@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1077: (2016-03-21 )
MVYLKSIDAIGFKSFADQTNVQFDKGVTAIVGPNGSGKSNITDAIKWVLGEQSAKSLRGSKMEDIIFSGAEHRKAQNYAEVQLRLDNHSKKLSVDENEVIVTRRLYRSGESEYYINNDRARLKDIADLFLDSGLGKEAYSIISQGRVDEILNAKPIDRRQIIEESAGVLKYKKRKAESLNKLDQTEDNLTRVEDILYDLEGRVEPLKEEAAIAKEYKTLSHQMKHSDIVVTVHDIDQYTNDNRQLDQRLNDLQGQQANKEADKQRLSQQIQQYKGKRHQLDNDVESLNYQLVKATEAFEKYTGQLNVLEERKKNQSETNARYEEEQENLMELLENISNEISEAQDTYKSLKSKQKELNAVIRELEEQLYVSDEAHDEKLEEIKNEYYTLMSEQSDVNNDIRFLKHTIEENEAKKSRLDSRLVEVFEQLKDIQGQIKTTKKEYQQTNKELSAVDKEIKNIEKDLTDTKKAQNEYEEKLYQAYRYTEKMKTRIDSLATQEEEYTYFFNGVKHILKAKNKELKGIHGAVAEIIDVPSKLTQAIETALGASLQHVIVDSEKDGRQAIQFLKERNLGRATFLPLNVIQSRVVATDIKSIAKEANGFISIASEAVKVAPEYQNIIGNLLGNTIIVDHLKHANELARAIKYRTRIVTLEGDIVNPGGSMTGGGARKSKSILSQKDELTTMRHQLEDYLRQTESFEQQFKELKIKSDQLSELYFEKSQKHNTLKEQVHHFEMELDRLTTQETQIKNDHEEFEFEKNDGYTSDKSRQTLSEKETHLESIKASLKRLEDEIERYTKLSKEGKESVTKTQQTLHQKQSDLAVVKERIKTQQQTIDRLNNQSQQTKHQLKDVKEKIAFFNSDEVMGEQAFQNIKDQINGQQETRTRLSDELDKLKQQRIELNEQIDAQEATLQVCHQDILAIENHYQDIKAEQSKLDVLIHHAIDHLNDEYQLTVERAKSEYTSDESIDALRKKVKLMKMSIDELGPVNLNAIEQFEELNERYTFLSEQRTDLRKAKETLEQIISEMDQEVTERFKETFHAIQGHFTAVFKQLFGGGDAELQLTEADYLTAGIDIVVQPPGKKLQHLSLLSGGERALTAIALLFAILKVRSAPFVILDEVEAALDEANVIRYAKYLNELSDETQFIVITHRKGTMEFADRLYGVTMQESGVTKLVSVNLNTIDDVLKEEQ
Atome Classification :
(20 SA)
.........10........20-...-.....30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.-.---..-.-..540.......550.......560...--...-.570........580.......590.....-..600.--........610-.......620.......630.......640.......650.......660.......670...-....680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810..------.....820.......830.......840.......850.......860.......870.......880.......---890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020----........1030......1040......1050......1060-......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
Y
L
KSIDAIG
F
K
SFADQTN
V
-
Q
FD-KG
V
T
A
I
VGPNGSGK
S
N
I
T
D
A
I
K
W
V
LGE
Q
S
A
K
S
LRGS
K
M
E
D
I
I
FSGAEHRKAQN
Y
A
E
V
Q
L
R
LDNHSKKLSVDEN
E
V
I
V
T
R
R
L
Y
RSGES
E
Y
Y
INN
D
R
A
R
L
K
D
I
A
D
L
F
L
DSGL
G
K
E
A
Y
S
I
I
SQG
R
V
D
E
I
LNAKPI
D
R
R
Q
I
I
E
ESA
G
V
L
K
Y
K
K
R
K
A
E
S
L
N
K
LDQTED
N
L
T
R
V
E
D
I
L
Y
DLEGRVE
P
L
K
E
E
A
A
I
A
K
E
Y
K
T
L
S
H
QMKHS
D
I
V
V
T
V
H
D
I
D
Q
YTND
N
R
Q
L
D
Q
R
L
N
D
LQGQQAN
K
E
A
D
K
Q
R
L
S
Q
Q
I
Q
Q
Y
KGKRHQLDN
D
V
E
S
L
N
Y
Q
L
V
K
A
T
E
A
F
E
K
Y
TGQ
L
N
V
L
E
E
R
KKNQSETNA
R
Y
E
E
E
Q
E
N
L
M
E
L
L
E
N
I
S
N
E
I
S
E
A
Q
D
T
Y
K
S
L
K
S
K
Q
K
E
L
N
A
V
I
R
E
L
E
E
QLYVSDE
A
H
D
E
K
L
E
E
I
K
N
E
Y
Y
T
L
MSEQSDV
N
N
D
I
R
F
L
K
H
T
I
E
E
N
E
A
K
K
S
R
L
D
S
R
L
V
E
V
F
E
Q
L
K
D
I
Q
G
Q
I
K
T
T
K
K
E
Y
Q
Q
T
N
K
E
L
S
A
V
D
K
E
I
K
N
I
E
K
D
L
T
D
T
K
K
A
Q
N
E
Y
E
E
K
L
Y
Q
A
Y
R
Y
T
E
K
M
K
T
R
I
D
S
L
ATQEE
E
Y
T
Y
F
F
N
G
V
K
H
I
L
K
AKNKELK
G
I
H
G
A
V
A
E
I
IDV
P
-
S
---
K
L
-
T
-
Q
A
I
E
T
A
L
G
A
S
L
Q
H
V
IVDSEKD
G
R
Q
A
I
Q
F
--
L
K
E-RNL-GR
A
T
F
L
P
L
N
V
I
Q
S
R
V
V
A
T
D
I
K
S
I
A
K
E-AN
G
--
F
--
I
S
I
A
S
E
A
V
KV
A
-
P
E
Y
Q
N
I
I
G
N
LLGN
T
I
I
V
D
H
L
K
H
A
N
E
L
A
R
A
I
K
YR
T
R
I
V
T
L
EG
D
I
VNPGGSMTGGGA
R
K
S
K
S
I
L
S-Q
K
D
E
L
T
T
M
R
H
Q
L
E
D
Y
L
R
Q
T
E
S
F
E
Q
Q
F
K
ELKIK
S
D
Q
L
S
E
L
Y
F
E
KSQKH
N
T
L
K
E
Q
V
H
H
F
E
M
E
L
D
R
LTTQETQIKND
H
E
E
F
E
FEKNDGYTSDKSRQ
T
L
S
E
K
E
T
H
L
E
S
I
K
A
S
L
K
R
L
E
D
E
I
E
R
Y
T
K
L
S
KEG
K
E
S
V
T
K
T
Q
Q
T
L
H
Q
------KQ
S
D
L
A
V
V
K
E
R
I
K
T
Q
Q
Q
T
I
D
R
LNN
Q
S
Q
Q
T
K
H
Q
L
K
D
V
K
E
K
I
AFFNS
D
E
V
M
G
E
Q
A
F
Q
N
I
K
D
QIN
G
Q
Q
E
T
R
T
R
L
S
D
E
L
---
D
K
L
K
Q
Q
R
I
E
L
NEQI
D
A
Q
E
A
T
L
Q
V
C
H
Q
D
I
L
A
I
E
N
H
Y
Q
D
I
K
A
E
Q
S
K
L
D
V
L
I
H
H
A
I
D
HLND
E
Y
Q
L
T
V
E
R
AKSEYTSD
E
S
I
D
A
L
R
K
K
V
K
L
M
K
M
S
I
DELGPV
N
L
N
A
I
E
Q
F
E
E
L
N
E
R
Y
T
F
L
S
E
Q
R
T
D
L
R
K
A
K
E
T
L
E
Q
I
------
I
S
E
M
D
Q
E
V
T
E
R
F
K
E
T
F
H
A
I
Q
G
H
F
T
A
V
F
K
Q
L
FGGGD
A
E
L
Q
L
TE-ADYLTAG
I
D
I
V
VQPPGK
K
L
Q
H
L
SLLSG
G
E
R
A
L
T
A
I
A
L
L
F
A
I
L
K
VRSA
P
F
V
I
L
D
E
V
E
A
A
L
D
E
A
N
V
I
R
Y
A
K
Y
L
N
E
LSDET
Q
F
I
V
I
T
HRKG
T
M
E
F
A
D
R
L
Y
G
V
T
MQESG
V
T
K
L
V
S
V
NL
N
T
I
D
D
V
L
KEEQ
113
Fugue
81.02
21%
-7
* C2 *
4UX3
2
SMC3_YEAST
A:
[3-527]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
R
V
I
I
K
G
F
K
T
Y
R
N
E
T
I
I
D
N
F
S
P
H
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
L
S
D
D
Y
S
N
L
K
R
E
E
R
Q
G
L
I
H
Q
GSGGSV
M
S
A
S
V
E
I
V
I
R
R
T
V
G
L
K
K
D
D
Y
Q
L
N
D
R
N
V
-
T
K
G
D
I
V
R
M
L
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
Q
-
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
GA
K
S
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
L
E
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
L
N
E
V
I
N
Q
M
E
T
S
D
Q
L
L
Q
R
L
N
D
M
N
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
------
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
P
R
G
T
A
K
L
I
I
H
--------
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
Q
L
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
E
N
K
-
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
---
5
PsiBlast_PDB
80.23
28%
-41
- C1 -
4RSJ
-
SMC_PYRFU
A:
[12-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
G
K
L
S
T
I
Q
A
K
R
I
K
V
E
K
E
I
E
A
K
S
N
E
L
E
K
V
S
K
E
L
E
S
S
E
R
E
L
I
-
A
A
E
A
Q
R
E
V
-----
R
G
N
R
A
A
E
E
L
K
R
----------------
S
G
I
G
-----------
G
I
Y
G
T
L
A
E
L
I
K
V
K
-
D
---
E
A
Y
A
-
L
A
I
E
V
A
L
G
N
R
A
D
N
V
V
V
E
D
E
L
V
A
E
K
A
I
K
Y
--
L
K
E
-
H
K
L
-
G
R
L
T
F
L
P
L
N
K
I
K
P
K
H
V
D
S
S
V
---------
G
--
L
--
P
A
V
--
D
V
I
E
Y
D
-
Q
K
I
E
N
A
V
K
F
A
L
G
D
T
V
I
V
N
S
M
----
E
E
A
R
P
H
I
G
K
V
R
M
V
T
I
E
G
E
L
Y
E
R
S
G
A
I
T
G
G
H
F
----
L
A
V
-----
D
T
T
K
L
R
E
K
V
E
S
L
R
R
R
K
E
A
L
E
G
E
L
N
S
L
K
I
E
L
R
S
L
E
N
A
S
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
79.83
29%
-31
- C2 -
1E69
-
?
A:
[1-1164]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
N
---
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
D
M
I
F
------------
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
E
-
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
L
K
D
I
R
D
R
F
A
G
T
GLGVDF
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
G
E
G
R
L
-------------
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
-
G
V
S
A
I
V
P
V
E
V
-----------
97
HHSearch
74.53
44%
-46
- C1 -
3KTA
1
?
B:
[6-160]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
P
E
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
-
D
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
----
21
PsiBlast_CBE
73.84
43%
-52
* C1 *
1XEX
1
?
B:
[8-161]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
---
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
Q
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
E
E
--
6
PsiBlast_PDB
72.21
30%
-39
- C1 -
4U4P
-
?
A:
[41-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
W
N
R
N
C
V
K
G
L
V
A
S
L
I
S
V
K
D
T
---
S
A
-
T
-
T
A
L
E
L
V
A
G
E
R
L
Y
N
V
V
V
D
T
E
V
T
G
K
K
L
L
E
R
GE
L
K
R
-
R
-----
Y
T
I
I
P
L
N
K
I
S
A
R
C
I
A
P
E
T
L
R
V
A
Q
N
-
L
V
G
--
P
DN
V
H
V
A
L
S
L
V
E
Y
K
-
P
E
L
Q
K
A
M
E
F
V
F
G
T
T
F
V
C
D
N
M
D
N
A
K
K
V
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
D
V
F
D
P
H
G
T
L
S
G
G
A
R
S
Q
A
A
S
I
L
T
-
K
F
Q
E
L
K
D
V
Q
D
E
L
R
I
K
E
N
E
L
R
A
L
E
E
E
L
A
G
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.49
31%
-38
- C1 -
2WD5
-
SMC3_MOUSE
B:
[530-680]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
H
G
I
V
M
N
N
F
E
C
E
-
P
---
A
F
-
Y
-
T
C
V
E
V
T
A
G
N
R
L
F
Y
H
I
V
D
S
D
E
V
S
T
K
I
L
M
E
--
F
N
K
-
M
N
L
P
G
E
V
T
F
L
P
L
N
K
L
D
V
R
D
T
A
Y
------
P
E
-
T
N
D
--
A
--
I
P
M
I
S
K
-
L
R
Y
N
-
P
R
F
D
K
A
F
K
H
V
F
G
K
T
L
I
C
R
S
M
E
V
S
T
Q
L
A
R
A
--
F
T
M
D
C
I
T
L
E
G
D
Q
V
S
H
R
G
A
L
T
G
G
Y
Y
D
T
R
---
L
E
L
Q
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.71
27%
-59
- C1 -
1GXL
-
?
A:
[495-679]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
R
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
-
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
---
K
Y
-
S
-
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
--
L
K
Q
-
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
--
N
R
I
S
G
L
E
N
E
--
R
G
--
F
--
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
R
S
S
N
V
F
E
-
R
R
I
K
L
K
H
L
E
Q
E
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.69
28%
-69
- C1 -
1GXJ
-
?
A:
[498-658]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
-
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
---
K
Y
-
S
-
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
--
L
K
Q
-
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
--
N
R
I
S
G
L
E
N
E
--
R
G
--
F
--
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
68.59
28%
-63
- C1 -
1GXJ
-
?
A:
[498-658]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
-
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
---
K
Y
-
S
-
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
--
L
K
Q
-
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
---
F
N
R
I
S
G
L
E
N
-
E
R
G
--
F
--
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.51
25%
-38
- C1 -
4RSI
1
A:
[58-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
C
Q
E
T
C
D
K
L
R
A
R
L
V
E
Y
G
F
D
P
S
R
I
K
D
L
K
Q
R
E
D
K
L
K
S
H
Y
Y
Q
T
C
K
N
S
E
Y
L
K
R
R
V
T
N
L
---
E
F
N
Y
T
K
P
Y
---------
P
N
F
E
A
S
F
V
H
G
V
V
G
Q
L
F
Q
I
D
-
N
DNI
R
Y
-
A
-
T
A
L
Q
T
C
A
G
G
R
L
F
N
V
V
V
---
Q
D
S
Q
T
A
T
Q
L
--
L
E
R
-
G
R
L
R
K
R
V
T
I
I
P
L
D
K
I
Y
T
R
P
I
S
S
Q
V
L
D
L
A
K
K
I
A
P
G
--
K
--
V
E
L
A
I
N
L
I
R
F
D
-
E
S
I
T
K
A
M
E
F
I
F
G
N
S
L
I
C
E
D
P
E
T
A
K
K
I
T
F
H
P
K
I
R
A
R
S
I
T
L
Q
G
D
V
Y
D
P
E
G
T
L
S
G
G
S
R
---
E
S
L
L
V
-
D
I
Q
K
Y
N
Q
I
Q
K
Q
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.21
38%
11
- C4 -
3KTA
2
SMC_PYRFU
A:
[3-169]
--
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
F
S
-
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
----
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.00
28%
-68
- C1 -
1GXK
-
?
A:
[501-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
V
R
A
V
F
E
E
K
E
R
-
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
---
K
Y
-
S
-
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
--
L
K
Q
-
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
--
N
R
I
S
G
L
E
N
E
--
R
G
--
F
--
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
66.59
39%
16
- C4 -
3KTA
2
SMC_PYRFU
A:
[2-169]
-
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
-
I
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
----
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.89
38%
0
- C4 -
1XEX
2
?
A:
[2-167]
-
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
F
S
-
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
K
N
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
65.57
29%
-59
- C1 -
1GXJ
-
?
A:
[512-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
-
E
---
K
Y
-
S
-
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
--
L
K
Q
-
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
I
S
G
---
L
E
N
-
E
R
G
--
F
--
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.78
38%
16
- C4 -
1XEW
-
SMC_PYRFU
X:
[1-167]
M
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
F
S
-
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
--------------------
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.97
30%
-34
- C1 -
3L51
5
A:
[10-155]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
W
N
R
N
S
V
K
G
L
V
A
S
L
I
N
V
K
-
D
---
N
S
-
T
A
T
A
L
E
V
V
A
G
E
R
L
Y
N
V
V
V
D
T
E
V
T
A
K
K
L
L
E
----
K
G
-
E
L
K
-
R
R
Y
T
I
I
P
L
N
K
I
S
A
R
C
I
A
P
E
T
L
R
V
A
Q
N
-
L
V
G
PD
N
--
V
H
V
A
L
S
L
V
D
Y
K
-
P
E
L
Q
K
G
M
E
F
V
F
G
T
T
F
V
C
N
N
M
D
N
A
K
K
V
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
D
V
F
D
P
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
62.21
27%
-36
- C1 -
3L51
2
B:
[16-160]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
G
I
Y
G
R
L
G
D
L
G
A
I
D
-
E
---
K
Y
-
D
-
I
A
I
S
S
C
C
H
-
A
L
D
Y
I
V
V
D
S
I
D
T
A
Q
E
C
V
N
F
--
L
K
K
-
H
N
I
-
G
I
A
T
F
I
G
L
D
K
M
T
V
W
A
K
K
M
S
----
K
I
Q
-
T
P
E
--
N
--
T
P
R
L
F
D
L
V
K
V
K
N
E
E
I
R
Q
A
F
Y
F
A
L
R
D
T
L
V
A
N
N
L
D
Q
A
T
R
V
A
Y
Q
R
D
R
R
W
R
V
V
T
L
Q
G
Q
I
I
E
Q
S
G
T
M
S
G
G
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
60.91
27%
-27
- C1 -
2WD5
-
SMC3_MOUSE
B:
[527-671]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
N
G
Y
H
G
I
V
M
N
N
F
E
C
E
-
P
---
A
F
-
Y
-
T
C
V
E
V
T
A
G
N
R
L
F
Y
H
I
V
D
S
D
E
V
S
T
K
I
L
M
E
--
F
N
K
M
N
L
P
-
G
E
V
T
F
L
P
L
N
K
L
D
V
R
D
T
A
------
Y
-
P
-
E
T
N
--
D
--
A
I
P
M
I
S
K
L
R
Y
N
-
P
R
F
D
K
A
F
K
H
V
F
G
K
T
L
I
C
R
S
M
E
V
S
T
Q
L
A
R
A
--
F
T
M
D
C
I
T
L
E
G
D
Q
V
S
H
R
G
A
L
T
G
G
Y
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------