@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1028: (2016-03-21 )
MEEHYYVSIDIGSSSVKTIVGEKFHNGINVIGTGQTYTSGIKNGLIDDFDIARQAIKDTIKKASIASGVDIKEVFLKLPIIGTEVYDESNEIDFYEDTEINGSHIEKVLEGIREKNDVQETEVINVFPIRFIVDKENEVSDPKELIARHSLKVEAGVIAIQKSILINMIKCVEACGVDVLDVYSDAYNYGSILTATEKELGACVIDIGEDVTQVAFYERGELVDADSIEMAGRDITDDIAQGLNTSYETAEKVKHQYGHAFYDSASDQDIFTVEQVDSDETVQYTQKDLSDFIEARVEEIFFEVFDVLQDLGLTKVNGGFIVTGGSANLLGVKELLSDMVSEKVRIHTPSQMGIRKPEFSSAISTISSSIAFDELLDYVTINYHDNEETEEDVIDVKDKDNESKLGGFDWFKRKTNKKDTHENEVESTDEEIYQSEDNHQEHKQNHEHVQDKDKDKEESKFKKLMKSLFE
Atome Classification :
(20 SA)
.........10........20........30........40-------........50....--....60........70----.....-....80-........--------.90...---...-----..100.......110.......--120.......130.......140.......150.......160..----.....170.----......180.......-190-------.-.--..-....200.......210.......220..-----.....230........240.....-------------------..250.......260.......270...--.--...280.......290.......300-----.........310.--......320.-......330.......340---------------------------.......350------------....-----....360.......370.......-------380......--------------.390.......400.......410.......420.......430.......440.......450.......460.......470----------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
E
H
Y
Y
V
S
I
D
IGS
S
S
V
K
T
I
V
G
E
K
FHN
G
I
N
V
I
GTG
Q
T
Y
T
S
G
I-------KNGLI
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
ASIASG
V
D
-----
I
K
E
V
F
-
L
KLPI--I
G
T
E
VYDE--------SNEIDF---YED-----TEI
N
G
S
H
I
E
K
V
L
E
G
I
R
EKNDVQ--ET
E
V
I
N
V
F
P
I
R
F
I
V
DKENEVS
D
P
K
E
L
I
A
R
HSLKVE
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
CG
V
D
V
L
D
V
Y
SDAYNY-GS--------
I
-
L
--
T
A
-
T
E
KEL
G
A
C
V
I
DIGE
D
V
T
Q
V
A
F
YERGELVD-----AD
S
I
EMA-GR
D
I
T
D
D
I
A
Q
G
LNTS
Y
-------------------
E
T
A
E
K
V
K
H
Q
YGHAFYDSASDQ
D
I
F
T
V
EQ--V--DSD
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
DLGL--
T
K
VNG
G
F
I
V
T-GGS
A
N
L
L
G
V
K
E
L
L
S
D
M
V
SE---------------------------
K
V
R
IHT
P
S
Q-------------MGIR-----KP
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
Y
V
-------
T
I
N
YHDNEE--------------TEE
D
V
I
DVKDKDNESKLG
G
F
D
W
F
K
RKTNKKDTHENEVE
S
T
D
E
E
I
YQSEDN
H
Q
E
H
K
Q
N
H
E
HVQDKDK
D
K
E
E
S
K
F
K
K
L
M
K
S
LFE------------------------------------------------------------------------------
3
PsiBlast_PDB
98.02
100%
-95
- C2 -
3WT0
1
FTSA_STAAW
A:
[20-395]
-
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
97.69
100%
-96
- C2 -
3WT0
2
FTSA_STAAW
C:
[22-395]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
97.53
100%
-95
- C2 -
3WT0
2
FTSA_STAAW
D:
[21-398]
--
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
Y
V
-------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
97.34
100%
-93
- C2 -
3WT0
1
FTSA_STAAW
B:
[20-395]
-
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.28
99%
-96
- C2 -
3WQT
4
FTSA_STAAR
A:
[20-393]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.74
99%
-96
- C2 -
3WQU
1
FTSA_STAAR
C:
[20-393]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.51
99%
-96
- C2 -
3WQU
1
FTSA_STAAR
A:
[20-393]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
96.47
97%
-95
- C2 -
3WT0
1
FTSA_STAAW
A:
[20-395]
-
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
IG
T
E
V
Y
D
E
S
----------
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
--------
L
-
T
--
A
--
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
96.12
99%
-94
- C2 -
3WQU
1
FTSA_STAAR
B:
[20-393]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
---
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.93
99%
-95
- C2 -
3WQU
1
FTSA_STAAR
D:
[21-393]
----
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
95.74
95%
-95
- C2 -
3WQT
4
FTSA_STAAR
A:
[20-393]
---
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
-
L
K
L
P
I
IG
T
E
V
Y
D
E
S
N
----------
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
--------
L
-
T
--
A
--
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
D
Q
D
I
F
T
V
E
Q
--
V
--
D
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
Q
-------------
M
G
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.19
99%
-106
- C2 -
3WQT
2
FTSA_STAAR
B:
[22-393]
-----
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
-------
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
-------
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
--
I
K
D
T
I
K
K
A
S
I
A
---
D
-----
I
K
E
V
F
-
L
K
L
P
I
--
I
G
T
E
V
Y
D
E
--------
S
N
E
I
D
F
---
Y
E
D
-----
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
--
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
----
L
I
N
M
I
K
C
V
E
----
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
-
G
S
--------
I
-
L
--
T
A
-
T
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
G
E
L
V
D
-----
A
D
S
I
E
M
A
-
G
R
D
I
T
D
D
I
A
Q
G
L
N
T
S
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
-------------------------
T
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
G
L
--
T
K
V
N
G
G
F
I
V
T
-
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
---------------------------
K
V
R
I
H
T
P
S
----------------
I
R
-----
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
62.94
19%
-54
- C2 -
1E4F
-
?
T:
[7-390]
--
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
-------
D
E
G
E
I
K
D
A
I
A
F
K
E
S
--
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
R
S
D
--
F
V
I
S
F
--
S
S
V
S
F
E
R
E
--------
D
T
V
I
E
R
DFG
E
E
K
-----
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
--
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
I
A
I
E
Y
T
S
I
V
V
P
L
K
V
----
Y
E
M
F
Y
N
F
L
Q
----
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
-
A
E
--------
G
V
L
--
T
T
-
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
-----
I
S
Y
V
P
V
G
-
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
-------------------
E
E
S
E
R
L
I
I
T
H
G
N
A
-
V
Y
N
D
L
K
E
E
E
I
Q
Y
R
G
--
L
--
D
G
N
T
I
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
-------
M
S
K
S
K
K
F
F
R
E
V
E
A
K-
I
G
I
P
G
G
V
V
L
T
-
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
---------------------------
P
V
R
T
G
C
Y
A
N
-------------
S
----------------------------------------------------------------------------------------------------------------------
D
R
P
S
I
I
N
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
N
V
F
A
------------------------------------------------------------------------------
6
PsiBlast_PDB
62.73
23%
-69
- C2 -
4A2B
2
?
A:
[9-357]
----
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
-------
D
E
G
E
I
K
D
A
I
A
F
K
E
S
--
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
R
S
D
F
V
I
S
F
S
S
--
V
S
F
E
R
E
D
T
--------
V
I
E
R
D
F
---
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
------
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
--------
L
D
M
K
A
S
K
I
A
I
E
Y
T
S
----
I
V
V
P
L
K
V
Y
E
----
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
-
K
S
S
L
V
S
T
A
E
G
V
-
L
--
T
T
-
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
-----
I
S
Y
V
P
V
G
-
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
-------------------
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
K
E
E
E
I
-
Q
Y
R
G
--
L
--
D
G
N
T
I
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
I
V
E
E
G
E
--
I
G
I
P
G
G
V
V
L
T
-
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
---------------------------
P
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.50
23%
-73
- C2 -
1E4F
-
?
T:
[9-357]
----
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
-------
D
E
G
E
I
K
D
A
I
A
F
K
E
S
--
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
R
S
D
F
V
I
S
F
S
S
--
V
S
F
E
R
E
D
T
--------
V
I
E
R
D
F
---
G
E
E
KRSIT
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
------
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
--------
L
D
M
K
A
S
K
I
A
I
E
Y
T
S
----
I
V
V
P
L
K
V
Y
E
----
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
-
K
S
SLVSTAEG
V
-
L
--
T
T
-
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
-----
I
S
Y
V
P
V
G
-
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
-------------------
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
K
E
E
E
I
-
Q
Y
R
G
--
L
--
D
G
N
T
I
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
MSKSKKF
F
R
E
V
E
A
K
--------
I
G
I
P
G
G
V
V
L
T
-
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
---------------------------
P
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.92
23%
-73
- C2 -
1E4G
2
?
T:
[9-357]
----
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
-------
D
E
G
E
I
K
D
A
I
A
F
K
E
S
--
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
R
S
D
F
V
I
S
F
S
S
--
V
S
F
E
R
E
D
T
--------
V
I
E
R
D
F
---
G
E
E
KRSIT
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
------
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
--------
L
D
M
K
A
S
K
I
A
I
E
Y
T
S
----
I
V
V
P
L
K
V
Y
E
----
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
-
K
S
SLVSTAEG
V
-
L
--
T
T
-
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
-----
I
S
Y
V
P
V
G
-
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
-------------------
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
K
E
E
E
I
-
Q
Y
R
G
--
L
--
D
G
N
T
I
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
MSKSKKF
F
R
E
V
E
A
K
---------
G
I
P
G
G
V
V
L
T
-
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
---------------------------
P
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.33
23%
-69
- C2 -
4A2A
2
?
A:
[9-357]
----
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
----
W
E
A
L
A
F
S
S
V
K
S
R
G
L
-------
D
E
G
E
I
K
D
A
I
A
F
K
E
S
--
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
R
S
D
F
V
I
S
F
S
S
--
V
S
F
E
R
E
D
T
--------
V
I
E
R
D
F
---
G
E
E
K
R
S
IT
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
------
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
--------
L
D
M
K
A
S
K
I
A
I
E
Y
T
S
----
I
V
V
P
L
K
V
Y
E
----
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
-
K
S
S
L
V
S
T
A
E
G
V
-
L
--
T
T
-
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
-----
I
S
Y
V
P
V
G
-
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
-------------------
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
K
E
E
E
I
-
Q
Y
R
G
--
L
--
D
G
N
T
I
K
T
T
T
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
----------
I
P
G
G
V
V
L
T
-
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
---------------------------
P
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
56.61
17%
-74
* C2 *
2YCH
3
?
A:
[11-374]
-
P
R
V
E
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
G
N
P
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
-------
M
E
G
M
V
A
E
P
A
A
L
A
Q
E
--
I
K
E
L
L
L
E
----
A
R
T
R
-----
K
R
Y
V
V
-
T
A
L
S
N
--
L
A
V
I
L
R
------------
P
I
Q
V
---
P
--------
K
M
P
L
K
E
M
E
E
A
V
R
W
E
A
E
R
Y
I
P
F
PI-
E
V
V
L
D
F
A
P
L
T
P
L
S
E
V
Q
-----------
E
-
G
E
Q
V
Q
V
M
V
A
A
A
R
Q
E
A
----
V
A
G
V
L
E
A
L
R
----
G
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
--------
L
-
E
A
R
L
A
-
E
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
G
D
K
P
L
A
-----
V
R
V
L
T
L
S
-
G
K
D
F
T
E
A
I
A
R
S
F
N
L
D
L
-------------------
L
A
A
E
E
V
K
R
T
Y
---------------------------------
G
R
I
Y
D
A
I
R
P
V
L
V
E
L
-------
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L--
S
P
E
V
G
Y
L
L
-
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
---------------------------
N
L
E
P
V
N
P
W
E
A
V
A
V
D
PKRFE
S
E
Q
L
Q
E
I
-----
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
51.06
17%
-17
- C2 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
----
T
P
F
G
L
D
L
G
N
N
--
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
SN
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
YHHPD
F
E
Q
E
S
-
K
H
F
T
S
--
K
L
V
E
L
D
D
K
K
T
G
A
E
V
RF
A
G
E
K
H
V
---
F
S
A
-----
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
--
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
----
G
I
F
K
T
D
L
P
E
GE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
--
S
--------
I
-
M
--
A
F
-
K
K
G
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
-----
A
D
E
F
K
T
K
Y
K
I
D
I
R
E
N
-
P
K
A
Y
N
R
I
L
-------------------
T
A
A
E
K
L
K
K
V
L
------
S
A
N
T
N
A
P
F
S
V
E
S
--
V
MN
D
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
-------
T
E
P
V
T
K
A
L
A
Q
A
K
L
--
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
P
L
S
TTLNQDE
A
I
A
K
G
A
A
F
I
C
A
IHSR
P
F
K
F
E
D
I
H
P
Y
S
-------------
V
S
Y
S
W
DKQV
E
D
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
LPPNTPEQI
A
N
W
E
I
T
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
E
D
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
EEYAPFAS
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEGFDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
37
HHSearch
47.39
19%
-63
- C2 -
3QFU
3
GRP78_YEAST
A:
[153-393]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
----
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
--------
Y
-
G
--
L
D
K
S
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
N
G
V
F
EVQ
A
T
S
G
D
T
H
L
G
-
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
------
T
R
I
E
I
D
S
FV
D
--
G
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
-------
L
K
P
V
E
K
V
L
Q
D
S
G
L
E-
K
K
D
V
D
D
I
V
L
V
-
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K--------------------------
K
A
S
K
G
--------------------
I
-----
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------