@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1188: (2016-03-23 )
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI
Atome Classification :
(60 SA)
.........10.-.......20........30.-.-.-.....40........50......--..60.......--.70........80...-.-.-...90.........100.......110.-------......120.......130.......140......-.-150.-......--160.--.---.......170------........180.......190.......200.......210---....-....-----------.220.......230.......240---........250..-......260..-.....-270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKQNNYSD
D
S
I
-
Q
V
L
E
G
L
E
A
V
R
KRP
G
M
Y
IGST-D-K-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
GYG--
N
E
I
D
V
T
INKDG--
S
I
S
IEDNGRGMPTGIH-K-S-GK
P
T
-
V
E
V
I
F
T
V
L
HAGGKFGQGGYKTSG-------GLH
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
HRDG
S
I
Y
H
Q
S
F
KNG-G-SPSS-GLVKKG--K--T--K---KTG
T
K
V
T
FK-------PDD
T
I
F
K
ASTSF
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R-----S
G
K
E
-
R
Q
E
H
-----------
Y
H
Y
E
E
G
I
K
E
F
V
S
Y
V
N
E
G
K
E
V
L
H
-
D
---
V
A
TFSGEAN
G
-
I
E
-
V
D
V
A
F
Q
YN
D
Q
Y
-
S
E
S
I
L
-
S
F
V
N
N
VRTKDGGTHE
V
G
F
K
T
A
M
T
R
V
F
N
D
Y
A
R
R
I
N
E
L
K
TKDKNL
D
G
N
D
I
R
E
G
L
T
A
V
V
SVRI
P
E
E
L
L
Q
FEGQTKSKLG
T
S
E
A
R
S
A
V
D
S
V
V
A
D
KL
P
F
Y
L
E
E
K
G
Q
L
S
K
S
L
V
K
K
A
I
K
A
Q
Q
A
R
E
A
A
R
K
A
R
E
D
A
RSGKKNKRKDTLLSGKLTPAQSKNTEK
N
E
L
Y
L
V
EGDSAGGSAKLGRDR
K
F
Q
A
ILPLR
G
K
VIN
T
E
K
A
R
L
E
D
I
F
KNE
E
I
N
T
I
I
H
T
IGAGVGT
D
F
K
I
EDSNY
N
R
V
I
I
M
TDADTDG
A
H
I
Q
V
L
L
L
T
F
F
F
K
Y
M
K
P
L
V
QA
G
R
V
F
I
ALPPL
Y
K
LEKGKGKT
K
R
V
E
Y
AW
T
D
E
E
L
N
K
L
Q
K
E
LGKG
F
T
L
Q
R
Y
KGLGEM
N
P
E
Q
L
W
E
T
TMNPE
T
R
T
L
I
R
V
Q
V
E
D
E
VRSSK
R
V
T
T
LMGDKV
Q
P
R
R
E
W
I
E
K
H
V
E
FGMQ
E
D
Q
S
ILDNS
E
V
Q
V
LENDQFDEEEI
1
PsiBlast_PDB
90.88
69%
-78
- C3 -
4JUO
4
PARE_STRPN
C:
[47-663]
--------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
-----------------
T
-
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
PK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
--
D
-
E
A
I
E
-----------
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
T
-
P
---
V
L
Y
F
E
G
E
D
N
G
-
F
Q
-
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
L
-
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-------------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
--------------------------
135
Fugue
67.49
51%
-51
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
---
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
---
E
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.37
50%
-54
- C2 -
4XTJ
5
GYRB_ECOLI
A:
[3-375]
-----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Fugue
67.19
50%
-50
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
---
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
-
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
---E--
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
---
K
E
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.08
50%
-54
- C2 -
4WUB
5
GYRB_ECOLI
A:
[3-375]
-----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.05
50%
-54
- C2 -
4WUD
4
GYRB_ECOLI
A:
[3-375]
-----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.94
50%
-53
- C2 -
4WUC
5
GYRB_ECOLI
A:
[3-375]
-----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
66.60
47%
-57
- C2 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
----
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------VK
S
R
T
------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
66.25
48%
-56
- C2 -
1KIJ
3
?
A:
[7-389]
----------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
-
P
E
E
-
G
K
P
A
-
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
-
E
-
V
T
E
P
--
L
R
V
V
G
EA
P
--
R
--
G
---
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
-----
H
G
---
K
E
E
V
-----------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
-
E
K
--
P
F
L
I
R
G
T
H
G
E
-
V
E
-
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
66.23
47%
-58
- C2 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQDE-----
R
A
A
E
S
T
APHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.06
47%
-59
- C2 -
3ZKD
3
GYRB_MYCTU
A:
[17-429]
------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------HKVK
S
R
T
----
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
-----
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
65.85
47%
-58
- C2 -
3ZKD
3
GYRB_MYCTU
E:
[17-427]
------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQ-----------PHKV
K
S
R
T
---
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
65.63
47%
-63
- C2 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
----
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------PHK
V
K
S
R
T
---
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
65.35
47%
-59
- C2 -
3ZKB
3
GYRB_MYCTU
D:
[14-427]
---
Q
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VTQ-----------STAPHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
65.31
47%
-59
- C2 -
3ZKD
3
GYRB_MYCTU
F:
[15-426]
----
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
VT------------K
V
K
S
R
T
-----
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.24
50%
-51
- C2 -
1EI1
5
GYRB_ECOLI
A:
[9-375]
-----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
65.17
47%
-57
- C2 -
3ZKB
4
GYRB_MYCTU
C:
[16-430]
-----
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
-
A
-
S
-
G
I
P
T
-
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
----
S
E
P
L
-
G
L
K
Q
G
A
--
P
--
T
--
K
---
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V-------------A
P
H
K
V
K
S
R
T
--
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
---
I
V
D
F
S
G
K
G
T
G
-
H
E
-
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.99
50%
-55
- C2 -
4PRV
2
GYRB_ECOLI
A:
[16-382]
-----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-------------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.97
50%
-51
- C2 -
1EI1
6
GYRB_ECOLI
B:
[9-375]
-----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
64.94
50%
-64
- C2 -
4ZVI
3
?
A:
[1-361]
------------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
--------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
64.10
45%
-52
- C2 -
1KIJ
3
?
B:
[7-372]
----------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
-
E
-
G
K
P
A
-
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
-
E
V
T
E
P
L
-
R
V
V
G
E
A
--
P
--
R
--
G
---
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
-----
H
G
K
E
---
E
V
-----------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
-
E
---
K
P
F
L
I
R
G
T
H
G
E
V
E
-
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
64.00
50%
-53
- C2 -
4PU9
3
GYRB_ECOLI
A:
[16-382]
-----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
-
I
G
-
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
-----------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
63.21
45%
-54
- C2 -
1KIJ
3
?
A:
[7-372]
----------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
-
E
-
G
K
P
A
-
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
-
E
V
T
E
P
L
-
R
V
V
G
E
A
--
P
--
R
--
G
---
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
-----
H
G
K
E
---
E
V
-----------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
-
E
---
K
P
F
L
I
R
G
T
H
G
E
V
E
-
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.83
37%
-46
- C2 -
1S16
4
PARE_ECOLI
B:
[5-383]
------
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
-
E
-
G
V
P
A
-
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
-
E
-
K
V
Q
D
L
Q
V
V
G
T
C
--
G
--
K
--
R
---
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
-----
N
N
T
E
-
Q
R
-------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
-
E
KPF
I
G
N
F
A
G
D
T
E
A
----
V
D
W
A
L
L
W
L
P
E
G
-
G
E
L
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
60.70
37%
-45
- C2 -
1S16
4
PARE_ECOLI
A:
[5-383]
------
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
-
E
-
G
V
P
A
-
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
-
E
-
K
V
Q
D
L
Q
V
V
G
T
C
--
G
--
K
--
R
---
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
-----
N
N
T
E
-
Q
R
-------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
-
E
K
P
F
I
G
N
F
A
G
D
T
E
A
----
V
D
W
A
L
L
W
L
P
E
G
-
G
E
L
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
60.36
36%
-50
- C2 -
1S16
4
PARE_ECOLI
A:
[4-383]
-----
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
-
R
-----
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
-
P
E
E
-
G
V
P
A
-
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
-
E
-
K
V
Q
D
--
L
Q
V
V
G
--
T
CG
K
--
R
---
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
-----
N
N
---
T
E
Q
R
-----------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
-
E
K
--
P
F
I
G
N
F
A
G
D
T
-
E
A
-
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
E
-
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
-
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
59.41
38%
-52
- C2 -
4HYM
1
?
A:
[7-377]
---------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
------
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
-
E
I
I
D
N
V
--
G
--
K
--
K
---
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
K
L
T
-----------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
P
A
-
E
---
P
F
I
I
D
N
F
S
N
G
-
D
S
Y
L
D
A
V
F
C
W
C
E
D
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
----
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
58.91
38%
-57
- C2 -
4HXZ
1
?
A:
[8-378]
----------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-----------------
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
-
E
I
I
D
N
V
--
G
--
K
--
K
---
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
K
L
T
-----------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
P
A
-
E
---
P
F
I
I
D
N
F
S
N
G
-
D
S
Y
L
D
A
V
F
C
W
C
E
D
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
58.35
38%
-59
- C2 -
4KQV
7
?
A:
[7-378]
---------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
-----------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
-
E
I
I
D
N
V
--
G
--
K
--
K
---
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
K
L
T
-----------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
-----
L
P
A
-
E
---
P
F
I
I
D
N
F
S
N
G
-
D
S
Y
L
D
A
V
F
C
W
C
-----
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
55.82
99%
-59
- C2 -
4URN
1
?
C:
[19-224]
-----------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
--
N
E
I
D
V
T
I
N
K
D
G
--
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
-
S
-
G
K
P
T
-
V
E
V
I
F
T
V
L
---------------------------
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
-
G
-
S
P
S
S
-
G
L
V
K
K
G
--
K
--
T
--
K
---
K
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
-----
S
G
K
E
-
R
Q
E
H
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
53.12
69%
-55
- C2 -
4MB9
2
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
G
-------------------
G
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
53.08
69%
-54
- C2 -
4LPB
1
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
52.80
69%
-55
- C2 -
4EM7
1
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
52.78
99%
-49
- C2 -
4URN
2
?
B:
[32-223]
------------------------------
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
--
N
E
I
D
V
T
I
N
K
D
G
--
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
-
S
-
G
K
P
T
-
V
E
V
I
F
T
V
L
-------------------------
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
-
G
-
S
P
S
S
-
G
L
V
K
K
G
--
K
--
T
--
K
---
K
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
-----
S
G
K
E
-
R
Q
E
H
-----------
Y
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
52.63
54%
-50
- C2 -
3G7E
1
GYRB_ECOLI
A:
[1-203]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
52.60
69%
-53
- C2 -
4MBC
1
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
51.81
69%
-55
- C2 -
5BOD
1
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
G
-------------------------
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
51.63
59%
-49
- C2 -
4URM
1
?
B:
[25-230]
------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
L
H
A
G
G
K
F
G
-------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
51.60
54%
-54
- C2 -
4HYP
2
GYRB_ECOLI
C:
[2-205]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
51.52
69%
-53
- C2 -
4MOT
1
?
A:
[17-224]
-------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
-
M
-
G
I
P
T
-
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
-
G
-
K
P
V
T
-
T
L
K
K
I
G
--
T
--
A
LK
S
---
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
-----
T
D
E
A
-
I
E
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
51.32
54%
-53
- C2 -
1AJ6
1
GYRB_ECOLI
A:
[11-216]
--------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
H
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
51.05
54%
-56
- C2 -
4HYP
2
GYRB_ECOLI
D:
[2-205]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
50.68
54%
-54
- C2 -
4HYP
2
GYRB_ECOLI
B:
[2-205]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
50.43
59%
-44
- C2 -
4URM
1
?
A:
[25-230]
------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
L
H
A
G
G
K
--------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.13
54%
-46
- C2 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
50.05
54%
-50
- C2 -
4DUH
1
GYRB_ECOLI
B:
[12-217]
--------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
-
E
-
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
49.58
54%
-55
- C2 -
4HYP
2
GYRB_ECOLI
A:
[2-205]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
49.20
59%
-44
- C2 -
4URO
1
GYRB_STAAU
B:
[26-230]
-------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
48.48
59%
-55
- C2 -
4URO
2
GYRB_STAAU
D:
[25-230]
------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
--------
P
A
-
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
47.88
54%
-43
- C2 -
4KFG
3
GYRB_ECOLI
B:
[2-205]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
--------
G
V
S
A
-
A
E
V
I
M
T
V
L
-------
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
47.79
59%
-49
- C2 -
4URO
1
GYRB_STAAU
A:
[26-230]
-------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
--------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
47.48
46%
-54
* C2 *
3FV5
1
PARE_ECOLI
A:
[1-201]
-----------------
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
------
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
-
P
E
E
-
G
V
P
A
-
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
-
E
-
K
V
Q
D
--
L
Q
V
V
G
--
T
C
G
K
--
R
---
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
-----
N
N
---
T
E
Q
R
-----------
W
C
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
47.27
59%
-48
- C2 -
4URM
2
?
C:
[25-230]
------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
47.08
54%
-46
- C2 -
4KFG
3
GYRB_ECOLI
A:
[2-206]
-----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-------
V
S
A
-
A
E
V
I
M
T
V
L
-----------
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
--
G
-
V
P
Q
A
-
P
L
A
V
T
G
--
E
--
T
--
E
---
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
-----
D
G
K
E
---
D
H
-----------
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
46.99
59%
-45
- C2 -
4URM
1
?
D:
[26-230]
-------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
46.50
59%
-46
- C2 -
4URO
1
GYRB_STAAU
C:
[25-230]
------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
-
M
-
G
R
P
A
-
V
E
V
I
L
T
----------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
G
---
V
P
Q
F
-
D
L
K
E
V
G
--
T
--
T
--
D
---
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
-----
D
E
E
N
V
R
E
D
S
-----------
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.71
38%
-48
- C2 -
4KQV
2
?
B:
[8-217]
----------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
---------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
-
E
I
I
D
N
V
--
G
--
K
--
K
---
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
K
L
T
-----------
W
H
F
E
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
45.51
38%
-54
- C2 -
4HY1
1
?
B:
[8-271]
----------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
-
T
K
D
L
-
E
I
I
D
N
V
--
G
--
K
--
K
---
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
K
L
T
-----------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
-
A
E
T
L
P
A
-
E
---------------------------
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
45.40
53%
-53
- C2 -
4BAE
2
GYRB_MYCSM
B:
[4-203]
-----------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
--
T
R
V
D
V
K
I
H
A
D
G
--
S
V
E
V
R
D
D
G
R
G
I
P
V
E
M
H
-
A
-
T
-
G
M
P
T
-
I
D
V
V
M
T
Q
L
-------------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
Y
Y
D
R
----
S
V
P
G
-
K
L
K
Q
G
G
--
E
--
T
--
K
---
E
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
E
-
T
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
-----
D
G
K
H
-
R
V
F
H
-----------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Fugue
44.86
51%
-39
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-219]
---
S
N
S
S
D
S
S
S
I
K
-
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
--HC
K
E
I
I
V
T
I
H
A
--DN
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
-
P
-
E
E
G
V
S
A
-
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-------NSYKVSG
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
----
H
G
V
-
P
Q
A
P
L
A
--
V
--
T
--
G
ETE
K
T
G
T
M
V
R
F
W
P
SLETFT-------
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-
K
-----
R
D
---
G
K
E
D
-----------
H
F
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------