@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1063: (2016-03-21 )
MIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILRATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYELDKMKTIAVPLKKEDLAKHISEHKSNQPKRETTQVPIVNGPAHHQQFQKPEGTVYEPKPKKKSTRKIVLLSLIFSLLMIALVSFVAMAMFGNKYEETPDVIGKSVKEAEQIFNKNNLKLGKISRSYSDKYPENEIIKTTPNTGERVERGDSVDVVISKGPEKVKMPNVIGLPKEEALQKLKSLGLKDVTIEKVYNNQAPKGYIANQSVTANTEIAIHDSNIKLYESLGIKQVYVEDFEHKSFSKAKKALEEKGFKVESKEEYSDDIDEGDVISQSPKGKSVDEGSTISFVVSKGKKSDSSDVKTTTESVDVPYTGKNDKSQKVKVYIKDKDNDGSTEKGSFDITSDQRIDIPLRIEKGKTASYIVKVDGKTVAEKEVSYDDI
Atome Classification :
(34 SA)
.........10........20........30........40--......-----..50........60.----...-....70.......--.80---.----.......-.90........--100.......110-.......120.......130.......140-...---.--...---..150.......160.......170.......180.------....-..190.......200.......210.......-----220.-...--.-...230.......240-.......250.......260...--....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
KLGGGG
M
S
T
V
Y
LAED
T
I
L
N
I
K
V
A
I
K
A
I
--FIPPR
E
-----
K
E
E
T
L
K
R
F
E
R
E
VHNS----SQL-
S
H
Q
N
I
V
S
MIDVDE--ED----
D
----
C
Y
Y
L
V
M
E
-
Y
IEGP
T
L
S
E
Y
I
--
E
SHGP
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
HRDIKP
Q
N
I
L
---IDS---N--
K
T
L
---
K
I
F
D
F
G
I
A
K
A
L
S
E
TSLTQTN
H
V
L
G
T
V
Q
YFSPEQAKG------EATD-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
VGEPPFNGE
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
DS--V-PN
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
RATEKDK
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
ENRANE
D
V
Y
E
L
DK
M
K
T
I
AVPL
K
K
E
D
L
A
K
H
I
S
E
HKSNQPKRETTQVPIVNG
P
A
H
H
Q
Q
FQKPEGTVYEPKPKKKST
R
K
I
V
L
L
S
L
I
F
S
L
L
M
I
A
L
V
S
F
V
A
M
A
M
FGNKYEE
T
P
D
V
I
G
K
S
V
K
E
A
E
Q
I
F
NKNN
L
K
LGKIS
R
S
YSDKYPEN
E
I
I
KTTPNT
G
E
RVERGD
S
V
D
V
V
ISKGPEKVKMPNVIGL
P
K
E
E
A
L
Q
K
L
K
SLGLK
D
V
T
I
E
K
V
YNNQAPK
G
Y
IANQSVTAN
T
E
I
A
I
HDS
N
I
K
L
Y
E
SLG
I
K
Q
V
Y
V
E
DFEH
K
S
F
S
K
A
K
K
A
L
E
EKGFKVE
S
K
E
EYSDDIDEGDVISQSPKGKSVDEG
S
T
I
S
F
V
V
SKGKKSDSSDVKTTTESVDVPYTGKNDKS
Q
K
V
K
V
Y
I
K
DKDNDGSTEKG
S
F
DITSD
Q
R
I
D
I
P
L
R
I
EKGK
T
A
S
Y
I
V
K
VDG
K
T
V
A
EKEVSYDDI
22
PsiBlast_CBE
91.44
100%
-100
- C1 -
4EQM
1
?
E:
[4-286]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.07
100%
-100
- C1 -
4EQM
1
?
F:
[4-286]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
90.69
100%
-97
- C1 -
4EQM
2
?
C:
[4-285]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.66
100%
-100
- C1 -
4EQM
1
?
D:
[4-286]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.98
100%
-96
- C1 -
4EQM
2
?
A:
[4-285]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
89.93
100%
-97
- C1 -
4EQM
2
?
B:
[4-285]
M
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
V
A
I
K
A
I
--
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
----
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
----
D
----
C
Y
Y
L
V
M
E
-
Y
I
E
G
P
T
L
S
E
Y
I
--
E
S
H
G
P
L
S
V
D
T
A
I
N
-
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
---
I
D
S
---
N
--
K
T
L
---
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
-----
K
-
H
I
-
Q
D
S
--
V
-
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
-
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
--
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.06
100%
-41
- C2 -
3PY9
4
?
A:
[8-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
D
V
I
G
K
S
V
K
E
A
E
Q
I
F
N
K
N
N
L
K
L
G
K
I
S
R
S
Y
S
D
K
Y
P
E
N
E
I
I
K
T
T
P
N
T
G
E
R
V
E
R
G
D
S
V
D
V
V
I
S
K
G
P
E
K
V
K
M
P
N
V
I
G
L
P
K
E
E
A
L
Q
K
L
K
S
L
G
L
K
D
V
T
I
E
K
V
Y
N
N
Q
A
P
K
G
Y
I
A
N
Q
S
V
T
A
-
T
E
I
A
I
H
D
S
N
I
K
L
Y
E
S
L
G
I
K
Q
V
Y
V
E
D
F
E
H
K
S
F
S
K
A
K
K
A
L
E
E
K
G
F
K
V
E
S
K
E
E
Y
S
D
D
I
D
E
G
D
V
I
S
Q
S
P
K
G
K
S
V
D
E
G
S
T
I
S
F
V
V
S
K
G
K
K
S
----
V
K
T
T
T
E
S
V
D
V
P
Y
T
G
K
N
D
K
S
Q
K
V
K
V
Y
I
K
D
K
D
N
D
G
S
T
E
K
G
S
F
D
I
T
S
D
Q
R
I
D
I
P
L
R
I
E
K
G
K
T
A
S
Y
I
V
K
V
D
G
K
T
V
A
E
K
E
V
S
Y
D
--
103
Fugue
72.83
98%
-34
- C2 -
3PY9
4
?
A:
[8-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
D
V
I
G
K
S
V
K
E
A
E
Q
I
F
N
K
N
N
L
K
L
G
K
I
S
R
S
Y
S
D
K
Y
P
E
N
E
I
I
K
T
T
P
N
T
G
E
R
V
E
R
G
D
S
V
D
V
V
I
S
K
G
P
E
K
V
K
M
P
N
V
I
G
L
P
K
E
E
A
L
Q
K
L
K
S
L
G
L
K
D
V
T
I
E
K
V
Y
N
N
Q
A
P
K
G
Y
I
A
N
Q
S
V
T
A
T
E
I
A
I
-
H
D
S
N
I
K
L
Y
E
S
L
G
I
K
Q
V
Y
V
E
D
F
E
H
K
S
F
S
K
A
K
K
A
L
E
E
K
G
F
K
V
E
S
K
E
E
Y
S
D
D
I
D
E
G
D
V
I
S
Q
S
P
K
G
K
S
V
D
E
G
S
T
I
S
F
V
V
S
K
G
K
K
S
----
V
K
T
T
T
E
S
V
D
V
P
Y
T
G
K
N
D
K
S
Q
K
V
K
V
Y
I
K
D
K
D
N
D
G
S
T
E
K
G
S
F
D
I
T
S
D
Q
R
I
D
I
P
L
R
I
E
K
G
K
T
A
S
Y
I
V
K
V
D
G
K
T
V
A
E
K
E
V
S
Y
D
--
13
PsiBlast_PDB
65.84
34%
-72
- C1 -
4OW8
2
PKNA_MYCTU
A:
[5-279]
-
V
G
V
T
L
S
G
R
Y
R
L
Q
R
L
I
A
T
G
G
M
G
Q
V
W
E
A
V
D
N
R
L
G
R
R
V
A
V
K
V
L
--
K
S
E
F
S
S
-----
D
P
E
F
I
E
R
F
R
A
E
A
R
T
T
----
A
M
L
-
N
H
P
G
I
A
S
V
H
D
Y
G
E
S
Q------
R
----
T
A
Y
L
V
M
E
-
L
V
N
G
E
P
L
N
S
V
L
--
K
R
T
G
R
L
S
L
R
H
A
L
D
-
M
L
E
Q
T
G
R
A
L
Q
I
A
H
A
A
G
L
V
H
R
D
V
K
P
G
N
I
L
---
I
T
P
---
T
--
G
Q
V
---
K
I
T
D
F
G
I
A
K
A
V
D
A
A
P
V
T
Q
T
G
M
V
M
G
T
A
Q
Y
I
A
P
E
Q
A
L
G
------
H
D
A
S
-
P
A
S
D
V
Y
S
L
G
V
V
G
Y
E
A
V
S
G
K
R
P
F
A
G
D
G
A
L
T
V
A
M
-----
K
-
H
I
-
K
E
P
--
P
-
P
P
L
P
P
D
L
P
P
N
V
R
E
L
I
E
-
I
T
L
V
----
K
N
P
A
M
R
Y
R
S
G
G
P
F
A
D
--
A
V
A
A
V
R
A
G
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.67
38%
-78
- C1 -
3ORK
3
?
A:
[10-279]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.14
38%
-72
- C1 -
3ORT
2
?
A:
[10-279]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
R
----------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.82
38%
-77
- C1 -
3F61
5
PKNB_MYCTU
A:
[10-279]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
-----------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.76
38%
-75
- C1 -
3ORM
2
?
A:
[13-279]
--------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
A
T
G
E
--
A
E
TPA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
R
A
I
A
------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.38
38%
-74
- C1 -
3ORP
1
?
A:
[10-279]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
PA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
--------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.05
39%
-79
- C1 -
2FUM
1
PKNB_MYCTU
C:
[27-296]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
----
T
PA
G
P
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
--------------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.41
39%
-70
- C1 -
2FUM
1
PKNB_MYCTU
A:
[27-296]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
----
T
PA
G
P
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
R
A
I
A
D
----------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.27
38%
-70
- C1 -
3ORO
2
?
A:
[12-279]
-------
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
TPA
G
P
----
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
R
A
I
A
------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.63
39%
-76
- C1 -
1O6Y
3
PKNB_MYCTU
A:
[27-296]
-----
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
R
D
V
A
V
K
V
L
--
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
----
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
----
T
PA
G
P
L
P
Y
I
V
M
E
-
Y
V
D
G
V
T
L
R
D
I
V
--
H
T
E
G
P
M
T
P
K
R
A
I
E
-
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
---
I
S
A
---
T
--
N
A
V
---
K
V
M
D
F
G
I
A
R
A
I
A
--------------
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
-----
Q
-
H
V
R
E
D
P
--
I
-
P
--
P
S
A
R
H
E
G
L
S
A
D
L
D
-
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
--
D
L
V
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
56.44
25%
-69
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[92-356]
-----
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--
E
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
----
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
S
----
S
----
F
M
F
L
V
F
D
-
L
M
R
K
G
E
L
F
D
Y
L
--
T
E
K
V
A
L
S
E
K
E
T
R
S
-
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
N
--
M
Q
I
---
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ETH
P
G
Y
G
-
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
-----
M
-
I
M
-
E
G
Q
--
Y
-
Q
F
S
S
-
P
E
W
D
D
R
S
S
T
V
K
-
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
55.50
33%
-83
- C1 -
3UC3
3
SRK2I_ARATH
A:
[18-290]
-----
D
S
D
R
Y
D
F
V
K
D
I
G
S
G
N
F
G
V
A
R
L
M
R
D
K
L
T
K
E
L
V
A
V
K
Y
I
--
E
R
G
A
A
---------
I
D
E
N
V
Q
R
E
I
I
N
H
----
R
S
L
-
R
H
P
N
I
V
R
F
K
E
V
I
L
--
T
P
----
T
----
H
L
A
I
I
M
E
-
Y
A
S
G
G
E
L
Y
E
R
I
--
C
N
A
G
R
F
S
E
D
E
A
R
F
-
F
F
Q
Q
L
L
S
G
V
S
Y
C
H
S
M
Q
I
C
H
R
D
L
K
L
E
N
T
L
---
L
D
G
---
S
PA
P
R
L
---
K
I
C
D
F
G
Y
S
-----------------
P
A
Y
I
A
P
E
V
L
L
R
------
Q
E
Y
D
G
K
I
A
D
V
W
S
C
G
V
T
L
Y
V
M
L
V
G
A
Y
P
F
E
----
P
R
D
Y
R
-----
K
-
T
I
-
Q
R
I
--
L
S
V
K
Y
S
I
P
D
D
I
R
I
S
P
E
C
C
-
H
L
I
S
R
I
F
V
A
D
P
A
T
R
I
S
-
I
P
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
52.80
32%
-78
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[16-272]
-----
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
E
----------------
E
N
E
I
A
V
L
----
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
G
----
G
----
H
L
Y
L
I
M
Q
-
L
V
S
G
G
E
L
F
D
R
I
--
V
E
K
G
F
Y
T
E
R
D
A
S
R
-
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
--
S
K
I
---
M
I
S
D
F
--------------------
P
G
Y
V
A
P
E
V
L
A
Q
------
K
P
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
-
F
-----
E
-
Q
I
-
L
K
A
--
E
-
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
-
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
51.39
32%
-78
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[16-272]
-----
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
----------------
S
M
E
N
E
I
A
V
L
----
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
G
----
G
----
H
L
Y
L
I
M
Q
-
L
V
S
G
G
E
L
F
D
R
I
--
V
E
K
G
F
Y
T
E
R
D
A
S
R
-
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
--
S
K
I
---
M
I
S
D
F
G
L
S
K
M
E
D
P
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
------
K
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
-
F
-----
E
-
Q
I
-
L
K
A
--
E
-
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
-
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
50.77
32%
-76
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[16-272]
-----
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
------------------
N
E
I
A
V
L
----
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
G
----
G
----
H
L
Y
L
I
M
Q
-
L
V
S
G
G
E
L
F
D
R
I
--
V
E
K
G
F
Y
T
E
R
D
A
S
R
-
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
--
S
K
I
---
M
I
S
D
F
G
-------
G
S
V
L
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
------
K
P
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
-
F
-----
E
-
Q
I
-
L
K
A
--
E
-
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
-
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
50.76
35%
-79
- C1 -
3Q5I
3
?
A:
[34-253]
-----
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K-----------------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
-
D
H
P
N
I
I
K
L
F
D
V
F
E
--
D
K
----
K
----
Y
F
Y
L
V
T
E
-
F
Y
E
G
G
E
L
F
E
Q
I
--
I
N
R
H
K
F
D
E
C
D
A
A
N
-
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
E
N
---
K
--
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
--
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
------
K
Y
N
E
-
K
C
-
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
49.77
32%
-79
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[16-272]
-----
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
E
-----------------
N
E
I
A
V
L
----
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
G
----
G
----
H
L
Y
L
I
M
Q
-
L
V
S
G
G
E
L
F
D
R
I
--
V
E
K
G
F
Y
T
E
R
D
A
S
R
-
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
--
S
K
I
---
M
I
S
D
F
-------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
------
K
P
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
-
F
-----
E
-
Q
I
-
L
K
A
--
E
-
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
-
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.15
30%
-48
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[55-369]
-----
L
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
-----
E
K
K
D
-----
R
L
K
N
I
N
R
F
F
Q
E
I
E
I
M
----
K
K
L
-
D
H
P
N
I
V
K
L
Y
E
T
Y
E
--
N
D
----
N
----
Y
I
Y
L
I
M
E
-
L
C
S
G
R
E
L
F
D
S
I
--
I
E
N
G
S
F
T
E
K
N
A
A
T
-
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
Q
S
ENK
D
--
S
L
L
---
K
I
I
D
F
G
L
S
K
N
L
-------------------------------
K
Y
D
K
-
K
C
-
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
---------------C
F
Y
-
E
N
D
--
W
-
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
M
T
K
S
H
V
E
L
S
S
T
L
L
K
N
L
K
N
--
F
K
K
E
N
E
L
K
K
I
A
L
T
I
----
I
A
K
H
L
C
D
V
E
I
N
N
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
47.56
32%
-76
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[16-272]
-----
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
-------------------
E
I
A
V
L
----
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
G
----
G
----
H
L
Y
L
I
M
Q
-
L
V
S
G
G
E
L
F
D
R
I
--
V
E
K
G
F
Y
T
E
R
D
A
S
R
-
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
--
S
K
I
---
M
I
S
D
F
----------
V
L
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
------
K
P
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
-
F
-----
E
-
Q
I
-
L
K
A
--
E
-
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
-
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
47.53
36%
-76
- C1 -
3NIZ
3
?
A:
[19-224]
-----
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
I
-
V
A
L
K
R
I
--
R
------------
G
I
P
S
T
A
I
R
E
I
S
L
L
----
K
E
L
-
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
E
----
R
----
C
L
T
L
V
F
E
-
F
M
E
K
-
D
L
K
K
V
L
--
D
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
---
I
N
S
---
D
--
G
A
L
---
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
H
E
V
V
-
T
L
W
Y
R
A
P
D
V
L
M
G
S-----
K
K
Y
S
-
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
46.16
33%
-69
- C1 -
3I7B
3
?
A:
[23-232]
----
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
R
Q
V
K
-----
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
----
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
K
----
G
----
Y
F
Y
L
V
G
E
-
V
Y
T
G
G
E
L
F
D
E
I
--
I
S
R
K
R
F
S
E
V
D
A
A
R
-
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
--
A
N
I
---
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
------
T
Y
D
E
-
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
45.49
31%
-51
- C1 -
2X4F
4
MYLK4_HUMAN
B:
[97-342]
---------------
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
--
K
T
R
G
M
K
-----
D
K
E
E
V
K
N
---
E
I
S
V
M
----
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
--
S
K
----
N
----
D
I
V
L
V
M
E
-
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
-
I
L
-
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
---
C
V
N
---
R
DA
K
Q
I
---
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
L
K
V
N
--
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
------
D
F
V
S
-
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
-----
N
-
N
I
-
L
A
C
--
R
-
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
-
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
45.09
33%
-68
- C1 -
3T3U
4
?
A:
[23-240]
----
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
R
Q
V
K
-----
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
----
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
K
----
G
----
Y
F
Y
L
V
G
E
-
V
Y
T
G
G
E
L
F
D
E
I
--
I
S
R
K
R
F
S
E
V
D
A
A
R
-
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
--
A
N
I
---
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
------
T
Y
D
E
-
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
43.62
36%
-70
- C1 -
2QKR
1
?
A:
[19-224]
-----
L
M
E
K
Y
--
L
E
K
V
G
E
G
---
V
V
Y
K
A
K
D
S
Q
-
R
I
-
V
A
L
K
R
I
------------------
S
T
A
I
R
E
I
S
L
L
----
K
E
L
-
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
E
---------
C
L
T
L
V
F
E
-
F
M
E
K
-
D
L
K
K
V
L
--
D
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
---
I
N
S
---
D
---
A
L
---
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-----
V
V
-
T
L
W
Y
R
A
P
D
V
L
M
G
S-----
K
K
Y
S
-
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
38.90
33%
-47
* C1 *
3LIJ
2
?
A:
[35-304]
-----
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
--
R
K
----------
S
S
N
S
K
L
L
E
-
E
V
A
V
L
----
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
--
D
K
----
R
----
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
R
M
K
F
N
E
V
D
A
A
V
--
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KEK
D
--
A
L
I
---
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
--
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
------
K
Y
D
E
-
K
C
-
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
-
Y
T
-
F
D
S
PE
W
-
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
-
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
38.54
34%
-57
- C1 -
3HZT
9
?
A:
[3-241]
------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
--
K
K
S
S
V
T
-----
T
T
S
N
S
G
A
L
L
D
E
V
A
V
L
----
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
K
----
R
----
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
--
L
R
Q
K
F
S
E
V
D
A
A
V
--
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSR
D
--
A
L
I
---
K
I
V
D
F
G
L
S
A
H
F
E
V
G
----------
T
A
Y
Y
I
A
P
E
V
L
R
K
------
K
Y
D
E
-
K
C
-
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------