@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0995: (2016-03-21 )
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQPPVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEFLGIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHELDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTVAGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIVELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKPQFTYDDVDVSLIPPRKRDYTSKSKGGKK
Atome Classification :
(23 SA)
--.....--....10........20....--...--.30........40........50..--...--...60........70........80........90........100.......---------------------110--------------------........-------120-------.-------.......130.......140.......150.......160.......-170.......180.......190.......200.......210.......220..-.....230.......240....-...250.......260------......---------...270.......-----------280.......290.-......300..-...--...310.......320.......330-.......340.......350.......360--------.....----------....370....--.-.-.-380.......390.......400.......410.----......420.......430.....-..440.......450.......460.......470.......480.......490.......500.......510.......520.......530...--.--...540-----------------.......550..-..--...-560....-----..--------.--570..--.......580......-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MAE
K
H
--
L
I
V
VGG
G
L
A
G
L
M
S
T
I
K
A
AEK--GA
H
--
V
D
L
F
S
VVPVKRSH
S
V
C
AQGGINGAV--NTK--GEGDS
P
W
I
H
FDDTVYGGDFLANQP
P
V
K
A
M
T
E
A
A
P
K
I
I
H
L
L
D
R
M
G
V
M
FNRTNE
G
---------------------
L
L
---------------------
D
F
R
R
FGGT-------LH--------H-------
R
T
AYAGA
T
T
G
Q
Q
L
L
Y
A
L
D
E
Q
V
R
A
Y
EVD
G
L
V
T
KYEG
W
E
F
L
G
I
V
KGDDD-SAR
G
I
V
AQNM
T
T
A
E
I
ETFGS
D
A
V
I
M
ATGGP
G
I
I
FGKTTNSMINTGS
A
A
S
I
V
Y
QQ
G
-
A
I
Y
ANG
E
F
I
Q
I
HPTAIPG
D
D
K
L
-
R
L
M
S
E
SARGEG
G
R
I
--------
W
T
YKDG---------K
P
W
Y
F
L
EEKYPDY-----------GNLVPR
D
I
A
T
R
E
I
F
-
D
V
C
INQK-LGI-NGE--
N
M
V
Y
L
DLSHKDP
H
E
L
D
V
KL
G
G
I
I
E
I
Y
-
E
K
FTGDDPRKV
P
M
K
I
F
P
A
V
H
YSMG
G
L
Y
V
----------DYDQM----------TNI
K
G
L
F
AAGE--C-D-F-SQHGGNRL
G
A
N
S
L
L
S
A
I
YGGTVAGP
N
A
I
D
Y
I
S
N
I----DRSYTD
M
D
E
S
I
F
E
K
R
K
A
E
E
Q
E
R
F
D
-
K
L
L
A
MRGT
E
N
A
Y
K
L
H
R
E
L
G
E
I
MTA
N
V
T
V
V
RE
N
E
K
L
L
E
T
D
K
K
I
V
E
L
M
K
R
YEDIDMEDTQTWSN
Q
A
V
F
F
T
R
Q
L
W
N
M
L
V
L
A
R
V
I
T
I
G
AYNRNESRGAHYKP--E--FPER
N
D
-----------------
E
E
W
L
K
T
T
M
A
S
F
Q
-GA--FEK-PQFTYDD-----V
D
--------
V
--S--LI--PPRKRDYTSKSKGGKK-------------------------------------------------
99
Fugue
90.81
33%
-65
- C3 -
1L0V
2
FRDA_ECOLI
A:
[1-577]
M
Q
T
F
Q
A
D
--
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
--
N
P
N
A
K
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
-----
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
---
P
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
D
D
--G
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
---
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
KNGYRY
L
Q
D
Y
G
M
---------
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
-
H
E
W
R
K
G
N
T
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
-
S
-
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
----
N
G
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
DE
G
--
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
F
R
D
-
A
D
---
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
81
HHSearch
89.27
32%
-57
- C3 -
2WDQ
4
SDHA_ECOLI
A:
[6-588]
---
R
E
F
D
--
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
Q
T
--
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
--
G
N
T
---
H
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
---------------------
Y
Q
R
P
F
G
G
Q
SKNFGG
E
Q
A
--------
A
-------
R
T
A
A
A
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
N
L
K
N
----
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
-
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
---
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
--------
L
N
K
------------
H
G
E
R
F
M
E
R
Y
A
P
N
A
-----------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
-
I
E
I
R
E
G
R
-
G
C
D
G
P
W
G
--
P
H
A
K
L
K
L
D
H
L
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
T
F
A
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
----------
K
V
T
G
Q
A
L
T
V
N
EKG
E
D
V
V
V
P
G
L
F
A
V
G
E
--
I
-
A
-
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
----
G
A
L
R
-
D
A
-
S
--
E
S
D
V
E
A
--
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
S
S
E
F
N
T
Q
R
V
E
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
--
D
--
F
P
D
R
D
D
-----------------
E
N
W
L
C
H
S
L
Y
L
P
E
-
S
---
E
----
S
M
T
R
R
S
V
NMEP
K
L
--------
R
--
P
--
A
F
--
P
P
K
I
R
T
Y
----------------------------------------------------------
3
PsiBlast_PDB
89.03
30%
-56
- C3 -
2BS3
3
FRDA_WOLSU
A:
[9-600]
----------
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G-
N
S
K
M-
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
MAIINAQK
T
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
----
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
--
P
L
F
P
S
G
-
I
L
L
T
E
G
C
R
G
D
G
G
I
L
-----------
R
D
V
---------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
-
I
R
K
G
-
K
G
V
-
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
C
W
-
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
--
E
Q
T
L
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
EM
E
I
--
A
P
G
Y
R
G
Y
G
A
K
-------------------------------------------------------
5
PsiBlast_PDB
88.95
30%
-56
- C3 -
2BS2
3
FRDA_WOLSU
A:
[9-600]
----------
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G-
N
S
K
M-
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
MAIINAQK
T
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
----
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
--
P
L
F
P
S
G
-
I
L
L
T
E
G
C
R
G
D
G
G
-----------
I
L
R
D
V
---------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
-
I
R
K
G
-
K
G
V
-
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
C
W
-
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
--
E
Q
T
L
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
EM
E
I
--
A
P
G
Y
R
G
Y
G
A
K
-------------------------------------------------------
79
HHSearch
88.93
33%
-67
* C3 *
1KF6
5
FRDA_ECOLI
A:
[4-577]
---
F
Q
A
D
--
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
NP
N
A
K
--
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
-------
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
D
-
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
--
G
-
I
L
M
T
E
G
C
R
G
E
G
G
I
L
--------
V
N
K
------------
N
G
Y
R
Y
L
Q
D
Y
G
M
G
P
ETPLG
E
P
K
N
KY
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
-
H
E
W
R
K
G
N
-
T
I
S
T
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
K
A
Y
-
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
-
S
-
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
N
-
E
--
A
A
I
E
A
Q
A
A
G
--
V
E
Q
R
L
K
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
F
R
D
-
A
D
--
G
T
--
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
100
Fugue
88.85
31%
-55
- C3 -
1E7P
1
FRDA_WOLSU
A:
[1-655]
--
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
GN
S
K
M
--
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
IINAQKT
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
----
S
I
Q
D
R
K
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
---
I
L
L
T
E
G
C
R
G
D
G
G
I
L
--------
R
D
V
D
G
H
---------
R
---
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
I
R
K
G
K
G
V
Q
S
-
P
Y
G
--
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
-
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
--
Q
T
L
-
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
--
E
M
EI
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
GKD
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
AKYKARNERLGD
1
PsiBlast_PDB
88.54
30%
-56
- C3 -
1QLB
3
FRDA_WOLSU
A:
[9-600]
----------
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G-
N
S
K
M-
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
IINAQKT
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
----
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
--
P
L
F
P
S
G
-
I
L
L
T
E
G
C
R
G
D
G
G
I
L
-----------
R
D
V
---------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
-
I
R
K
G
-
K
G
V
-
Q
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P
Y
G
Q
H
L
W
L
D
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I
L
G
R
K
H
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L
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D
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Q
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C
-
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F
A
G
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P
A
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W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
C
W
-
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
S
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
--
E
Q
T
L
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
EM
E
I
--
A
P
R
Y
R
G
Y
G
A
K
-------------------------------------------------------
80
HHSearch
88.50
31%
-56
- C3 -
2H88
4
SDHA_CHICK
A:
[17-621]
---
H
E
F
D
--
A
V
V
V
G
A
G
G
A
G
L
R
A
A
F
G
L
S
E
A
--
G
F
N
--
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
--
G
N
M
---
E
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
---------------------
K
I
---------------------
Y
Q
R
A
F
G
G
Q
-------
S
L
QFGKGGQA
H
-------
R
C
C
C
V
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
S
L
R
Y
----
D
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
-
N
G
-
E
C
R
G
V
I
A
L
C
I
E
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
-
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
A
--
G
-
C
L
I
T
E
G
C
R
G
E
G
G
I
L
--------
I
N
S
------------
Q
G
E
R
F
M
E
R
Y
A
P
V
A
-----------
K
D
L
A
S
R
D
V
V
S
R
S
M
T
-
I
E
I
R
E
G
R
-
G
C
G
-
P
E
K
--
D
H
V
Y
L
Q
L
H
H
L
P
P
Q
Q
L
A
T
R
L
P
G
I
S
E
T
A
M
I
F
-
A
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
----------
N
Y
K
G
Q
V
I
T
H
V
NG
E
D
-
K
V
V
P
G
L
Y
A
C
G
E
--
A
-
A
-
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
----
E
P
V
-
P
S
I
K
P
---
N
A
G
E
E
--
S
V
A
N
L
D
K
L
R
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
A
H
L
K
T
F
D
R
G
I
V
W
N
T
D
L
V
E
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
--
D
--
Y
K
L
R
I
D
EFDYSKPLQG
Q
Q
K
R
P
FE
E
H
W
R
K
H
T
L
S
Y
V
D
-
V
K
S-
G
K
--
V
T
L
K
Y
R
P
-----
V
I
DRTLNEED
C
--
S
--
S
V
--
P
P
A
I
R
S
Y
----------------------------------------------------------
4
PsiBlast_PDB
88.46
30%
-56
- C3 -
2BS4
3
FRDA_WOLSU
A:
[9-600]
----------
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G-
N
S
K
M-
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
I
INAQK
T
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
----
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
--
P
L
F
P
S
G
-
I
L
L
T
E
G
C
R
G
D
G
G
I
L
-----------
R
D
V
---------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
-
I
R
K
G
-
K
G
V
-
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
C
W
-
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
--
E
Q
T
L
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
EM
E
I
--
A
P
G
Y
R
G
Y
G
A
K
-------------------------------------------------------
2
PsiBlast_PDB
88.36
30%
-57
- C3 -
1E7P
1
FRDA_WOLSU
A:
[9-600]
----------
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G-
N
S
K
M-
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
IINAQKT
T
I
T
E
E
DFRHG
L
I
---------------------
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
----
E
A
I
A
L
I
H
-
Q
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
--
P
L
F
P
S
G
-
I
L
L
T
E
G
C
R
G
D
G
G
I
L
-----------
R
D
V
---------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
-
I
R
K
G
-
K
G
V
-
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
C
W
-
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
-------
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
-
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
--
E
Q
T
L
P
T
L
E
Y
E
A
-----
L
D
--------
V
--
N
EM
E
I
--
A
P
G
Y
R
G
Y
G
A
K
-------------------------------------------------------
78
HHSearch
88.06
31%
-58
- C3 -
2BS2
3
FRDA_WOLSU
A:
[4-602]
---
Q
Y
C
D
--
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
L
S
--
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
--
G
N
S
KM
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---------------------
D
R
MAIINAQK
T
T
I
T
E
E
DFRHG
L
I
H
S
R
D
F
G
G
T
-------
K
K
--------
W
-------
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
----
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
H
Q
-
D
G
-
K
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
---
I
L
L
T
E
G
C
R
G
D
G
G
I
L
--------
R
D
V
------------
D
G
H
R
F
M
P
D
Y
E
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
-
E
H
I
R
K
G
K
-
G
V
Q
S
P
Y
G
--
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
-
E
Y
F
A
G
I
D
P
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
----------
D
Y
R
G
E
----------
A
K
L
K
G
L
F
S
A
G
E
--
A
-
A
-
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
----
Q
V
D
L
E
-
T
-
K
T
L
E
K
F
V
K
G
--
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
--
D
--
Y
P
K
R
D
D
-----------------
I
N
W
L
N
R
T
L
A
S
W
P
-
N
P
EQ
T
L
--
P
T
L
E
Y
E
A
-----
L
D
--------
V
NE
M
--
E
I
--
A
P
G
Y
R
G
Y
G
A
K
G
N
-----------------------------------------------------
9
PsiBlast_PDB
85.51
33%
-54
- C3 -
1L0V
2
FRDA_ECOLI
A:
[33-577]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
8
PsiBlast_PDB
85.37
33%
-51
- C3 -
1KFY
2
FRDA_ECOLI
A:
[33-577]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
23
PsiBlast_CBE
85.10
33%
-51
- C3 -
1KFY
2
FRDA_ECOLI
M:
[33-577]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
7
PsiBlast_PDB
85.03
33%
-53
- C3 -
1KF6
5
FRDA_ECOLI
A:
[33-577]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
26
PsiBlast_CBE
84.65
32%
-52
- C3 -
4KX6
1
FRDA_ECOLI
M:
[33-576]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
---------------------------------------------------------------
14
PsiBlast_PDB
84.51
32%
-52
- C3 -
4KX6
1
FRDA_ECOLI
A:
[33-576]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
---------------------------------------------------------------
12
PsiBlast_PDB
84.51
32%
-51
- C3 -
3P4Q
2
FRDA_ECOLI
A:
[33-576]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
---------------------------------------------------------------
24
PsiBlast_CBE
84.35
33%
-49
- C3 -
1KF6
4
FRDA_ECOLI
M:
[33-577]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
A
--------------------------------------------------------------
28
PsiBlast_CBE
84.21
32%
-48
- C3 -
3P4R
2
FRDA_ECOLI
M:
[33-576]
------------------------------------
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
---
S
A
--
A
V
A
--
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---------------------
S
V
---------------------
N
V
R
R
F
G
G
M
-------
K
I
--------
E
-------
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
---
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
V
-
D
D
G
-
H
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
---
M
T
E
G
C
R
G
E
G
G
-
I
--------
L
V
N
K
N
G
YRYLQDYGM
G
P
E
T
P
L
G
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
-
I
S
T
-
P
R
G
--
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
A
Y
V
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
----------
D
Q
N
C
E
----------
T
R
I
K
G
L
F
A
V
G
E
--
C
S
S
-
V
-
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
----
G
N
G
----
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
-
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
--
D
EG
C
T
E
R
D
D
-----------------
V
N
F
L
K
H
T
L
A
-
F
R
-
D
A
--
D
G
T
-
T
R
L
E
Y
S
D
-----
V
K
--------
I
--
T
--
T
L
--
P
P
---------------------------------------------------------------
16
PsiBlast_PDB
80.44
31%
-51
- C3 -
1NEN
3
SDHA_ECOLI
A:
[24-558]
-----------------------
L
Q
I
S
Q
S
--
G
Q
T
--
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
--
G
N
T
--
H
E
D
N
W
E
W
-
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
---------------------
Y
Q
R
P
F
G
G
Q
-------
S
K
--------
N
F
G
GEQAA
R
T
A
A
A
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
----
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
-
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
V
---
L
V
T
E
G
C
R
G
E
G
G
Y
L
--------
L
N
-
K
H
G
---------
E
--
R
F
M
E
R
Y
A
P
N
A
-----------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
--
I
E
I
R
E
G
-
R
G
C
-
D
G
P
WG
P
H
A
K
L
K
L
D
H
L
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
T
F
A
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
VTG
Q
A
L
T
V
N
E
K
G
E
D
----------
V
V
V
P
G
L
F
A
V
G
E
IA
C
---
V
-
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
L
R
D
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
-
D
P
V
A
I
R
---------
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
S
S
E
F
N
T
Q
R
V
E
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
--
D
--
F
P
D
R
D
D
-----------------
E
N
W
L
C
H
S
L
--------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.31
31%
-50
- C3 -
1NEK
3
SDHA_ECOLI
A:
[24-558]
-----------------------
L
Q
I
S
Q
S
--
G
Q
T
--
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
--
G
N
T
--
H
E
D
N
W
E
W
-
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
---------------------
Y
Q
R
P
F
G
G
Q
-------
S
K
--------
N
F
G
GEQAA
R
T
A
A
A
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
----
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
-
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
V
---
L
V
T
E
G
C
R
G
E
G
G
Y
L
--------
L
N
-
K
H
G
---------
E
--
R
F
M
E
R
Y
A
P
N
A
-----------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
--
I
E
I
R
E
G
-
R
G
C
-
D
G
P
WG
P
H
A
K
L
K
L
D
H
L
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
T
F
A
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
VTG
Q
A
L
T
V
N
E
K
G
E
D
----------
V
V
V
P
G
L
F
A
V
G
E
IA
C
---
V
-
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
L
R
D
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
-
D
P
V
A
I
R
---------
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
S
S
E
F
N
T
Q
R
V
E
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
--
D
--
F
P
D
R
D
D
-----------------
E
N
W
L
C
H
S
L
--------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.58
31%
-51
- C3 -
2ACZ
2
SDHA_ECOLI
A:
[24-558]
-----------------------
L
Q
I
S
Q
S
--
G
Q
T
--
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
--
G
N
T
--
H
E
D
N
W
E
W
-
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
---------------------
R
I
---------------------
Y
Q
R
P
F
G
G
Q
-------
S
K
--------
N
F
G
GEQAA
R
T
A
A
A
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
----
N
L
K
N
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
-
A
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
V
---
L
V
T
E
G
C
R
G
E
G
G
Y
L
--------
L
N
-
K
H
G
---------
E
--
R
F
M
E
R
Y
A
P
N
A
-----------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
--
I
E
I
R
E
G
-
R
G
C
-
D
G
P
WG
P
H
A
K
L
K
L
D
H
L
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
T
F
A
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
KVTG
Q
A
L
T
V
N
E
K
G
E
D
----------
V
V
V
P
G
L
F
A
V
G
E
IA
C
---
V
-
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
L
R
D
A
S
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
-
D
P
V
A
I
R
---------
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
S
S
E
F
N
T
Q
R
V
E
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
--
D
--
F
P
D
R
D
D
-----------------
E
N
W
L
C
H
S
L
--------------------------------------------------------------------------------------------------------------