@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1064: (2016-03-21 )
MKTGRIVKSISGVYQVDVNGERFNTKPRGLFRKKKFSPVVGDIVEFEVQNINEGYIHQVFERKNELKRPPVSNIDTLVIVMSAVEPNFSTQLLDRFLVIAHSYQLNARVLVTKKDKTPIEKQFEINELLKIYENIGYETEFIGNDDDRKKIVEAWPAGLIVLSGQSGVGKSTFLNHYRPELNLETNDISKSLNRGKHTTRHVELFERQNGYIADTPGFSALDFDHIDKDEIKDYFLELNRYGETCKFRNCNHIKEPNCNVKHQLEIGNIAQFRYDHYLQLFNEISNRKVRY
Atome Classification :
(20 SA)
-.......---..---10.......--.----20.----.......30........40....--.----...50.-.......60........--70---..-.......80.......-.-90........100.......110.......120.-..---.....-130.-..---..---..140.--.--.--...--.150...------------------....160........170.......-180-.......190.......200....-..-.210........220..-.....-230.......240-.....---...250-.......260.......270.......280.......290-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MKT
G
R
I
V
---
K
S---IS
G
V
Y
Q
V
DV--N----GER----FNTKPRGLFRKKKFSPVV
G
D
I
V
E
--
F
----
E
V
QNIN-
E
G
Y
I
H
Q
V
F
E
R
K
N
ELKRP--P----VS-NI
D
T
L
V
I
V
M
SAVEPN
F
-
S
-
T
Q
L
L
D
R
F
L
V
I
AHS
Y
Q
L
N
A
R
V
L
V
TKKDKTP
I
E
K
-
Q
-
F
E
---
I
N
E
L
L
-
K
I
Y
E
-NI---GY---ETEFIG--N--
D
--
D
D
R
--
K
K
I
V
E
AW------------------PA
G
L
I
-
V
L
SGQSGVGK
S
T
F
L
N
HYRP-ELN-LE
T
N
D
I
S
K
S
L
NRGKHT
T
R
H
V
E
L
F
E-RQ-NG-
Y
I
ADTPGFSALDFD-HI
D
K
D
-
E
I
K
D
Y
F
L
E
L
N
RY--GETCK---FRNCNH-IKEPNCN
V
K
H
Q
L
EIG
N
I
A
Q
F
R
Y
D
H
Y
L
Q
L
F
N
E
ISNRKVRY--
71
HHSearch
95.35
45%
-92
- C3 -
1T9H
11
RSGA_BACSU
A:
[10-307]
-
M
P
E
G
K
I
I
---
K
A
---
L
S
G
F
Y
Y
V
L
D
--
E
SEDS
D
K
V
----
I
Q
C
R
G
R
G
I
F
R
K
N
K
I
T
P
L
V
G
D
Y
V
V
--
Y
----
Q
A
E
N
D
K
-
E
G
Y
L
M
E
I
K
E
R
T
N
E
L
I
R
P
--
P
----
I
C
-
N
V
D
Q
A
V
L
V
F
S
A
V
Q
P
S
F
-
S
-
T
A
L
L
D
R
F
L
V
L
V
E
A
N
D
I
Q
P
I
I
C
I
T
K
M
D
L
I
E
D
Q
D
-
T
E
D
T
---
I
Q
A
Y
A
-
E
D
Y
R
-
N
I
---
G
Y
---
D
V
Y
L
T
S
--
S
--
K
DQ
D
S
L
--
A
D
I
I
P
H
F
------------------
Q
D
K
T
T
-
V
F
A
G
Q
S
G
V
G
K
S
S
L
L
N
A
I
S
P
---------------------
T
R
H
V
E
L
I
H
-
T
S
-
G
G
-
L
V
A
D
T
P
G
F
S
S
L
E
F
T
-
D
I
E
E
E
-
E
L
G
Y
T
F
P
D
I
R
E
K
--
S
S
S
C
K
---
F
R
G
C
L
H
-
L
K
E
P
K
C
A
V
K
Q
A
V
E
D
G
E
L
K
Q
Y
R
Y
D
H
Y
V
E
F
M
T
E
I
K
D
R
K
P
R
Y
--
1
PsiBlast_PDB
94.57
44%
-98
- C3 -
1T9H
11
RSGA_BACSU
A:
[10-307]
-
M
P
E
G
K
I
I
---
K
A
---
L
S
G
F
Y
Y
V
L
D
--
E
----
S
E
D
SD
K
V
I
Q
C
R
G
R
G
I
F
R
K
N
K
I
T
P
L
V
G
D
Y
V
V
--
Y
----
Q
A
E
N
D
K
-
E
G
Y
L
M
E
I
K
E
R
T
N
E
L
I
R
P
--
P
----
I
C
-
N
V
D
Q
A
V
L
V
F
S
A
V
Q
P
S
F
-
S
-
T
A
L
L
D
R
F
L
V
L
V
E
A
N
D
I
Q
P
I
I
C
I
T
K
M
D
L
--
I
E
D
-
Q
-
D
T
E
D
T
I
Q
A
Y
A
-
E
D
Y
R
-
N
I
---
G
Y
---
D
V
Y
L
T
S
SK
D
--
Q
--
D
S
L
--
A
D
I
I
P
H
F
------------------
Q
D
K
T
T
-
V
F
A
G
Q
S
G
V
G
K
S
S
L
L
N
A
I
S
P
---------------------
T
R
H
V
E
L
I
H
-
T
S
-
G
G
-
L
V
A
D
T
P
G
F
S
S
L
E
F
T
-
D
I
E
E
E
-
E
L
G
Y
T
F
P
D
I
R
E
K
--
S
S
S
C
K
---
F
R
G
C
L
H
-
L
K
E
P
K
C
A
V
K
Q
A
V
E
D
G
E
L
K
Q
Y
R
Y
D
H
Y
V
E
F
M
T
E
I
K
D
R
K
P
R
Y
--
72
HHSearch
88.77
32%
-78
- C3 -
2YV5
3
RSGA_AQUAE
A:
[6-296]
-
L
K
R
G
L
V
V
---
D
R
---
E
A
Q
M
I
G
V
Y
L
--
F
ED--
G
K
T
----
Y
R
G
I
P
R
G
K
V
L
K
K
T
-
K
I
Y
A
G
D
Y
V
W
--
G
----
E
V
V
D
P
N
-
T
F
A
I
E
E
V
E
E
R
K
N
L
L
I
R
P
--
K
----
V
A
-
N
V
D
R
V
I
I
V
E
T
L
K
M
P
E
F
-
N
-
N
Y
L
L
D
N
M
L
V
V
Y
E
Y
F
K
V
E
P
V
I
V
F
N
K
I
D
L
L
N
E
E
E
-
K
-
K
E
---
L
E
R
W
I
-
S
I
Y
R
-
D
A
---
G
Y
---
D
V
L
K
V
S
--
A
--
K
TG
E
G
I
--
D
E
L
V
D
Y
L
------------------
E
G
F
I
C
-
I
L
A
G
P
S
G
V
G
K
S
S
I
L
S
R
L
T
G
-
E
-
E
-
L
R
T
Q
E
V
---------
T
T
T
G
V
R
L
I
P
-
F
G
K
G
S
-
F
V
G
D
T
P
G
F
S
K
V
E
A
T
M
F
V
K
P
R
-
E
V
R
N
Y
F
R
E
F
L
R
----
Y
Q
C
K
---
Y
P
D
C
T
H
-
T
N
E
P
G
C
A
V
K
E
A
V
K
N
G
E
I
S
C
E
R
Y
K
S
Y
L
K
I
I
K
V
Y
L
E
E
I
K
----
3
PsiBlast_PDB
88.42
33%
-86
- C3 -
2YV5
3
RSGA_AQUAE
A:
[6-288]
-
L
K
R
G
L
V
V
DRE
A
Q
---
M
I
G
V
Y
L
F
E
---
D
----
G
K
T
----
Y
R
G
I
P
R
G
K
V
L
K
K
T
-
K
I
Y
A
G
D
Y
V
W
--
G
----
E
V
V
D
P
N
-
T
F
A
I
E
E
V
E
E
R
K
N
L
L
I
R
P
--
K
----
V
A
-
N
V
D
R
V
I
I
V
E
T
L
K
M
P
E
F
-
N
-
N
Y
L
L
D
N
M
L
V
V
Y
E
Y
F
K
V
E
P
V
I
V
F
N
K
I
D
L
L
N
E
E
E
-
K
-
K
E
---
L
E
R
W
I
-
S
I
Y
R
-
D
A
---
G
Y
---
D
V
L
K
V
S
AK
T
--
G
--
E
G
I
--
D
E
L
V
D
Y
L
------------------
E
G
F
I
C
-
I
L
A
G
P
S
G
V
G
K
S
S
I
L
S
R
L
T
G
-
E
-
E
-
L
R
T
Q
E
V
---------
T
T
T
G
V
R
L
I
P
-
F
G
-
K
G
S
F
V
G
D
T
P
G
F
S
K
V
E
A
T
-
M
F
V
K
P
R
E
V
R
N
Y
F
R
E
F
L
R
Y
----
Q
C
K
---
Y
P
D
C
T
H
-
T
N
E
P
G
C
A
V
K
E
A
V
K
N
G
E
I
S
C
E
R
Y
K
S
Y
L
K
I
I
------------
74
HHSearch
85.69
35%
-80
- C3 -
1U0L
2
RSGA_THEMA
A:
[12-299]
---
R
G
I
V
V
---
S
F
---
H
S
N
M
V
T
V
E
D
--
E
ET--
G
E
R
----
I
L
C
K
L
R
G
K
F
R
L
Q
N
L
K
I
Y
V
G
D
R
V
E
--
Y
----
T
P
D
E
T
G
-
S
G
V
I
E
N
V
L
H
R
K
N
L
L
T
K
P
--
H
----
V
A
-
N
V
D
Q
V
I
L
V
V
T
V
K
M
P
E
T
-
S
-
T
Y
I
I
D
K
F
L
V
L
A
E
K
N
E
L
E
T
V
M
V
I
N
K
M
D
L
Y
D
E
D
D
-
L
-
R
K
---
V
R
E
L
E
-
E
I
Y
S
--
G
---
L
Y
---
P
I
V
K
T
S
--
A
--
K
TG
M
G
I
--
E
E
L
K
E
Y
L
------------------
K
G
K
I
S
-
T
M
A
G
L
S
G
V
G
K
S
S
L
L
N
A
I
N
P
-
G
L
K
-
L
R
-------------
T
T
T
T
A
Q
L
L
K
-
F
D
F
G
G
-
Y
V
V
D
T
P
G
F
A
N
L
E
I
N
-
D
I
E
P
E
-
E
L
K
H
Y
F
K
E
F
G
D
----
K
Q
C
F
---
F
S
D
C
N
H
-
V
D
E
P
E
C
G
V
K
E
A
V
E
N
G
E
I
A
E
S
R
Y
E
N
Y
V
K
M
F
Y
E
L
L
G
R
R
-----
61
Fugue
83.94
34%
-75
- C3 -
1U0L
2
RSGA_THEMA
A:
[9-299]
L
R
R
R
G
I
V
V
---
S
F
---
H
S
N
M
V
T
V
E
D
EE
T
----
G
E
R
----
I
L
C
K
L
R
G
K
F
R
L
Q
N
L
K
I
Y
V
G
D
R
V
E
--
Y
----
T
P
D
E
T
G
-
S
G
V
I
E
N
V
L
H
R
K
N
L
L
T
K
P
--
H
----
V
A
-
N
V
D
Q
V
I
L
V
V
T
V
K
M
P
E
T
-
S
-
T
Y
I
I
D
K
F
L
V
L
A
E
K
N
E
L
E
T
V
M
V
I
N
K
M
D
L
Y
D
E
D
D
-
L
-
R
K
---
V
R
E
L
E
-
E
I
Y
S
-
G
----
L
Y
---
P
I
V
K
T
S
--
A
--
K
--
T
G
M
G
I
E
E
L
K
E
Y
L
------------------
K
G
K
I
S
-
T
M
A
G
L
S
G
V
G
K
S
S
L
L
N
A
I
N
P
---------------
G
L
K
L
R
T
T
T
T
A
Q
L
L
K
F
D
F
-
G
G
-
Y
V
V
D
T
P
G
F
A
N
L
E
I
N
-
D
I
E
P
E
-
E
L
K
H
Y
F
K
E
F
G
D
----
K
Q
C
F
---
F
S
D
C
N
H
-
V
D
E
P
E
C
G
V
K
E
A
V
E
N
G
E
I
A
E
S
R
Y
E
N
Y
V
K
M
F
Y
E
L
L
G
R
R
-----
22
PsiBlast_CBE
83.53
35%
-83
- C3 -
1U0L
2
RSGA_THEMA
B:
[30-299]
---------------------------
T
----
G
E
R
----
I
L
C
K
L
R
G
K
F
R
L
Q
N
L
K
I
Y
V
G
D
R
V
E
--
Y
----
T
P
D
E
T
G
-
S
G
V
I
E
N
V
L
H
R
K
N
L
L
T
K
P
--
H
----
V
A
-
N
V
D
Q
V
I
L
V
V
T
V
K
M
P
E
T
-
S
-
T
Y
I
I
D
K
F
L
V
L
A
E
K
N
E
L
E
T
V
M
V
I
N
K
M
D
L
Y
D
E
D
D
-
L
-
R
K
---
V
R
E
L
E
-
E
I
Y
S
-
G
L
---
Y
P
---
I
V
K
T
S
A
--
K
--
T
--
G
M
G
--
I
E
E
L
K
E
Y
------------------
L
K
G
K
I
S
T
M
A
G
L
S
G
V
G
K
S
S
L
L
N
A
I
N
P
-
G
L
K
-
L
R
-------------
T
T
T
T
A
Q
L
L
K
-
F
D
F
G
G
-
Y
V
V
D
T
P
G
F
A
N
L
E
I
N
-
D
I
E
P
E
-
E
L
K
H
Y
F
K
E
F
G
----
D
K
Q
C
F
---
F
S
D
C
N
H
-
V
D
E
P
E
C
G
V
K
E
A
V
E
N
G
E
I
A
E
S
R
Y
E
N
Y
V
K
M
F
Y
E
L
L
G
R
R
-----
73
HHSearch
83.37
31%
-89
- C3 -
2RCN
3
RSGA_SALTY
A:
[48-345]
--
A
E
G
I
V
I
---
S
R
---
F
G
M
H
A
D
V
E
S
--
A
D---
G
E
V
----
H
R
C
N
I
R
R
T
I
R
----
S
L
V
T
G
D
R
V
V
--
W
----
R
P
G
K
-
V
-
K
G
I
V
E
A
V
H
E
R
T
S
V
L
T
R
P
---VKPI
A
A
-
N
I
D
Q
I
V
I
V
S
A
I
-
L
P
E
L
-
S
-
L
N
I
I
D
R
Y
L
V
G
C
E
T
L
Q
V
E
P
L
I
V
L
N
K
I
D
L
L
D
D
E
G
-
M
-
D
F
---
V
N
E
Q
M
-
D
I
Y
R
-
N
I
---
G
Y
---
R
V
L
M
V
S
--
S
--
H
TQ
D
G
L
--
K
P
L
E
E
A
L
------------------
T
G
R
I
S
-
I
F
A
G
Q
S
G
V
G
K
S
S
L
L
N
A
L
L
G
-
L
Q
N
E
I
L
T
N
-------------
T
A
A
R
L
Y
H
-
F
P
H
G
G
-
D
V
I
D
S
P
G
V
R
E
F
G
L
W
-
H
L
E
P
E
-
Q
I
T
Q
G
F
V
E
F
H
D
Y
--
L
G
H
C
K
---
Y
R
D
C
K
H
-
D
A
D
P
G
C
A
I
R
E
A
V
E
N
G
A
I
A
E
T
R
F
E
N
Y
H
R
I
L
E
S
M
A
--------
2
PsiBlast_PDB
81.96
35%
-78
- C3 -
1U0L
2
RSGA_THEMA
A:
[30-299]
---------------------------
T
----
G
E
R
----
I
L
C
K
L
R
G
K
F
R
L
Q
N
L
K
I
Y
V
G
D
R
V
E
--
Y
----
T
P
D
E
T
G
-
S
G
V
I
E
N
V
L
H
R
K
N
L
L
T
K
P
--
H
----
V
A
-
N
V
D
Q
V
I
L
V
V
T
V
K
M
P
E
T
-
S
-
T
Y
I
I
D
K
F
L
V
L
A
E
K
N
E
L
E
T
V
M
V
I
N
K
M
D
L
Y
D
E
D
D
-
L
-
R
K
---
V
R
E
L
E
-
E
I
Y
S
-
G
L
---
Y
P
---
I
V
K
T
S
A
--
K
--
T
--
G
M
G
--
I
E
E
L
K
E
Y
------------------
L
K
G
K
I
S
T
M
A
G
L
S
G
V
G
K
S
S
L
L
N
A
I
N
P
-
G
L
K
-
L
R
-------------
T
T
T
T
A
Q
L
L
K
-
F
D
F
G
G
-
Y
V
V
D
T
P
G
F
A
N
L
E
I
N
-
D
I
E
P
E
-
E
L
K
H
Y
F
K
E
F
G
----
D
K
Q
C
F
---
F
S
D
C
N
H
-
V
D
E
P
E
C
G
V
K
E
A
V
E
N
G
E
I
A
E
S
R
Y
E
N
Y
V
K
M
F
Y
E
L
L
G
R
R
-----
21
PsiBlast_CBE
81.41
35%
-82
- C3 -
1U0L
2
RSGA_THEMA
C:
[30-299]
---------------------------
T
----
G
E
R
----
I
L
C
K
L
R
G
K
F
R
L
Q
N
L
K
I
Y
V
G
D
R
V
E
--
Y
----
T
P
D
E
T
G
-
S
G
V
I
E
N
V
L
H
R
K
N
L
L
T
K
P
--
H
----
V
A
-
N
V
D
Q
V
I
L
V
V
T
V
K
M
P
E
T
-
S
-
T
Y
I
I
D
K
F
L
V
L
A
E
K
N
E
L
E
T
V
M
V
I
N
K
M
D
L
Y
D
E
D
D
-
L
-
R
K
---
V
R
E
L
E
-
E
I
Y
S
-
G
L
---
Y
P
---
I
V
K
T
S
A
--
K
--
T
--
G
M
G
--
I
E
E
L
K
E
Y
------------------
L
K
G
K
I
S
T
M
A
G
L
S
G
V
G
K
S
S
L
L
N
A
I
N
P
-
G
L
K
-
L
R
-------------
T
T
T
T
A
Q
L
L
K
-
F
D
F
G
G
-
Y
V
V
D
T
P
G
F
A
N
L
E
I
N
-
D
I
E
P
E
-
E
L
K
H
Y
F
K
E
F
G
----
D
K
Q
C
F
---
F
S
D
C
N
H
-
V
D
E
P
E
C
G
V
K
E
A
V
E
N
G
E
I
A
E
S
R
Y
E
N
Y
V
K
M
F
Y
E
L
L
G
R
R
-----
4
PsiBlast_PDB
80.63
32%
-98
- C3 -
2RCN
3
RSGA_SALTY
A:
[74-345]
-----------------------------------------------
I
R
R
T
I
R
S
L
V
T
G
D
R
V
V
--
W
R
P
G
K------V
K
G
I
V
E
A
V
H
E
R
T
S
V
L
T
R
P
VK
P
----
I
A
A
N
I
D
Q
I
V
I
V
-
S
A
I
L
P
E
L
-
S
-
L
N
I
I
D
R
Y
L
V
G
C
E
T
L
Q
V
E
P
L
I
V
L
N
K
I
D
L
L
D
D
E
G
-
M
-
D
F
---
V
N
E
Q
M
-
D
I
Y
R
-
N
I
---
G
Y
---
R
V
L
M
V
S
--
S
HT
Q
--
D
G
L
--
K
P
L
E
E
A
L
------------------
T
G
R
I
S
-
I
F
A
G
Q
S
G
V
G
K
S
S
L
L
N
A
L
L
G
-
L
Q
N
E
I
L
T
N
-------------
T
A
A
R
L
Y
H
F
P
H
-
G
G
-
D
V
I
D
S
P
G
V
R
E
F
G
L
W
-
H
L
E
P
E
-
Q
I
T
Q
G
F
V
E
F
H
D
Y
--
L
G
H
C
K
---
Y
R
D
C
K
H
-
D
A
D
P
G
C
A
I
R
E
A
V
E
N
G
A
I
A
E
T
R
F
E
N
Y
H
R
I
L
E
S
M
A
--------
5
PsiBlast_PDB
76.61
30%
-86
- C3 -
4A2I
-
RSGA_ECOLI
V:
[74-345]
-----------------------------------------------
I
R
R
T
I
R
S
L
V
T
G
D
R
V
V
--
W
----
R
P
G
K
V
--
K
G
I
V
E
A
V
H
E
-
T
S
V
L
T
R
P
VK
P
----
I
A
A
N
I
D
Q
I
V
I
V
-
S
A
I
L
P
E
L
-
S
-
L
N
I
I
D
R
Y
L
V
G
C
E
T
L
Q
V
E
P
L
I
V
L
N
K
I
D
L
L
D
D
E
G
-
M
-
D
F
---
V
N
E
Q
M
-
D
I
Y
R
-
N
I
---
G
Y
---
R
V
L
M
V
S
--
S
HT
Q
--
D
G
L
--
K
P
L
E
E
A
L
------------------
T
G
R
I
S
-
I
F
A
G
Q
S
G
V
G
K
S
S
L
L
N
A
L
----
L
G
-
L
Q
N
E
I
L
T
N
T
A
A
R
L
Y
H
F
P
---------
H
-
G
G
-
D
V
I
D
S
P
G
V
R
E
F
G
L
W
-
H
L
E
P
E
-
Q
I
T
Q
G
F
V
E
F
H
D
Y
--
L
G
H
C
K
---
Y
R
D
C
K
H
-
D
A
D
P
G
C
A
I
R
E
A
V
E
N
G
A
I
A
E
T
R
F
E
N
Y
H
R
I
L
E
S
M
A
--------
76
HHSearch
54.62
23%
-66
- C3 -
1PUJ
2
RBGA_BACSU
A:
[19-180]
--------------------------------------------------------------------------------------------
E
--
K
----
L
K
-
L
I
D
I
V
Y
E
L
V
D
A
R
I
P
M
S
S
R
-
N
P
M
I
E
D
I
L
K
-----
N
K
P
R
I
M
L
L
N
K
A
D
K
A
D
A
A
V
--------
T
Q
Q
W
K
-
E
H
F
E
-
N
Q
---
G
I
---
R
S
L
S
I
N
--
S
--
V
NG
Q
G
L
--
N
Q
I
V
P
A
S
K
E
I
L
Q
E
K
F
D
R
M
R
A
K
GVKP
R
A
I
R
A
-
L
I
I
G
I
P
N
V
G
K
S
T
L
I
N
R
L
A
K
-
K
N
I
-
A
-------------------
Q
W
V
K
-
V
G
K
E
L
-
E
L
L
D
T
P
G
I
L
W
P
K
F
------------------------------------------------------------------------------
77
HHSearch
48.86
18%
-62
- C3 -
3H2Y
1
?
A:
[67-225]
----------------------------------------------------------------------------------------------------
G
K
-
S
D
A
L
V
V
K
I
V
D
I
F
D
F
N
G
----
S
W
L
P
G
L
H
R
F
V
--
G
N
N
K
V
L
L
V
G
N
K
A
D
L
I
P
K
S
V
K
H
-
D
K
---
V
K
H
W
M
-
R
Y
S
A
K
Q
L
---
G
L
K
P
E
D
V
F
L
I
S
--
A
--
A
KG
Q
G
I
--
A
E
L
A
D
A
I
E
Y
Y
R
--------------
G
G
K
D
V
-
Y
V
V
G
C
T
N
V
G
K
S
T
F
I
N
R
M
I
K
-
E
F
S
-
D
E
T
E
N
V
I
T
-
T
S
H
F
P
----
D
L
I
D
I
P
-
L
D
E
E
S
-
S
L
Y
D
T
P
G
I
I
N
H
H
-------------------------------------------------------------------------------
75
HHSearch
48.06
19%
-68
- C3 -
3CNL
1
RBGA_THEMA
A:
[16-159]
-------------------------------------------------------------------------------------------
K
D
--
L
----
L
R
-
L
V
N
T
V
V
E
V
R
D
A
R
A
P
F
A
-
T
S
A
Y
G
V
D
-------
F
S
R
K
E
T
I
I
L
L
N
K
V
D
I
A
D
E
K
T
--------
T
K
K
W
V
-
E
F
F
K
-
K
Q
---
G
K
-----
R
V
I
T
--
T
--
H
KG
E
P
R
--
K
V
L
L
K
K
L
SFD---------------
R
L
A
R
V
-
L
I
V
G
V
P
N
T
G
K
S
T
I
I
N
K
L
K
G
-
K
R
A
------------------
K
G
I
Q
W
F
S
-
L
E
N
G
V
-
K
I
L
D
T
P
G
I
L
Y
K
N
I
------------------------------------------------------------------------------
78
HHSearch
42.61
19%
-58
- C3 -
3EC1
1
?
A:
[69-226]
----------------------------------------------------------------------------------------------------
G
E
-
S
K
A
L
V
V
N
I
V
D
I
F
D
F
N
G
----
S
F
I
P
G
L
P
R
F
A
--
A
D
N
P
I
L
L
V
G
N
K
A
D
L
L
P
R
S
V
-
K
Y
P
K
---
L
L
R
W
M
-
R
R
M
A
E
E
L
GLC
P
V
---
D
V
C
L
V
S
--
A
--
A
KG
I
G
M
--
A
K
V
M
E
A
I
N
R
Y
R
--------------
E
G
G
D
V
-
Y
V
V
G
C
T
N
V
G
K
S
T
F
I
N
R
I
I
E
-
E
A
T
-
G
K
G
N
V
I
T
T
S
--
Y
F
P
G
T
T
L
D
M
I
E
I
P
-
L
E
S
G
A
-
T
L
Y
D
T
P
G
I
I
N
H
H
-------------------------------------------------------------------------------
62
Fugue
36.30
15%
-26
* C5 *
3WZM
1
?
A:
[15-278]
-
M
R
T
R
S
T
I
---
S
T
PNG
I
T
W
Y
Y
E
Q
E
G
--
T
----
G
P
D
----
V
V
L
V
P
D
G
L
G
E
C
Q
M
F
D
S
S
V
S
Q
I
A
A
Q
G
F
----
R
V
T
T
F
D
-
M
P
G
M
S
R
S
A
K
A
P
P
E
T
Y
T
E
--
V
----------
T
A
Q
K
L
A
S
Y
V
I
S
V
L
-
D
-
A
L
D
I
K
H
A
T
V
W
G
C
A
S
G
A
S
T
V
V
A
L
L
L
G
Y
P
D
R
I
-
R
-
N
-
A
M
---
C
H
E
L
P
T
K
L
L
D
-
H
L
---
S
N
---
T
A
V
L
-----------
E
D
--
E
E
I
S
K
I
L
------------------
A
N
V
M
L
-
N
--
D
V
S
G
-
G
S
E
A
W
Q
------------------
A
M
G
D
E
V
H
A
R
L
H
K
N
Y
P
V
-
W
A
-
R
G
-
Y
P
R
T
I
P
P
S
A
P
V
K
-----
D
L
E
-
A
L
R
G
K
P
L
D
W
T
V
G
--
A
A
T
P
T
ESF
F
D
N
I
V
T
-
A
T
K
A
G
V
N
I
G
L
L
P
G
M
H
F
P
Y
V
S
H
P
D
V
F
A
K
Y
V
V
E
T
T
Q
K
H
L
----
68
Fugue
34.72
17%
-14
- C5 -
4HHT
4
RNH2_THEMA
A:
[1-229]
-
G
I
D
E
L
Y
K
---
K
E
---
F
G
I
V
A
G
V
D
E
--
A
----
S
---------------
R
G
C
L
A
G
P
V
V
A
A
A
V
V
--
L
E
K--
E
I
E
G
I
N
-
D
S
------
R
L
L
D
E
I
M
E
K
--
A
----
A
V
-
G
I
G
I
A
------------
S
-
P
E
E
I
D
L
Y
N
-
I
F
N
A
T
K
L
A
M
N
R
A
L
E
N
L
S
V
K
P
------------
S
F
V
L
-
V
D
G
K
-
G
I
---
E
L
---
S
V
P
G
T
C
--
L
--
V
--
K
G
D
--
Q
K
-----------------------
S
K
L
I
G
-
A
A
S
I
V
A
K
V
F
R
D
R
L
M
S
E
F
H
R
-
M
Y
P
-----
Q
F
S
F
H
K
H
K
G
Y
A
T
K
E
H
L
N
E
I
R
-
K
N
-
G
V
-
L
P
I
H
R
L
S
F
E
P
V
L
-
E
-
L
L
T
D
D
-
L
L
R
E
F
F
E
K
-----------------------------------
G
L
I
S
E
N
R
F
E
R
I
L
N
L
L
G
A
R
K
S
V
V
F
R
K
E
R
8
PsiBlast_PDB
34.44
30%
-1
- C3 -
3RWO
2
YPT32_YEAST
B:
[13-122]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
V
L
I
G
D
S
G
V
G
K
S
N
L
L
S
R
F
T
T
D
E
F
N
-
I
E
----
S
K
S
T
I
G
V
E
F
A
T
R
T
I
E
V
E
N
-
K
K
I
K
A
-
Q
I
W
D
T
A
G
L
E
R
--
Y
R
-
A
I
T
S
A
-
Y
Y
R
G
A
V
G
A
L
I
V
Y
D
I
S
K
S
S
S
---
Y
E
N
C
N
H
W
L
T
E
L
R
E
N
A
D
D
N
V
A
V
G
L
I
G
-----------------------
7
PsiBlast_PDB
33.14
30%
5
- C3 -
3RWM
3
YPT32_YEAST
B:
[13-122]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
V
L
I
G
D
S
G
V
G
K
S
N
L
L
S
R
F
T
T
D
E
F
N
-
I
E
----
S
K
S
T
I
G
V
E
F
A
T
R
T
I
E
V
E
N
-
K
K
I
K
A
-
Q
I
W
D
T
A
G
L
E
R
--
Y
R
-
A
I
T
S
A
-
Y
Y
R
G
A
V
G
A
L
I
V
Y
DI
S
K
S
S
S
---
Y
E
N
C
N
H
W
L
T
E
L
R
E
N
A
D
D
N
V
A
V
G
L
I
G
-----------------------