@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1226: (2016-03-23 )
MTKLAVVGATGLVGTKMLETLNRKNIPFDELVLFSSARSAGQEVEFQEKTYTVQELTDARASEHFDYVLMSAGGGTSEHFAPLFEKAGAIVIDNSSQWRMAEDIDLIVPEVNEPTFTRGIIANPNCSTIQSVVPLKVLQDAYGLKRVAYTTYQAVSGSGMKGKKDLAEGVNGKAPEAYPHPIYNNVLPHIDVFLENGYTKEEQKMIDETRKILNAPDLKVTATCARVPVQDSHSVEIDVTLDKETTAEDIKALFDQDDRVVLVDNPENNEYPMAINSTNKDEVFVGRIRRDDSLENTFHVWCTSDNLLKGAALNAVQVLEQVMRLKGAN
Atome Classification :
(35 SA)
.........10........20........30......-..40......-----.-------.50.......--.60......-----..70........80........90........100.......110....----.-----------.-------.120.......130.......140.......150.......160----......---.170.-----------------..--------------.-----....-------180.......190..--....--.200.......210....--------...220.......230.......240.......250.......260....---..------.270...-.--...280.......290..--..--...300.......310.......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
L
A
V
V
GAT
G
L
V
G
T
K
M
L
E
T
L
NRKNI
P
F
D
E
L
V
L
F
S
S
A-RSAGQ
E
V
E
F
Q-----E-------KTY
T
V
Q
E
L
T
D
--
A
R
A
SEH
F
D
Y
-----
V
L
M
SAGGGT
S
E
H
F
A
P
L
F
EKA
G
A
I
V
IDNSSQ
W
R
MAED
I
D
L
IVPEVNEPTF----T-----------R-------GIIANP
N
C
S
T
I
Q
S
VV
P
L
K
V
L
Q
D
AYGL
K
R
V
A
Y
T
T
Y
Q
AVSGSGMKG----
K
K
D
L
A
E---GVN-G-----------------KA--------------P-----EAYP-------H
P
I
Y
NNVL
P
H
I
D
V
F
L--ENGY--
T
K
E
E
Q
K
M
I
D
E
T
R
K
I
LNAP--------D
L
K
V
T
A
T
C
ARVPVQDS
H
S
V
E
I
D
V
T
LDKET
T
A
E
D
I
K
A
L
FDQDD
R
V
V
L
V
DNP---EN------NEY
P
M
AI-N--STNKD
E
V
F
V
G
R
IRRDDSL--E
N
--
T
F
H
V
W
CTSDNLL
K
G
A
A
L
N
A
V
Q
V
L
E
Q
V
M
R
LKGAN
20
PsiBlast_PDB
97.89
42%
-87
- C2 -
2QZ9
-
DHAS2_VIBCH
A:
[8-335]
---
V
A
I
F
G
A
T
G
A
V
G
E
T
M
L
E
V
L
Q
E
R
E
F
P
V
D
E
L
F
L
L
A
S
E
-
R
S
E
G
K
T
Y
R
F
N
-----
G
-------
K
T
V
R
V
Q
N
V
--------
E
E
F
D
W
SQVH
I
A
L
F
S
A
G
G
E
L
S
A
K
W
A
P
I
A
A
E
A
G
V
V
V
I
D
N
T
S
H
F
R
Y
D
Y
D
I
P
L
V
V
P
E
V
N
P
E
A
I
----
A
EFRN-------
R
-------
N
I
I
A
N
P
N
C
S
T
I
Q
M
L
V
A
L
K
P
I
Y
D
A
V
G
I
E
R
I
N
V
T
T
Y
Q
S
V
S
G
A
G
K
A
G
----
I
D
E
L
A
----
G
Q
T
-
A
-----------------
K
L
--------------
L
-----
N
G
Y
P
A
E
T
N
TFS
Q
Q
I
A
F
N
C
I
P
Q
I
D
Q
F
M
--
D
N
G
Y
--
T
K
E
E
M
K
M
V
W
E
T
Q
K
I
F
N
D
P
--------
S
I
M
V
N
P
T
C
V
R
V
P
V
F
Y
G
H
A
E
A
V
H
V
E
T
R
A
P
I
D
A
E
Q
V
M
D
M
L
E
Q
T
D
G
I
E
L
F
------
R
G
------
A
D
F
P
T
Q
V
R
D
--
A
G
G
K
D
H
V
L
V
G
R
V
R
N
D
I
S
H
--
H
S
--
G
I
N
L
W
V
V
A
D
N
V
R
K
G
A
A
T
N
A
V
Q
I
A
E
L
L
V
R
-----
23
PsiBlast_CBE
96.85
42%
-76
- C2 -
4R51
8
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
12
PsiBlast_PDB
96.79
42%
-79
- C2 -
3Q1L
1
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
24
PsiBlast_CBE
96.78
42%
-76
- C2 -
4R4J
7
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
10
PsiBlast_PDB
96.75
42%
-74
- C2 -
3PZB
6
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
37
PsiBlast_CBE
96.71
42%
-76
- C2 -
3PWK
8
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
29
PsiBlast_CBE
96.71
42%
-76
- C2 -
3Q1L
1
?
C:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
26
PsiBlast_CBE
96.68
42%
-74
- C2 -
4R3W
8
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
6
PsiBlast_PDB
96.68
42%
-75
- C2 -
3PWK
8
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
5
PsiBlast_PDB
96.56
42%
-71
- C2 -
2GZ3
2
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
36
PsiBlast_CBE
96.55
42%
-75
- C2 -
3PWS
2
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
27
PsiBlast_CBE
96.50
42%
-75
- C2 -
4R3N
10
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
9
PsiBlast_PDB
96.37
42%
-73
- C2 -
3PYX
6
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
4
PsiBlast_PDB
96.37
42%
-78
- C2 -
2GZ2
1
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
22
PsiBlast_CBE
96.34
42%
-74
- C2 -
4R54
4
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
14
PsiBlast_PDB
96.29
42%
-76
- C2 -
4R3W
8
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
42
PsiBlast_CBE
96.28
42%
-75
- C2 -
2GZ1
1
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
19
PsiBlast_PDB
96.20
42%
-74
- C2 -
4R5H
8
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
39
PsiBlast_CBE
96.09
42%
-75
- C2 -
2GZ3
2
?
C:
[5-341]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
32
PsiBlast_CBE
96.06
42%
-75
- C2 -
3PZB
5
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
21
PsiBlast_CBE
95.82
42%
-75
- C2 -
4R5H
6
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
25
PsiBlast_CBE
95.81
42%
-74
- C2 -
4R41
8
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
31
PsiBlast_CBE
95.74
42%
-74
- C2 -
3Q11
5
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
33
PsiBlast_CBE
95.53
42%
-73
- C2 -
3PYX
6
?
B:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
AH---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
ILET
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CDLHA
E
I
L
P
SGGDKKH
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
7
PsiBlast_PDB
95.50
42%
-76
- C2 -
3PWS
3
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
18
PsiBlast_PDB
95.46
42%
-75
- C2 -
4R54
4
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
15
PsiBlast_PDB
95.43
42%
-76
- C2 -
4R41
10
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
59
HHSearch
95.36
41%
-75
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
-------
Q
E
I
E
V
E
D
A
E
T
--
A
D
P
-
S
G
L
D
I
-----
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
D
AHRR
P
-----------
K
-------
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
----
V
A
E
L
A
E
---
Q
A
R
-
A
V
IGGAEQLVYDGGALEF
P
P
--------------
P
-----
N
T
Y
V
-------
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
DD
G
S
G
E
--
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
---------------
V
P
T
P
L
-
A
--
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
PD
G
R
--
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
-----
16
PsiBlast_PDB
95.34
42%
-73
- C2 -
4R4J
6
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
13
PsiBlast_PDB
95.30
42%
-74
- C2 -
4R3N
7
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
17
PsiBlast_PDB
95.23
42%
-76
- C2 -
4R51
12
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
11
PsiBlast_PDB
95.13
42%
-73
- C2 -
3Q11
5
?
A:
[5-339]
---
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
-------
Q
D
I
T
I
E
E
T
T
E
--
T
-
A
F
E
G
V
D
I
-----
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
----
D
A
H---------
N
-------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
---
V
L
N
D
G
-----------------
V
K
--------------
P
CD
L
H
A
E
I
L
P
SGGDK
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
A
--
E
K
--
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
---------
44
PsiBlast_CBE
94.26
39%
-80
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[3-338]
--
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
-------
Q
E
I
E
V
E
D
A
E
T
--
A
D
P
S
-
G
L
D
I
-----
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
---
F
----
E
-----------
R
DAHRRPK
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
----
V
A
E
L
A
E
Q
A
R
A
V
I
-
G
-----------------
G
A
EQLVYDGGALEFPP
P
-----
N
T
Y
V
-------
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
V
P
-------------
T
P
L
A
-----
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
--
P
D
GR
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
---------
43
PsiBlast_CBE
93.99
39%
-82
- C2 -
3VOS
9
DHAS_MYCTU
A:
[21-356]
--
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
----
K
L
A
F
R
-----
G
-------
Q
E
I
E
V
E
D
A
E
T
--
A
D
P
S
-
G
L
D
I
-----
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
---
F
----
E
-----------
R
DAHRRPK
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
----
V
A
E
L
A
E
Q
A
R
A
V
I
-
G
-----------------
G
A
EQLVYDGGALEFPP
P
-----
N
T
Y
V
-------
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
V
P
-------------
T
P
L
A
-----
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
V
--
P
D
GR
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
---------
70
HHSearch
78.20
34%
-57
- C2 -
1YS4
4
DHAS_METJA
A:
[8-354]
K
I
K
V
G
V
L
G
A
T
G
S
V
G
Q
R
F
V
Q
L
L
A
D
--
H
P
M
F
E
L
T
A
L
A
A
S
E
R
S
A
G
K
K
Y
K
D
A
C
YWFQ
D
RDIPENI
K
D
M
V
V
I
P
T
D
P
KH
E
E
F
-
E
D
V
D
I
-----
V
F
S
A
L
P
S
D
L
A
K
K
F
E
P
E
F
A
K
E
G
K
L
I
F
S
N
A
S
A
Y
R
M
E
E
D
V
P
L
V
I
P
E
V
N
A
D
H
L
E---
L
I
E
I
Q
R
E
K
RGWD
G
-------
A
I
I
T
N
P
N
C
S
T
I
C
A
V
I
T
L
K
P
I
M
D
K
F
G
L
E
A
V
F
I
A
T
M
Q
A
V
S
G
A
G
Y
N
G
----
V
P
S
-------------------------------------------------------------
M
A
I
L
D
N
L
I
P
F
I
K
------------
N
E
E
E
K
M
Q
T
E
S
L
K
L
L
G
T
L
K
DGKVELA
N
F
K
I
S
A
S
C
N
R
V
A
V
I
D
G
H
T
E
S
I
F
V
K
T
K
E
G
A
E
P
E
E
I
K
E
V
M
D
K
F
D
P
L
K
D
L
N
L
P
TYA
K
P
I
V
I
R
EE
I
D
R
P
Q
P
R
L
D
RN
E
G
N
G
M
S
I
V
V
G
R
I
R
K
D
P
I
----
F
--
D
V
K
Y
T
A
L
E
H
N
T
I
R
G
A
A
G
A
S
V
L
N
A
E
Y
F
V
K
K
Y
I
--