520.......530.......540.......550.......560.......570
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
K
D
V
I
K
L
L
E
Q
I
A
T
Y
M
E
LKGEN
T
F
K
I
S
A
Y
R
K
A
A
Q
SLEL--DER
P
L
D
E
I
S
-----
D
-----
V
T
E
L
K
G
I
G
K
G
V
A
E
V
I
N
D
Y
R
ET
G
E
S
Q
Y
L
Q
Q
L
-
Q
E
EVPEG
L
I
P
L
L
-
K
IQGL
G
S
K
K
I
A
K
L
Y
K
E
LNIVDK
A
S
-
L
Q
V
A
CENG
K
V
S
E
L
S
G
F
A
K
K
T
E
Q
N
I
L
E
A
V
K
Q
LGAKKDRY
P
I
D
Q
M
R
R
L
N
Q
E
I
I
D
Y
I
D
T
L
N
Y
I
D
Q
YSSAG
S
F
R
R
F
K
E
M
SKDL
D
F
I
I
--------STD
N
P
-------
K
A
V
Q
Q
---
Q
L
L
NI
P
N
K
V
K
E
V
-AVG-----N
T
K
---
V
S
L
E
L
A
YDD---
E
T
----I
G
V
D
F
R
LI
E
P
R
A
F
Y
H
T
L
Q
H
FTGSKEH-
N
I
R
I
R
Q
L
A
K
A
R
D
E
K
V
S
EY-----GIEQAD-----------
G
T
L
I
Q
YDSE
A
K
I
Y
E
HFNVNFIP
P
A
M
RE----D
G
S
E
----
F
D
----
K
----
D
L
S
N
I
I
T
L
DDING
D
I
H
M
H
T
TYSDG
A
F
S
I
R
D
M
V
E
A
N
IAKG
Y
K
F
M
V
I
TDHSQSLRVAN
G
L
Q
V
E
R
L
L
RQN
E
E
I
K
A
L
D
K
EYSEIDIYSGTE
M
D
ILPDGSLD
Y
D
D
E
I
L
A
Q
L
D
Y
V
I
G
A
I
H
Q
S
FNQ
S
E
E
Q
I
M
E
R
L
A
N
A
C
RN
P
Y
V
R
H
IAHPT
G
R
I
IGRRDGYKP
N
I
E
Q
L
M
A
L
A
EET
N
T
V
L
E
INANP
H
R
LDL-
N
A
-
E
I
V
R
K-Y--P
N
V
K
L
T
I
--NTDAHHTN
H
L
D
F
M
NY
G
V
A
T
AQKGF
V
T
K
D
R
V
I
N
A
L
S
R
E
A
F
K
D
F
I
ENNIKLKK
4
PsiBlast_PDB
91.61
32%
-73
- C1 -
3B0Y
7
?
A:
[1-570]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
-
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
---
A
T
V
F
L
---
K
---
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
D
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
V
E
A
A
L
E
----
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
--
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
-------
3
PsiBlast_PDB
91.43
32%
-74
- C1 -
3B0X
8
?
A:
[1-570]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
-
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
---
A
T
V
F
L
---
K
---
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
A
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
V
E
A
A
L
E
----
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
--
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
-------
21
PsiBlast_CBE
91.31
32%
-69
- C1 -
3AUO
4
?
B:
[1-570]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
-----
E
KGKEA
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
-
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
---
A
T
V
F
L
---
K
---
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
K
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
VEAA
L
E
----
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
--
Y
G
M
G
L
W
I
SL
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
-------
23
HHSearch
91.26
32%
-74
- C1 -
3B0X
8
?
A:
[1-573]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
E
K
G
K
E
A
-----
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
Q
V
K
E
V
Y
-
A
K
G
-----
K
E
R
---
A
T
V
F
L
K
------
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
A
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
----
V
E
A
A
L
E
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
Y
G
M
G
L
W
I
S
L
--
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
R
----
1
PsiBlast_PDB
91.21
32%
-74
* C1 *
3AU2
9
?
A:
[1-570]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
-
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
---
A
T
V
F
L
---
K
---
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
K
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
V
E
A
A
L
E
----
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
--
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
-------
2
PsiBlast_PDB
90.39
32%
-67
- C1 -
3AUO
4
?
A:
[1-570]
M
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
--
L
D
T
P
I
E
E
I
A
-----
E
KG
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
-
S
R
K
V
P
R
G
V
L
E
V
M
-
E
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
-
L
K
A
A
L
D
R
G
D
L
T
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
R
A
V
E
---
G
F
V
R
L
P
-
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
---
A
T
V
F
L
---
K
---
N
G
----
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
Y
L
T
G
S
K
A
H
-
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
----
D
Q
G
E
V
E
A
A
L
E
----
G
----
R
L
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
D
-
D
L
A
R
M
-
A
--
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
-------
24
HHSearch
80.91
32%
-58
- C1 -
2W9M
4
?
A:
[9-561]
-
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
---
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
E
E
--
L
N
------------------
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
-
A
G
Q
L
P
P
G
L
L
D
L
L
-
G
V
R
G
L
G
P
K
K
I
R
S
L
W
L
-
A
G
I
D
S
L
E
R
-
L
R
E
A
A
E
S
G
E
L
A
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
A
L
---
T
-
D
L
S
P
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
--------
T
G
T
P
--------
D
D
V
L
A
---
R
L
P
E
L
T
---------------------
V
Q
---
V
L
S
G
D
Y
-
E
G
----
V
P
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
L
R
S
-
G
E
H
F
-
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
----
P
E
H
D
----
D
L
WQTL
P
----
D
P
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
R
--
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
D
W
R
-
E
A
L
R
W
-
R
--
E
R
L
K
F
A
I
--
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
Q
R
A
---
22
PsiBlast_CBE
80.91
32%
-56
- C1 -
2W9M
4
?
B:
[9-556]
-
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
G
G
E
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
E
E
LN
E
E
T
P
E
L
L
A
R
-----
E
-----
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
-
A
G
Q
L
P
P
G
L
L
D
L
L
-
G
V
R
G
L
G
P
K
K
I
R
S
L
W
--
L
A
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
---------
T
G
T
P
-------
D
D
V
L
A
---
R
L
P
E
L
T
V
Q
G
D
G
V
-
L
S
G
-----
D
-----------
Y
E
G
---
V
P
----
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
L
R
----
S
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
PEHD
D
L
W
Q
----
T
L
----
P
----
D
P
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
R
--
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
W
R
E
A
L
R
W
-
R
--
E
R
L
K
F
A
I
--
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
--------
44
Fugue
80.83
31%
-57
- C1 -
2W9M
4
?
A:
[8-564]
P
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
D
---
F
K
S
R
A
Y
R
S
A
A
R
S
L
E
E
--
L
-------------
N
-----
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
-
A
G
Q
L
P
P
G
L
L
D
L
L
-
G
V
R
G
L
G
P
K
K
I
R
S
L
W
L
A
-
G
I
D
S
L
E
R
-
L
R
E
A
A
E
S
G
E
L
A
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
--------
T
G
T
P
D
-------
D
V
L
A
R
-------
L
P
E
L
T
V
Q
V
-
L
S
G
-----
D
Y
E
----------------
G
----
V
P
V
E
I
A
C
A
-
P
A
E
A
R
G
A
L
D
L
L
R
S
G
E
H
F
-
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
-
G
-----------
D
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
----
P
E
H
D
----
D
L
----
W
QTLP
D
P
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
R
A
--
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
W
-
R
E
A
L
R
W
R
--
E
R
L
K
F
A
I
--
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
Q
R
A
A
R
G
5
PsiBlast_PDB
80.31
32%
-61
- C1 -
2W9M
4
?
A:
[9-556]
-
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
---
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
E
E
LN--------------------
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
-
A
G
Q
L
P
P
G
L
L
D
L
L
-
G
V
R
G
L
G
P
K
K
I
R
S
L
W
--
L
A
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
---------
T
G
T
P
-------
D
D
V
L
A
---
R
L
P
E
L
T
V
Q
---
V
-
L
S
G
-----
D
-----------
Y
E
G
---
V
P
----
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
L
R
----
S
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
PEHD
D
L
W
Q
----
T
L
----
P
----
D
P
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
R
--
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
W
R
E
A
L
R
W
-
R
--
E
R
L
K
F
A
I
--
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
--------
6
PsiBlast_PDB
51.06
23%
-46
- C1 -
3OGU
6
DPOLB_HUMAN
A:
[15-335]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
-
R
Q
D
D
T
S
S
S
I
N
L
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
K
T
K
F
M
G
V
C
Q
L
P
S
K
N
D
---
E
K
EY
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
M
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.01
22%
-48
- C1 -
4MFA
8
DPOLB_HUMAN
A:
[5-325]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
--
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
--
D
---
E
K
E
Y
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.81
22%
-46
- C1 -
4M2Y
5
DPOLB_HUMAN
A:
[5-325]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
-----------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
--
D
---
E
K
EY
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
50.72
22%
-47
- C1 -
4MFC
7
DPOLB_HUMAN
A:
[5-325]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE------------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
--
D
---
E
K
E
Y
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
50.53
22%
-48
- C1 -
4MF2
5
DPOLB_HUMAN
A:
[5-325]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE----
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
D
---
E
K
E
Y
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.49
22%
-47
- C1 -
4MFF
8
DPOLB_HUMAN
A:
[5-325]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
---
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
-
D
---
E
K
E
Y
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
50.31
22%
-44
- C1 -
4NY8
8
DPOLB_HUMAN
A:
[6-326]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
--
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
D
---
E
K
E
Y
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
49.87
21%
-37
- C1 -
2BCQ
9
DPOLL_HUMAN
A:
[12-335]
-
H
N
L
H
I
T
E
K
L
E
V
L
A
K
A
Y
S
V
Q
-
G
D
K
W
R
A
L
G
Y
A
K
A
I
N
A
L
K
S
--
F
H
K
P
V
T
S
Y
Q
-----
E
-----
A
C
S
I
P
G
I
G
K
R
M
A
E
K
I
I
E
I
L
E
S
G
H
L
R
K
L
D
H
I
-
S
E
S
V
P
-
V
L
E
L
F
S
-
N
I
W
G
A
G
T
K
T
A
Q
M
W
Y
Q
-
Q
G
F
R
S
L
E
D
-
I
R
S
Q
A
S
-------------
L
T
T
Q
Q
A
I
G
L
K
H
Y
S
D
F
L
E
R
M
P
R
E
E
A
T
E
I
E
Q
T
V
Q
K
A
A
Q
A
F
N
S
G
L
L
C
V
A
C
G
S
Y
R
R
G
K
A
T
C
G
D
V
D
V
L
I
--------
T
H
P
D
G
RSHRGI
F
S
R
L
L
D
---
S
L
R
Q
E
G
F
L
T
D
D
L
-
V
S
Q
EENGQ
Q
Q
K
---
Y
L
G
V
C
R
L
P
G
P
G
R
R
H
----
R
R
L
D
I
I
V
V
P
Y
S
E
F
A
C
A
L
L
Y
F
T
G
S
A
H
F
-
N
R
S
M
R
A
L
A
K
T
K
G
M
S
L
S
E
H
-----
A
L
S
T
A
V
V
R
N
THGCKVGP
G
R
V
L
P
T
P
T
E
K
D
V
F
R
L
L
G
L
P
Y
R
E
P
A
E
R
D
----
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.56
22%
-45
- C1 -
4P2H
8
DPOLB_HUMAN
A:
[6-326]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
--
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
D
---
E
K
EY
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.58
22%
-35
- C1 -
4TUS
9
DPOLB_HUMAN
A:
[6-326]
-----
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
A
K
--
Y
P
H
K
I
K
S
G
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
-
R
V
S
G
I
G
P
S
A
A
R
K
F
------
V
D
E
G
I
--------
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
-
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
----
E
K
EY
P
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
Y
F
T
G
S
D
I
F
-
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
S
----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------