@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1036: (2016-03-21 )
MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQHPFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRQDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETVNHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLETRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVHLADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNASEFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVDELTHLCPRCQQVVKSLV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100--.....----...-.110-------.-------..--...----.---120.......130.......140.......150....--...160.......170.......180.......190..-----....--.--200.----------.--..-------....210.....------..--------------------------220.......230.......240.......250....----.--..260.......270.......280.......290.....----..300---.---......310.......320.......330....----------...340...---.------...350------.......-----------------------.--.--360.......370.......380.......390.......400.......410.....--..420......--.430..---..-----.--.-.440.......450.......460...---....-470.......480.--...------...490.........500....-...----510------...-----------.-....520.......530-------.---....-------------..-----540--.----------.------..------.---...550......------.560-----.......570..-.....580.......--------590--------------------------------------------...-------------------------...--------------------...600.......610.......620-..-.-.-...----630.......640-.-----.......650.......660...-....670.-...-...680.......690.......700.......710.......720.......730.......740.......750.......760.......770----------...----.----....780.....--..790.......800.......810.......820.......-----830--......--.840.......850..-----.....860.......870.......880....----...890.......900.......910.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
Y
K
E
TLLMPKTDFPMRGGLPNKEP
Q
I
Q
E
KWDA
E
D
Q
Y
H
K
A
L
E
KNKGN
E
T
F
I
LHDGPPYANG
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
TMQGFYAPYVPGWDTHGL
P
----
I
E
Q
A
L
----
T
KK-GVDR-------K-------KM--
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
RLGVRGDFND
P
Y
I
T
LK--PEYE
A
A
Q
I
R
I
F
G
EMADK
G
L
I
YKGKK
P
V
Y
WSPSSESSLA-----
E
A
E
I
--
E
--
Y
H-D----------K--R
S
-------
A
S
I
Y
V
A
F
DVKDD------K
G
--------------------------
V
VDADA
K
F
I
I
W
TTTPWTIPS
N
V
A
I
T
V
HPELKY
G
Q
Y
NV----N--G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
LDWDK
A
S
I
K
L
EKEYTG
K
E
L
E
Y
V
V
----
A
QHPF---L---DRE
S
L
V
ING
D
H
VTTDAGTG
C
V
HTAPGHGEDD
Y
I
----------VG
Q
K
YELPV---I------SPID--------DKGVFTE-----------------------E--G--GQFE
G
M
F
YDKA
N
K
A
V
T
D
L
L
TEKG
A
L
L
K
L
D
F
ITHSYPHDWRTKK
P
V
I
F
RA
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E--NT
N
F
K
V
---NW-----G--
K
-
T
R
I
Y
N
M
V
R
DRG
E
W
V
I
SRQRVWGVPL
P
V
---
F
Y
AE-N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
EH--GSN
I
W
F
ER
E
A
K
D
LLPE-GFT----HP-------GSP-----------N-GTFTKET
D
I
M
D
V
W
FDSG-------S---SHRG-------------VL-----ET---R----------P------EL------S---FPA
D
M
Y
LEGSD
Q
------
Y
R
G
W-----FNSSI
T
T
S
V
A
TR-GV
S
P
Y
K
F
L
L
SHG
F
V
M--------D----------------------------------------------GEG-------------------------
K
K
M
--------------------
S
K
S
LGNVIV
P
D
Q
V
V
K
QKGA
D
I
A
R
L
WV-SS-T-D-
Y
L
A
----
D
V
RI
S
D
E
I
L
K
Q
-
T
-
S
-----
D
V
Y
R
K
I
R
N
T
L
R
F
M
LGNINDFNPD-TDSI
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
INNYEN
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
LDYG
K
D
I
L
Y
I
EQR
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
SHT-----------PHV----K----EESVHLADM
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
ARNEKVIGKSL
E
A
K
V
-----
T
I
A--SNDKF
N
--
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
KLDDQATAYEHG
D
I
V
I
EHAD
G
E
K
C
----
E
R
C
WNY
S
E
D
LG
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
LV
76
Fugue
99.66
99%
-84
- C2 -
1QU2
5
SYI1_STAAU
A:
[1-917]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
----
T
K
K
-
G
V
D
R
-------
K
-------
K
M
--
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
-----
E
A
E
I
--
E
--
Y
H
-
D
----------
K
--
R
S
-------
A
S
I
Y
V
A
F
N
V
K
D
D
------
K
G
--------------------------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
--
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
Y
T
G
K
E
L
E
W
V
V
----
A
Q
H
P
F
---
L
---
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
P
V
---
I
------
S
P
I
D
--------
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
V
---
N
W
-----
G
--
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
-
N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
E
H
--
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
----
H
P
-------
G
S
P
-----------
N
-
G
T
F
T
K
E
T
D
I
M
D
V
W
F
D
S
G
-------
S
---
S
H
R
G
-------------
V
L
-----
E
T
---
R
----------
P
------
E
L
------
S
---
F
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
W
-----
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
--------
D
----------------------------------------------
G
E
G
-------------------------
K
K
M
--------------------
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
-
S
S
-
T
-
D
-
Y
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
-
S
-----
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
-
T
D
S
I
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
-----------
P
H
V
----
K
----
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
-----
T
I
A
--
S
N
D
K
F
N
--
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
----
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
3
PsiBlast_PDB
99.57
99%
-84
- C2 -
1FFY
5
SYI1_STAAU
A:
[1-917]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
----
T
K
K
-
G
V
D
R
-------
K
-------
K
M
--
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
-----
E
A
E
I
--
E
--
Y
H
-
D
----------
K
--
R
S
-------
A
S
I
Y
V
A
F
N
V
K
D
D
------
K
G
--------------------------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
--
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
Y
T
G
K
E
L
E
W
V
V
----
A
Q
H
P
F
---
L
---
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
P
V
---
I
------
S
P
I
D
--------
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
V
---
N
W
-----
G
--
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
-
N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
E
H
--
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
----
H
P
-------
G
S
P
-----------
N
-
G
T
F
T
K
E
T
D
I
M
D
V
W
F
D
S
G
-------
S
---
S
H
R
G
-------------
V
L
-----
E
T
---
R
----------
P
------
E
L
------
S
---
F
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
W
-----
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
--------
D
----------------------------------------------
G
E
G
-------------------------
K
K
M
--------------------
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
-
S
S
-
T
-
D
-
Y
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
-
S
-----
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
-
T
D
S
I
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
-----------
P
H
V
----
K
----
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
-----
T
I
A
--
S
N
D
K
F
N
--
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
----
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
1
PsiBlast_PDB
99.57
99%
-84
- C2 -
1QU2
5
SYI1_STAAU
A:
[1-917]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
----
T
K
K
-
G
V
D
R
-------
K
-------
K
M
--
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
-----
E
A
E
I
--
E
--
Y
H
-
D
----------
K
--
R
S
-------
A
S
I
Y
V
A
F
N
V
K
D
D
------
K
G
--------------------------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
--
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
Y
T
G
K
E
L
E
W
V
V
----
A
Q
H
P
F
---
L
---
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
P
V
---
I
------
S
P
I
D
--------
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
V
---
N
W
-----
G
--
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
-
N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
E
H
--
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
----
H
P
-------
G
S
P
-----------
N
-
G
T
F
T
K
E
T
D
I
M
D
V
W
F
D
S
G
-------
S
---
S
H
R
G
-------------
V
L
-----
E
T
---
R
----------
P
------
E
L
------
S
---
F
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
W
-----
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
--------
D
----------------------------------------------
G
E
G
-------------------------
K
K
M
--------------------
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
-
S
S
-
T
-
D
-
Y
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
-
S
-----
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
-
T
D
S
I
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
-----------
P
H
V
----
K
----
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
-----
T
I
A
--
S
N
D
K
F
N
--
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
----
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
52
HHSearch
98.47
98%
-81
- C2 -
1FFY
5
SYI1_STAAU
A:
[1-917]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
----
T
K
K
-
G
V
D
--------
R
-------
K
K
M-
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
-----
E
A
E
I
--
E
--
Y
H
-
D
----------
K
--
R
S
-------
A
S
I
Y
V
A
F
N
V
K
D
D
------
K
G
--------------------------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
--
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
Y
T
G
K
E
L
E
W
V
V
----
A
Q
H
P
F
---
L
---
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
P
V
---
I
------
S
P
I
D
--------
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
V
---
N
W
-----
G
--
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
-
N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
E
H
--
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
----
H
P
-------
G
S
P
-----------
N
-
G
T
F
T
K
E
T
D
I
M
D
V
W
F
D
S
G
-------
S
---
S
H
R
G
-------------
V
L
-----
E
T
---
R
----------
P
------
E
L
------
S
---
F
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
W
-----
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
--------
D
----------------------------------------------
G
E
G
-------------------------
K
K
M
--------------------
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
-
S
S
-
T
-
D
-
Y
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
-
S
-----
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
-
T
D
S
I
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
-----------
P
H
V
----
K
----
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
-----
T
I
A
--
S
N
D
K
F
N
A
S
E
F
L
T
S
-
F
-
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
----
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
2
PsiBlast_PDB
96.22
99%
-86
- C2 -
1QU3
2
SYI1_STAAU
A:
[2-881]
-
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
----
T
K
K
-
G
V
D
R
-------
K
-------
K
M
--
S
T
A
----
E
---
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
--
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
-----
E
A
E
I
--
E
--
Y
H
-
D
----------
K
--
R
S
-------
A
S
I
Y
V
A
F
N
V
K
D
D
------
K
G
--------------------------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
--
G
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
D
K
A
S
I
K
L
E
K
E
Y
T
G
K
E
L
E
W
V
V
----
A
Q
H
P
F
---
L
---
D
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
G
Q
Q
Y
E
L
P
V
---
I
------
S
P
I
D
--------
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
V
---
N
W
-----
G
--
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
Y
A
E
-
N
G
E
I
I
M
T
K
E
T
V
N
H
V
--
A
D
L
------
F
A
E
H
--
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
----
H
P
-------
G
S
P
-----------
N
-
G
T
F
T
K
E
T
D
I
M
D
V
W
F
D
S
G
-------
S
---
S
H
R
G
-------------
V
L
-----
E
T
---
R
----------
P
------
E
L
------
S
---
F
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
W
-----
F
N
S
S
I
T
T
S
V
A
T
R
-
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
M
--------
D
----------------------------------------------
G
E
G
-------------------------
K
K
M
--------------------
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
-
S
S
-
T
-
D
-
Y
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
-
S
-----
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
-
T
D
S
I
P
E
S
E
-
L
L
E
-
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
-----------
P
H
V
----
K
----
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
-----
T
I
A
--
S
N
D
K
F
N
--
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
-----
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
----------------------------------------
5
PsiBlast_PDB
73.75
30%
-63
- C2 -
1JZS
3
SYI_THET8
A:
[10-810]
-------------------
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
----
E
K
K
L
G
L
K
S
-------
K
-------
R
E
--
I
E
A
Y
G
I
E
R
---
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
-----
S
H
E
V
--
A
L
G
Y
K
-
E
----------
I
--
Q
D
-------
P
S
V
Y
V
R
F
P
L
K
E
P
------
K
K
--------------------------
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
--
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
------
G
E
G
T
Q
V
L
K
T
F
P
G
K
A
L
E
G
L
P
----
Y
T
P
P
Y
PQA
L
---
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
P
L
---
L
------
K
T
V
D
--------
E
E
G
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
------
R
N
N
Q
E
I
---
H
W
VPPHI
K
--
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
----
Q
A
C
G
K
E
E
A
I
G
S
F
--
Q
E
L
------
K
A
------------
R
A
T
K
P
L
P
E
-
P
F
D
-----
P
-------
H
R
P
Y
V
D
Q
V
E
L
A
C
AC
G
-
G
T
M
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
-------
A
---
M
P
F
A
-------------
S
L
-----
H
Y
---
P
----------
F
------
E
H
E
E
V
F
R
E
S
---
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
W
-----
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
-
A
-
P
-
P
E
A
----
D
R
R
F
G
P
N
L
V
R
E
-
T
V
R
-----
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
-
L
K
N
P
P
P
P
E
K
R
P
E
-
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
-----------
V
R
S
VRLE
A
----
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
R
A
V
L
K
V
V
D
---------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.24
30%
-64
- C2 -
1JZQ
3
SYI_THET8
A:
[10-810]
-------------------
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
----
E
K
K
L
G
L
K
S
-------
K
-------
R
E
--
I
E
A
Y
G
I
E
R
---
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
-----
S
H
E
V
--
A
L
G
Y
K
-
E
----------
I
--
Q
D
-------
P
S
V
Y
V
R
F
P
L
K
E
P
------
K
K
--------------------------
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
--
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
------
G
E
G
T
Q
V
L
K
T
F
P
G
K
A
L
E
G
L
P
----
Y
T
P
P
Y
PQA
L
---
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
P
L
---
L
------
K
T
V
D
--------
E
E
G
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
------
R
N
N
Q
E
I
---
H
W
VPPHI
K
--
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
----
Q
A
C
G
K
E
E
A
I
G
S
F
--
Q
E
L
------
K
A
------------
R
A
T
K
P
L
P
E
-
P
F
D
-----
P
-------
H
R
P
Y
V
D
Q
V
E
L
A
C
AC
G
-
G
T
M
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
-------
A
---
M
P
F
A
-------------
S
L
-----
H
Y
---
P
----------
F
------
E
H
E
E
V
F
R
E
S
---
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
W
-----
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
-
A
-
P
-
P
E
A
----
D
R
R
F
G
P
N
L
V
R
E
-
T
V
R
-----
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
-
L
K
N
P
P
P
P
E
K
R
P
E
-
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
-----------
V
R
S
VRLE
A
----
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
R
A
V
L
K
V
V
D
---------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.00
30%
-64
- C2 -
1ILE
2
SYI_THET8
A:
[10-810]
-------------------
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
----
E
K
K
L
G
L
K
S
-------
K
-------
R
E
--
I
E
A
Y
G
I
E
R
---
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
-----
S
H
E
V
--
A
L
G
Y
K
-
E
----------
I
--
Q
D
-------
P
S
V
Y
V
R
F
P
L
K
E
P
------
K
K
--------------------------
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
--
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
------
G
E
G
T
Q
V
L
K
T
F
P
G
K
A
L
E
G
L
P
----
Y
T
P
P
Y
PQA
L
---
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
P
L
---
L
------
K
T
V
D
--------
E
E
G
K
L
L
V
-----------------------
E
------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
------
R
N
N
Q
E
I
---
H
W
VPPHI
K
--
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
----
Q
A
C
G
K
E
E
A
I
G
S
F
--
Q
E
L
------
K
A
------------
R
A
T
K
P
L
P
E
-
P
F
D
-----
P
-------
H
R
P
Y
V
D
Q
V
E
L
A
CAC
G
-
G
T
M
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
-------
A
---
M
P
F
A
-------------
S
L
-----
H
Y
---
P
----------
F
------
E
H
E
E
V
F
R
E
S
---
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
W
-----
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
-
A
-
P
-
P
E
A
----
D
R
R
F
G
P
N
L
V
R
E
-
T
V
R
-----
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
-
L
K
N
P
P
P
P
E
K
R
P
E
-
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
-----------
V
R
S
VRLE
A
----
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
R
A
V
L
K
V
V
D
---------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
71.63
30%
-61
* C2 *
1ILE
2
SYI_THET8
A:
[4-820]
-------------
E
V
G
E
P
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
----
E
K
K
-
L
G
L
K
S------
K
R
E
I
----
E
A
Y
-
G
I
E
----
R
---
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
--
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
-----
S
H
E
V
A
L
G
--
Y
K
-
E
----------
I
--
Q
D
-------
P
S
V
Y
V
R
F
P
L
K
E
P
------
K
K
--------------------------
L
G
L
E
K
A
S
L
L
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
--
D
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
G
----
T
--
Q
V
L
K
T
F
P
G
K
A
L
E
G
L
P
----
Y
T
P
P
Y
---
P
QAL
E
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
A
R
V
Y
G
L
P
L
---
L
------
K
T
V
D
--------
E
E
G
K
L
L
V
-----------------------------
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
--
L
F
K
D
E
L
I
R
N
N
Q
--
E
I
H
W
V
P
---
P
H
-----
I
--
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
V
C
Q
A
C
G
K
E
E
----
A
I
G
S
F
--
Q
E
L
------
K
A
R
A
TK
P
L
P
E
P
F
D
P
-
H
R
P
Y
V
D
Q
V
E
L
A
----
C
--------
A
C
G
-----------
G
--
T
M
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
-------
A
---
M
P
F
A
-------------
S
L
-----
H
Y
---
P
----------
F
EH
E
E
V
F
R
E
------
S
---
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
W
-----
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
S
I
A
F
K
N
V
I
C
H
G
L
I
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
-
Y
V
-
S
A
P
-
P
E
A
----
D
R
R
F
G
P
N
L
V
R
E
T
V
-
R
-----
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
L
K
N
P
P
P
P
E
K
-
R
P
E
-
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
D
-
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
-----------
V
R
S
----
V
RLEA
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
R
A
V
L
K
V
V
----
D
L
A
R
A
A
R
A
K
S
G
-------------------------------------------------------------------------------------------------------------------
78
Fugue
67.81
23%
-52
- C2 -
1GAX
3
SYV_THETH
A:
[1-862]
M
D
L
P
K
A
Y
-----------
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
F
V
---
A
N
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
----
T
Q
V
V
V
E
R
LL
L
K
E
-
G
K
T
R
-------
H
-------
D
L
--
G
R
E
----
K
---
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
-----
D
L
E
V
--
E
--
T
E
-
P
----------
T
--
P
G
-------
K
L
Y
T
L
R
Y
E
V
E
G
G
------
G
F
--------------------------
I
-------
E
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
---------------
D
E
R
Y
------------------------
R
H
L
L
G
K
R
A
R
I
---------
P
L
---
T
---
E
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
K
P
---
V
------
S
V
I
N
--------
L
E
G
R
M
E
G
-----------------------
E
--
R
VP
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
G
L
R
--
R
G
D
I
A
F
---
V
P
-----
E
RW
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
-
D
C
-----------------------------
Q
A
V
N
V
P
R
P
E
R
Y
L
E
D
P
T
-
S
C
E
----
A
C
-------
G
S
P
-----------
R
---
L
K
R
D
E
D
V
F
D
T
W
F
S
S
A
-------
L
---
W
P
L
S
-------------
T
L
GWPEE
T
E
---
D
----------
L
------
K
A
------
F
---
Y
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
W
-----
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
-
I
Y
L
A
-
T
-
G
G
Q
----
D
I
R
L
D
L
R
W
L
E
M
-
A
-
R
-----
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
K
-
E
D
T
P
T
------
L
-
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
TGKEELALEAW
P
E
P
----
G
----
G
R
D
E
E
A
E
R
A
F
E
A
--
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
V
F
R
-----
F
L
S
R
A
D
L
L
P
E
R
--
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
LEGL
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
FREK
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
8
PsiBlast_PDB
67.07
24%
-52
- C2 -
1IVS
1
SYV_THETH
A:
[13-786]
-----------------------
E
P
K
W
A
E
K
W
-
A
K
N
P
F
--
V
A
N
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
----
L
K
E
-
G
K
T
R
-------
H
-------
D
L
--
G
R
E
----
K
---
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
-----
D
L
E
V
--
E
--
T
E
-
P
----------
T
--
P
G
-------
K
L
Y
T
L
R
Y
E
V
-
E
G
------
G
G
--------------------------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
---------------
D
E
R
Y
------------------------
R
H
L
L
G
K
R
---------
A
R
I
P
L
---
T
---
E
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
K
P
---
V
------
S
V
I
N
--------
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
G
L
R
--
R
G
D
I
A
F
VPE
R
W
-----
K
--
K
-
V
N
M
-
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
-
D
C
Q
A
V
N
V
P
R
P
E
R
Y
L
--
E
D
---------------------------
P
T
-
S
C
E
----
A
C
-------
G
S
P
-----------
R
---
L
K
R
D
E
D
V
F
D
T
W
F
S
S
A
-------
L
WPL
S
T
L
G
-------------
W
P
-----
E
E
---
T
----------
E
------
D
L
------
K
A
F-
Y
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
W
-----
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
----
A
-
L
-
I
-
Y
L
A
TGG
Q
D
I
R
L
D
L
R
W
L
E
M
-
A
-
R
-----
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
K
-
E
D
T
P
T
L
A
-------
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
--
K
A
G
N
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
----
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
-------------
T
----
G
----
K
E
E
L
A
L
E
A
W
P
E
P
--
G
G
R
D
E
---
E
A
E
R
A
F
E
A
L
K
Q
A
V
T
-
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
--
V
E
E
N
L
E
--
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
-----
K
A
L
V
K
A
M
P
R
V
---------------------------------------------------------
7
PsiBlast_PDB
66.89
24%
-50
- C2 -
1GAX
3
SYV_THETH
A:
[13-786]
-----------------------
E
P
K
W
A
E
K
W
-
A
K
N
P
F
--
V
A
N
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
----
L
K
E
-
G
K
T
R
-------
H
-------
D
L
--
G
R
E
----
K
---
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
-----
D
L
E
V
--
E
--
T
E
-
P
----------
T
--
P
G
-------
K
L
Y
T
L
R
Y
E
V
-
E
G
------
G
G
--------------------------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
---------------
D
E
R
Y
------------------------
R
H
L
L
G
K
R
---------
A
R
I
P
L
---
T
---
E
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
K
P
---
V
------
S
V
I
N
--------
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
G
L
R
--
R
G
D
I
A
F
VPE
R
W
-----
K
--
K
-
V
N
M
-
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
-
D
C
Q
A
V
N
V
P
R
P
E
R
Y
L
--
E
D
---------------------------
P
T
-
S
C
E
----
A
C
-------
G
S
P
-----------
R
---
L
K
R
D
E
D
V
F
D
T
W
F
S
S
A
-------
L
WPL
S
T
L
G
-------------
W
P
-----
E
E
---
T
----------
E
------
D
L
------
K
A
F-
Y
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
W
-----
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
----
A
-
L
-
I
-
Y
L
A
TGG
Q
D
I
R
L
D
L
R
W
L
E
M
-
A
-
R
-----
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
K
-
E
D
T
P
T
L
A
-------
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
--
K
A
G
N
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
----
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
-------------
T
----
G
----
K
E
E
L
A
L
E
A
W
P
E
P
--
G
G
R
D
E
---
E
A
E
R
A
F
E
A
L
K
Q
A
V
T
-
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
--
V
E
E
N
L
E
--
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
-----
K
A
L
V
K
A
M
P
R
V
---------------------------------------------------------
53
HHSearch
65.71
25%
-57
- C2 -
1GAX
3
SYV_THETH
A:
[2-750]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
-
F
V
A
N
--
P
K
S
G
K
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
----
T
Q
V
V
V
----
E
R
L
-
L
L
K
E
GKT----
R
-------
H
D
L-
G
R
E
----
K
---
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
--
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
-----
D
L
E
V
--
E
--
T
E
-
P
----------
T
--
P
G
-------
K
L
Y
T
L
R
Y
E
V
E
G
---------------------------------------
G
G
F
I
E
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
D
E
R
Y
--------------------------------------------
R
H
L
L
G
K
R
----
A
R
I
P
L
---
T
---
E
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
G
E
R
H
G
L
K
P
---
V
------
S
V
I
N
--------
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
P
---
E
R
-----
W
--
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
Y
C
E
D
C
Q
A
V
N
V
P
------------------------
R
P
--------
E
R
Y
L
E
D
-
P
T
S
----
C
E
-------
A
C
G
-----------
S
-
P
R
L
K
R
D
E
D
V
F
D
T
W
F
S
S
A
-------
L
---
W
P
L
S
-------------
T
L
-----
G
W
---
P
----------
E
ET
E
D
L
-
K
A
------
F
---
Y
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
W
-----
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
E
R
P
F
K
T
V
L
L
H
G
L
V
L
--------
D
----------------------------------------------
E
K
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
-
I
Y
-
L
A
T
-
G
G
Q
----
D
I
R
L
D
L
R
W
L
E
M
-
A
-
R
-----
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
K
------
E
D
T
-
P
T
L
-
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
-----------
T
G
K
----
E
------
E
L
A
L
E
A
W
P
E
P
--
G
G
R
D
E
E
A
E
R
A
F
E
A
L
K
Q
A
V
----
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
-----
Y
L
E
--
G
-----------------------------------------------------------------------------------------------
57
HHSearch
62.35
24%
-51
- C2 -
2V0C
10
?
A:
[2-813]
---------------
E
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
E
E
K
G
F
M
K
A
K
D
L
-
P
---
G
K
Q
Y
V
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
----
L
K
F
-
G
V
---------------------
H
P
--------------
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
--
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
-----
N
E
Q
V
--
V
--
E
G
R
C
WRHED
T
P
V
E
K
R
--
E
L
-------
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
L
E
G
LNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
PE
K
R
E
E
V
L
--
A
Y
V
E
A
A
K
R
K
T
E
I
E
R
---
Q
A
E
G
R
E
K
T
G
V
F
L
G
A
Y
----
A
L
N
P
A
---
T
---
G
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
A
R
K
F
G
L
P
I
---
K
------
K
V
I
E
--------
R
P
G
E
P
L
P
-----------------------
E
------------------
P
L
E
R
A
Y
E
E
P
G
I
M
V
------
N
S
G
P
F
D
G
T
E
S
---------------
E
--
E
G
K
R
K
V
I
A
W
--------
L
E
---
E
K
-----
G
L
G
K
-
G
R
V
---
T
Y
R
L
R
D
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
H
C
E
A
C
G
V
V
P
V
P
E
E
E
L
P
V
L
--
L
P
D
LKDVED
I
R
P
K
--
G
K
S
P
-
L
E
A
-
H
P
E
F
Y
---
E
T
T
----
C
P
-------
K
C
G
-----------
G
--
P
A
K
R
D
T
D
T
M
D
T
F
F
D
S
S
-------
W
---
Y
Y
L
R
-------------
Y
T
-----
D
P
---
H
NDRLPFD
P
E
K
A
------
N
A
------
W
---
M
P
V
D
Q
Y
I
G
G
V
E
H
------
A
V
L
H
L
L
Y
S
R
F
F
T
K
F
L
H
D
L
G
M
V
K
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
L
--------
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
G
T
L
H
L
W
K
P
------------------
A
V
M
--------------------
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
-
L
F
-
A
A
P
-
P
E
N
----
E
M
V
W
T
E
E
G
V
Q
G
-
A
-
W
-----
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
T
S
G
V
----
F
Q
A
E
A
-
L
E
G
-
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
-
A
L
-
Y
E
Y
R
K
---
D
R
------------
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
H
W
F
-----------
W
P
D
-----------
S
L
F
E
A
G
W
P
E
L
--
D
E
K
-
A
L
E
---------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
60.49
20%
-54
- C2 -
1WZ2
-
SYL_PYRHO
A:
[4-850]
-----------------
L
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
R
D
K
P
K
E
K
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
----
E
R
I
-
K
N
R
D
P
K
T
I
W
I
Y
R
-------
D
V
YK
V
P
E
----
E
I
L
W
T
F
E
D
P
I
N
I
V
K
Y
F
M
K
A
A
K
E
T
F
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
T
S
LF
P
P
F
S
K
F
I
E
W
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
-----
D
H
D
L
--
M
--
E
G
-
E
----------
D
V
P
I
L
-------
D
Y
I
I
I
K
F
E
L
R
E
N
------
G
------------------------------
E
V
I
Y
L
P
A
A
T
L
R
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
KD
K
--
E
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
D
R
E
--
I
--
E
V
I
E
E
F
K
G
E
K
L
I
G
K
Y
----
V
R
N
P
V
---
S
---
G
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
ALEDL
K
R
E
T
E
I
L
E
K
Y
D
I
D
P
R
I
V-----------FPAVEEVN
K
L
G
I
K
S
Q
KDKEKLEQATK
T
I
Y
K
A
E
YHK
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
M
L
E
K
G
I
A
E
I
M
Y
E
F
A
E
K
N
V
I
S
R
F
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
G
N
P
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
P
---
E
T
-----
R
--
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
A
C
A
R
K
I
G
L
G
T
P
L
P
W
---
D
P
E
W
-
V
I
E
S
L
S
D
S
T
-----------------------
I
Y
M
A
Y
Y
T
I
S
R
-
H
I
N
K
-
L
R
--------------
Q
E
G
-----------
K
L
D
P
E
K
L
T
P
E
F
F
D
Y
I
F
L
E
E
-------
F
---
S
E
D
K
E
K
E
L
E
KKTGIP
A
E
I
I
-----
H
E
M
K
E
E
----------
F
------
E
Y
------
W
---
Y
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
H
-----
L
T
F
F
I
F
N
H
V
A
I
F
R
E
E
H
W
P
K
G
I
A
V
N
G
F
G
T
-------------------------------------------------------
L
E
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
-
M
S
-
L
-
A
E
H
D
S
----
D
F
D
W
R
R
K
E
V
G
K
-
L
-
R
-----
K
Q
I
E
R
F
Y
E
L
I
S
Q
F
A
E
Y
E
--
V
K
-------
G
N
V
E
-
L
K
D
-
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
Y
S
I
M
N
D
L
-
R
W
Y
L
R
R
T
E
G
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
-----------
G
G
E
----
G
------
F
V
S
L
A
K
W
P
E
P
VE
E
W
W
N
E
T
I
E
A
E
E
E
F
I
R
S
V
M
E
D
I
K
E
I
I
---------------------------------------------------------------------------------------------------------------------------
56
HHSearch
59.82
20%
-52
- C2 -
1WKB
8
SYL_PYRHO
A:
[4-810]
-----------------
L
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
R
D
K
P
K
E
K
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
----
E
R
I
-
K
N
R
D
-------
P
K
T
I
W
I
Y
R
D
V
Y-
K
V
P
E
E
I
L
W
---
T
F
E
D
P
I
N
I
V
K
Y
F
M
K
A
A
K
E
T
F
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
T
S
LF
P
P
F
S
K
F
I
E
W
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
-----
D
H
D
L
--
M
--
E
G
-
E
----------
D
V
P
I
L
-------
D
Y
I
I
I
K
F
E
L
R
E
N
------
G
------------------------------
E
V
I
Y
L
P
A
A
T
L
R
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
KD
K
--
E
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
D
R
--
E
I
--
E
V
I
E
E
F
K
G
E
K
L
I
G
K
Y
----
V
R
N
P
V
---
S
---
G
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
A
L
E
D
L
K
R
E
TE
I
L
E
K
Y
D
I
D
P
---
R
IVFPAV
E
E
V
N
--------
K
L
G
I
K
S
Q
KDKEK
L
E
Q
A
T
K
T
I
Y
K
A
E
Y
H
K
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
M
L
E
K
G
I
A
E
I
M
Y
E
F
A
E
K
N
V
I
S
R
F
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
G
N
P
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
P
---
E
T
-----
R
--
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
A
C
A
R
K
I
G
L
G
T
P
L
P
W
DPE
W
V
I
E
S
L
S
D
----
S
T
-----------------------
I
Y
M
A
Y
Y
T
I
S
R
-
H
I
N
--
K
L
------
R
-------
Q
E
G
-----------
K
L
D
P
E
K
L
T
P
E
F
F
D
Y
I
F
L
E
E
-------
F
---
S
E
D
K
E
K
E
L
E
K
K
T
GIP
A
E
I
I
-----
H
E
---
M
K
E
E
-------
F
------
E
Y
------
W
---
Y
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
H
-----
L
T
F
F
I
F
N
H
V
A
I
F
R
E
E
H
W
P
K
G
I
A
V
N
G
F
G
T
-------------------------------------------------------
L
E
G
-------------------------
Q
K
M
--------------------
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
-
M
S
-
L
-
A
E
H
D
S
----
D
F
D
W
R
R
K
E
V
G
K
-
L
-
R
-----
K
Q
I
E
R
F
Y
E
L
I
S
Q
F
A
E
Y
E
V
--
K
-------
G
N
V
E
-
L
K
D
-
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
Y
S
I
M
N
D
L
-
R
W
Y
L
R
R
T
E
G
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
-----------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.86
22%
-54
- C2 -
1OBC
6
?
A:
[42-791]
--------------------------------------------------------
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
----
L
K
F
-
G
V
H
P
-------
K
-------
D
W
--
T
Y
A
----
N
---
I
R
Q
------------
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
--
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
NEQVV
E
G
R
C
--
W
--
R
H
-
E
D
T
P
V
E
-----
K
--
R
E
L
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
L
------
E
G
LNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
--
P
E
K
-------
R
E
E
V
L
A
Y
V
E
A
A
K
R
K
T
E
I
E
R
Q
A
E
G
R
E
K
T
G
V
F
LG
A
Y
A
L
N
P
A
---
T
---
G
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
A
R
K
F
G
L
P
I
---
K
------
K
V
I
E
--------
R
P
G
-----------------------------------------
E
P
L
P
E
P
L
E
R
A
Y
E
E
P
G
I
M
V
------
N
S
G
P
F
D
---------------
G
T
E
S
E
--
E
G
K
R
K
V
I
A
W
L
E
--
E
K
G
L
------------
G
--
K
-
G
R
V
T
Y
R
L
R
D
---
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
H
C
E
-
A
C
G
V
V
P
V
P
E
E
E
L
P
V
LL
P
D
L
-------------------
K
D
V
E
D
I
R
P
K
-
G
K
S
PLEA
H
P
EFYETTC
P
K
C
-----------
G
-
G
P
A
K
R
D
T
D
T
M
D
T
F
F
D
S
S
W
Y
Y
L
R
Y
T
D
---
P
H
N
D
-------------
R
L
-----
P
F
---
D
----------
P
------
E
K
------
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
H
AVL
H
L
L
Y
S
R
F
-----
F
T
K
F
L
H
D
L
G
M
V
K
-
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
L
AWTDF
G
P
V
E
----------------------------------------------
V
E
G
S
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
EDG
T
L
H
L
W
K
P
A
VM
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
-
L
F
-
A
-
A
-
P
P
E
----
N
E
M
V
W
T
E
E
G
V
Q
-
G
-
A
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
--------
E
-
T
S
G
V
F
Q
A
E
-
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
A
-------------
L
Y
E
Y
R
K
D
R
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
----
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.66
22%
-53
- C2 -
2V0C
10
?
A:
[42-791]
--------------------------------------------------------
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
----
L
K
F
-
G
V
H
P
-------
K
-------
D
W
--
T
Y
A
----
N
---
I
R
Q
------------
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
--
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
NEQVV
E
G
R
C
--
W
--
R
H
-
E
D
T
P
V
E
-----
K
--
R
E
L
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
L
------
E
G
LNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
--
P
E
K
-------
R
E
E
V
L
A
Y
V
E
A
A
K
R
K
T
E
I
E
R
Q
A
E
G
R
E
K
T
G
V
F
LG
A
Y
A
L
N
P
A
---
T
---
G
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
A
R
K
F
G
L
P
I
---
K
------
K
V
I
E
--------
R
P
G
-----------------------------------------
E
P
L
P
E
P
L
E
R
A
Y
E
E
P
G
I
M
V
------
N
S
G
P
F
D
---------------
G
T
E
S
E
--
E
G
K
R
K
V
I
A
W
L
E
--
E
K
G
L
------------
G
--
K
-
G
R
V
T
Y
R
L
R
D
---
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
H
C
E
-
A
C
G
V
V
P
V
P
E
E
E
L
P
V
LL
P
D
L
-------------------
K
D
V
E
D
I
R
P
K
-
G
K
S
PLEA
H
P
EFY
E
T
T
C
P
K
C
-----------
G
-
G
P
A
K
R
D
T
D
T
M
D
T
F
F
D
S
S
W
Y
Y
L
R
Y
T
D
---
P
H
N
D
-------------
R
L
-----
P
F
---
D
----------
P
------
E
K
------
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
H
AVL
H
L
L
Y
S
R
F
-----
F
T
K
F
L
H
D
L
G
M
V
K
-
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
L
AWTDF
G
P
V
E
----------------------------------------------
V
E
G
S
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
EDG
T
L
H
L
W
K
P
A
VM
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
-
L
F
-
A
-
A
-
P
P
E
----
N
E
M
V
W
T
E
E
G
V
Q
-
G
-
A
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
--------
E
-
T
S
G
V
F
Q
A
E
-
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
A
-------------
L
Y
E
Y
R
K
D
R
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
----
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.57
22%
-55
- C2 -
1H3N
7
?
A:
[42-791]
--------------------------------------------------------
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
----
L
K
F
-
G
V
H
P
-------
K
-------
D
W
--
T
Y
A
----
N
---
I
R
Q
------------
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
--
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
NEQVV
E
G
R
C
--
W
--
R
H
-
E
D
T
P
V
E
-----
K
--
R
E
L
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
L
------
E
G
LNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
--
P
E
K
-------
R
E
E
V
L
A
Y
V
E
A
A
K
R
K
T
E
I
E
R
Q
A
E
G
R
E
K
T
G
V
F
LG
A
Y
A
L
N
P
A
---
T
---
G
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
A
R
K
F
G
L
P
I
---
K
------
K
V
I
E
--------
R
P
G
-----------------------------------------
E
P
L
P
E
P
L
E
R
A
Y
E
E
P
G
I
M
V
------
N
S
G
P
F
D
---------------
G
T
E
S
E
--
E
G
K
R
K
V
I
A
W
L
E
--
E
K
G
L
------------
G
--
K
-
G
R
V
T
Y
R
L
R
D
---
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
H
C
E
-
A
C
G
V
V
P
V
P
E
E
E
L
P
V
LL
P
D
L
-------------------
K
D
V
E
D
I
R
P
K
-
G
K
S
PLEA
H
P
EFYETTC
P
K
C
-----------
G
-
G
P
A
K
R
D
T
D
T
M
D
T
F
F
D
S
S
W
Y
Y
L
R
Y
T
D
---
P
H
N
D
-------------
R
L
-----
P
F
---
D
----------
P
------
E
K
------
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
H
AVL
H
L
L
Y
S
R
F
-----
F
T
K
F
L
H
D
L
G
M
V
K
-
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
L
A
WTDF
G
P
V
E
----------------------------------------------
V
E
G
S
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
EDG
T
L
H
L
W
K
P
A
VM
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
-
L
F
-
A
-
A
-
P
P
E
----
N
E
M
V
W
T
E
E
G
V
Q
-
G
-
A
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
--------
E
-
T
S
G
V
F
Q
A
E
-
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
A
-------------
L
Y
E
Y
R
K
D
R
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
----
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.54
22%
-54
- C2 -
2BTE
15
?
A:
[42-791]
--------------------------------------------------------
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
----
L
K
F
-
G
V
H
P
-------
K
-------
D
W
--
T
Y
A
----
N
---
I
R
Q
------------
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
--
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
NEQVV
E
G
R
C
--
W
--
R
H
-
E
D
T
P
V
E
-----
K
--
R
E
L
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
L
------
E
G
LNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
--
P
E
K
-------
R
E
E
V
L
A
Y
V
E
A
A
K
R
K
T
E
I
E
R
Q
A
E
G
R
E
K
T
G
V
F
LG
A
Y
A
L
N
P
A
---
T
---
G
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
A
R
K
F
G
L
P
I
---
K
------
K
V
I
E
--------
R
P
G
-----------------------------------------
E
P
L
P
E
P
L
E
R
A
Y
E
E
P
G
I
M
V
------
N
S
G
P
F
D
---------------
G
T
E
S
E
--
E
G
K
R
K
V
I
A
W
L
E
--
E
K
G
L
------------
G
--
K
-
G
R
V
T
Y
R
L
R
D
---
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
H
C
E
-
A
C
G
V
V
P
V
P
E
E
E
L
P
V
LL
P
D
L
-------------------
K
D
V
E
D
I
R
P
K
-
G
K
S
PLEA
H
P
EFYETTC
P
K
C
-----------
G
-
G
P
A
K
R
D
T
D
T
M
D
T
F
F
D
S
S
W
Y
Y
L
R
Y
T
D
---
P
H
N
D
-------------
R
L
-----
P
F
---
D
----------
P
------
E
K
------
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
H
AVL
H
L
L
Y
S
R
F
-----
F
T
K
F
L
H
D
L
G
M
V
K
-
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
L
A
WTDF
G
P
V
E
----------------------------------------------
V
E
G
SVVRLP
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
EDG
T
L
H
L
W
K
P
A
VM
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
-
L
F
-
A
-
A
-
P
P
E
----
N
E
M
V
W
T
E
E
G
V
Q
-
G
-
A
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
--------
E
-
T
S
G
V
F
Q
A
E
-
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
A
-------------
L
Y
E
Y
R
K
D
R
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
----
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------