@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1043: (2016-03-21 )
MNHLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYEEYGYFEGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVIDELLK
Atome Classification :
(52 SA)
-----.........10........20.....---...30--.--....-....40....-....50........60........-70-.--.......80........90....--....100.......110---.--.--......120.......130.......140.......150.......160.......170-...-.--...180.-----.---------..-..-.190--------..------....-..------.---200.......210.......220.......230..--.....240..-.....250..--.....260.......270.......280.......290.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MNHL
L
S
M
E
HL
S
T
D
Q
I
Y
K
L
I
Q
K
A
S
Q
FK---SGER---Q--LPNF-E
G
K
Y
V
A
N
L
F
F-ENSTR
T
K
C
S
F
E
M
A
E
L
K
LG
L
K
T
I
S
F
-ET-S--TSSVSK
G
E
S
L
Y
D
T
C
K
T
L
E
SIGC
D
--
L
L
V
I
RH
P
F
N
N
Y
Y
E
K
L
-A---N--I--N
I
P
I
ANAGDGSGQH
P
T
Q
S
L
L
D
L
M
T
I
Y
E
EYGYFEG
L
N
V
L
I
CGDIKNS
R
V
ARSNY
H
S
L
K
A
L-GA
N
-
V
--
M
FNSPNA-----W---------ID-DS-LE----------AP------YV
N
I
-
D
D
------
V
---
I
E
T
V
D
I
V
M
L
L
R
I
Q
H
E
RHG
L
A
E
E
TRFAA
D
D
Y
H
Q
KHG--L
N
E
V
R
Y
N
K
L
Q
-E
H
A
I
V
MHPAP--VNRGV
E
I
Q
S
D
L
V
E
A
S
K
S
R
I
F
K
Q
MEN
G
V
Y
L
R
M
A
V
I
D
E
LLK-----
26
PsiBlast_CBE
96.64
55%
-103
- C6 -
3R7F
7
PYRB_BACSU
C:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
1
PsiBlast_PDB
96.59
55%
-106
- C6 -
3R7D
3
PYRB_BACSU
A:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
101
HHSearch
96.44
57%
-105
- C6 -
3R7F
7
PYRB_BACSU
A:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
----
T
--
D
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
-
V
---
S
--
Q
V-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
-
E
E
N
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
----
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
27
PsiBlast_CBE
96.22
55%
-107
- C6 -
3R7F
8
PYRB_BACSU
B:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
2
PsiBlast_PDB
95.86
55%
-104
- C6 -
3R7F
7
PYRB_BACSU
A:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
28
PsiBlast_CBE
95.35
55%
-105
- C6 -
3R7D
4
PYRB_BACSU
C:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
29
PsiBlast_CBE
95.11
55%
-105
- C6 -
3R7D
2
PYRB_BACSU
B:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
22
PsiBlast_CBE
94.56
55%
-99
- C6 -
3R7L
3
PYRB_BACSU
E:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
23
PsiBlast_CBE
94.18
55%
-101
- C6 -
3R7L
3
PYRB_BACSU
D:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
25
PsiBlast_CBE
94.10
55%
-99
- C6 -
3R7L
3
PYRB_BACSU
B:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
3
PsiBlast_PDB
93.52
55%
-100
- C6 -
3R7L
3
PYRB_BACSU
A:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
21
PsiBlast_CBE
93.47
55%
-99
- C6 -
3R7L
3
PYRB_BACSU
F:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
24
PsiBlast_CBE
93.16
55%
-99
- C6 -
3R7L
3
PYRB_BACSU
C:
[1-290]
-----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
---
S
G
K
T
---
D
---
N
Q
L
-
T
G
K
F
A
A
N
L
F
F
-
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
G
-
T
--
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
--
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
---
Q
--
V
--
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
-
V
--
L
F
S
G
P
S
E
-----
W
---------
Q
D
E
E
N
-
T
F
----------
G
T
------
Y
V
S
M
-
D
E
------
A
---
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
----
Q
S
A
V
S
Q
E
G
Y
L
N
K
Y
G
--
L
T
V
E
R
A
E
R
M
K
-
R
H
A
I
I
M
H
P
A
P
--
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
5
PsiBlast_PDB
81.43
38%
-94
- C6 -
3D6N
1
PYRB_AQUAE
B:
[1-285]
-----
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
---
E
G
K
E
---
E
--
T
I
-----
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
--
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
-
K
---
S
--
L
--
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
-
I
--
G
V
C
G
P
K
T
-----
L
---------
I
P
-
R
D
-
V
E
----------
V
F
------
K
V
D
V
F
D
D
------
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
--
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
F
G
--
L
T
K
E
R
F
E
K
V
K
----
L
Y
M
H
P
G
P
--
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------
7
PsiBlast_PDB
81.32
36%
-99
- C6 -
1ML4
1
PYRB_PYRAB
A:
[8-301]
--------
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
---
R
E
L
K
E
KG
Q
--
L
E
Y
A
-
K
G
K
I
L
A
T
L
F
F
-
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
A
-
S
--
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
--
V
I
V
I
R
H
P
K
E
G
A
A
R
L
A
-
A
---
E
--
V
A-
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
-
L
--
Y
L
I
S
P
E
L
-----
L
RMP
R
H
----
I
V
-
E
E
-
L
R
E
K
GMK
V
----
V
E
------
T
T
T
L
-
E
D
------
V
---
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
E
Y
L
K
V
K
G
S
Y
Q
------
V
N
L
K
V
L
E
K
A
K
-
D
E
L
R
I
M
H
P
L
P
----
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
----------
105
HHSearch
80.20
36%
-93
- C6 -
1ML4
1
PYRB_PYRAB
A:
[5-306]
-----
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
R
L
E
---
R
E
L
K
E
KG
Q
--
L
E
Y
A
-
K
G
K
I
L
A
T
L
F
F
-
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
-
A
E
A
S
--
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
--
V
I
V
I
R
H
P
K
E
G
A
A
R
L
A
-
A
---
E
--
V
A-
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
-
L
--
Y
L
I
S
P
E
L
-----
L
---------
R
M
-
P
R
H
I
V
E
E
L
R
E
K
GMK
V
V
E
------
T
T
T
L
-
E
D
------
V
---
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
----
Q
E
Y
L
K
V
K
G
S
Y
Q
--
V
N
L
K
V
L
E
K
A
K
-
D
E
L
R
I
M
H
P
L
P
--
R
V
--
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
-----
6
PsiBlast_PDB
79.96
38%
-94
- C6 -
4BJH
14
PYRB_AQUAE
B:
[32-316]
-----
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
---
E
G
K
E
---
E
--
T
I
-----
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
G
-
S
--
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
-
K
---
S
--
L
--
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
-
I
--
G
V
C
G
P
K
T
-----
L
---------
I
P
-
R
D
-
V
E
----------
V
F
------
K
V
D
V
F
D
D
------
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
--
K
E
N
Y
I
P
S
E
S
S
Y
F
K
Q
F
G
--
L
T
K
E
R
F
E
K
V
K
----
L
Y
M
H
P
G
P
--
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------
30
PsiBlast_CBE
79.45
34%
-97
- C6 -
2BE7
2
?
C:
[25-316]
-------
H
I
V
S
I
N
D
I
S
R
N
E
L
E
L
I
V
K
T
A
A
K
L
K
-----
E
Q
---
P
--
Q
P
E
L
L
K
N
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
A
I
Q
R
L
G
G
S
V
I
G
F
-
D
N
-
A
GN
T
S
L
A
K
K
G
E
T
L
A
D
S
I
S
V
I
S
S
Y
-
A
D
--
A
F
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
---
S
EF
S
--
N
V
P
V
I
N
G
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
S
I
Y
E
T
Q
G
R
L
D
N
L
N
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
A
Q
A
L
A
K
F
D
G
C
K
-
F
--
H
F
I
A
P
D
A
LAMPE
Y
---------
I
C
-
D
E
-
L
D
EQNISY----
A
T
------
Y
A
S
I
-
E
E
------
V
---
V
P
E
I
D
V
L
Y
M
T
R
V
Q
K
E
R
F
---
D
E
T
E
Y
Q
----
H
M
K
A
G
FI
L
S
A
S
S
L
V
H
A
K
-
P
N
L
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
E
N
G
V
Y
A
R
E
A
L
L
----------
122
Fugue
79.32
34%
-104
- C6 -
3CSU
-
PYRB_ECOLI
A:
[1-310]
ANPLY
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
------PQ
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
-----
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
--
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
A
-
T
---
E
--
F
SG
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
-
F
--
Y
F
I
A
P
D
A
-----
L
AMP
Q
Y
I
L
D
M
L
D
-
E
K
---------------G
I
A
W
S
L
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
----------------------
F
V
--
L
R
A
S
D
L
H
N
A
K
-
A
N
M
K
V
L
H
P
L
P
RV----
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
RDLVL
50
PsiBlast_CBE
79.12
33%
-102
- C6 -
2RGW
1
PYRB_METJA
C:
[1-301]
-----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
K
M
E
ELL
N
T
K
R
---
P
--
L
K
L
L
-
E
G
K
I
L
A
T
V
F
Y
-
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
L
-
K
--
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
-
A
D
--
I
I
V
L
R
H
P
S
E
G
A
-
A
R
L
-
A
---
S
EY
S
--
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
-
S
L
-
F
E
N
-
V
EM
Y
F
V
S
P
K
E
-----
L
RLPKD----
I
I
-
E
D
-
L
K
----------
A
K
------
N
I
K
F
-
Y
E
KESLDD
L
---
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
-------
D
P
N
E
Y
E
K
V
K
G
--
S
Y
K
I
K
R
E
Y
V
E
G
K
K
F
I
I
M
H
P
L
P
----
R
V
D
E
I
D
Y
D
V
D
D
L
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
-----
74
PsiBlast_CBE
76.50
33%
-83
- C6 -
2FZG
1
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
81
PsiBlast_CBE
76.04
33%
-79
- C6 -
1ZA2
3
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
62
PsiBlast_CBE
75.68
33%
-75
- C6 -
4KGV
1
?
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
55
PsiBlast_CBE
75.56
33%
-77
- C6 -
4KH0
1
?
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
72
PsiBlast_CBE
75.41
33%
-79
- C6 -
2FZK
1
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
77
PsiBlast_CBE
75.26
33%
-76
- C6 -
2FZC
1
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
75
PsiBlast_CBE
75.21
33%
-74
- C6 -
2FZG
1
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
76
PsiBlast_CBE
75.19
33%
-79
- C6 -
2FZC
1
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
96
PsiBlast_CBE
74.94
33%
-75
- C6 -
1EKX
3
PYRB_ECOLI
C:
[9-301]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
60
PsiBlast_CBE
74.92
33%
-74
- C6 -
4KGX
1
?
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
80
PsiBlast_CBE
74.86
33%
-80
- C6 -
1ZA2
2
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
79
PsiBlast_CBE
74.80
33%
-82
- C6 -
2AIR
2
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
98
PsiBlast_CBE
74.76
33%
-78
- C6 -
1EKX
2
PYRB_ECOLI
A:
[9-301]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
69
PsiBlast_CBE
74.64
33%
-76
* C6 *
2IPO
2
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
54
PsiBlast_CBE
74.61
33%
-73
- C6 -
4KH1
2
?
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
65
PsiBlast_CBE
74.60
33%
-76
- C6 -
4F04
1
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
82
PsiBlast_CBE
74.56
33%
-82
- C6 -
1R0C
2
PYRB_ECOLI
G:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
71
PsiBlast_CBE
74.55
33%
-75
- C6 -
2H3E
1
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
83
PsiBlast_CBE
74.53
33%
-79
- C6 -
1R0C
2
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
53
PsiBlast_CBE
74.51
33%
-77
- C6 -
4KH1
1
?
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
97
PsiBlast_CBE
74.45
33%
-80
- C6 -
1EKX
3
PYRB_ECOLI
B:
[9-301]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
61
PsiBlast_CBE
74.42
33%
-74
- C6 -
4KGV
1
?
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
59
PsiBlast_CBE
74.31
33%
-73
- C6 -
4KGX
1
?
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
78
PsiBlast_CBE
74.13
33%
-81
- C6 -
2AIR
2
PYRB_ECOLI
G:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
56
PsiBlast_CBE
74.12
33%
-75
- C6 -
4KH0
1
?
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
64
PsiBlast_CBE
74.11
33%
-78
- C6 -
4F04
1
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
70
PsiBlast_CBE
73.75
33%
-74
- C6 -
2H3E
1
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
68
PsiBlast_CBE
73.75
33%
-77
- C6 -
2IPO
4
PYRB_ECOLI
C:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
73
PsiBlast_CBE
73.39
33%
-77
- C6 -
2FZK
1
PYRB_ECOLI
A:
[8-300]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
------
M
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
----------
52
PsiBlast_CBE
72.09
33%
-73
- C6 -
2HSE
2
PYRB_ECOLI
C:
[8-304]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
TEF
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
EKGIAW----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
A
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
M
------
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
14
PsiBlast_PDB
71.52
33%
-71
- C6 -
2HSE
4
PYRB_ECOLI
A:
[8-304]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMP
Q
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
A
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
M
------
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
13
PsiBlast_PDB
69.49
33%
-67
- C6 -
2A0F
1
PYRB_ECOLI
A:
[8-304]
-------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
---
A
N
P
----
Q
--
P
E
L
L
-
K
H
K
V
I
A
S
C
F
F
-
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
-
S
AN
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
--
A
I
V
M
R
H
P
-
Q
E
G
A
A
R
L
-
A
T
E
F
S
--
G
--
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
-
D
G
N
R
F
--
Y
F
I
A
P
D
A
LAMPQ
Y
---------
I
L
-
D
M
-
L
D
E
K
G
I
A
W
----
S
L
------
H
S
S
I
-
E
E
------
V
---
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
A
P
S
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
--
L
H
N
A
K
A
N
M
------
K
V
L
H
P
L
P
----
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------