@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1199: (2016-03-23 )
MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQIIERPYHYLTTKINEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNSTKSDLENRVNKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQLSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEITGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVRP
Atome Classification :
(22 SA)
---.........10--...----.....20---...--.....30........40........50.-.......60.---...-------------------------------------.-----...70........80....-...--------.90..---------------------......100........110-........120..-.....130.......140.......150.---.....----------.160.....-...170.....--.-----.180.......-190...--....200.......210.......220.......230.......240..-.....250.......260.----.----..------...270.....--..--280.........290......------.300----.........310.......320.......330.......340.......-----350.......360..-.-....370.......380.......390.......400.......410.......420.......430.......440.......450.......460......-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MD
I
F
Y
K
K
IKAN--V
T
P
----
E
V
L
A
Q
L
H---S
K
K
--
I
I
L
ESTNQQQTKG
R
Y
S
V
V
I
F
D
I
Y
G
T
L
T
L-DND
V
L
S
V
S
T
L
---
K
E
S
-------------------------------------
Y
-----
Q
I
I
E
R
P
Y
H
Y
L
T
TKIN
E
D
YH-NI
Q
--------
D
E
Q
L
K---------------------SLPFISG-Y
V
G
T
C
S
F
D
L
V
R
--
H
EFPKL
Q
S
I
QLED-HKQH
D
V
R
L
Y
M
V
E
Q
V
Y
V
F
DHYK
D
E
L
Y
I
I
A
T---NQFSN----------S
T
K
-
S
D
L
E
N
-
R
V
N
K
S
I
E
D
L
T
K--I-----QPFMPTQDFDF-
K
T
K
E
I
Q
--
S
NI
S
E
E
R
F
I
E
M
I
Q
Y
F
K
E
KITEG
D
M
F
Q
V
V
P
S
R
I
Y
K
Y
A
H
H
A
S
Q
H
L
N
Q
L
S
F
Q
-
L
Y
Q
N
L
K
RQNPS
P
Y
M
Y
Y
L
NI----D----Q
P
------
Y
IVGSSP
E
S
F
V
--
S
V
--K--
D
Q
I
V
TTNPIA
G
T
IQRGET------TQ------I
D
N
E
N
M
K
Q
L
LN
D
P
K
E
C
S
EH
R
M
L
V
DLG
R
N
D
I
H
R
V
S
K
I
G
T
S
K
I
T
K
L
M
V
I
E
K
-----
Y
E
H
V
M
H
I
V
S
E
I
T
G
K
I-N-QNL
S
P
M
T
V
I
A
N
LLPTGTVSGA
P
K
L
R
A
I
E
R
I
Y
E
QYPHKRGVYSG
G
V
G
Y
I
NCNHNL
D
F
A
L
A
I
R
T
M
M
ID
E
Q
Y
I
N
VEAGC
G
V
V
YDSI
P
E
K
E
L
N
E
T
K
L
K
A
K
S
L
LEVRP-----
1
PsiBlast_PDB
94.33
32%
-72
- C1 -
5CWA
6
?
A:
[43-499]
-------
Y
R
K
L
A
A
N
---------------
R
---
P
G
T
--
F
L
L
E
S
A
E
N
G
R
S
W
S
R
W
S
F
I
G
A
G
A
P
T
A
L
T
V
R
E
G
Q
A
V
W
L
G
A
V
---
P
K
D
-------------------------------------
A
-----
P
T
G
G
D
P
L
R
A
L
--
Q
V
T
L
E
L
L
-
A
T
A
--------
D
----P--------------------
G
L
P
P
L
S
G
G
M
V
G
F
F
A
Y
D
M
V
R
--
R
-
L
E
R
L
P
E
R
A
V
D
D
-
L
C
L
P
D
M
L
L
L
L
A
T
D
V
A
A
V
D
H
H
E
G
T
I
T
L
I
A
N
---
A
V
N
W
N
----------
G
T
D
-
E
R
V
D
W
-
A
Y
D
D
A
V
A
R
L
D
V
--
M
T
A
A
L
G
Q
P
-
L
P
S
T
V
A
T
F
-
S
R
P
E
P
R
H
R
A
Q
R
T
V
E
E
Y
G
A
I
V
E
Y
L
V
D
Q
I
A
A
G
E
A
F
Q
V
V
P
S
Q
R
F
E
------
M
D
T
D
V
D
P
I
D
-
V
Y
R
I
L
R
V
T
N
P
S
P
Y
M
Y
L
L
Q
V
----
P
----
N
S
DGAVD
F
S
I
V
G
S
S
P
E
A
L
V
--
T
V
--
H
--
E
G
W
A
T
T
H
P
I
A
G
T
R
W
R
G
R
T
------
D
D
------
E
D
V
L
L
E
K
E
L
L
A
D
D
K
E
R
A
E
H
L
M
L
V
D
L
G
R
N
D
L
G
R
V
C
T
P
G
T
V
R
V
E
D
Y
S
H
I
E
R
-----
Y
S
H
V
M
H
L
V
S
T
V
T
G
K
L
-
G
-
E
G
R
T
A
L
D
A
V
T
A
C
F
P
A
G
T
L
S
G
A
P
K
V
R
A
M
E
L
I
E
E
V
E
K
T
R
R
G
L
Y
G
G
V
V
G
Y
L
D
F
A
G
N
A
D
F
A
I
A
I
R
T
A
L
M
R
N
G
T
A
Y
V
Q
A
G
G
G
V
V
A
D
S
N
G
S
Y
E
Y
N
E
A
R
N
K
A
R
A
V
L
---------
27
HHSearch
91.52
28%
-67
- C1 -
1I1Q
1
TRPE_SALTY
A:
[12-511]
-------
T
C
D
A
A
Y
R
--
E
N
P
T
---
A
L
F
H
Q
V
C
GDR
P
A
T
--
L
L
L
E
S
A
D
I
D
S
K
D
D
L
K
S
L
L
L
V
D
S
A
L
R
I
T
A
-
L
G
D
T
V
T
I
Q
A
L
S
D
N
G
A
S
L
L
P
L
L
D
T
A
LPAG
V
E
N
D
V
L
PA
G
R
V
L
R
F
P
P
V
S
PLLD
E
N
A
R
-----
L
C
S
L
S
V
F
D
A
F
R
L
L
Q
G
V
-
V
N
-
I
-
P
--------
T
Q
-
E
R
---------------------
E
A
M
F
F
----
G
G
L
F
A
Y
D
L
V
A
--
G
F
E
A
L
P
H
---
L
E
A
G
N
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
Q
A
S
---
L
F
T
A
S
----------
D
R
E
K
Q
R
L
N
A
-
R
L
A
Y
L
S
Q
Q
L
T
Q
--
P
-----
A
P
P
---
L
P
V
T
P
V
P
D
M
R
C
E
--
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
------
P
-
S
P
L
A
-
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
----
N
----
D
F
------
T
L
F
G
A
S
P
E
S
S
L
--
K
Y
--
D
AA
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
ADGTLD
R
D
------
L
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
-
R
-
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
-----
40
Fugue
91.46
28%
-68
- C1 -
1I1Q
1
TRPE_SALTY
A:
[5-516]
K
P
T
L
E
L
L
T
C
D
A
A
Y
R
--
E
N
P
T
A
L
F
H
Q
V
C
G
D
R
---
P
A
T
--
L
L
L
E
S
A
D
I
D
S
K
D
D
L
K
S
L
L
L
V
D
S
A
L
R
I
T
A
-
L
G
D
T
V
T
I
Q
A
L
---
S
D
N
-------------------------------------
G
A
S
L
L
P
L
L
D
T
A
L
P
A
G
V
E
N
D
V
L
P
A
G
R
-
V
L
R
F
P
P
V
S
PLL
D
E
N
A
R
L
C
SLSVFD
A
F
R
L
L
Q
G
V
V
N
I
P
T
Q
E
R
E
A
M
F
-
F
G
G
L
F
A
Y
D
L
V
A
--
G
-
F
E
A
L
P
H
L
E
-
A
G
-
N
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
Q
A
S
L
--
F
T
A
S
D
----------
R
E
K
-
Q
R
L
N
A
-
R
L
A
Y
L
S
Q
Q
L
T
Q
---------
P
A
P
P
L
P
V
T
P
V
-
P
D
M
R
C
E
--
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
S
-------
P
L
A
-
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
----
N
----
D
F
------
T
L
F
G
A
S
P
E
S
S
L
--
K
Y
D
A
A
--
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
ADGTLD
R
D
------
L
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
-
R
-
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
T
A
H
HA
42
Fugue
89.97
28%
-72
- C1 -
1K0E
2
PABB_ECOLI
A:
[3-453]
--T
L
S
P
A
V
I
T
L
L
W
R
QD
A
A
E
----
F
Y
F
S
R
L
S
---
H
L
P
W
A
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
-
F
G
K
E
T
V
V
S
E
S
---
E
K
R
-------------------------------------
T
-----
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
D
R
--
A
-
D
I
R
--------
P
T
H
N
E
---------------------
D
L
P
F
Q
G
G
-
A
L
G
L
F
G
Y
D
L
G
R
--
R
-
F
E
S
L
P
E
I
A
E
Q
D
-
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
---
N
D
-
V
N
----------
A
R
R
-
A
W
L
E
S
-
Q
Q
F
S
P
Q
E
D
F
T
L
--
T
-----
S
D
W
--------------
Q
--
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
G
D
------
E
W
Q
-
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
----
E
----
Q
G
------
A
I
L
S
L
S
P
E
R
F
I
--
L
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
A
--------------------------
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
-----
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
-
P
-
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
K----
25
HHSearch
88.79
27%
-68
- C1 -
1K0E
2
PABB_ECOLI
A:
[7-452]
------
A
V
I
T
L
L
W
R
--
Q
D
A
A
E
--
F
Y
F
S
R
L
S
HL-
P
W
A
--
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
-
F
G
K
E
T
V
V
S
E
S
---
E
K
R
-------------------------------------
T
-----
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
D
R
-
A
D
-
I
R
P
--------
T
H
-
N
E
---------------------
D
L
P
F
Q
G
G
-
A
L
G
L
F
G
Y
D
L
G
R
--
R
F
E
S
L
P
E
--
I
A
E
Q
D
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
---
N
D
V
N
A
----------
R
----------
R
A
W
L
E
S
Q
Q
F
S
---------
P
----
Q
E
D
F
T
-
L
T
S
D
W
Q
--
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
------
S
G
D
E
W
Q
-
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
----
E
----
Q
G
------
A
I
L
S
L
S
P
E
R
F
I
--
L
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
-----
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
-
P
-
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
-----
6
PsiBlast_PDB
88.43
28%
-79
- C1 -
1K0E
2
PABB_ECOLI
A:
[32-449]
--------------------------------------
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
-
F
G
K
E
T
V
V
S
E
S
---
E
K
R
-------------------------------------
T
-----
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
--
D
R
A
-
D
I
R
--------
P
T
H
N
E
---------------------
D
L
P
F
Q
G
G
-
A
L
G
L
F
G
Y
D
L
G
R
--
R
-
F
E
S
L
P
E
I
A
E
Q
D
-
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
---
N
D
V
-
N
----------
A
R
R
-
A
W
L
E
S
--------------------
Q
Q
F
S
P
Q
E
D
F
T
L
--
T
S
D
W
Q
--
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
G
D
E
------
W
Q
-
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
----
E
----
Q
G
------
A
I
L
S
L
S
P
E
R
F
I
--
L
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
-----
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
-
P
-
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
7
PsiBlast_PDB
85.44
28%
-81
- C1 -
1K0G
2
PABB_ECOLI
A:
[32-449]
--------------------------------------
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
-
F
G
K
E
T
V
V
S
E
S
---
E
K
R
-------------------------------------
T
-----
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
L
--
D
R
A
-
D
I
R
--------
P
T
H
N
E
---------------------
D
L
P
F
Q
G
G
-
A
L
G
L
F
G
Y
D
L
G
R
--
R
-
F
E
S
L
P
E
I
A
E
Q
D
-
I
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
---
N
D
V
-
N
----------
A
R
R
-
A
W
L
E
S
--------------------
Q
Q
F
S
P
Q
E
D
F
T
L
--
T
S
D
W
Q
--
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
S
G
D
E
------
W
Q
-
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
----
E
----
Q
G
------
A
I
L
S
L
S
P
E
R
F
I
--
L
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
------------------------------------
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
--------------
L
V
S
T
I
T
A
Q
L
-
P
-
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
4
PsiBlast_PDB
83.03
32%
-66
- C1 -
1I7S
1
TRPE_SERMA
A:
[147-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
---
A
G
F
E
N
L
P
A
L
R
-
Q
D
-
Q
R
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
Q
A
S
VFS
E
Q
A
S
E
----------
A
Q
R
---
L
Q
H
-
R
L
E
Q
L
Q
A
E
L
Q
Q
--
P
-----
P
--
Q
P
I
P
H
Q
K
L
-
E
N
M
Q
L
S
--
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
A
P
-------
L
G
-
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
----
D
----
D
F
------
T
L
F
G
A
S
P
E
S
A
L
K
Y
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
GSLD
L
D
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
-
R
-
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
-------
21
PsiBlast_CBE
81.45
32%
-62
- C1 -
1I7S
1
TRPE_SERMA
C:
[147-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
---
A
G
F
E
N
L
P
A
L
R
-
Q
D
-
Q
R
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
Q
A
S
VFS
E
Q
A
S
E
----------
A
Q
R
---
L
Q
H
-
R
L
E
Q
L
Q
A
E
L
Q
Q
--
P
-----
P
--
Q
P
I
P
H
Q
K
L
-
E
N
M
Q
L
S
--
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
A
P
-------
L
G
-
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
----
D
----
D
F
------
T
L
F
G
A
S
P
E
S
A
L
KY
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
GSLDLD
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
-
R
-
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
-------
5
PsiBlast_PDB
81.21
31%
-66
- C1 -
1I1Q
1
TRPE_SALTY
A:
[146-509]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
G
L
F
A
Y
D
L
V
A
GF
E
A
L
P
H
L
E
A
----
G
-
N
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
-------
Q
A
S
L
----------
F
T
A
-
S
D
R
E
K
Q
R
L
N
A
R
L
A
Y
L
S
Q
Q
L
T
-----
Q
P
A
P
P
L
P
V
T
P
V
-
P
D
M
R
C
E
--
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
S
P
-------
L
A
-
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
----
N
----
D
F
------
T
L
F
G
A
S
P
E
S
S
L
K
Y
D
A
--
A
--
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
GTLD
R
D
L
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
-
R
-
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
-------
2
PsiBlast_PDB
80.44
30%
-57
- C1 -
4GRH
6
?
A:
[32-452]
--------------------------------------
L
L
M
E
S
T
A
S
---
Q
G
R
W
S
L
L
L
V
A
Q
G
D
G
L
R
L
-
D
A
D
----
G
Q
V
---
R
D
Q
-------------------------------------
H
-----
D
L
V
Q
-
P
G
T
F
L
Q
A
L
D
R
A
W
Q
H
E
R
L
S
--------
H
D
G
S
H
---------------------
S
L
P
F
R
G
G
-
W
A
L
M
L
D
Y
E
V
A
S
--
Q
I
E
P
V
L
P
A
R
A
R
G
D
-
G
R
P
T
A
L
A
L
R
C
P
A
A
V
-
L
H
D
H
H
N
E
A
S
F
V
I
A
E
---
A
G
E
Q
A
----------
L
L
D
-
A
L
V
A
L
-
A
S
A
A
L
P
E
A
G
Q
G
--
W
-----
Q
P
------------
P
Q
A
V
--
G
E
D
A
P
Q
R
F
T
D
G
V
R
R
V
I
E
Y
L
R
A
G
D
V
F
Q
V
N
L
S
R
R
W
N
-----
A
Q
F
A
A
P
V
S
P
Q
A
L
Y
A
Q
L
R
R
A
N
P
A
P
F
A
G
L
F
S
A
----
H
----
G
R
------
H
V
V
S
S
S
P
E
R
L
V
--
S
V
--
H
--
A
G
H
A
Q
T
R
P
I
A
G
T
R
P
R
F
E
G
------
D
D
--------------------
E
R
A
E
H
V
M
L
I
D
L
E
R
N
D
L
G
R
I
C
L
P
G
T
V
V
V
D
E
L
M
T
V
E
S
-----
Y
A
H
V
H
H
I
V
S
N
V
S
G
H
L
-
R
-
P
E
V
T
P
G
E
V
I
A
A
T
F
P
G
G
T
I
T
G
C
P
K
V
R
C
M
Q
I
I
S
E
L
E
Q
V
P
R
G
A
Y
T
G
A
F
G
W
L
N
R
D
G
D
L
D
L
N
I
L
I
R
T
A
E
V
D
G
H
E
V
S
F
R
T
G
A
G
I
V
V
D
S
D
P
D
K
E
L
D
E
T
R
A
K
A
R
G
L
L
R
A
-------
22
PsiBlast_CBE
78.90
32%
-58
- C1 -
1I7Q
4
TRPE_SERMA
C:
[147-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
---
A
G
F
E
N
L
P
A
L
R
-
Q
D
-
Q
R
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
Q
A
S
VFS
E
Q
A
S
E
----------
A
Q
R
---
L
Q
H
-
R
L
E
Q
L
Q
A
E
L
Q
Q
--
P
-----
P
--
Q
P
I
P
H
Q
K
L
-
E
N
M
Q
L
S
--
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
A
P
-------
L
G
-
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
----
D
----
D
F
------
T
L
F
G
A
S
P
E
S
A
L
KY
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
GSLDLD
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
-
R
-
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
-------
3
PsiBlast_PDB
77.93
32%
-62
- C1 -
1I7Q
4
TRPE_SERMA
A:
[147-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
---
A
G
F
E
N
L
P
A
L
R
-
Q
D
-
Q
R
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
Q
A
S
V
FS
E
Q
A
S
E
----------
A
Q
R
---
L
Q
H
-
R
L
E
Q
L
Q
A
E
L
Q
Q
--
P
-----
P
--
Q
P
I
P
H
Q
K
L
-
E
N
M
Q
L
S
--
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
P
A
P
-------
L
G
-
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
----
D
----
D
F
------
T
L
F
G
A
S
P
E
S
A
L
K
Y
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
GSLD
L
D
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
-----
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
-
R
-
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
-------
26
HHSearch
73.08
35%
-33
- C- -
1QDL
-
TRPE_SULSO
A:
[2-419]
------
E
V
H
P
I
S
E
F
--
A
S
P
F
---
E
V
F
K
C
I
E
R
D
F
K
V
A
--
G
L
L
E
S
I
G
------
R
Y
S
V
I
A
W
S
T
N
G
Y
L
K
I
--------------------------------------------------------------
H
D
D
P
V
N
I
L
N
G
Y
L
K
D
-
L
K
-
L
-----------
A
-
D
I
---------------------
P
G
L
F
K
G
G
-
M
I
G
Y
I
S
Y
D
A
V
R
--
F
W
E
K
I
R
D
--
L
K
P
A
A
E
D
W
P
Y
A
E
F
F
T
P
D
N
I
I
I
Y
D
H
N
E
G
K
V
Y
V
N
A
D
---
L
S
S
V
G
-----------------------
G
----
C
G
D
--
I
-------------
G
E
F
-
K
V
S
F
Y
D
--
E
S
L
N
K
N
S
Y
E
R
I
V
S
E
S
L
E
Y
I
R
S
G
Y
I
F
Q
V
V
L
S
R
F
Y
R
Y
I
F
------
S
G
D
P
L
R
-
I
Y
Y
N
L
R
R
I
N
P
S
P
Y
M
F
Y
L
K
F
----
D
----
E
K
------
Y
L
I
G
S
S
P
E
L
L
F
--
R
V
--
Q
--
D
N
I
V
E
T
Y
P
I
A
G
T
R
P
R
G
A
D
------
Q
E
------
E
D
L
K
L
E
L
E
L
M
N
S
E
K
D
K
A
E
H
L
M
L
V
D
L
A
R
N
D
L
G
K
V
C
V
P
G
T
V
K
V
P
E
L
M
Y
V
E
K
-----
Y
S
H
V
Q
H
I
V
S
K
V
I
G
T
L
-
K
-
K
K
Y
N
A
L
N
V
L
S
A
T
F
P
A
G
T
V
S
G
A
P
K
P
M
A
M
N
I
I
E
T
L
E
E
Y
K
R
G
P
Y
A
G
A
V
G
F
I
S
A
D
G
N
A
E
F
A
I
A
I
R
T
A
F
L
N
K
E
L
L
R
I
H
A
G
A
G
I
V
Y
D
S
N
P
E
S
E
Y
F
E
T
E
H
K
L
K
A
L
K
T
A
I
G
-----
46
Fugue
69.32
21%
-63
- C1 -
3HWO
3
ENTC_ECOLI
A:
[16-394]
-------------------------
M
A
T
L
A
---
P
N
R
--
F
F
F
M
S
P
Y
R
----------------
S
F
T
T
-
S
G
---
C
F
A
R
F
---
D
E
P
-------------------------------------
A
-----
V
N
G
D
S
P
D
S
P
F
Q
Q
K
L
A
A
L
F
A
-
D
A
K
--------
A
Q
G
I
K
---------------------
N
P
V
M
V
-----
G
A
I
P
F
D
--------------------
P
R
Q
P
S
S
L
Y
I
P
E
S
W
Q
S
F
S
R
Q
E
K
Q
A
S
A
R
R
F
---
T
R
S
Q
S
----------
L
----------------------------------------
N
V
V
E
R
Q
--
A
I
P
E
Q
T
T
F
E
Q
M
V
A
R
A
A
A
L
T
A
T
P
Q
V
D
K
V
V
L
S
R
L
I
D
I
T
T
D
A
A
I
D
----
S
G
V
-
L
L
E
R
L
I
A
Q
N
P
V
S
Y
N
F
H
V
P
L
----
A
----
D
G
G
-----
V
L
L
G
A
S
P
E
L
L
L
--
R
K
--
D
--
G
E
R
F
S
S
I
P
L
A
G
S
A
R
R
Q
P
D
------
E
V
------
L
D
R
E
A
G
N
R
L
L
A
S
E
K
D
R
H
E
H
E
L
V
T
Q
A
M
K
E
V
L
R
--
E
R
S
S
E
L
H
V
P
S
S
P
Q
L
I
T
-----
T
P
T
L
W
H
L
A
T
P
F
E
G
K
A
-
N
-
S
Q
E
N
A
L
T
L
A
C
L
L
H
P
T
P
A
L
S
G
F
P
H
Q
A
A
T
Q
V
I
A
E
L
E
P
F
D
R
E
L
F
G
G
I
V
G
W
C
D
S
E
G
N
G
E
W
V
V
T
I
R
C
A
K
L
R
E
N
Q
V
R
L
F
A
G
A
G
I
V
P
A
S
S
P
L
G
E
W
R
E
T
G
V
K
L
S
T
M
L
N
V
F
G
LH---
44
Fugue
68.61
17%
-45
- C1 -
3BZM
1
MENF_ECOLI
A:
[1-429]
M
Q
S
L
T
T
A
L
E
N
L
L
R
H
--
L
S
Q
----
E
I
P
A
T
P
G
---
I
R
V
--
I
D
I
P
F
P
L
K
D
A
F
D
------
A
L
S
W
L
A
S
Q
Q
T
-
Y
P
Q
F
Y
W
Q
Q
R
-----------------------------------------------------
N
G
D
E
E
A
V
V
L
G
A
I
T
R
F
T
-
S
L
D
--------
Q
A
Q
R
F
---------------------
L
R
Q
H
-----------------
P
E
H
A
D
L
R
I
W
G
L
N
A
-
F
D
P
S
Q
G
N
L
L
L
P
R
L
E
W
R
R
C
G
G
K
A
T
L
R
L
T
L
F
---
S
----------------
E
-
S
S
L
Q
H
-
D
A
I
Q
A
K
E
F
I
A
T
--
L
-----
V
S
I
K
P
L
P
G
L
H
L
-
T
T
T
R
E
Q
--
H
W
P
D
K
T
G
W
T
Q
L
I
E
L
A
T
K
T
I
A
E
G
E
L
D
K
V
V
L
A
R
A
T
D
L
H
F
A
S
P
V
N
----
A
A
A
-
M
M
A
A
S
R
R
L
N
L
N
C
Y
H
F
Y
M
A
F
----
D
G---
E
N
------
A
F
L
G
S
S
P
E
R
L
W
--
R
R
--
R
--
D
K
A
L
R
T
E
A
L
A
G
T
V
A
N
N
P
D
------
D
K
------
Q
A
Q
Q
L
G
E
W
L
M
A
D
D
K
N
Q
R
E
N
M
L
V
V
E
D
I
C
Q
R
L
Q
A
D
T
Q
T
L
D
V
L
---
P
P
Q
V
L
R
-----
L
R
K
V
Q
H
L
R
R
C
I
W
T
S
L
-
N
-
K
A
-
D
D
V
I
C
L
H
Q
L
Q
P
T
A
A
V
A
G
L
P
R
D
L
A
R
Q
F
I
A
R
H
E
P
F
T
R
E
W
Y
A
G
S
A
G
Y
L
S
-
L
Q
Q
S
E
F
C
V
S
L
R
S
A
K
I
S
G
N
V
V
R
L
Y
A
G
A
G
I
V
R
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
R
T
L
L
Q
-----
43
Fugue
64.85
18%
-44
- C1 -
2EUA
1
MENF_ECOLI
A:
[2-429]
---------
Q
S
L
T
T
--
A
L
E
----
N
L
L
R
H
L
S
---
Q
E
I
-----------
P
A
T
P
G
I
R
V
I
D
I
P
F
P
L
K
D
A
F
-
D
-----------------------------------------------------------------------
A
L
S
W
L
A
-
S
Q
Q
--------
T
Y
P
Q
F
---------------------
Y
W
Q
Q
R
N
G
-
D
E
E
A
V
V
L
G
-
A
I
--
T
R
F
T
S
L
D
Q
A
Q
R
F
L
-
R
Q
H
P
E
H
A
D
L
R
I
W
G
L
N
A
F
D
P
S
Q
G
N
L
L
L
P
R
L
---
E
W
R
R
C
GG
K
A
T
L
R
L
T
L
F
S
E
-
S
S
L
Q
H
-
D
A
I
Q
A
K
E
F
I
A
T
--
L
-----
V
S
I
K
P
L
P
G
L
H
L
-
T
T
T
R
E
Q
--
H
W
P
D
K
T
G
W
T
Q
L
I
E
L
A
T
K
T
I
A
E
G
E
L
D
K
V
V
L
A
R
A
T
D
L
H
F
A
S
P
V
N
----
A
A
A
-
M
M
A
A
S
R
R
L
N
L
N
C
Y
H
F
Y
M
A
F
----
D
G---
E
N
------
A
F
L
G
S
S
P
E
R
L
W
--
R
R
--
R
--
D
K
A
L
R
T
E
A
L
A
G
T
V
A
N
N
P
D
------
D
K
------
Q
A
Q
Q
L
G
E
W
L
M
A
D
D
K
N
Q
R
E
N
M
L
V
V
E
D
I
C
Q
R
L
Q
A
D
T
Q
T
L
D
V
L
P
---
P
Q
V
L
R
-----
L
R
K
V
Q
H
L
R
R
C
I
W
T
S
L
-
N
-
K
A
-
D
D
V
I
C
L
H
Q
L
Q
P
T
A
A
V
A
G
L
P
R
D
L
A
R
Q
F
I
A
R
H
E
P
F
T
R
E
W
Y
A
G
S
A
G
Y
L
S
-
L
Q
Q
S
E
F
C
V
S
L
R
S
A
K
I
S
G
N
V
V
R
L
Y
A
G
A
G
I
V
R
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
R
T
L
L
Q
-----
12
PsiBlast_PDB
60.59
28%
-63
- C1 -
3OS6
10
?
A:
[133-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
K
D
G
D
L
K
K
I
V
L
S
R
S
L
D
V
--
K
S
S
G
K
I
D
K
Q
--
K
-
L
L
R
E
L
A
E
H
N
K
H
G
Y
T
F
A
V
N
L
PKDE
N
----
S
K
------
T
L
I
G
A
S
P
E
L
L
V
--
S
R
--
H
--
G
M
Q
V
I
S
N
P
L
A
G
S
R
P
R
S
D
D
------
P
V
------
E
D
K
R
R
A
E
E
L
L
S
S
P
K
D
L
H
E
H
A
V
V
V
E
A
V
A
A
A
L
R
P
Y
C
H
T
-------
L
Y
V
P
E
K
P
S
V
I
H
S
E
A
M
W
H
L
S
T
E
V
K
G
E
L
K
N
-
P
N
T
S
S
L
E
L
A
I
A
L
H
P
T
P
A
V
C
G
T
P
M
E
E
A
R
E
A
I
Q
K
I
E
P
F
D
R
E
F
F
T
G
M
L
G
W
S
D
L
N
G
D
G
E
W
I
V
T
I
R
C
A
E
V
Q
E
N
T
L
R
L
Y
A
G
A
G
V
V
A
E
S
K
P
E
D
E
L
A
E
T
S
A
K
F
Q
T
M
L
K
A
-------
30
HHSearch
59.96
27%
-55
- C1 -
3OS6
10
?
A:
[112-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
E
M
T
--
P
V
P
D
H
E
V
Y
M
K
G
V
K
Q
G
I
E
K
I
K
D
G
D
L
K
K
I
V
L
S
R
S
L
D
V
K
S
-
S
G
---
K
I
D
K
Q
K
-
L
L
R
E
L
A
E
H
N
K
H
G
Y
T
F
A
V
N
L
----
P
KDEN
S
K
------
T
L
I
G
A
S
P
E
L
L
V
--
S
R
--
H
--
G
M
Q
V
I
S
N
P
L
A
G
S
R
P
R
S
D
D
------
P
V
------
E
D
K
R
R
A
E
E
L
L
S
S
P
K
D
L
H
E
H
A
V
V
V
E
A
V
A
A
A
L
R
P
Y
C
H
--
T
L
Y
V
P
E
K
P
S
V
I
H
-----
S
E
A
M
W
H
L
S
T
E
V
K
G
E
L
-
K
N
P
N
T
S
S
L
E
L
A
I
A
L
H
P
T
P
A
V
C
G
T
P
M
E
E
A
R
E
A
I
Q
K
I
E
P
F
D
R
E
F
F
T
G
M
L
G
W
S
D
L
N
G
D
G
E
W
I
V
T
I
R
C
A
E
V
Q
E
N
T
L
R
L
Y
A
G
A
G
V
V
A
E
S
K
P
E
D
E
L
A
E
T
S
A
K
F
Q
T
M
L
K
A
L
G
-----
31
HHSearch
59.01
24%
-59
- C1 -
3HWO
3
ENTC_ECOLI
A:
[121-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
Q
--
A
I
P
E
Q
T
T
F
E
Q
M
V
A
R
A
A
A
L
T
A
T
P
Q
V
D
K
V
V
L
S
R
L
I
D
I
T
T
-
D
A
---
A
I
D
S
G
V
-
L
L
E
R
L
I
A
Q
N
P
V
S
Y
N
F
H
V
P
L
----
A
D---
G
G
------
V
L
L
G
A
S
P
E
L
L
L
--
R
K
--
D
--
G
E
R
F
S
S
I
P
L
A
G
S
A
R
R
Q
P
D
------
E
V
------
L
D
R
E
A
G
N
R
L
L
A
S
E
K
D
R
H
E
H
E
L
V
T
Q
A
M
K
E
V
L
R
E
R
S
S
--
E
L
H
V
P
S
S
P
Q
L
I
T
-----
T
P
T
L
W
H
L
A
T
P
F
E
G
K
A
-
N
-
S
Q
E
N
A
L
T
L
A
C
L
L
H
P
T
P
A
L
S
G
F
P
H
Q
A
A
T
Q
V
I
A
E
L
E
P
F
D
R
E
L
F
G
G
I
V
G
W
C
D
S
E
G
N
G
E
W
V
V
T
I
R
C
A
K
L
R
E
N
Q
V
R
L
F
A
G
A
G
I
V
P
A
S
S
P
L
G
E
W
R
E
T
G
V
K
L
S
T
M
L
N
V
F
G
-----
9
PsiBlast_PDB
44.89
31%
-32
- C1 -
2FN1
3
?
A:
[238-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
F
S
P
E
L
V
M
--
S
V
--
T
--
G
N
K
V
V
T
E
P
L
A
G
T
R
D
R
M
G
N
------
P
E
------
H
N
K
A
K
E
A
E
L
L
H
D
S
K
E
V
L
E
H
I
L
S
V
K
E
A
I
A
E
L
E
A
V
C
L
P
G
S
V
V
V
E
D
L
M
S
V
R
Q
-----
R
G
S
V
Q
H
L
G
S
G
V
S
G
Q
L
-
A
-
E
N
K
D
A
W
D
A
F
T
V
L
F
P
S
I
T
A
S
G
I
P
K
N
A
A
L
N
A
I
M
Q
I
E
K
T
P
R
E
L
Y
S
G
A
I
L
L
L
D
-
D
T
R
F
D
A
A
L
V
L
R
S
V
F
Q
D
S
Q
R
C
W
I
Q
A
G
A
G
I
I
A
Q
S
T
P
E
R
E
L
T
E
T
R
E
K
L
A
S
I
----------
23
PsiBlast_CBE
44.84
31%
-30
- C1 -
2FN1
3
?
B:
[238-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
F
S
P
E
L
V
M
--
S
V
--
T
--
G
N
K
V
V
T
E
P
L
A
G
T
R
D
R
M
G
N
------
P
E
------
H
N
K
A
K
E
A
E
L
L
H
D
S
K
E
V
L
E
H
I
L
S
V
K
E
A
I
A
E
L
E
A
V
C
L
P
G
S
V
V
V
E
D
L
M
S
V
R
Q
-----
R
G
S
V
Q
H
L
G
S
G
V
S
G
Q
L
-
A
-
E
N
K
D
A
W
D
A
F
T
V
L
F
P
S
I
T
A
S
G
I
P
K
N
A
A
L
N
A
I
M
Q
I
E
K
T
P
R
E
L
Y
S
G
A
I
L
L
L
D
-
D
T
R
F
D
A
A
L
V
L
R
S
V
F
Q
D
S
Q
R
C
W
I
Q
A
G
A
G
I
I
A
Q
S
T
P
E
R
E
L
T
E
T
R
E
K
L
A
S
I
----------