@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1144: (2016-03-22 )
MNKNKPFIVVIVGPTASGKTELSIELAKRINGEIISGDSMQVYKHMNIGTAKVTPEEMDGIPHHLIDILNPDDTFSAYEFKRLAEDLITDITNRGKVPIIAGGTGLYIQSLIYNYELEDETVTPAQLSIVKQKLSALEHLDNQQLHDYLAQFDAVSAENIHPNNRQRVLRAIEYYLKTKKLLSNRKKVQQFTENYDTLLLGIEMSRKTLYSRINKRVDIMLDHGLFREVQQLVEQGYESCQSMQAIGYKELIPVINGQMIYEDAVNDLKQHSRQYAKRQMTWFKNKMSVHWLDKENMSLQMMLDEITTQIK
Atome Classification :
(21 SA)
.........10........20........30--........40........50........60........70.-.......80........90........100.......110.......120.......130.-..--....140.......150.......160.......170-.........180.......190..-.....200-.-......210.......220.......230...------.--.-------.--------.240--.......250......-----------------.-260.......270.......280...------..------..290......-----.300.......310---------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKNK
P
F
I
V
V
I
VGPTASG
K
T
E
L
S
I
E
L
A
K
RIN--
G
E
IISGD
S
M
Q
V
Y
K
H
MNIGTAKV
T
P
E
E
MDGI
P
H
H
L
I
D
ILNPD-DT
F
S
A
Y
E
F
K
R
L
A
E
D
L
I
T
D
I
TNRGK
V
P
I
I
AGG
T
G
L
Y
I
Q
S
L
I
Y
N
Y
ELEDETV
T
P
A
Q
L
S
I
V
K
Q
K
-
L
S
--
A
L
E
HL
D
N
Q
Q
L
H
D
Y
L
A
Q
FDAVSAENIHPN
N
R
Q
R
V
L
R
---
A
I
E
Y
Y
L
K
T
K
K
L
L
S
N
R
K
K
V
Q
Q
F
T
EN-Y
D
T
L
L
L
G
I
-E-
M
S
R
K
T
L
Y
S
R
I
N
K
R
V
D
I
M
LD
H
G
L
F
R
E
V
Q
Q
L
V
E
Q
------
G
--
Y
-------
E
--------
S
C
Q
S
--
M
Q
A
I
G
Y
K
E
L
I
P
VING
Q
-----------------
M
-
I
Y
E
D
A
V
N
D
L
K
Q
H
S
R
Q
Y
A
K
R
Q
M
T
W
F
KN------K
M
------
S
V
H
W
LDKEN
M
S
-----
L
Q
M
M
L
D
E
I
T
TQIK----------------------------------------------------------------------------------
24
PsiBlast_CBE
83.02
35%
-95
- C3 -
3EPH
4
MOD5_YEAST
B:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
YSQNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
MLIPDI
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.98
35%
-92
- C3 -
3EPK
4
MOD5_YEAST
A:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
Y
S
QNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.93
35%
-93
- C3 -
3EPK
6
MOD5_YEAST
B:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
YSQNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
MLIPDI
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.86
35%
-95
- C3 -
3EPH
5
MOD5_YEAST
A:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
Y
S
QNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
81.53
35%
-92
- C3 -
3EPJ
3
MOD5_YEAST
B:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
YSQNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
MLIPDI
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.12
35%
-90
- C3 -
3EPJ
2
MOD5_YEAST
A:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
Y
S
QNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
52
Fugue
80.01
34%
-87
- C3 -
3EPH
6
MOD5_YEAST
A:
[1-409]
----
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
K
L
T
R
K
Q
L
D
I
L
-------
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
------
Y
--
S
-------
Q
NKFTPEQC
E
N
G
V
--
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
V
K
--------------------
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
------
M
L
I
P
D
I
KG
D
I
Y
L
L
D
A
T
D
L
S
QWDTN
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
NRPIKQERAPKALEELLSKGETTMKKLDDW
T
H
Y
T
CNVCRNADGK
N
V
V
A
I
G
E
K
Y
W
K
I
H
L
G
S
R
R
H
K
S
N
L
K
R
N
T
R
Q
A
D
F
E
K
W
K
I
25
PsiBlast_CBE
78.65
36%
-79
- C3 -
3FOZ
2
MIAA_ECOLI
B:
[10-299]
-----
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
-----
L
E
G
L
S
P
L
P
S
A
D
P
E
V
R
A
R
-
I
E
Q
Q
A
A
E
Q
-
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
---
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
-
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
DL
H
-------
T
--------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.04
44%
-103
- C3 -
2QGN
1
MIAA_BACHD
A:
[2-301]
----
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
--
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
-
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
------------------------------------------------------------------------------
E
T
P
S
P
Y
N
L
V
M
I
G
L
-
T
-
M
E
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
D
R
------
G
--
I
-------
R
--------
D
C
Q
S
--
V
Q
A
I
G
Y
K
E
M
Y
D
Y
L
D
G
N
-----------------
V
-
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
------
K
A
------
N
V
T
W
F
D
M
T
D
V
D
-----
F
D
K
K
I
M
E
I
---------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.99
35%
-85
- C3 -
3EPL
2
MOD5_YEAST
B:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
YSQNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
MLIPDI
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
36
HHSearch
77.84
36%
-80
- C3 -
3FOZ
-
MIAA_ECOLI
A:
[7-300]
--
A
S
L
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
P
L
P
S
-
A
D
P
-
E
---
V
R
A
R
I
E
Q
--
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
-
A
L
--
P
-
Y
Q
V
H
Q
F
A
I
-
A
P
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
D-
L
-------
H
T-------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
P
-----------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.43
35%
-81
- C3 -
3EPL
1
MOD5_YEAST
A:
[4-309]
-------
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
-
F
N
K
R
V
D
T
K
S
---
S
E
R
K
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
---
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
Y
S
QNKF
T
--
P
-------
E
--------
Q
C
E
N
GV
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
-------------------
V
-
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
K
G
------
D
I
Y
L
L
D
A
T
D
L
S
----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.18
36%
-77
- C3 -
2ZM5
-
MIAA_ECOLI
A:
[10-299]
-----
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
-----
L
E
G
L
S
P
L
P
S
A
D
P
E
V
R
A
R
-
I
E
Q
Q
A
A
E
Q
-
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
---
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
-
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
DL
H
-------
T
--------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.06
36%
-78
- C3 -
3FOZ
-
MIAA_ECOLI
A:
[10-299]
-----
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
-----
L
E
G
L
S
P
L
P
S
A
D
P
E
V
R
A
R
-
I
E
Q
Q
A
A
E
Q
-
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
---
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
-
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
DL
H
-------
T
--------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.99
36%
-78
- C3 -
2ZXU
2
MIAA_ECOLI
A:
[10-299]
-----
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
-----
L
E
G
L
S
P
L
P
S
A
D
P
E
V
R
A
R
-
I
E
Q
Q
A
A
E
Q
-
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
---
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
-
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
DL
H
-------
T
--------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.41
36%
-76
- C3 -
2ZXU
2
MIAA_ECOLI
B:
[10-299]
-----
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
--
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
-----
L
E
G
L
S
P
L
P
S
A
D
P
E
V
R
A
R
-
I
E
Q
Q
A
A
E
Q
-
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
---
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
-
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
------
G
DL
H
-------
T
--------
D
L
P
S
--
I
R
C
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
------
W
E
------
G
V
H
W
L
D
S
E
K
------------------------------------------------------------------------------------------------------
34
HHSearch
75.59
35%
-92
* C3 *
3EPH
5
MOD5_YEAST
A:
[2-292]
-----
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
--
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
-
S
E
R
-
K
--
L
T
R
K
Q
-
L
D
--
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
-
T
L
--
K
-
F
D
T
L
F
L
W
L
-
Y
-
S
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
E
Y
------
Y
--
S
QNKFTPE
Q
C-------
E
N
G
V
--
W
Q
V
I
G
F
K
E
F
L
P
W
L
T
--------------------V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
------
M
L
---------------------------------------------------------------------------------------------------------------------
37
HHSearch
72.69
31%
-99
- C3 -
3A8T
2
IPT_HUMLU
A:
[38-294]
---
R
K
E
K
L
L
V
L
M
G
A
T
G
T
G
K
S
R
L
S
I
D
L
A
A
H
F
P
--
L
E
V
I
N
S
D
K
M
Q
V
Y
K
G
L
D
I
T
T
N
K
I
S
V
P
D
R
G
G
V
P
H
H
L
L
G
E
V
D
P
A
R
G
E
L
T
P
A
D
F
R
S
L
A
G
K
A
V
S
E
I
T
G
R
R
K
L
P
V
L
V
G
G
S
N
S
F
I
H
A
L
L
V
D
R
F
D
S
---
S
G
P
-----------------------------------------------------------------------
E
L
--
R
-
Y
D
C
C
F
L
W
V
-
D
-
V
S
V
K
V
L
T
D
Y
L
A
K
R
V
D
D
M
L
E
L
G
M
F
D
E
L
A
E
F
Y
S
P
------
E
--
D
EDHDEDS
A
T-------
R
T
G
L
--
R
K
A
I
G
V
P
E
F
D
R
Y
F
E
K
F
RPGDVEGEDPGR
D
R
V
R
R
G
-
A
F
E
E
A
V
R
A
I
K
E
N
T
C
H
L
A
K
R
Q
I
G
K
I
L
R
------
L
K
------
G
A
G
W
-----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.70
33%
-94
- C3 -
3CRR
4
MIAA_PSEAE
A:
[5-302]
-----
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
--
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
-----
L
E
G
-----------------------------------------------------------------------------
L
P
Y
T
-
V
A
Q
L
A
I
A
P
-
E
--
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
R
------
S
DL
H
-------
A
--------
G
L
P
S
--
I
R
A
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
-----------------
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
------
W
S
------
H
L
H
W
M
D
---------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.03
33%
-92
- C3 -
3CRQ
2
MIAA_PSEAE
A:
[5-302]
-----
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
--
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
-----
L
E
G
-----------------------------------------------------------------------------
L
P
Y
T
-
V
A
Q
L
A
I
A
P
-
E
--
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
R
------
S
DL
H
-------
A
--------
G
L
P
S
--
I
R
A
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
-----------------
L
-
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
------
W
S
------
H
L
H
W
M
D
---------------------------------------------------------------------------------------------------------
48
HHSearch
28.99
40%
1
- C3 -
3W34
2
URK_THET8
A:
[4-42]
---
P
K
P
F
V
I
G
I
A
G
G
T
A
S
G
K
T
T
L
A
Q
A
L
A
R
T
L
G
ER
V
A
L
L
P
M
D
H
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------