@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1184: (2016-03-23 )
MAANFKEQSKKHFDLNGQSYTYYDLKAVEEQGITKVSNLPYSIRVLLESLLRQEDDFVITDDHIKALSQFGKDGNEGEVPFKPSRVILQDFTGVPAVVDLASLRKAMDDVGGDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYNAVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPGVQHLPLADRATIANMAPEYGATCGFFPVDDESLKYMKLTGRSDEHIALVKEYLKQNHMFFDVEKEDPNYTDVIELDLSTVEASLSGPKRPQDLIFLSDMKSSFENSVTAPAGNQGHGLDKSEFDKKAEINFKDGSKATMKTGDIAIAAITSCTNTSNPYVMLGAGLVAKKAVEKGLKVPEYVKTSLAPGSKVVTGYLRDAGLQPYLDDLGFNLVGYGCTTCIGNSGPLLPEIEKAIADEDLLVTSVLSGNRNFEGRIHPLVKANYLASPQLVVAYALAGTVDIDLQNEPIGKGNDGEDVYLKDIWPSIKEVSDTVDSVVTPELFIEEYNNVYNNNELWNEIDVTDQPLYDFDPNSTYIQNPSFFQGLSKEPGTIVPLNGLRVMGKFGDSVTTDHISPAGAIGKDTPAGKYLQDHQVPIREFNSYGSRRGNHEVMVRGTFANIRIKNQLAPGTEGGFTTYWPTNEVMPIFDAAMKYKEDGTGLVVLAGNDYGMGSSRDWAAKGTNLLGVKTVIAQSYERIHRSNLVMMGVLPLEFKKGESADSLGLDGTEEISVNIDENVQPHDYVKVTAKKQDGDLVEFDAMVRFDSLVEMDYYRHGGILQMVLRNKLAQ
Atome Classification :
(21 SA)
.........10........20........30.........40........50........60........70...-..-.-..80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200....-..-.210.......220.......230.......240.......250.......260.......270.......280.........290.......300.......310.......320..-.....330......-------.340.......350....--.....--360.......370.......380.......390.......400.......410.......420.......430.......440.......450..-.....460.......470.......480.......490.......500.......510......--.520.......530.......540.....--..550....-....560.......570.......580.......590.......600.......610.......620.......630...-....640.......650.......---660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840...-....--850.......860.......870.......880.......890.......900
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAA
N
F
K
E
QSKKHFDLNGQ
S
Y
T
Y
Y
D
L
K
A
V
E
E
-QGI
T
K
VSNL
P
Y
S
I
R
V
L
L
E
S
L
LRQED
D
F
V
I
T
D
D
H
I
K
A
L
S
QFGKDG-NE-G-EVPFKP
S
R
V
I
L
Q
DFTG
V
P
A
V
V
D
L
A
S
L
R
K
A
M
D
D
VGG
D
I
TKINPEV
P
V
D
L
V
IDHSVQVDSYA
N
P
E
A
L
E
RN
M
K
L
E
F
ERN
Y
E
R
Y
Q
F
L
N
W
A
T
K
AFDNYNAVPPATG
I
V
H
Q
V
N
L
E
Y
L
A
S
V
V
H
V
RDVDGEKTAFPD-
T
L
-VGTDSH
T
T
M
I
N
G
I
G
V
L
GWGVGGIEAEAGMLGQPSYFP
I
P
E
V
I
G
V
R
L
V
N
SLPQGA
T
A
T
D
L
A
L
R
V
T
Q
E
L
R
KKGV--
V
G
K
F
V
E
F
FGPGVQHLPLA
D
R
A
T
I
A
NMAPEYGATCGFFPVDDES
L
-
K
Y
M
K
LTGRSD
E
H
I
A
-------
L
V
K
E
Y
L
KQN
H
M
F
--
F
D
V
E--KEDPN--Y
T
D
V
I
E
L
D
L
S
T
V
E
A
SLSGPKRPQ
D
L
I
F
L
S
D
M
K
S
S
FENSVTAPAGNQGHGL
D
K
S
E
FDKK
A
E
I
N
FKDGS
K
A
TMKTG
D
I
A
I
A
A
I
TSCTNTSN
P
Y
V
M
L
G
-
A
G
L
V
A
K
K
A
V
E
KGLK
V
P
E
Y
V
K
T
SLAPGS
K
V
V
T
G
Y
L
R
DAGL
Q
P
Y
L
D
D
LGF
N
L
V
GYGCTTCIGNSGP--L
L
P
E
I
E
K
A
IADE
D
L
L
V
T
S
V
LSGNRNFE
G
R
--
I
H
P
L
-
V
K
AN-YLASP
Q
L
V
V
A
Y
A
LA
G
T
V
D
I
DLQNEPIGKGNDG
E
D
V
Y
L
K
D
I
W
P
S
I
K
E
V
S
D
T
V
D
SVV
T
P
E
L
F
I
E
E
Y
N
N
VYNNNELWNEIDVT-DQPLYDFDPNS
T
Y
IQN
P
S
F
F
QGLS---KEP
G
T
I
V
PLNG
L
R
V
M
GKFGDSVTTDHISPAGAIGKDTPAGKY
L
Q
DHQ
V
P
I
R
E
F
N
S
YGSRRGN
H
E
V
M
V
R
G
T
F
A
N
I
R
I
K
NQLAPGTEGG
F
T
T
YWPTNE
V
M
P
I
F
D
A
A
M
KYKEDG
T
G
L
V
V
L
AGNDYGMGSSRDWAAKGT
N
L
L
G
V
K
T
V
I
A
Q
S
Y
E
R
I
H
RSN
L
V
M
M
GVLP
L
E
FKKGESADSLGLDGT
E
E
I
S
V
N-IDEN--VQPH
D
Y
V
K
V
T
A
KKQDG
D
L
V
E
F
D
A
M
V
R
F
D
S
L
V
E
M
D
Y
Y
RHG
G
I
L
Q
M
V
L
R
N
KLAQ
2
PsiBlast_PDB
99.36
52%
-76
- C2 -
2B3Y
4
ACOC_HUMAN
A:
[20-888]
---------------------
F
F
N
L
N
K
L
E
D
----
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
-
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
-
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
-------
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
-
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
---
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
--
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
-
K
M
A
K
21
PsiBlast_CBE
99.22
52%
-77
- C2 -
2B3Y
4
ACOC_HUMAN
B:
[20-888]
---------------------
F
F
N
L
N
K
L
E
D
----
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
-
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
-
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
-------
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
-
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
LDL
Q
P
P
K
S
I
V
---
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
--
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
-
K
M
A
K
73
HHSearch
99.15
52%
-74
- C2 -
2B3Y
4
ACOC_HUMAN
A:
[7-887]
--------
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
K
L
E
D
----
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
-
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
----
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
-
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
-------
Y
I
K
K
Y
L
Q
A
V
G
M
F
--
R
D
F
N
DP
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
-
P
E
H
H
N
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
---
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
-
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
N
---
L
K
P
Q
M
K
V
Q
V
K
L
--
D
T
G
--
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
--
1
PsiBlast_PDB
98.92
52%
-78
- C2 -
2B3X
3
ACOC_HUMAN
A:
[20-888]
---------------------
F
F
N
L
N
K
L
E
D
----
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
-
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
-
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
-------
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
-
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
LDL
Q
P
P
K
S
I
V
---
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
--
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
-
K
M
A
K
4
PsiBlast_PDB
94.45
52%
-85
- C2 -
3SN2
-
ACOC_RABIT
A:
[16-889]
------
Q
P
G
K
K
F
F
N
L
N
K
L
D
Y
S
R
Y
--------------
G
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
-
H
M
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
---------------------
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
-
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
-------
Q
I
R
K
Y
L
Q
A
V
G
M
F
--
R
D
Y
S
DP
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
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D
M
K
K
D
F
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C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
N
D
-
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
--------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
---
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
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R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
--
L
T
P
R
M
H
V
Q
V
--
K
L
D
T
G
K
--
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
-
K
M
A
K
3
PsiBlast_PDB
94.35
52%
-83
- C2 -
3SNP
-
ACOC_RABIT
A:
[16-889]
------
Q
P
G
K
K
F
F
N
L
N
K
L
D
Y
S
R
Y
--------------
G
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
-
H
M
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
------------------
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
-
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
-------
Q
I
R
K
Y
L
Q
A
V
G
M
F
--
R
D
Y
S
DP
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
N
D
-
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
--
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
W
---------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
LDL
Q
P
P
K
S
I
V
---
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
--
L
T
P
R
M
H
V
Q
V
--
K
L
D
T
G
K
--
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
-
K
M
A
K
19
PsiBlast_PDB
73.39
27%
-59
- C2 -
1NIT
2
ACON_BOVIN
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
18
PsiBlast_PDB
73.25
27%
-59
- C2 -
1NIS
2
ACON_BOVIN
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
7
PsiBlast_PDB
73.05
27%
-59
- C2 -
7ACN
2
ACON_PIG
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
14
PsiBlast_PDB
73.04
27%
-59
- C2 -
1FGH
2
ACON_BOVIN
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
9
PsiBlast_PDB
73.00
27%
-60
- C2 -
1C97
3
ACON_BOVIN
A:
[63-744]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
74
HHSearch
72.87
29%
-56
- C2 -
1C96
3
ACON_BOVIN
A:
[14-752]
------------------
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
------
Q
E
I
---------
E
-
R
G
K
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
-------
G
-
L
P
K
V
A
V
P
S
---
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
--------------
Y
A
Y
P
G
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
-------
L
A
D
E
F
K
D
---
H
L
--
V
P
D
----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
---------------------------
E
G
W
-----
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
-
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
KD
I
K
K
G
---------
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
--
N
D
A
N
P
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
-
K
D
G
K
K
F
K
--
L
E
A
P
D
A
D
E
L
P
R
A
E
F
---------------
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
--------
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
-------------
L
I
G
A
I
N
I
E
N
R
K
A
-----
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
--
K
I
H
P
V
D
K
L
T
I
---
Q
G
L
KD
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
-
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
--
11
PsiBlast_PDB
72.82
27%
-59
- C2 -
1B0M
2
ACON_PIG
A:
[63-744]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
Q
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
13
PsiBlast_PDB
72.79
27%
-59
- C2 -
1ACO
2
ACON_BOVIN
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
12
PsiBlast_PDB
72.69
27%
-58
- C2 -
1C96
3
ACON_BOVIN
A:
[63-744]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
A
-
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
15
PsiBlast_PDB
72.68
27%
-60
- C2 -
8ACN
2
ACON_BOVIN
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
8
PsiBlast_PDB
72.48
27%
-60
- C2 -
1B0J
2
ACON_PIG
A:
[64-745]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
10
PsiBlast_PDB
72.13
27%
-59
- C2 -
1B0K
3
ACON_PIG
A:
[63-744]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
P
G
C
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
--
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
E
-
T
Q
I
E
W
F
R
A
G
S
A
L
----------
16
PsiBlast_PDB
69.21
28%
-58
- C2 -
1AMI
2
ACON_BOVIN
A:
[64-682]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
-----------------
D
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
----
R
K
D
I
K
K
--
G
E
K
N
T
I
V
T
S
Y
---
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
--
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
-----------
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
----
D
S
S
-
G
Q
R
V
-
D
V
S
P
T
S
Q
R
L
Q
---
L
L
E
P
F
D
---
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
-----------------
P
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
-----
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
-----
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
-------------------------------------------------------------------------------
17
PsiBlast_PDB
68.99
28%
-58
- C2 -
1AMJ
3
ACON_BOVIN
A:
[64-682]
------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
---------
S
G
L
P
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
-
K
Y
L
S
K
T
G
R
A
D
--
I
A
-------
N
L
A
D
E
F
K
-
D
H
L
V
--
P
D
-----
S
G
C
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
---------------
F
T
P
D
L
A
H
P
V
A
E
V
G
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V
A
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K
E
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W
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L
-----------------
D
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G
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C
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S
S
--
Y
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D
M
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A
A
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A
K
Q
A
L
A
H
G
L
K
C
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--
Q
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A
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A
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C
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----
R
K
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--
G
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T
I
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---
N
R
N
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ND
A
N
P
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-
T
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--
F
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T
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D
G
K
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L
-----------
E
A
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A
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L
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A
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----
D
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-
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-
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---
L
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---
K
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--
D
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D
L
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I
L
I
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V
K
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C
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T
D
H
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A
A
G
-----------------
P
W
L
K
F
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G
H
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D
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N
N
L
L
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-----
G
A
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A
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-----
T
Q
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A
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N
L
K
K
Q
G
L
L
P
L
T
F
-------------------------------------------------------------------------------
65
Fugue
58.60
30%
-70
- C2 -
1C96
3
ACON_BOVIN
A:
[33-479]
------------------------------------------
R
P
L
T
L
S
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K
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---------
H
L
D
D
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A
N
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---------
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-------------
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--GG
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A
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A
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F
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---------
L
--
V
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--------------------------------
D
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---
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--
K
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K
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F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------