@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1240: (2016-03-23 )
MSDRFIKFNDEQLDAKQVMMLQDLARLLLKNEQTQVKIQKFPYYNPVQNVLITSWFWSHRPSHIEMAGLKTDVMLAAYGYHMMDVQIVNEVVQDKTFKHPKFYQQLFKLLEDMRVLNSIKVERPSTAKLIDLRLDTRVSYTESQIKVYRTKTQYTDLLFLYLEHAFLSQDFFDIPSIHSDLDDILVNMFLYLPNFFQNQNSEDNMYLAQRIMYQVDDILKEDMLNEYYYLPKTLYNTLASPEFDDLKRTDASQVDGQDDTSEDDDNESEKADSKSADSESKGGAYLEMELHEGQNSETLGNDEAREGDATDDMTDMMTKKGKGSNDTLNREEGDAVGQSQAFQLDGVNKNVEIKWQIPEIEPQYVLEYQESKQDVQYEIKDLIQIIKKTIEREQRDARFNLTKGRLQKDLINWFIDDQYKLFYKKQDLSKSFDATFTLLIDASASMHDKMAETKKGVVLFHETLKALNIKHEILSFSEDAFDSDDHAQPNIINEIINYDYSTFEKDGPRIMALEPQDDNRDGVAIRVASERLMRRNQHQRFLIVFSDGEPSAFNYSQDGIIDTYEAVEMSRKFGIEVFNVFLSQDPITEDVEQTIHNIYGQYAIFVEGVAHLPGHLSPLLKKLLLKSL
Atome Classification :
(20 SA)
---------------------.........10........20.---.......30---........40........50...------.....60........70........80........90........100.......110........120.......130----.........140.----------......150.......-------160---------------.......170..--------.....180...-....190.....------..200..----.....210-------.......220.......-------230------------.......------240.......250--.........260.......270.......---280.......290------.......300.......310.......320....-----------------------...330.........340.......350......------------.360.......370.......380......-------.390.-......400.---......410.......420.-......430.-----------......440......-------.450.......460....--.-----------------..470..----------------------.....480....-------------------.------.------------------.-----------------490....--....500--.......510--------...---.-----.-----..--..520--.----........530-....-----.-----------.----...--540.......550..----------------------..------------------------.---..560..------...------...570.......580---..-...--------.---------.--590.-----...-..-.600.--...---.-.--.-.-.610.......620......-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------MSD
R
F
I
K
FNDEQL
D
A
K
Q
V
M
M
L
Q
---
D
L
A
R
L
L
LKN---EQ
T
Q
V
K
I
QKFPYYN
P
V
Q
N
V
L
I
T
S
------
W
FWSHRPS
H
I
E
MAGLKT
D
V
M
L
A
AYG
Y
H
M
M
D
V
Q
I
V
N
E
V
V
QDKTFKH
P
K
F
Y
Q
Q
L
F
K
L
L
E
-
D
M
R
V
L
N
S
IKVERPST
A
K
L
I
------
D
L
R
LD
T
R
V
SYTES----------
Q
I
K
V
Y
R
TKTQ
Y
T
D
L
L
F
-------
L
Y
L
---------------
E
H
A
F
L
S
Q
D
FFDI--------
P
S
I
H
S
D
L
D
D
I
L
-
V
N
M
F
L
YL
P
N
F
FQ------NQNSE
D
N
----
M
Y
L
A
Q
R
I
M
-------
Y
Q
V
D
D
I
L
K
E
D
M
L
N
E
YYY-------
L
P
K
------------
T
L
Y
N
T
LA------SP
E
F
D
D
LKRTD----ASQVDGQDDTSEDDDNESEKADSKSADSE---SKG
G
A
Y
L
E
M
E
LHE------GQNSETLGNDEAREGDAT
D
D
M
T
D
M
M
TKKGKGSND-----------------------TLNR--EEGDAVGQS
Q
A
F
Q
LDGVNK
N
V
E
I
K
W
QIP------------EI
E
P
Q
Y
V
L
E
Y
Q
ESK
Q
D
V
Q
Y
E
I
K
D
L
I
Q
I
I
K
K
-------
T
I
E
R
E
-
Q
RDARFNL
T
K
---
G
R
L
Q
K
D
L
I
N
W
F
IDD
Q
Y
K
L
F
Y
-
K
K
Q
D
L
SKSFD-----------
A
T
F
T
L
L
IDASA
S
M
H
D
-------
K
M
A
E
TKK
G
V
V
L
F
H
E
T
L
K
A
--
L
-----------------
N
I
K
H
E
I
L
----------------------SFSEDAFDSDDH-------------------A------Q------------------
P
-----------------
N
-
I
I
N
E
I
--INYDYST--FEKDG
P
R
I
----------
M
A
L---E-----P-----QD--DNR----D----
G
V
A
I
R
V
A
S
E
---
R
L
M
R
-----R-----------N----QH
Q
--
R
F
L
I
V
FSDGEPSAFN----------------------YS------------------------Q---DGI-
I
D
T
------
Y
E
A
------
V
E
M
S
R
K
F
G
I
E
V
F
N
V
F
L---SQ-DP
I
--------
T
---------
E
--
D
V
E
Q
-----
T
I
H
-
N
I
-YG--
Q
--
Y
A
I
---
F
-
V
--
E
-
G
-
V
A
HLPG
H
L
S
P
L
L
K
K
L
L
LKSL-----------------------------
44
Fugue
76.38
19%
-25
- C2 -
4WZ9
4
?
A:
[40-926]
QAVDERYRLPTT
S
I
P
I
H
YD
L
H
L
R
T
E
-
I
H
R
N
E
R
T
F
T
G
T
V
G
I
Q
L
Q
V
VQ
A
T
D
K
L
V
M
H
N
R
GL
V
M
S
S
A
K
V
S
S
L
P
N
G
V
T
G
A
P
T
L
I
G
D
------
V
Q
Y
S
T
D
T
T
F
-
E
H
I
T
F
T
S
P
T
I
L
Q
P
-
G
T
Y
L
L
E
V
A
F
Q
G
R
L
A
T
N
D
----
D
G
F
Y
V
S
S
Y
V
A
D
N
G
E
R
R
Y
L
A
T
T
Q
F
E
S
T
S
A
R
M
A
F
PCYDEP
G
L
K
A
T
F
T
V
S
I
T
H
S
LS
Y
K
A
I
S
NMP
Q
K
T
T
T
D
I
E
T
D
M
R
T
T
F
F
E
K
T
P
A
M
S
T
Y
L
L
A
F
V
V
SD
F
Q
L
R
L
S
GA
Q
R
V
Y
V
R
P
N
A
F
N
E
A
T
F
A
L
E
A
G
V
K
I
L
K
V
L
D
D
H
L
G
I
P
Y
D
T
Y
M
P
K
L
D
Q
I
A
I
PDF
A
A
G
A
M
E
N
WG
L
V
T
Y
R
E
Q
A
L
L
FNPAVST
Y
R
G
K
T
N
V
A
T
T
I
A
H
E
Y
A
H
QWFGNLV
S
P
E
WWEY
I
W
L
N
E
G
F
A
T
L
Y
E
F
Y
A
L
D
M
A
Y
P
G
Q
E
Y
W
E
L
F
N
Q
Q
V
I
Q
Y
A
M
G
Q
D
G
Q
A
S
T
R
P
M
N
W
N
A
A
T
P
G
E
I
S
A
L
F
D
R
VAY
D
K
S
G
S
V
L
N
M
M
R
H
V
L
G
D
D
N
W
K
A
G
L
K
A
Y
L
T
D
R
A
L
Q
G
A
V
D
E
Q
L
Y
A
G
L
Q
S
A
I
E
G
K
G
V
LPNGVT
V
A
Q
I
M
R
T
W
T
N
E
A
G
Y
P
V
L
N
V
R
R
SY
D
T
G
D
V
I
I
S
Q
E
R
F
Y
N
D
R
K
V
P
N
T
N
I
-
W
M
I
P
Y
N
Y
V
H
QAKADFN
E
F
D
D
F
Q
W
L
A
T
K
A
A
R
I
E
T
T
V
P
A
N
E
W
I
V
F
N
K
Q
QVGY
Y
R
V
N
Y
D
E
H
-
N
W
E
L
I
T
N
A
L
H
E
NW
A
S
I
H
R
L
N
R
A
Q
L
I
D
D
A
Y
W
L
A
R
S
G
R
L
D
L
R
V
A
L
R
F
M
TYLRNERE
Y
A
P
W
T
A
A
N
V
A
L
T
Y
F
N
N
-------
R
L
R
G
T
A
E
-
Y
H
N
F
L
I
F
V
D
A
--
L
IEDIYSLLTIDAVSPDD
T
L
L
H
K
Y
L
V
Q
T
I
S
T
W
A
C
S
M
GY
T
D
C
L
M
K
T
A
A
L
L
K
A
E
A
S
G
T
G
P
A
-------------------
V
------
H
------------------
P
-----------------
D
-
I
A
S
V
T
--
Y
C
Y
G
M
R
S
--
A
L
E
S
E
F
Q
Y
----------
L
Y
R
---
K
-----
M
-----
M
N
--
S
K
N
----------
L
A
E
R
T
M
L
I
---
D
S
L
G
-----
C
-----------
S
----
N
N
K
--
E
F
L
K
A
F
L
T
T
A
L
G
S
I
N
----------------------
Y
R
------------------------
A
---
D
E
R
-
R
R
V
------
V
Q
A
------
I
Y
S
G
G
R
T
G
V
D
A
L
I
E
F
L
---
M
D
-
P
A
L
--------
V
---------
N
--
E
F
V
S
T
L
S
T
S
T
L
N
-
S
A
-
L
S
--
A
--
I
A
S
R
TN
N
-
V
--
E
-
E
-
M
N
K
L
N
A
L
I
T
A
L
G
S
R
V
N
S
Q
T
A
A
N
L
R
T
T
A
Q
A
N
L
D
W
V
N
G
F
E
G
L
M
L
S
N
F
L
AEA
26
HHSearch
61.65
16%
-61
- C2 -
1MF7
-
ITAM_HUMAN
A:
[131-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----------
S
D
I
A
F
L
I
D
G
S
G
S
I
I
P
H
------
D
F
R
R
M
K
E
F
V
S
T
V
M
E
Q
L
K
K
--
S
-----------------
K
T
L
F
S
L
M
----------------------
Q
Y
S
E
E
F
R
I
----------------------------------------------------------------------
H
F
T
F
--
K
E
F
Q
N
N
----
P
N
P
R
S
L
V
----------
K
P
I
---
T
Q----
L
-----
L
G
--
R
T
H
----
T
----
A
T
G
I
R
K
V
V
R
---
E
L
F
N
-----
I
TNGAR------
K
----
N
A
F
--
K
I
L
V
V
I
T
D
G
E
K
F
G
D
-------------------------------------------------------
P
-
L
G
Y
------
E
D
V
------
I
P
E
A
D
R
E
G
V
I
R
Y
V
I
G
V
---
G
D
-
A
F
R
SEK-----
S
---------
R
--
Q
E
L
N
-----
T
I
A
-
S
K
-
P
P
--
R
D-
H
V
F
---
Q
-
V
--
N
-
N
-
F
E
A
L
K
T
I
Q
N
Q
L
R
E
K
I
----------------------------------
22
HHSearch
57.58
18%
-53
* C2 *
1N3Y
-
ITAX_HUMAN
A:
[129-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
-----------
Q
D
I
V
F
L
I
D
G
S
G
S
I
S
S
R
------
N
F
A
T
M
M
N
F
V
R
A
V
I
S
Q
F
Q
R
--
P
-----------------
S
T
Q
F
S
L
M
----------------------
Q
F
S
N
K
F
Q
T
----------------------------------------------------------------------
H
F
T
F
--
E
E
F
R
R
S
----
S
N
P
L
S
L
L
----------
A
S
V
H--
Q
-----
L
-----
Q
G
--
F
T
Y
----
T
----
A
T
A
I
Q
N
V
V
H
---
R
L
F
H
ASYGA
R
-----------
R
----
D
A
A
--
K
I
L
I
V
I
T
D
G
K
K
E
G
D
S
--------------------------------------------------------
L
D
Y
------
K
D
V
------
I
P
M
A
D
A
A
G
I
I
R
Y
A
I
G
V
---
G
L
-
A
F
Q
N
R
N
-----
S
---------
W
--
K
E
L
N
-----
D
I
A
-
S
K
-
P
S
Q-
E
--
H
I
F
---
K
-
V
--
E
-
D
-
F
D
A
L
K
D
I
Q
N
Q
L
K
E
K
I
----------------------------------
47
Fugue
57.08
17%
-4
- C2 -
4PE2
2
MALE_ECOLI
A:
[3-498]
--------------------I
E
E
G
K
L
V
I
W
I
N
G
D
---
K
G
Y
N
G
L
A
---
E
V
G
K
K
F
E
K
D
---
T
G
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
A
T
GDGPD
I
I
F
W
A
----
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
-------------
E
I
T
P
D
K
A
F
Q
D
-
K
L
Y
P
F
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
------
N
K
D
L
L
P
N
P
P
K
T
W
E
----------
E
I
P
A
L
D
K
E
L
K
A
K
G
K
S
A
-------
L
M
F
---------------
N
---
L
Q
E
P
Y
F
T
W
--------
P
L
I
A
A
D
G
G
-----
Y
A
F
K
Y
E
N
G
K
Y
D
------
I
K
D
V
G
V
D
----
N
A
G
A
K
A
G
L
-------
T
F
L
V
D
L
I
K
N
K
H
M
N
----------------------------------------------------------------
A
D
T
D
Y
S
I
A
E
A
A
F
N
K
G
E
T
A
M
---
T
I
N
G
P
W
A
W
S
N
I
D
T
------
S
K
V
N
--------------
Y
G
V
T
V
L
P
T
F
K
G
Q
P
S
K
-------------------------------------
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
------------
E
F
L
E
N
Y
L
L
-
T
D
E
G
L
E
A
V
N
K
D
-
K
P
L
G
A
V
A
L
K
-------
S
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
M
---
E
N
A
Q
K
G
E
I
----------
M
P
-
N
I
P
Q
M
S
A
F
W
Y
-----------
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
T
-----------
V
D
E
A
L
K
D
A
Q
T
N
A
A
A
--
S
-----------------
N
I
N
K
A
K
V
----------------------
A
S
V
E
S
D
Y
S
S
V
K
S
-------------------
A
------
A
------------------
L
-----------------
S
-
Y
Y
S
D
K
-------
N
T
--
M
P
P
S
G
E
-
L
----------
D
A
L
---
E
-----
T
-----
Y
M
--
D
T
L
----
P
----
D
K
A
D
I
G
G
G
Y
---
K
L
L
L
-----
V
-----------
N
----
N
----
K
L
A
L
K
I
G
D
G
T
A
A
-------------------------------------------------------
D
S
V
T
L
T
K
------
A
Q
I
------
E
K
L
L
S
D
I
G
P
---
K
K
I
Y
---
T
E
-
N
T
L
--------
K
---------
T
--
E
L
Q
K
-----
N
S
T
-
L
K
-
D
G
--
T
--
L
Y
I
---
V
-
L
--
I
-
D
-
N
------------------------------------------------
35
HHSearch
57.03
12%
-54
- C2 -
3FCS
4
ITB3_HUMAN
B:
[107-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
Y
P
-----------
V
D
I
Y
Y
L
M
D
L
S
Y
S
M
K
D
-------
D
L
W
S
I
Q
N
L
G
T
K
L
A
T
Q
M
R
K
--
L
TS---------------
N
L
R
I
G
F
G
----------------------
A
F
V
D
K
P
V
S
P
Y
M
Y
-------------------
I
------
S
P
P
E
A
L
E
NPCYDMK
T
T
C
L
P
M
-----------------
F
-
G
Y
K
H
V
--
L
T
L
T
D
Q
V
---
T
R
F
N
E
E
V
----------
K
K
Q
---
S
-----
V
-----
S
R
--
N
R
D
----
A
PEG
G
F
D
A
I
M
Q
A
T
V
CDE
K
I
G
W
-----
R
-----------
N
----
D
A
S
--
H
L
L
V
F
T
T
D
A
K
T
H
I
A
L
DGRLAGIVQPNDGQCHVGSDNH
Y
S
------------------------
A
STT
M
D
Y
-
P
S
L
------
G
L
M
------
T
E
K
L
S
Q
K
N
I
N
L
I
F
A
V
T
---
E
N
-
V
V
---------
N
-------------
L
Y
Q
-----
N
Y
S
-
E
L
-
I
P
--
G
--
T
T
V
G
--
V
L
S
--
M
-
D
-
S
S
N
V
L
Q
L
I
V
D
A
Y
G
K
-----------------------------------
32
HHSearch
56.88
12%
-58
- C2 -
3T3P
6
ITB3_HUMAN
B:
[96-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
K
N
F
S
-
I
Q
V
R
Q
V
E
D
Y
P
-----------
V
D
I
Y
Y
L
M
D
L
S
Y
S
M
K
D
-------
D
L
W
S
I
Q
N
L
G
T
K
L
A
T
Q
M
R
K
--
L
TS---------------
N
L
R
I
G
F
G
----------------------
A
F
V
D
K
P
V
S
P
Y
M
Y
-------------------
I
------
S
------------------
P
P
E
A
L
E
NPCYDMK
T
T
C
L
P
M
F
G
Y
K
H
V
--
L
T
L
T
D
Q
V
---
T
R
F
N
E
E
V
----------
K
K
Q
---
S
-----
V
-----
S
R
--
N
R
D
APEG
G
----
F
D
A
I
M
Q
A
T
V
CDE
K
I
G
W
-----
R
-----------
N
----
D
A
S
--
H
L
L
V
F
T
T
D
A
K
T
H
I
A
L
DGRLAGIVQPNDGQCHVGSDNH
Y
S
------------------------
A
STT
M
D
Y
-
P
S
L
------
G
L
M
------
T
E
K
L
S
Q
K
N
I
N
L
I
F
A
V
T
---
E
N
-
V
V
----------------------
N
L
Y
Q
-----
N
Y
S
-
E
L
-
I
P
--
G
--
T
T
V
G
--
V
-
L
--
S
M
D
-
S
S
N
V
L
Q
L
I
V
D
A
Y
G
K
I
----------------------------------
43
Fugue
56.70
14%
-36
- C2 -
1SHU
1
ANTR2_HUMAN
X:
[2-182]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
C
R
R
A
-----------
F
D
L
Y
F
V
L
D
K
S
G
S
V
A
N
-------
N
W
I
E
I
Y
N
F
V
Q
Q
L
A
E
R
F
V
S
--
P
-----------------
E
M
R
L
S
F
I
----------------------
V
F
S
S
Q
A
T
I
I
L
P
L
-------------------
T
------
G
------------------------------------------------
D
R
G
K
--
I
S
K
G
L
E
D
L
----------
K
R
V
---
S
-----
P
-----
V
G
--
E
T
Y
----
I
----
H
E
G
L
K
L
A
N
E
---
Q
I
Q
K
-----
A
-----------
G
----
G
L
K
TS
S
I
I
I
A
L
T
D
G
K
L
D
---------------------------------------------------
G
---
L
V
P
-
S
Y
A
------
E
K
E
------
A
K
I
S
R
S
L
G
A
S
V
Y
C
V
G
V
LDF
E
Q
-
A
Q
L
--------
E
---------
R
IA
D
S
K
E
-----
Q
V
F
-
P
V
-
K
G
--
G
--
F
Q
A
---
L
-
K
--
G
-
I
-
I
N
S
I
L
A
Q
S
C
----------------------------------------
30
HHSearch
56.66
15%
-51
- C2 -
1V7P
1
ITA2_HUMAN
C:
[6-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------
I
D
V
V
V
V
C
D
E
S
N
S
I
Y
P
--------
W
D
A
V
K
N
F
L
E
K
F
V
Q
G
L
D
I
GP
T
-----------------
K
T
Q
V
G
L
I
----------------------
Q
Y
A
N
N
P
R
V
----------------------------------------------------------------------
V
F
N
L
--
N
T
Y
K
T
K
----
E
E
M
I
V
A
T
----------
S
Q
T
SQ-
Y
-----
G
-----
G
D
--
L
T
N
----
T
----
F
G
A
I
Q
Y
A
R
K
---
Y
A
Y
S
AASGG
R
-----------
R
----
S
A
T
--
K
V
M
V
V
V
T
D
G
E
S
H
D
G
---------------------------------------------------------
S
M
L
------
K
A
V
------
I
D
Q
C
N
H
D
N
I
L
R
F
G
I
A
V
---
L
G
-
Y
L
---------
N
R
N
ALDT
K
N
L
I
--
K
E
I
K
-----
A
I
A
-
S
I
-
P
T
--
E
R-
Y
F
F
---
N
-
V
--
S
-
D
-
E
A
A
L
L
E
K
A
G
T
L
G
E
Q
I
----------------------------------
27
HHSearch
55.67
18%
-45
- C2 -
3N2N
5
ANTR1_HUMAN
F:
[6-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-----------
F
D
L
Y
F
I
L
D
K
S
G
S
V
L
H
-------
H
W
N
E
I
Y
Y
F
V
E
Q
L
A
H
K
F
I
S
--
P
-----------------
Q
L
R
M
S
F
I
----------------------
V
F
S
T
R
G
T
T
----------------------------------------------------------------------
L
M
K
L
--
T
E
---
D
R
---
E
Q
I
R
Q
G
L
----------
E
E
L
QKV
L
-----
P
-----
G
G
--
D
T
Y
----
M
----
H
E
G
F
E
R
A
S
E
---
Q
I
Y
Y
-----
E
-----------
N
RQGY
R
T
A
--
S
V
I
I
A
L
T
D
G
E
L
H
E
D
L
------------------------------------------------------
F
-
F
Y
S
------
E
R
E
------
A
N
R
S
R
D
L
G
A
I
V
Y
A
V
G
V
---
K
D
-
F
----------
N
---------
E
--
T
Q
L
A
-----
R
I
A
-
D
S
-
K
D
--
H
---
V
F
---
P
-
V
--
N
-
D
G
F
Q
A
L
Q
G
I
I
H
S
I
L
K
------------------------------------
33
HHSearch
54.43
13%
-55
- C2 -
3V4V
6
ITB7_HUMAN
B:
[117-370]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
Q
Q
L
Q
-
V
R
F
L
R
A
E
G
Y
P
-----------
V
D
L
Y
Y
L
M
D
L
S
Y
S
M
K
D
-------
D
L
E
R
V
R
Q
L
G
H
A
L
L
V
R
L
Q
E
--
V
TH---------------
S
V
R
I
G
F
G
----------------------
S
F
V
D
K
T
V
L
P
F
V
S
-------------------
T
V
P
S
K
L
R
H
------------------
P
CPTRL
E
R
C
Q
S-------
P
F
S
F
H
H
V
--
L
S
L
T
G
D
A
---
Q
A
F
E
R
E
V
----------
G
R
Q
---
S
-----
V
-----
S
G
--
N
L
D
SPEG
G
----
F
D
A
I
L
Q
A
A
L
C
QE
Q
I
G
W
-----
R
-----------
N
-----
V
S
--
R
L
L
V
F
T
S
D
D
T
F
H
T
A
G
DGKLGGIFMPSDGHCHLDSNGL
Y
S
------------------------
R
STE
F
D
Y
-
P
S
V
------
G
Q
V
------
A
Q
A
L
S
A
A
N
I
Q
P
I
F
A
V
T
---
S
A
-
A
L
----------------------
P
V
Y
Q
-----
E
L
S
-
K
L
-
I
P
--
K
--
S
A
V
G
--
E
-
L
--
S
E
D
-
S
S
N
V
V
Q
L
I
M
D
A
Y
N
S
L
----------------------------------
28
HHSearch
54.39
10%
-44
- C2 -
1IJB
-
A:
[511-693]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
-----------
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
------
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
V
--
S
QK---------------
W
V
R
V
A
V
V
----------------------
E
Y
H
D
G
S
H
A
----------------------------------------------------------------------
Y
I
G
L
--
K
D
R
K
R
P
----
S
E
L
R
R
I
A
----------
S
Q
V
---
K
-----
Y
-----
A
G
SQ
V
A
S
----
T
----
S
E
V
L
K
Y
T
L
F
---
Q
I
F
S
KID--
R
-----------
P
----
E
A
S
--
R
I
A
L
L
L
M
A
S
Q
E
P
Q
R
------------------------------------------------------
M
S
-
R
N
F
------
V
R
Y
------
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
---
G
P
-
H
A
---------
N
---------
L
--
K
Q
I
R
-----
L
I
E
-
K
Q
A
P
E
--
N
--
K
A
F
---
V
-
L
--
S
-
S
-
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
-----------------------------------
42
HHSearch
54.19
12%
-41
- C2 -
1MJN
1
ITAL_HUMAN
A:
[2-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
L
V
F
L
F
D
G
S
M
S
L
Q
P
D
------
E
F
Q
K
I
L
D
F
M
K
D
V
M
K
K
C
S
N
--
T
-----------------
S
Y
Q
F
A
A
V
----------------------
Q
F
S
T
S
Y
K
T
E
----------------------------------------------------------------------
F
D
F
--
S
D
Y
V
K
R
----
K
D
P
D
A
L
L
----------
K
H
V
---
K
H----
M
-----
L
L
--
L
T
N
----
T
----
F
G
A
I
N
Y
V
A
T
---
E
V
F
R
EELGA
R
-----------
P
----
D
A
T
--
K
V
L
I
I
I
T
D
G
E
A
T
D
S
G
---------------------------------------------------------
N
I
------------------
D
A
A
K
D
I
I
R
Y
I
I
G
I
---
G
K
-
H
F
Q
T
K
E
-----
S
---------
Q
--
E
T
L
H
-----
K
F
A
-
S
K
-
P
A
--
S
E-
F
V
K
---
I
-
L
--
D
-
T
-
F
E
K
L
K
D
L
C
T
E
L
Q
K
------------------------------------
29
HHSearch
54.11
10%
-57
- C2 -
2IUE
-
ITB2L_MOUSE
A:
[3-210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------
V
D
L
Y
F
L
M
G
L
S
G
S
A
Q
G
-------
H
L
S
N
V
Q
T
L
G
S
D
L
L
K
A
L
N
E
--
I
S
R---------------
S
G
R
I
G
F
G
----------------------
S
I
V
N
M
T
F
Q
---------------------------------------------------------------------
H
I
-----
L
K
L
T
A
D
S
---
S
Q
F
Q
R
E
L
----------
R
K
Q
---
L
-----
V
-----
S
G
--
K
L
A
TPKG
Q
----
L
D
A
V
V
Q
V
A
I
CLG
E
I
G
W
-----
R
-----------
N
-----
G
T
--
R
F
L
V
L
V
T
D
N
D
F
H
L
A
K
----------------------
D
K
TLGTRQNTSDG
R
C
H
L
D
DGMYRSRG
E
---
P
D
Y
-
Q
S
V
------
V
Q
L
------
A
S
K
L
A
E
N
N
I
Q
P
I
F
V
V
P
---
S
R
-
M
--------------------
V
--
K
T
Y
E
-----
K
L
T
-
T
F
-
I
P
--
K
--
L
T
I
---
G
-
E
L
S
D
-
D
-
S
S
N
V
A
Q
L
I
R
N
A
Y
S
------------------------------------
23
HHSearch
54.08
16%
-40
- C2 -
1SHU
1
ANTR2_HUMAN
X:
[5-179]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
-----------
F
D
L
Y
F
V
L
D
K
S
G
S
V
A
N
-------
N
W
I
E
I
Y
N
F
V
Q
Q
L
A
E
R
F
V
S
--
P
-----------------
E
M
R
L
S
F
I
----------------------
V
F
S
S
Q
A
T
I
----------------------------------------------------------------------
I
L
P
L
--
T
G
D
R
G
K
I
---
S
K
G
L
E
D
L
----------
K
R
V
---
S
-----
P
-----
V
G
--
E
T
Y
----
I
----
H
E
G
L
K
L
A
N
E
---
Q
I
Q
K
-----
A
-----------
G
GL--
K
T
S
--
S
I
I
I
A
L
T
D
G
K
L
D
G
L
V
------------------------------------------------------
P
-
S
Y
A
------
E
K
E
------
A
K
I
S
R
S
L
G
A
S
V
Y
C
V
G
V
---
L
D
-
F
----------
E
---------
Q
--
A
Q
L
E
-----
R
I
A
-
D
S
-
K
E
-----
Q
V
F
---
P
-
V
--
K
G
G
-
F
Q
A
L
K
G
I
I
N
S
I
L
A
------------------------------------
36
HHSearch
53.19
11%
-53
- C2 -
2B2X
1
ITA1_RAT
A:
[22-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------
L
D
I
V
I
V
L
D
G
S
N
S
I
Y
P
--------
W
E
S
V
I
A
F
L
N
D
L
L
K
R
M
D
I
GP
K
-----------------
Q
T
Q
V
G
I
V
----------------------
Q
Y
G
E
N
V
T
H
----------------------------------------------------------------------
E
F
N
L
--
N
K
Y
S
S
T
----
E
E
V
L
V
A
A
----------
N
K
I
---
V
-----
Q
RG---
G
R
--
Q
T
M
----
T
----
A
L
G
I
D
T
A
R
K
---
E
A
F
T
EARGA
R
-----------
R
----
G
V
K
--
K
V
M
V
I
V
T
D
G
E
S
H
D
--------------------------------------------------------
N
-
Y
R
L
------
K
Q
V
------
I
Q
D
C
E
D
E
N
I
Q
R
F
S
I
A
I
---
L
G
-
H
Y
---------
N
LST
E
K
F
---
V
--
E
E
I
K
-----
S
I
A
S
E
P
-
T
E
--
K
--
H
F
F
---
N
-
V
--
S
-
D
-
E
L
A
L
V
T
I
V
K
A
L
G
E
R
I
----------------------------------
39
HHSearch
52.81
12%
-42
- C2 -
2ODP
3
A:
[7-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
H
-----------
L
N
L
Y
L
L
L
D
A
S
Q
S
V
S
E
N
------
D
F
L
I
F
K
E
S
A
S
L
M
V
D
R
I
F
S
--
F
E
I
---------------
N
V
S
V
A
I
I
----------------------
T
F
A
S
E
P
K
V
----------------------------------------------------------------------
L
M
S
V
--
L
N
D
N
S
R
D
--
M
T
E
V
I
S
S
L
----------
E
N
A
---
N
-----
Y
KDHEN
G
T
--
G
T
N
----
T
----
Y
A
A
L
N
S
V
Y
L
---
M
M
N
N
-----
Q
M
R
L
L
GMET
M
A
W
Q
----
E
I
R
--
H
A
I
I
L
L
T
D
G
K
S
N
M
G
G
-----------------------------------------------------
S
P
-
K
T
A
------
V
D
H
I
R
E
I
L
N
I
N
Q
K
R
N
D
Y
L
D
I
Y
A
I
G
V
---
G
K
L
D
V
---------
D
---------
W
--
R
E
L
N
-----
E
L
G
-
S
K
-
K
D
--
G
ER
H
A
F
---
I
-
L
--
Q
-
D
-
T
K
A
L
H
Q
V
F
E
H
M
L
D
------------------------------------
31
HHSearch
52.01
10%
-49
- C2 -
1PT6
2
ITA1_HUMAN
A:
[7-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------
L
D
I
V
I
V
L
D
G
S
N
S
I
Y
P
--------
W
D
S
V
T
A
F
L
N
D
L
L
K
R
M
D
I
GP
K
-----------------
Q
T
Q
V
G
I
V
----------------------
Q
Y
G
E
N
V
T
H
----------------------------------------------------------------------
E
F
N
L
--
N
K
Y
S
S
T
----
E
E
V
L
V
A
A
----------
K
K
I
---
V
-----
Q
-----
R
G
GR
Q
T
M
----
T
----
A
L
G
T
D
T
A
R
K
---
E
A
F
T
EAR
G
A
R
-----------
R
----
G
V
K
--
K
V
M
V
I
V
T
D
G
E
S
H
D
N
---------------------------------------------------------
H
R
L
------
K
K
V
------
I
Q
D
C
E
D
E
N
I
Q
R
F
S
I
A
I
---
L
G
-
S
Y
N
R
G
NLST
E
K
F
---------
V
--
E
E
I
K
-----
S
I
A
-
S
E
-
P
T
E-
K
--
H
F
F
---
N
-
V
--
S
-
D
-
E
L
A
L
V
T
I
V
K
T
L
G
E
R
I
----------------------------------
41
HHSearch
51.33
12%
-31
- C2 -
1RRK
4
A:
[2-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
I
Y
L
V
L
D
G
S
D
S
I
G
A
S
------
N
F
T
G
A
K
K
V
L
V
N
L
I
E
K
V
A
S
--
Y
G
V
---------------
K
P
R
Y
G
L
V
----------------------
T
Y
A
T
Y
P
K
I
W
----------------------------------------------------------------------
V
K
V
--
S
E
A
D
S
S
N
--
A
D
W
V
T
K
Q
L
----------
N
E
I
---
N
YEDHK
L
-----
K
S
--
G
T
N
----
T
----
K
K
A
L
Q
A
V
Y
S
---
M
M
S
W
-----
P
GW---------
N
----
R
T
R
--
H
V
I
I
L
M
T
D
G
L
H
N
M
G
G
----------------------
D
P
------------------------
I
---
T
V
I
-
D
E
I
R
D
L
L
YI
G
K
D
------
R
-
N
P
R
E
D
Y
L
D
V
Y
V
F
G
V
---
G
P
-
L
V
---------
N
---------
Q
--
V
N
I
N
-----
A
L
A
-
S
K
-
K
D
NE
Q
--
H
V
C
---
K
-
V
--
K
-
D
-
M
E
C
L
E
D
V
F
Y
Q
M
I
D
E
S
----------------------------------
40
HHSearch
50.36
14%
-32
- C2 -
1ATZ
-
VWF_HUMAN
A:
[925-1096]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
-----------
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
------
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
--
G
PR---------------
L
T
Q
V
S
V
L
----------------------
Q
Y
G
S
I
T
T
I
----------------------------------------------------------------------
D
V
P
W
--
N
V
V
P
E
K
----
A
H
L
L
S
L
V
----------
D
V
M
---
Q
R----
E
-----
G
G
--
P
S
Q
----
I
----
G
D
A
L
G
F
A
V
R
---
Y
L
T
S
-----
E
MHGAR------
P
G---
A
S
K
--
A
V
V
I
L
V
T
D
V
S
V
D
S
------------------------------------------------------------
V
------
D
A
A
------
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
---
G
D
-
R
Y
---------
D
---------
A
--
A
Q
L
R
-----
I
L
A
-
G
P
-
A
G
--
D
S-
N
V
V
---
K
-
L
--
Q
-
R
-
I
E
D
L
P
T
-------------------------------------------
38
HHSearch
45.36
16%
-25
- C2 -
3TVY
1
?
A:
[9-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
-----------
L
D
V
V
V
L
L
D
N
S
N
S
M
N
N
ERANNSQ
R
A
L
K
A
G
E
A
V
E
K
L
I
D
K
I
T
S
N-
K
-----------------
D
N
R
V
A
L
V
----------------------
T
Y
A
S
T
I
F
D
G
T
E
A
T
V
S
K
G
V
A
D
QNG
K
A
L
N
DSVS
W
------
D
YHKT
T
F
------------
T
-----------------
A
-
T
T
H
N
Y
SY
L
N
L
T
N
D
A
N
E
V
N
I
L
K
S
R
I
PKEAEHINGD
R
T
L
---
Y
-----
Q
-----
F
G
--
A
T
F
----
T
----
Q
K
A
L
M
K
A
N
E
---
I
L
E
T
QS---
S
-----------
N
----
A
R
K
--
K
L
I
F
H
V
T
D
G
V
P
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------