@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1103: (2016-03-22 )
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRIASDIGVKYLTLYAFSTENWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVHSIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCIKIYQSRQRRFGGLSEE
Atome Classification :
(49 SA)
.........10....----.-...20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....---..170.......180........190..----.....200.......210.......220.......230.......240.......250....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
K
K
LINKKNTINNY----N-EELDSSNIP
E
H
I
A
I
I
MDGNGR
W
A
K
KRKMPRI
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
IG
V
K
Y
L
T
L
Y
A
FSTENWSRP
E
S
E
V
N
Y
I
M
NL
P
V
N
F
L
K
T
F
L
P
E
L
I
EKN
V
K
V
E
T
IGFTDKL
P
K
S
T
I
E
A
I
N
N
A
K
EKTANNT
G
L
K
L
I
F
A
INYG
G
R
A
E
L
V
H
S
I
K
N
M
F
D
---
E
L
H
Q
QGLNSDI
I
D
-
E
T
YINNHLMTKDYP----
D
P
E
L
L
I
RTS
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
NQKLWPDF
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
RFGGLSEE
2
PsiBlast_PDB
97.74
100%
-100
- C8 -
4U82
3
ISPT_STAAN
A:
[19-254]
-----------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
---
E
L
H
Q
Q
G
L
N
S
D
I
I
D
-
E
T
Y
I
N
N
H
L
M
T
K
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
S
--
3
PsiBlast_PDB
97.66
100%
-94
- C8 -
3WYI
2
?
A:
[17-247]
---------------------
E
E
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
---
E
L
H
Q
Q
G
L
N
S
D
I
I
D
-
E
T
Y
I
N
N
H
L
M
T
K
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
---------
1
PsiBlast_PDB
97.64
100%
-102
- C8 -
4H8E
3
ISPT_STAAN
A:
[19-253]
-----------------------
L
D
S
S
N
I
P
E
H
I
A
I
I
M
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
D
---
E
L
H
Q
Q
G
L
N
S
D
I
I
D
-
E
T
Y
I
N
N
H
L
M
T
K
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
---
6
PsiBlast_PDB
84.36
53%
-86
- C8 -
4Q9O
2
ISPT_STRR6
A:
[11-240]
--------------------------
T
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
---
D
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
I
G
N
Y
L
F
T
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
---------
22
PsiBlast_CBE
83.68
53%
-92
- C8 -
4Q9O
2
ISPT_STRR6
B:
[12-240]
---------------------------
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
---
D
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
I
G
N
Y
L
F
T
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
---------
65
HHSearch
83.08
66%
-97
- C8 -
1F75
1
UPPS_MICLU
A:
[14-242]
----------------------
N
I
N
A
A
Q
I
P
K
H
I
A
I
I
M
D
G
N
G
R
W
A
K
Q
K
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
V
R
K
I
T
R
Y
A
S
D
L
G
V
K
Y
L
T
L
Y
A
F
------------
N
Y
L
M
K
L
P
G
D
F
L
N
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
I
D
D
L
P
D
H
T
K
K
A
V
L
E
A
K
E
K
T
K
H
N
T
G
L
T
L
V
F
A
L
N
Y
G
G
R
K
E
I
I
S
A
V
Q
L
I
A
E
---
R
Y
K
S
G
E
I
S
L
D
E
I
S
-
E
T
H
F
N
E
Y
L
F
T
A
N
M
P
----
D
P
E
L
L
I
R
T
S
G
E
E
R
L
S
N
F
L
I
W
Q
C
S
Y
S
E
F
V
F
I
D
E
F
W
P
D
F
N
E
E
S
L
A
Q
C
I
S
I
Y
Q
N
R
----------
23
PsiBlast_CBE
83.08
53%
-91
- C8 -
4Q9M
8
ISPT_STRR6
B:
[12-239]
---------------------------
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
---
D
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
I
G
N
Y
L
F
T
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
----------
5
PsiBlast_PDB
82.91
53%
-89
- C8 -
4Q9M
12
ISPT_STRR6
A:
[11-240]
--------------------------
T
Q
V
P
A
H
I
G
I
I
M
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
Q
---
D
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
I
G
N
Y
L
F
T
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
---------
4
PsiBlast_PDB
82.56
64%
-96
- C8 -
1F75
1
UPPS_MICLU
A:
[14-242]
-------------------
N
---
I
N
A
A
Q
I
P
K
H
I
A
I
I
M
D
G
N
G
R
W
A
K
Q
K
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
V
R
K
I
T
R
Y
A
S
D
L
G
V
K
Y
L
T
L
Y
A
F
------------
N
Y
L
M
K
L
P
G
D
F
L
N
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
I
D
D
L
P
D
H
T
K
K
A
V
L
E
A
K
E
K
T
K
H
N
T
G
L
T
L
V
F
A
L
N
Y
G
G
R
K
E
I
I
S
A
V
Q
L
I
A
E
---
R
Y
K
S
G
E
I
S
L
D
E
I
S
-
E
T
H
F
N
E
Y
L
F
T
A
N
M
P
----
D
P
E
L
L
I
R
T
S
G
E
E
R
L
S
N
F
L
I
W
Q
C
S
Y
S
E
F
V
F
I
D
E
F
W
P
D
F
N
E
E
S
L
A
Q
C
I
S
I
Y
Q
N
R
----------
73
Fugue
82.53
64%
-97
- C8 -
1F75
1
UPPS_MICLU
A:
[14-242]
----------------------
N
I
N
A
A
Q
I
P
K
H
I
A
I
I
M
D
G
N
G
R
W
A
K
Q
K
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
V
R
K
I
T
R
Y
A
S
D
L
G
V
K
Y
L
T
L
Y
A
F
N
------------
Y
L
M
K
L
P
G
D
F
L
N
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
I
D
D
L
P
D
H
T
K
K
A
V
L
E
A
K
E
K
T
K
H
N
T
G
L
T
L
V
F
A
L
N
Y
G
G
R
K
E
I
I
S
A
V
Q
L
I
A
E
---
R
Y
K
S
G
E
I
S
L
D
E
I
S
-
E
T
H
F
N
E
Y
L
F
T
A
N
M
P
----
D
P
E
L
L
I
R
T
S
G
E
E
R
L
S
N
F
L
I
W
Q
C
S
Y
S
E
F
V
F
I
D
E
F
W
P
D
F
N
E
E
S
L
A
Q
C
I
S
I
Y
Q
N
R
----------
21
PsiBlast_CBE
82.25
64%
-103
- C8 -
1F75
1
UPPS_MICLU
B:
[19-242]
---------------------------
Q
I
P
K
H
I
A
I
I
M
D
G
N
G
R
W
A
K
Q
K
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
V
R
K
I
T
R
Y
A
S
D
L
G
V
K
Y
L
T
L
Y
A
F
------------
N
Y
L
M
K
L
P
G
D
F
L
N
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
I
D
D
L
P
D
H
T
K
K
A
V
L
E
A
K
E
K
T
K
H
N
T
G
L
T
L
V
F
A
L
N
Y
G
G
R
K
E
I
I
S
A
V
Q
L
I
A
E
---
R
Y
K
S
G
E
I
S
L
D
E
I
S
-
E
T
H
F
N
E
Y
L
F
T
A
N
M
P
----
D
P
E
L
L
I
R
T
S
G
E
E
R
L
S
N
F
L
I
W
Q
C
S
Y
S
E
F
V
F
I
D
E
F
W
P
D
F
N
E
E
S
L
A
Q
C
I
S
I
Y
Q
N
R
----------
49
PsiBlast_CBE
80.58
42%
-87
- C8 -
1X08
3
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
54
PsiBlast_CBE
80.53
38%
-77
- C8 -
2VG3
7
DPDS_MYCTU
B:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
59
PsiBlast_CBE
80.38
38%
-75
- C8 -
2VG2
9
DPDS_MYCTU
A:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
11
PsiBlast_PDB
80.26
43%
-90
- C8 -
1X07
3
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
10
PsiBlast_PDB
80.16
43%
-87
- C8 -
1X06
4
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
48
PsiBlast_CBE
80.12
42%
-88
- C8 -
1X09
3
UPPS_ECOLI
A:
[20-239]
-------------------------------
H
V
A
I
I
M
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
----------
64
HHSearch
79.98
38%
-75
- C8 -
2VG3
6
DPDS_MYCTU
A:
[31-283]
----
P
Y
G
G
P
C
R
P
P
Q
H
TSKA
A
A
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
----
47
PsiBlast_CBE
79.87
43%
-91
- C8 -
1UEH
9
UPPS_ECOLI
B:
[20-241]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
--------
50
PsiBlast_CBE
79.79
38%
-80
- C8 -
4ONC
2
DPDS_MYCTU
B:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
52
PsiBlast_CBE
79.74
38%
-82
- C8 -
2VG3
3
DPDS_MYCTU
D:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
56
PsiBlast_CBE
79.73
38%
-82
- C8 -
2VG2
5
DPDS_MYCTU
D:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
55
PsiBlast_CBE
79.69
38%
-76
- C8 -
2VG3
6
DPDS_MYCTU
A:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
9
PsiBlast_PDB
79.53
43%
-90
- C8 -
1V7U
2
UPPS_ECOLI
A:
[20-239]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
----------
58
PsiBlast_CBE
79.41
38%
-77
- C8 -
2VG2
6
DPDS_MYCTU
B:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
51
PsiBlast_CBE
79.37
38%
-79
- C8 -
4ONC
1
DPDS_MYCTU
A:
[40-280]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
-------
57
PsiBlast_CBE
79.33
38%
-77
- C8 -
2VG2
8
DPDS_MYCTU
C:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
53
PsiBlast_CBE
79.18
38%
-80
- C8 -
2VG3
6
DPDS_MYCTU
C:
[40-282]
--------
Q
H
T
S
K
A
A
----
A
-
P
R
I
P
A
D
R
L
P
N
H
V
A
I
V
M
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
---
E
V
A
A
G
R
L
N
P
E
R
I
T
-
E
S
T
I
A
R
H
L
Q
R
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
-----
19
PsiBlast_PDB
77.97
43%
-93
- C8 -
3SGT
1
UPPS_ECOL6
B:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
---
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
35
PsiBlast_CBE
77.75
43%
-95
- C8 -
3WYJ
1
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
-----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
12
PsiBlast_PDB
77.73
43%
-87
- C8 -
2E98
4
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
13
PsiBlast_PDB
77.57
43%
-85
- C8 -
2E99
3
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
44
PsiBlast_CBE
77.37
43%
-93
- C8 -
2E99
2
UPPS_ECOLI
B:
[20-243]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
------
43
PsiBlast_CBE
77.20
43%
-93
- C8 -
2E9A
1
UPPS_ECOLI
B:
[20-242]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
------------
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
-------
39
PsiBlast_CBE
77.14
43%
-96
- C8 -
3SGX
2
UPPS_ECOLI
A:
[20-238]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
-----------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
-----------
40
PsiBlast_CBE
77.08
43%
-91
- C8 -
3SGV
3
UPPS_ECOLI
A:
[20-238]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
-----------
26
PsiBlast_CBE
76.80
43%
-95
- C8 -
4H3C
2
UPPS_ECOLI
A:
[20-239]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
---------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
----------
16
PsiBlast_PDB
76.23
43%
-89
- C8 -
2E9D
2
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
14
PsiBlast_PDB
76.22
43%
-92
- C8 -
2E9A
2
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
---------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
36
PsiBlast_CBE
75.57
43%
-91
- C8 -
3TH8
1
UPPS_ECOLI
B:
[20-239]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
---------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
----------
42
PsiBlast_CBE
75.44
43%
-89
- C8 -
2E9C
1
UPPS_ECOLI
B:
[20-239]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
----------
45
PsiBlast_CBE
75.35
43%
-92
- C8 -
2E98
3
UPPS_ECOLI
B:
[20-243]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
------
20
PsiBlast_PDB
75.22
43%
-96
- C8 -
3SGV
2
UPPS_ECOLI
B:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
63
HHSearch
74.78
42%
-86
* C8 *
3SGV
2
UPPS_ECOLI
B:
[13-240]
------------------------
L
P
A
H
G
C
R
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-----------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
15
PsiBlast_PDB
74.16
43%
-90
- C8 -
2E9C
3
UPPS_ECOLI
A:
[20-240]
-------------------------------
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
S
E
-------------------
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
E
---
K
V
Q
Q
G
N
L
Q
P
D
Q
I
D
-
E
E
M
L
N
Q
H
V
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
---------
60
PsiBlast_CBE
73.55
39%
-82
- C8 -
2DTN
1
ISPT_HELPY
B:
[15-242]
--------------------------
T
--
L
K
H
L
A
I
I
M
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
----------------
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
------
L
E
S
P
--------L
E
N
E
I
S
N
R
L
D
T
R
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
F
G
E
----
62
PsiBlast_CBE
71.40
32%
-98
- C8 -
3UGS
2
ISPT_CAMJE
A:
[4-224]
--------------------------
M
N
E
L
K
H
L
A
V
V
M
D
G
N
R
----------------
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
K
KL
E
L
N
E
E
N
L
T
Q
N
L
--------------
D
L
P
L---
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
-----
66
HHSearch
71.22
33%
-97
- C8 -
3UGS
2
ISPT_CAMJE
B:
[4-225]
--------------------------
M
N
E
L
K
H
L
A
V
V
M
D
G
N
R
--------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
---
K
K
-------
L
E
L
N
-
E
E
N
L
T
Q
N
L
D
L
--
P
L
----
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
----
61
PsiBlast_CBE
70.50
32%
-98
- C8 -
3UGS
2
ISPT_CAMJE
B:
[4-224]
--------------------------
M
N
E
L
K
H
L
A
V
V
M
D
G
N
R
--------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
E
K
KL
E
L
N
E
E
N
L
T
Q
N
L
--------------
D
L
P
L---
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
-----