@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1093: (2016-03-22 )
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20-------------------------.-------------------.-------------......30------.........40--------.--..-----..-...-.50.---.-....--..-60........70........80........90........--100--........110.......120.......--130.......140.......150......-.-----160-------.........170.......180.......190.......200-.-...-...210------.......220.......230........240.......250.......260.......270.......280.......290.......300......--.310.......320--..--.....--.------.-330-........340.........350-------.--........360---.........370......--.380.......390.....--..400.....--.--.410.......420.......430.......440.......450.......460......-----------------.470.......480.......490.-..-....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAD
N
L
V
I
V
ESPAK
A
K
T
I
E
K
Y
L-------------------------G-------------------
K
-------------
K
Y
K
V
I
A
S-------MG
H
V
RDL
P
R
S
---------Q--MG-----VD-TED-NYEP---
K
-
Y
I
T
I
--RG-KG
P
V
V
K
E
L
K
K
H
A
K
K
AK
N
V
F
LASDPDREG
E
A
I
A
W
H
L
S
K
I
L
E
--LE---DSKEN
R
V
V
F
N
E
I
T
K
D
A
V
K
E
S
FKNP
R
E
I
E
--
M
NLV
D
A
Q
Q
A
R
R
I
L
D
R
L
VGYNI
S
P
V
L
W
K
K
V
-
K
-----K---------GLSAG
R
V
Q
S
V
A
L
R
L
V
IDRENEIRNFKPE
E
Y
W
T
IE
G
E
F
R
Y
KKS-K-FN
A
-
K
F
L
HYK------NK
P
F
K
LK
T
K
K
D
V
E
K
I
T
A
AL-DGD
Q
F
E
ITNVT
K
K
EKTRNPANPF
T
T
S
T
L
Q
Q
E
A
A
R
KL
N
F
K
A
R
K
T
M
M
V
A
Q
Q
L
Y
EGIDLKKQG
T
I
G
L
I
T
Y
M
RTDSTRIS
D
--
T
A
K
A
E
A
K
Q
Y
I
T
D
----
K
Y--G
E
S
YT--S------K-RK--ASGKQGD
Q
D
--
A
H
E
AIRPSST---------M--R
T
P
D
D
M
K
S
F
-----
L
T
K
D
Q
Y
R
L
Y
K
L
I
W
E
R
F
V
A
--
S
Q
M
A
P
A
I
L
D
T
V
S
L
D
I
TQ
G
D
--
I
K
F
R
ANG
Q
T
I
--
K
--
F
K
G
F
M
T
L
Y
V
E
TKDDSD
S
E
K
ENKLPKLEQGD
K
V
T
A
T
QIEP
A
Q
HYTQPPPR
Y
T
E
A
R
L
V
K
T
L
E
-----------------
E
LKIGRPSTYAP
T
I
D
T
I
QKR
N
Y
V
K
L-ES-KRFV
P
T
E
L
G
E
I
V
H
E
Q
V
K
E
YF
P
E
I
I
D
V
E
F
T
V
N
M
E
T
L
L
D
K
I
AEGD
I
T
W
R
K
V
I
D
G
F
F
S
S
F
K
Q
D
V
E
R
A
E
E
E
M
E
K
I
EIKDEPAGE
D
C
E
VCGS
P
M
V
I
K
MGRYG
K
F
M
A
CSNFPDC
R
N
T
K
A
I
V
K
S
IGVKCPKCNDG
D
V
V
E
RKSKKN
R
V
F
YGCSKYPECDFISWDKPIGRDCP
K
C
N
Q
Y
L
V
ENKKG
K
T
T
Q
V
I
CSNC
D
Y
K
E
AAQK
9
PsiBlast_PDB
93.06
42%
-59
- C4 -
1MW8
7
TOP1_ECOLI
X:
[2-584]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
S
GDERGALVN
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
S
-----
E
--
A
R
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
--------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
33
HHSearch
92.93
45%
-60
- C4 -
1MW9
9
TOP1_ECOLI
X:
[2-581]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
---------------ERGAL
V
N
R
M
G
V
D
P
W
H
N
WEA
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
-
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
--
P
------
E
-
S
P
NQ
Y
A
----------
R
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
-------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
-------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.79
43%
-64
- C4 -
1CY6
4
TOP1_ECOLI
A:
[4-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
---------
A
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.46
42%
-60
- C4 -
1MW9
9
TOP1_ECOLI
X:
[2-584]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
-ERGALVN--
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
----------
R
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
-------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.25
43%
-64
- C4 -
1CY4
4
TOP1_ECOLI
A:
[4-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
----------
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
----------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.10
43%
-61
- C4 -
1ECL
-
TOP1_ECOLI
A:
[2-584]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
----------
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
---------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.09
43%
-60
- C4 -
1CY8
3
TOP1_ECOLI
A:
[4-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
----------
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
---
K
G
D
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
92.07
42%
-58
- C4 -
2GAJ
-
TOP1_THEMA
A:
[9-586]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
-------------------------
G
-------------------
N
-------------
E
Y
E
V
F
A
S
-------
M
G
H
I
I
D
L
P
K
S
---------
K
--
F
G
-----
V
D
-
L
E
K
-
D
F
E
P
---
E
-
F
A
V
I
--
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
--
T
L
---
G
R
K
-
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
--
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-----
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
-
I
D
V
-
K
----
E
------
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
I
-------
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
--
Y
A
K
E
E
A
R
N
L
I
T
E
----
V
F
--
G
E
E
Y
V
--
G
-----------------------
A
H
E
A
I
R
P
T
N
V
---------
F
--
M
T
P
E
E
A
G
K
Y
-----
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
--
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
E
K
V
W
K
T
E
R
N
T
G
E
------
F
P
-
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
-
I
R
-
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
-----
I
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
--------------------------------------------------------------------------------
11
PsiBlast_PDB
91.83
42%
-70
- C4 -
3PX7
3
TOP1_ECOLI
A:
[2-584]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
----------
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
---------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.67
43%
-61
- C4 -
1CY2
3
TOP1_ECOLI
A:
[4-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
---------
A
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
---------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.58
42%
-60
- C4 -
3PWT
3
TOP1_ECOLI
A:
[2-584]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
-
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
---------
A
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.49
42%
-57
- C4 -
2GAI
-
TOP1_THEMA
A:
[9-586]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
-------------------------
G
-------------------
N
-------------
E
Y
E
V
F
A
S
-------
M
G
H
I
I
D
L
P
K
S
---------
K
--
F
G
-----
V
D
-
L
E
K
-
D
F
E
P
---
E
-
F
A
V
I
--
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
--
T
L
---
G
R
K
-
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
--
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-----
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
-
I
D
V
-
K
----
E
------
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
I
-------
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
--
Y
A
K
E
E
A
R
N
L
I
T
E
----
V
F
--
G
E
E
Y
V
--
G
-----------------------
A
H
E
A
I
R
P
T
N
V
---------
F
--
M
T
P
E
E
A
G
K
Y
-----
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
--
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
E
K
V
W
K
T
E
R
N
T
G
E
------
F
P
-
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
-
I
R
-
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
-----
I
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
--------------------------------------------------------------------------------
1
PsiBlast_PDB
91.42
43%
-62
- C4 -
1CY1
4
TOP1_ECOLI
A:
[4-586]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--R
G
A
L
V
N
---
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
------
E
--
A
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
----------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
----------------------------------------------------------------------------------------------------------------------------
55
Fugue
90.90
42%
-49
- C4 -
2GAI
-
TOP1_THEMA
A:
[7-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
-------------------------
G
-------------------
N
-------------
E
Y
E
V
F
A
S
-------
M
G
H
I
I
D
L
P
K
S
---------
K
--
F
G
-----
V
D
-
L
E
K
-
D
F
E
P
---
E
-
F
A
V
I
--
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
---
T
---
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
--
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-----
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
-
I
D
V
-
K
----------------
E
K
K
F
F
D
A
E
T
L
K
E
I
Q
-
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
D
-
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
--
Y
A
K
E
E
A
R
N
L
I
T
E
----
V
F
--
G
E
E
Y
-----------------------
V
G
--
A
H
E
A
I
R
P
T
N
V
---------
F
--
M
T
P
E
E
A
G
K
Y
-----
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
--
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
GK
Y
R
F
K
G
T
V
L
K
K
--
I
--
F
D
G
Y
E
K
V
W
K
T
E
R
N
T
-------
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
-
I
R
-
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
------
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
K
N
D
---
E
I
A
V
I
D
D
G
K
I
F
L
--------------------------------------------------------------
31
HHSearch
90.85
41%
-49
- C4 -
2GAI
-
TOP1_THEMA
A:
[7-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
-------------------------
G
-------------------
N
-------------
E
Y
E
V
F
A
S
-------
M
G
H
I
I
D
L
P
K
S
---------
K
--
F
G
-----
V
D
-
L
E
K
-
D
F
E
P
---
E
-
F
A
V
I
--
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
--
T
L
----
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
--
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-----
S
---------
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
-
I
D
---
V
K
-----------
E
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
----
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
-
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
--
Y
A
K
E
E
A
R
N
L
I
T
E
----
V
F
--
G
E
E
Y
V
--
G
-----------------------
A
H
E
A
I
R
P
T
N
V
---------
F
--
M
T
P
E
E
A
G
K
Y
-----
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
--
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
K
K
I
--
F
D
G
Y
E
K
V
W
K
T
E
R
N
-------
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
-----------------
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
-
I
R
-
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
-----
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
----
C
G
K
T
R
S
V
K
N
---------
D
E
I
A
V
----
I
D
D
G
K
I
F
L
----------------------------------------------------
5
PsiBlast_PDB
90.49
43%
-63
- C4 -
1CY0
1
TOP1_ECOLI
A:
[4-574]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
-------------------------
G
-------------------
S
-------------
D
Y
V
V
K
S
S
-------
V
G
H
I
R
D
L
P
--A
L
V
N
-----
R
--
M
G
-----
V
D
-
P
W
H
-
N
W
E
A
---
H
-
Y
E
V
L
--
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
--
G
D
---
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
--
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-----
R
---------
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
-
A
L
A
L
Q
V
T
H
Q
N
------
D
K
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
--
D
A
V
N
M
V
R
G
Y
I
S
D
----
N
F
--
G
K
K
Y
L
PE
S
------
P
-
N
Q
--
Y
A
S
K
E
N
S
Q
E
--
A
H
E
A
I
R
P
S
D
V
---------
N
--
V
M
A
E
S
L
K
D
------
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
--
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
-------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
-----------------
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
-
E
N
-
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
----------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
83.89
31%
-39
- C4 -
1GKU
-
RGYR_ARCFU
B:
[1-1054]
------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAASLCLFPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRNFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWVGEARGCLMVSTATAKKGKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESISTLSSILEKLGTGGIIYARTGEEAEEIYESLKNKFRIGIVTATKKGDYEKFVEGEIDHLIGTAHRGLDLPERIRFAVFVGCPSFRVTIEDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERHIDEVREILKKVMGKERPQAKDVVVREGEVIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSIDEVDFEKLSRELDESRDRYRRRQEFDL
I
K
P
A
L
F
I
V
E
S
P
T
K
A
R
Q
I
S
R
F
F
-------------------------
G
KPSVKVLDGAVVYEIPMQK
Y
-------------
V
L
M
V
T
A
S
-------
I
G
H
V
V
D
L
I
T
N
---------
R
GF
H
G
-----
V
L
-
V
N
G
-
R
F
V
P
---
V
-
Y
A
S
I
--
K
D
N
S
R
S
R
I
E
A
L
R
K
L
A
H
D
A
E
F
V
I
V
G
T
D
P
D
T
E
G
E
K
I
A
W
D
L
K
N
L
L
S
---
G
---
C
G
A
V
K
R
A
E
F
H
E
V
T
R
R
A
I
L
E
A
L
E
S
L
R
D
V
D
--
E
N
L
V
K
A
Q
V
V
R
R
I
E
D
R
W
I
G
F
V
L
S
Q
K
L
W
E
R
F
-
N
N----
R
---------
N
L
S
A
G
R
A
Q
T
L
V
L
G
W
I
I
D
R
F
Q
E
S
R
E
R
R
K
I
A
I
V
--------------------------------------
R
D
F
D
L
V
L
E
H
D
E
-
E
E
F
D
L
T
I
K
L
V
E
E
R
E
E
L
R
T
P
L
P
P
Y
T
T
E
T
M
L
S
D
A
N
R
I
L
K
F
S
V
K
Q
T
M
Q
I
A
Q
E
L
F
E
N
---------
G
L
I
T
Y
H
R
T
D
S
T
R
V
S
D
--
V
G
Q
R
I
A
K
E
Y
L
G
D
----
D
F
--
V
--------------------
G
R
E
W
G
E
S
G
--
A
H
E
C
I
R
P
T
R
P
LTRDDVQRL
I
--
Q
E
G
V
L
V
V
E
G
-----
L
R
W
E
H
F
A
L
Y
D
L
I
F
R
R
F
M
A
--
S
Q
C
R
P
F
K
V
V
V
K
K
Y
S
I
E
F
D
G
--
K
T
A
E
E
E
R
I
V
R
--
A
--
E
G
R
A
Y
E
L
Y
R
A
V
W
V
K
N
E
L
P
T
G
-------------
T
F
R
V
K
A
E
V
K
S
V
P
K
V
L
P
F
T
Q
S
E
I
I
Q
M
M
K
-----------------
E
R
G
I
G
R
P
S
T
Y
A
T
I
V
D
R
L
F
M
R
N
Y
V
V
E
-
K
Y
-
G
R
M
I
P
T
K
L
G
I
D
V
F
R
F
L
V
R
R
Y
A
K
F
V
S
E
D
R
T
R
D
L
E
S
R
M
D
A
I
E
R
G
E
L
D
Y
L
K
A
L
E
D
M
Y
A
E
I
K
S
I
D
-------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
82.28
29%
-23
- C4 -
4DDU
3
RGYR_THEMA
A:
[2-1103]
AVN
S
K
Y
H
HSCINCGGLNT
D
E
R
N
E
R
GLPCEVCLPEDSPSD
I
Y
R
A
L
L
E
R
KTLKE
Y
R
F
Y
H
E
F
W
N
E
Y
E
D
F
R
S
F
F
K
K
K
F
G
K
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
K
S
F
T
MVAPTGVG
K
T
T
F
G
M
M
T
A
L
W
L
A
R
K
G
K
K
S
A
L
V
F
PT
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
ADEK
V
K
I
F
G
F
Y
SSMK
K
E
E
K
E
K
F
E
K
S
F
E
EDDYH
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
K
L
S
Q
KRFD
F
V
F
V
DD
V
D
A
V
L
KA
S
R
N
I
D
T
L
L
M
M
VGIP
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
PKN
L
K
P
G
I
L
V
V
S
S
ATAKPRGIRP
L
L
F
R
D
L
LNFTVGRLVSVARN
I
T
H
V
R
I
SSRS
K
E
K
L
V
E
L
L
E
I
F
RDG
I
L
I
F
A
QT
E
E
E
G
K
E
L
Y
E
Y
L
K
R
F
KFNVGETWSEF
E
K
N
F
E
D
F
K
V
GKIN
I
L
I
G
V
Q
A
Y
Y
G
K
L
TRGVDLPERIK
Y
V
I
F
WG
T
P
S
M
R
F
S
LELDKAP
R
F
V
L
A
R
V
L
K
E
M
GLIK
A
Q
E
N
P
D
V
E
E
L
R
K
I
A
KEHLT
Q
K
E
F
V
E
K
V
K
E
M
FRGVVVKDEDL
E
L
I
I
P
D
V
Y
T
Y
I
Q
A
S
G
RSSRILNGVL
V
K
G
V
S
V
I
F
E
ED
E
E
I
F
E
S
L
K
T
R
L
L
L
IAE
E
E
I
I
E
EAEAN
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
E
L
T
D
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
GRA
S
S
R
K
E
RN
I
I
V
H
E
A
V
T
GE
G
V
I
L
F
T
A
T
R
G
H
V
Y
D
L
V
T
K
G
G
I
H
G
V
E
E
E
N
-------------------------
G
-------------------
K
-------------
F
V
P
V
Y
N
S
-------
L
K
R
C
R
D
C
-
G
Y
---------
Q
--
F
T
-----
E
D
-
R
D
E
-
C
P
V
C
---
S
-
S
K
N
I
--
D
D
-
K
T
E
T
L
R
A
L
R
E
I
S
L
E
A
D
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
--
P
S
---
T
R
S
L
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
S
V
R
F
V
D
--
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
-----
S
---------
N
L
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
-----------------
Y
K
K
S
-
E
-
K
D
F
-
T
L
L
V
L
E
------
N
G
V
--------
N
L
E
V
E
G
K
I
-
A
D
D
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
Y
T
T
S
S
A
L
S
E
I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
E
K
---------
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
--
E
G
Q
N
V
A
R
T
Y
L
R
K
----
I
G
--
K
E
D
I
F
--
M
------
G
-
R
S
--
W
S
----
T
E
G
--
A
H
E
A
I
R
P
V
K
P
---------
I
D
A
R
E
L
E
E
M
I
E
E
GLIAD
L
T
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
--
S
Q
S
A
A
-------
V
K
V
K
K
Q
I
--
V
T
V
D
V
D
G
K
R
M
--
G
--
I
E
Q
I
V
E
I
L
R
D
G
W
N
L
F
V
P
L
T
V
S
--
P
R
F
E
H
-
R
T
Y
K
I
K
E
K
K
F
Y
K
K
H
T
V
P
L
--
F
T
Q
A
S
I
V
E
E
M
K
-----------------
K
R
G
I
G
R
P
S
T
Y
A
K
I
V
E
V
L
F
R
R
G
Y
V
Y
E
D
K
Y
-
K
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
K
E
R
Y
E
K
Y
V
T
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
G
E
-----------
E
D
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
------------------------------------------------------------------------------------------------------------------------
32
HHSearch
79.70
22%
-35
* C4 *
1I7D
3
TOP3_ECOLI
A:
[1-620]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
-------------------------
P
-------------------
K
P
H
R
K
G
DG
F
I
E
C
G
N
G
Q
V
V
T
W
C
-------
I
G
H
L
L
E
Q
A
Q
P
DAYDSR---
Y
--
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
---
E
K
W
Q
L
Q
P
R
P
S
-
V
T
K
Q
L
N
V
I
K
R
F
L
H
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
--
L
A
P
E
K
R
Q
Q
V
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
EF
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
-
R
N
A
GYQ
G
---------
V
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
A
H
I
V
T
P
A
D
E
R
-
F
T
A
-
I
W
Q
P
S
E
ACEPYQ
D
E
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
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S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
T
--------
H
K
L
I
T
F
P
R
S
D
C
R
Y
L
P
E
--
E
H
F
A
G
R
H
A
V
M
N
A
----
I
S
V
H
A
P
D
L
L
--
P
QPVVDP
D
I
R
N
--
R
C
W
D
D
K
K
V
D
--
A
H
H
A
I
I
P
T
A
R
---------
S
--
S
-
A
I
N
---------
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
--
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
--
G
K
F
V
A
K
A
R
F
L
--
A
--
E
A
G
W
R
T
L
L
G
S
K
E
R
D
E
-
E
N
D
G
T
P
L
P
V
V
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
IARFVQD
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
L
L
F
K
R
G
F
L
T
K
-
K
G
-
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
---
E
M
A
T
R
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
I
D
Q
A
K
R
T
P
-----
V
R
Q
F
R
G
I
V
A
P
---------------------------------------------------------------------------------------------------------------
60
Fugue
77.83
25%
-42
- C4 -
4CGY
1
TOP3A_HUMAN
A:
[22-640]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FS
R
A
A
M
E
M
A
L
RG
V
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
GR
M
R
R
R
E
G
LSKF
N
K
I
Y
E
F
D
Y
H
L
Y
G
-------------------
Q
-------------
N
V
T
M
V
M
T
S
V
SGHL
L
A
H
D
F
Q
M
Q
F
R
K
---------
W
--
Q
S
-----
C
N
-
P
L
V
-
L
F
E
A
---
E
-
I
E
K
Y
C
P
E
N
-
F
V
D
I
K
K
T
L
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R
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T
R
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C
Q
A
L
V
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W
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C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
V
K
P
---
N
L
Q
V
L
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A
R
F
S
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T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
--
Q
R
V
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D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
-
Q
-----
R
I
F
PEVLAEQ
L
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
V
T
H
D
H
K
D
G
--------
I
V
E
F
N
------
W
K
R
H
R
L
F
N
H
T
A
C
L
V
L
Y
Q
L
C
V
E
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
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R
K
L
R
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N
A
K
E
T
M
R
I
A
E
K
L
Y
T
Q
---------
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
DL
N
L
T
V
L
V
E
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Q
T
P
D
PRW
G
A
F
--
A
Q
S
I
L
--
E
------
R
-
G
G
--
P
T
P
R
N
G
N
K
S
DQ
A
H
P
P
I
H
P
--
T
---------
K
--
Y
T
N
N
----------
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
--
A
Q
--
E
R
F
V
A
H
G
L
M
I
--
L
--
A
R
N
Y
L
D
V
Y
-----
P
Y
D
H
W
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
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T
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V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
-----------------
K
H
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
-
T
P
D
K
R
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
S
M
G
Y
E
M
S
K
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
-----------------------------------------------------------------------------------------------
K
K
L
D
E
A
L
A
Q
Y
F
G
N
G
T
----------------