@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1311: (2016-03-24 )
MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIGDVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRFLTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGANVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIHNDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDANTIFIENGKFHGGIIAQNMLAKKQTPLES
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20...--.--.--.-..30.-..----.....40-...--.----..--...50....---...-.----60--------..-..-----..-..70....-----------.-...80.------------.-----------......90........100...-.....110.--.----.-......120......--...-130.......140--------.-.-----------..--.--.----------------.-.--150-------.-----.-----...-----------...160.......170...-----------------------....180.....----..190.---------.-....------.200...--..---..210.......--220...-.-------.----.----.---230..-----.--......240........250--..-..--.--..260.......270.......280.......290......-.------300.......310.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQK
V
E
S
I
I
IGGGPC
G
L
S
A
A
I
E
Q
K
R--K--G--I-
D
T
L
I
I
-EK----G
N
V
V
E
S
--
I
YN--Y----PT--
H
Q
T
FFSSSD---KLS-I----GD--------V
P
-
F
I
-----VE-ESKPRRN
Q
-----------
A
-
L
V
Y
Y
R
E
------------
V
-----------
V
K
H
H
Q
L
K
V
N
A
F
E
E
V
L
T
V
-
K
KMN-N
K
F
T
I
T
--T--T----K-D
V
Y
E
C
R
F
--
L
T
I
A
T
G--YYG-QH
N
T
L
E
VEGAD
L
---------
P
-
K
-----------
V
F
--
H
--
Y
----------------
F
-
K
--
E
-A-------H-----P-----YFD-----------Q
D
V
V
I
IGGKNS
A
I
D
A
A
L
E
L
-----------------------EKAGA
N
V
T
V
L
Y
R----GGDYSP---------S-IKPW------ILP
N
F
T
A
--LV---NH
E
K
I
D
M
E
FNAN--
V
T
Q
ITE-
D
-------
T
----
V
----
T
---
Y
--
E
V-----N--GES
K
T
I
HN-
D
Y
V
F
A
M
IGYHP--
D
Y
-
E
F
--
L
--
K
SVG
I
Q
I
NTNEFGTAPMYNK
E
T
YETNIE
N
C
Y
I
A
G
V
I
AAGND-A------
N
T
I
F
I
ENGKFH
G
G
I
I
A
Q
N
M
L
A
KKQTPLES
8
PsiBlast_PDB
78.10
25%
-92
- C1 -
3CGE
3
?
A:
[40-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
--
N
--
A
-
N
V
V
T
L
-
E
K
----
G
----
E
--
I
Y
S
--
Y
----
A
Q
--
C
G
L
P
Y
V
I
S
G
---
A
I
A
-
S
----
T
E
---------
K
-
L
I
-----
A
R
-
N
V
K
T
F
R
D
K
-----------
Y
-
G
I
D
A
K
-------------------------
V
R
H
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
-
E
H
--------
T
--
K
--
T
----
K
-
D
V
F
E
F
S
Y
D
R
L
L
I
A
T
G
--
V
---
R
P
V
M
P
E
W
E
G
R
D
L
QG
V
H
L
L
KT
I
P
-
D
-----------
A
E
--
R
--
I
----------------
L
-
K
--
T
-
L
-------
E
-----
T
-----
N
K
V
-----------
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-----------------------
V
E
L
G
K
K
V
R
M
I
E
R
NDHI
G
T
I
Y
D
G
---------
D
-
M
A
E
Y
------
I
Y
K
E
------
A
---
D
K
H
H
I
E
I
L
T
N
E
N
--
V
K
A
F
K
G
-
N
-------
E
----
R
----
V
---
E
--
A
V
-----
E
--
T
D
K
G
T
Y
K
A
-
D
L
V
L
V
S
V
G
V
K
P
--
N
T
-
D
F
--
L
--
E
--
G
T
N
I
R
T
N
H
K
G
A
I
E
V
--
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
-----------------------------------------
92
Fugue
77.56
21%
-77
- C1 -
1HYU
4
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
--
K
--
G
--
I
-
R
T
G
L
M
-
G
E
RFG-
G
Q
V
L
D
T
VD
I
E
N
--
Y
----
I
S
--
V
P
K
-----------------------------
T
-
E
G
-----
Q
K
-
L
A
G
A
L
K
A
H
-----------
V
-
S
D
Y
D
V
D
------------
V
-----------
I
D
S
Q
S
-----
A
S
K
L
V
P
A
-
A
T
E
G
-
G
L
H
Q
I
E
--
T
--
A
----
S
G
A
V
L
K
A
R
S
--
I
I
I
A
T
G
--
A
K
W
-
R
N
M
N
V
P
G
E
D
Q
Y
R
---------
T
-
K
-----------
G
V
--
T
--
Y
----------------
C
-
P
HC
D
-
G
-------
P
-----
L
-----
F
K
G
-----------
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
-----------------------
A
G
I
V
E
H
V
T
L
L
E
F
----
A
P
E
M
K
A
---------
D
------------
Q
V
L
Q
D
K
--
V
R
---
S
L
K
N
V
D
I
I
L
N
A
Q
--
T
T
E
V
K
G
-
D
GSKVV
G
L
E
----
Y
----
R
---
D
--
R
V
-----
S
--
G
D
I
H
S
V
A
L
-
A
G
I
F
V
Q
I
G
L
L
P
--
N
T
-
H
W
--
L
--
E
G
---
A
L
E
R
N
R
M
G
E
I
I
I
--
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
-
K
------
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
---
6
PsiBlast_PDB
76.97
25%
-92
- C1 -
3CGC
2
?
A:
[40-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
--
N
--
A
-
N
V
V
T
L
-
E
K
----
G
----
E
--
I
Y
S
--
Y
----
A
Q
--
C
G
L
P
Y
V
I
S
G
---
A
I
A
-
S
----
T
E
---------
K
-
L
I
-----
A
R
-
N
V
K
T
F
R
D
K
-----------
Y
-
G
I
D
A
K
-------------------------
V
R
H
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
-
E
H
--------
T
--
K
--
T
----
K
-
D
V
F
E
F
S
Y
D
R
L
L
I
A
T
G
--
V
---
R
P
V
M
P
E
W
E
G
R
D
L
QG
V
H
L
L
K
T
I
P
-
D
-----------
A
E
--
R
--
I
----------------
L
-
K
--
T
-
L
-------
E
-----
T
-----
N
K
V
-----------
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-----------------------
V
E
L
G
K
K
V
R
M
I
E
R
NDHI
G
T
I
Y
D
G
---------
D
-
M
A
E
Y
------
I
Y
K
E
------
A
---
D
K
H
H
I
E
I
L
T
N
E
N
--
V
K
A
F
K
G
-
N
-------
E
----
R
----
V
---
E
--
A
V
-----
E
--
T
D
K
G
T
Y
K
A
-
D
L
V
L
V
S
V
G
V
K
P
--
N
T
-
D
F
--
L
--
E
--
G
T
N
I
R
T
N
H
K
G
A
I
E
V
--
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
-----------------------------------------
81
HHSearch
76.40
21%
-86
- C1 -
1MO9
2
XECC_XANP2
A:
[42-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
Y
D
A
I
F
I
G
G
G
A
A
G
R
F
G
S
A
Y
L
R
A
--
M
--
G
--
G
-
R
Q
L
I
V
-
D
R
----
W
P
F
L
G
G
--
S
C
P
--
H
NA
C
V
P
H
--
H
L
-
F
S
D
C
A
A
---
E
L
M
L
A
----
R
T
F
SGQ----
Y
W
-
F
P
-----
D
M
T
E
K
V
V
G
I
K
E
-----------
V
-
V
D
L
F
R
A
G
R
N
G
P
H
G
I
M
N
F
Q
S
-----------
K
E
Q
L
N
L
E
Y
I
L
N
C
P
A
K
V
I
-
D
N
H
-----
T
V
E
--
A
--
A
----
G
-
K
V
F
K
A
K
N
--
L
I
L
A
V
G
--
A
G
---
P
G
T
L
D
V
P
G
V
N
A
---------
K
-
G
-----------
V
F
--
D
--
H
A
T
--------------
L
-
V
--
E
E
L
-------
D
-----
Y
-----
E
P
G
-----------
S
T
V
V
V
V
G
G
S
K
T
A
V
E
Y
G
C
F
F
-----------------------
N
A
T
G
R
R
T
V
M
L
V
R
----
T
E
P
L
K
L
---------
I
-
K
D
N
E
------
T
R
A
Y
V
L
D
--
R
M
---
K
E
Q
G
M
E
I
I
S
G
S
N
--
V
T
R
I
E
E
-
D
-------
A
NGR-
V
----
Q
A
V
V
A
--
M
T
-----
P
--
N
G
E
M
R
I
E
T
-
D
F
V
F
L
G
L
G
E
Q
P
--
R
S
A
E
L
--
A
--
K
I
L
G
L
D
L
G
P
---
K
G
E
V
L
V
N
-
E
Y
L
Q
T
S
V
P
N
V
Y
A
V
G
D
L
I
G
G
P
M
-----------
E
M
F
K
A
R
K
S
G
C
Y
A
A
R
N
V
M
G
E
K
------
2
PsiBlast_PDB
76.24
24%
-103
- C1 -
3AB1
1
FENR_CHLTE
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
--
N
--
N
--
I
-
S
C
R
I
I
-
E
S
MPQL
G
G
Q
L
A
A
--
L
Y
--------
P
E
--
K
H
I
Y
----
D
---
V
A
G
-
F
----
P
E
--------
V
P
-
A
I
D
L
V
E
S
L
W
-
A
Q
A
E
R
Y
N
P
-----------
D
-
V
V
L
N
E
T
------------
V
-----------
T
K
Y
T
K
L
D
D
G
T
F
E
--------------
T
R
T
--
N
--
T
----
G
-
N
V
Y
R
S
R
A
--
V
L
I
A
A
G
--
L
G
A
-------
F
E
P
R
K
L
---------
P
-
Q
LGNIDHLTGSS
V
Y
--
Y
--
A
----------------
V
-
K
--
S
-
V
-------
E
-----
D
-----
F
K
G
-----------
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
-----------------------
I
K
N
A
A
S
V
T
L
V
H
R
----
G
H
E
F
Q
G
---------
H
-
G
K
--------
T
A
H
E
V
E
R
--
A
R
---
A
N
G
T
I
D
V
Y
L
E
T
E
--
V
A
S
I
E
E
S
N
-------
G
----
V
----
L
---
T
--
R
V
H
L
R
S
S
D
--
G
S
K
W
T
V
E
A
-
D
R
L
L
I
L
I
G
F
K
S
--
N
L
-
G
P
--
L
--
A
R
W
D
L
E
L
Y
E
N
-----
A
L
V
V
D
S
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
-----------------------------------------
7
PsiBlast_PDB
75.73
25%
-89
- C1 -
3CGD
3
?
A:
[40-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
--
N
--
A
-
N
V
V
T
L
-
E
K
----
G
----
E
--
I
Y
S
--
Y
----
A
Q
--
C
G
L
P
Y
V
I
S
G
---
A
I
A
-
S
----
T
E
---------
K
-
L
I
-----
A
R
-
N
V
K
T
F
R
D
K
-----------
Y
-
G
I
D
A
K
-------------------------
V
R
H
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
-
E
H
--------
T
--
K
--
T
----
K
-
D
V
F
E
F
S
Y
D
R
L
L
I
A
T
G
--
V
---
R
P
V
M
P
E
W
E
G
R
D
L
QG
V
H
L
L
KT
I
P
-
D
-----------
A
E
--
R
--
I
----------------
L
-
K
--
T
-
L
-------
E
-----
T
-----
N
K
V
-----------
E
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
-----------------------
V
E
L
G
K
K
V
R
M
I
E
R
NDHI
G
T
I
Y
D
G
---------
D
-
M
A
E
Y
------
I
Y
K
E
------
A
---
D
K
H
H
I
E
I
L
T
N
E
N
--
V
K
A
F
K
G
-
N
-------
E
----
R
----
V
---
E
--
A
V
-----
E
--
T
D
K
G
T
Y
K
A
-
D
L
V
L
V
S
V
G
V
K
P
--
N
T
-
D
F
--
L
--
E
--
G
T
N
I
R
T
N
H
K
G
A
I
E
V
--
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
-----------------------------------------
5
PsiBlast_PDB
75.15
22%
-81
- C2 -
1EBD
1
DLDH1_GEOSE
A:
[5-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
--
L
--
G
--
Q
-
K
V
T
I
V
-
E
K
----
G
N
L
-------------------------
G
G
V
---
C
L
N
-
V
----
G
C
--------
I
P
-
S
K
-----
A
L
-
I
S
A
S
H
R
Y
E
-----------
Q
-
A
K
H
S
E
E
------------
M
G----------
I
K
A
E
N
V
T
I
D
-
F
A
K
V
Q
E
W
-
K
A
S
V
-
V
K
K
L
T
G
--
G
--
V
----
E
-
G
L
L
K
G
N
K
--
V
E
I
V
K
G
E
A
Y
F
V
-
D
A
N
T
V
R
V
V
N
G
D
S
---------
A
-
Q
-----------
T
Y
--
T
--
F
K
N
A
I
I
AT
G
S
R
P
I
ELPN
F
-
K
--
F
-
S
-------
N
-----
R
-----
I
L
D
S
T
G
A
L
N
LGEVP
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
-----------------------
A
N
F
G
T
K
V
T
I
L
E
G
----
A
G
E
I
L
S
---------
G
-
F
E
K
Q
------
M
A
A
I
I
K
K
--
R
L
---
K
K
K
G
V
E
V
V
T
N
A
L
--
A
K
G
A
E
E
-
R
ED
G
V
---
T
----
V
----
T
---
Y
--
E
A
-----
N
--
G
E
T
K
T
I
D
A
-
D
Y
V
L
V
T
V
G
R
R
P
NT
D
E
-
L
G
--
L
--
E
Q
I
G
I
K
M
T
N
R
G
L
----
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
---------------------------------------
93
Fugue
74.87
20%
-71
- C1 -
4USR
2
?
A:
[1-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPAM
P
P
I
L
D
V
I
V
I
G
G
G
Q
A
A
L
T
T
A
Y
F
L
R
R
--
T
--
S
--
L
-
S
Y
L
L
L
D
E
Q
----
P
G
P
G
G
A
--
W
L
H
--
A
----
W
D
--
S
L
R
L
F
S
P
A
A
---
W
S
S
-
I
----
A
G
--------
W
P
-
M
P
SP---
T
E
-
P
G
N
P
T
R
N
D
-----------
V
-
I
D
Y
L
R
R
------------
Y
-----------
E
D
R
Y
Q
F
P
I
Q
R
P
V
R
V
D
T
V
-
T
R
L
D
-
D
L
W
R
V
Q
--
A
--
G
----
D
-
Q
Q
W
L
A
R
A
--
V
I
S
A
T
G
--
T
W
S
-
K
P
F
I
P
P
Y
E
G
R
E
L
---------
F
-
Q
-----------
G
A
--
Q
--
I
H
SAH------------
Y
-
R
--
T
-
P
-------
A
-----
P
-----
F
A
G
-----------
K
R
V
M
V
V
G
G
G
N
S
G
A
Q
V
L
A
E
L
S
S
V
S
E
T
L
W
I
T
QEP
P
A
F
L
P
DEVDG
R
V
L
F
E
R
A
T
A
R
W
K
----
A
Q
Q
E
G
R
---------
S
-
I
D
E
P
AGGFGD
I
V
M
V
P
P
V
--
R
E
---
A
R
E
R
G
V
L
V
A
E
R
P
--
F
A
R
F
T
E
-
T
-------
G
----
V
----
E
---
W
--
A
------
D
--
G
R
R
E
N
L
---
D
A
V
I
W
C
S
G
F
R
P
--
A
L
-
D
H
--
L
--
R
E
L
G
V
V
E
A
D
G
K
V
Q
V
E
-----
D
T
R
V
V
K
Q
P
N
L
W
L
V
G
Y
G
D
W
T
G
M
-
A
------
S
A
T
L
I
G
V
T
R
T
A
R
S
T
A
D
Q
V
V
Q
A
L
T
A
T
P
---
64
HHSearch
74.78
21%
-90
- C1 -
3LZW
3
FENR2_BACSU
A:
[5-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
--
R
--
Q
--
A
-
S
V
K
I
I
-
E
S
----
L
P
Q
L
G
G
--
Q
L
S
AL
Y
----
P
E
--
K
Y
I
Y
----------
D
-
V
----
A
G
--------
F
P
-------------
K
I
R
A
Q
E
-----------
L
-
I
N
N
L
K
E
------------
Q
-----------
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
-
E
K
Q
A
D
G
V
F
K
L
V
--
T
--
N
----
E
-
E
T
H
Y
S
K
T
--
V
I
I
T
A
G
--
N
G
A
F
K
P
R
K
L
E
L
E
N
A
E
Q
YEG------
K
-
N
-----------
L
H
--
Y
--
F
----------------
V
-
D
--
D
-
L
-------
Q
-----
K
-----
F
A
G
-----------
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
-----------------------
E
P
I
A
K
E
V
S
I
I
H
R
----
R
D
K
F
R
A
---------
H
-------------
E
H
S
V
E
--
N
L
---
H
A
S
K
V
N
V
L
T
P
F
V
--
P
A
E
L
I
G
-
E
-------
D
KIE
Q
L
----
V
---
L
--
E
E
-----
V
KG
D
R
K
E
I
L
E
I
-
D
D
L
I
V
N
Y
G
F
V
S
--
S
L
-
G
P
--
I
--
K
N
W
G
L
D
I
E
----
K
N
S
I
V
V
K
-
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
-
K
-------
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
------
80
HHSearch
74.46
18%
-96
- C1 -
1GES
1
GSHR_ECOLI
A:
[3-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
A
S
I
N
R
A
A
M
--
Y
--
G
--
Q
-
K
C
A
L
I
-
E
A
----
K
E
L
G
G
T
--
C
V
N
--
V
G
C
V
-
P
K
--
K
V
-
M
W
H
A
A
Q
---
I
R
E
A
I
HMYG
P
D
--------
Y
G
-
F
D
-----
T
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
-
H
T
S
Y
E
N
------------
V
-----------
L
G
K
N
N
V
D
V
I
K
G
F
-
A
R
F
V
-
D
A
-----
K
T
L
E
--
V
--
N
----
G
-
E
T
I
T
A
D
H
--
I
L
I
A
T
G
--
G
---
R
P
S
H
P
D
I
P
G
V
E
Y
-----------------------
G
I
--
D
-------------------
S
-
D
--
G
-
F
F
A
-----
L
-----
P
-----
A
L
P
-----------
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
-----------------------
N
G
L
G
A
K
T
H
L
F
E
M
----
F
D
A
P
L
P
---------
S
-
F
D
P
M
------
I
S
E
T
L
V
E
--
V
M
---
N
A
E
G
P
Q
L
H
T
N
A
I
--
P
K
A
V
V
K
-
N
TDG----
S
----
L
----
T
---
L
--
E
L
-----
E
--
D
-
G
R
S
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
--
A
N
-
D
N
IN
L
--
E
A
A
G
V
K
T
N
E
---
K
G
Y
I
V
V
D
-
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
G
A
V
E
-----------
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
-------
66
HHSearch
73.12
20%
-92
- C1 -
3KLJ
1
NROR_CLOAB
A:
[8-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
--
K
--
C
--
D
-
D
I
T
M
I
-
N
S
----
E
K
Y
L
P
Y
----
Y
--
R
----
P
R
--
L
N
E
I
I
A
----------------
K
-----------------------
N
K
S
I
D
D
-----------
I
-
L
I
K
K
N
D
------------
W
-----------
Y
E
K
N
N
I
K
V
I
T
S
E
F
A
T
S
I
-
D
P
N
N
-
K
--
L
V
T
--
L
--
K
S---
G
-
E
K
I
K
Y
E
K
--
L
I
I
A
S
G
--
S
I
---
A
N
K
I
K
V
P
H
A
D
E
---------
I
-
F
-----------
S
L
--
Y
--
S
----------------
Y
-
D
--
D
-
A
-------
L
-----
K
I
K
D
E
C
K
N
K
-----------
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
-----------------------
I
D
S
G
T
P
A
S
I
G
I
I
----
L
E
Y
P
L
E
---------
R
Q
L
D
R
D
------
G
G
L
F
L
K
D
--
K
L
---
D
R
L
G
I
K
I
Y
T
N
S
N
--
F
E
E
M
----------------------------------------
G
D
L
I
R
S
-
S
C
V
I
T
A
V
G
V
K
P
--
N
L
-
D
F
--
I
--
K
D
T
E
I
A
--
S
---
K
R
G
I
L
V
N
-
D
H
M
E
T
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
Y
G
-
K
------
N
P
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
E
D
------
65
HHSearch
72.83
21%
-84
- C1 -
3D1C
6
BVMO_STAAM
A:
[2-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
H
H
K
V
A
I
I
G
A
G
A
A
G
I
G
M
A
I
T
L
K
D
--
F
--
G
--
I
T
D
V
I
I
L
-
E
K
----
G
T
V
G
H
S
--
F
K
H
--
W
----
P
K
--
S
T
R
T
I
T
P
S
F
TSN
G
F
G
-
M
----
P
D
MNAISMDT
S
P
A
F
T
-----
F
N
-
E
E
H
I
S
G
E
T
-----------
Y
-
A
E
Y
L
Q
V
------------
V
-----------
A
N
H
Y
E
L
N
I
F
E
N
T
V
V
T
N
I
-
S
A
D
D
-
A
Y
Y
T
I
A
--
T
--
T
----
T
-
E
T
Y
H
A
D
Y
--
I
F
V
A
T
G
--
D
Y
N
-
F
P
K
K
P
F
K
Y
G
I
H
Y
---------------------------
S
--
E
----------------
I
-
E
--
D
-
F
-------
D
-----
N
-----
F
N
K
-----------
G
Q
Y
V
V
I
G
G
N
E
S
G
F
D
A
A
Y
Q
L
-----------------------
A
K
N
G
S
D
I
A
L
Y
T
S
-----------------------
P
S
VR----
L
S
P
Y
T
R
Q
--
R
L
G
N
V
I
K
Q
G
A
R
I
E
M
N
V
H
YT
V
K
D
I
D
F
-
N
NG-----
Q
----
Y
----
H
---
I
--
S
F
-----
D
--
S
G
Q
S
V
H
T
P
-
H
E
P
I
L
A
T
G
F
D
A
--
T
K
N
P
I
--
V
--
Q
Q
L
F
V
T
--
T
---
N
Q
D
I
K
L
T
T
H
D
E
S
T
R
Y
P
N
I
F
M
I
G
A
T
V
E
N
D
N
-
A
------
K
L
C
Y
I
Y
K
F
R
A
R
F
A
V
L
A
H
L
L
T
Q
R
E
G
L
P
A
--
67
HHSearch
72.04
16%
-96
- C1 -
2V3A
9
RURE_PSEAE
A:
[4-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
--
L
--
D
GE
T
-
P
L
L
M
I
-
T
A
----
D
D
G
--
R
--
S
Y
S
--
K
----
P
M
--
L
S
T
G
F
----------------
S
K
--------
N
K
---------------
D
A
D
G
-----------
L
A
M
A
E
P
G
A
------------
M
-----------
A
E
Q
L
N
A
R
I
L
T
H
T
R
V
T
G
I
-
D
P
G
H
-
Q
--
R
I
W
--
I
--
G
----
E
-
E
E
V
R
Y
R
D
--
L
V
L
A
W
G
--
A
E
---
P
I
R
V
P
V
E
G
D
A
Q
---------
D
-
A
-----------
L
Y
--
P
I
N
D
----------------
L
-
E
--
D
-
Y
-------
A
R
F
R
Q
A
A
-----
A
G
K
-----------
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
-----------------------
S
S
G
G
Y
Q
L
D
V
V
A
P
----
C
E
Q
V
M
P
---------
G
L
L
H
P
A
------
A
A
K
A
V
Q
A
--
G
L
---
E
G
L
G
V
R
F
H
L
G
P
V
--
L
A
S
L
K
K
-
A
-------
G
E
G
--
L
----
E
---
A
--
H
L
-----
S
--
D
-
G
E
V
I
P
C
-
D
L
V
V
S
A
V
G
L
R
P
--
R
T
-
E
L
--
A
--
F
A
A
G
L
A
V
N
----
R
G
-
I
V
V
D
-
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
D
G
-
L
------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
-------
70
HHSearch
72.01
20%
-97
- C1 -
3OC4
1
?
A:
[3-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
K
--
K
Y
P
Q
--
A
-
E
I
S
L
I
-
D
K
----
Q
A
T
V
G
Y
--
L
S
G
----------------------------------------------------------------------------
R
Y
I
T
E
E
------------
E
-----------
L
R
R
Q
K
I
Q
L
L
L
N
R
E
V
V
A
M
-
D
V
E
N
-
Q
L
I
A
W
T
R
K
E
--
E
----
Q
-
Q
W
Y
S
Y
D
K
--
L
I
L
A
T
G
--
A
---
S
Q
F
S
T
Q
I
R
G
S
Q
T
---------
E
-
K
-----------
L
L
--
K
Y
K
F
----------------
L
-
S
-----AV
P
----
L
-----
L
-----
E
N
S
-----------
Q
T
V
A
V
I
G
A
G
P
I
G
M
E
A
I
D
F
L
-----------------------
V
K
M
K
K
T
V
H
V
F
E
S
----
L
E
N
L
L
P
---------
K
Y
F
D
K
E
------
M
V
A
E
V
Q
K
--
S
L
---
E
K
Q
A
V
I
F
H
F
E
E
T
--
V
L
G
I
E
E
-
T
AN-----
G
----
I
----
V
---
L
--
E
T
---------
S
E
Q
E
I
S
C
-
D
S
G
I
F
A
L
N
L
H
P
--
Q
L
-
A
Y
--
L
--
D
K
-
K
I
Q
R
N
L
---
D
Q
T
I
A
V
D
-
A
Y
L
Q
T
S
V
P
N
V
F
A
I
G
D
C
I
S
V
M
N
-
E
PVA
E
T
F
Y
A
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
L
E
E
K
-------
84
HHSearch
71.65
21%
-85
- C1 -
1EBD
1
DLDH1_GEOSE
A:
[1-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
--
L
--
G
--
Q
-
K
V
T
I
V
-
E
K
----
G
N
L
G
G
V
--
C
L
N
--
V
----
G
C
I
P
S
K
A
L
I
S
A
S
H
---
R
Y
E
-
Q
----
A
K
H
SEE----
M
G
-
I
K
-----
A
E
-
N
V
T
I
D
F
A
K
-----------
V
-
Q
E
W
K
A
S
------------
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
-
E
A
Y
F
V
-
D
A
N
---
T
V
R
V
V
--
N
GD
S
----
A
-
Q
T
Y
T
F
K
N
--
A
I
I
A
T
G
--
S
R
---
P
I
E
L
--
P
N
F
K
F
---------
S
N
R
-----------
I
L
--
D
--
S
----------------
T
-
G
--
A
L
N
-------
L
-----
G
-----
E
V
P
-----------
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
-----------------------
A
N
F
G
T
K
V
T
I
L
E
G
----
A
G
E
I
L
S
---------
G
-
F
E
K
Q
------
M
A
A
I
I
K
K
--
R
L
---
K
K
K
G
V
E
V
V
T
N
A
L
--
A
K
G
A
E
E
-
R
ED-----
G
----
V
----
T
---
V
T
Y
E
A
-----
N
--
G
E
T
K
T
I
D
A
-
D
Y
V
L
V
T
V
G
R
R
P
--
N
T
-
D
E
--
L
GL
E
Q
I
G
I
K
M
T
N
---
R
G
L
I
E
V
D
-
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
P
A
-----------
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
------
72
HHSearch
71.35
17%
-112
- C1 -
1XHC
1
?
A:
[9-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
-----
T
--
Y
-
E
V
T
V
I
-
D
K
----
E
P
V
P
Y
Y
--
S
----
K
----
P
M
--
L
S
H
Y
I
----------------
A
G
--------
F
---------------
I
P
R
N
R
-----------
L
-
F
P
Y
S
L
D
------------
W
-----------
Y
R
K
R
G
I
E
I
R
L
A
E
E
A
K
L
I
-
D
R
G
R
---
K
V
V
I
--
T
--
E
----
K
-
G
E
V
P
Y
D
T
--
L
V
L
A
T
G
--
A
R
---
A
R
E
P
Q
I
K
G
K
E
Y
-----------------------
L
L
T
L
R
--
T
----------------
I
-
F
--
D
-
A
-------
D
R
I
K
E
S
I
-----
E
N
S
-----------
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
-----------------------
A
E
A
G
Y
H
V
K
L
I
H
R
----
G
A
M
F
L
----------
G
-
L
D
E
E
------
L
S
N
M
I
K
D
--
M
L
---
E
E
T
G
V
K
F
F
L
N
S
E
--
L
L
E
A
N
E
-
E
-------
G
----
V
----
L
---
T
---
N
----------
S
G
F
I
E
G
-
K
V
K
I
C
A
I
G
I
V
P
--
N
V
-
D
L
--
A
--
R
R
S
G
I
H
T
G
----
R
G
-
I
L
I
D
-
D
N
F
R
T
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
-
I
------
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
E
-------
83
HHSearch
71.31
20%
-89
- C1 -
3F8D
3
?
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
--
Y
--
M
--
L
-
K
T
L
V
I
-
G
E
----
T
P
-
G
G
---
Q
L
T
--
E
-----
A
--
G
I
V
D
----------
D
-
Y
----
L
G
--------
L
I
-------------
E
I
Q
A
S
D
-----------
M
-
I
K
V
F
N
K
------------
H
-----------
I
E
K
Y
E
V
P
V
L
L
-
D
I
V
E
K
I
-
E
N
R
---
E
F
V
V
K
--
T
--
K
R---
K
-
G
E
F
K
A
D
S
--
V
I
L
G
I
G
--
V
K
---
R
R
K
L
G
V
P
G
E
Q
E
F--------
A
G
R
-----------
G
I
--
S
YC
S
----------------
V
-
A
--
D
-
A
-------
P
-----
L
-----
F
K
N
-----------
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
-----------------------
S
S
Y
S
T
K
V
Y
L
I
H
R
----
R
D
T
F
K
A
---------
Q
------------
P
I
Y
V
E
T
--
V
K
---
K
K
P
N
V
E
F
V
L
N
S
V
--
V
K
E
I
K
G
-
D
-------
K
----
V
VK
Q
V
V
---
V
--
E
N
LK---
T
--
G
E
I
K
E
L
N
V
-
N
G
V
F
I
E
I
G
F
D
P
--
P
T
-
D
F
--
A
--
K
S
N
G
I
E
T
D
T
---
N
G
Y
I
K
V
D
-
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
------
R
--
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
14
PsiBlast_PDB
71.27
24%
-99
- C1 -
3LZW
3
FENR2_BACSU
A:
[12-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
--
R
--
Q
--
A
-
S
V
K
I
I
-
E
S
LPQL
G
G
Q
L
S
A
--
L
----
Y
----
P
E
--
K
Y
I
Y
----------
D
-
V
----
A
G
--------
F
P
-------------
K
I
R
A
Q
E
-----------
L
-
I
N
N
L
K
E
------------
Q
-----------
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
Q
A
D
-
G
V
F
K
L
V
--
T
--
N
----
E
-
E
T
H
Y
S
K
T
--
V
I
I
T
A
G
--
N
G
A
F
K
P
R
K
L
E
L
E
N
A
E
Q
YE-------
G
-
K
-----------
N
L
--
H
--
Y
----------------
F
V
D
--
D
-
L
-------
Q
-----
K
-----
F
A
G
-----------
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
-----------------------
E
P
I
A
K
E
V
S
I
I
H
R
----
R
D
K
F
R
A
H
E
H
S
V
E
N
L
H
A
-
S
K
V
N
------
V
L
T
P
F
V
P
A
E
L
I
---
G
E
D
K
I
--------------
E
-
Q
-------
L
----
V
----
L
---
E
--
E
V
-----
K
--
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
--
S
L
-
G
P
--
I
--
K
N
W
G
L
D
I
E
K
N
S
-----
I
V
V
K
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
-----------------------------------------
15
PsiBlast_PDB
71.25
24%
-103
- C1 -
3LZX
3
FENR2_BACSU
A:
[12-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
--
R
--
Q
--
A
-
S
V
K
I
I
-
E
S
LPQL
G
G
Q
L
S
A
--
L
----
Y
----
P
E
--
K
Y
I
Y
----------
D
-
V
----
A
G
--------
F
P
-------------
K
I
R
A
Q
E
-----------
L
-
I
N
N
L
K
E
------------
Q
-----------
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
Q
A
D
-
G
V
F
K
L
V
--
T
--
N
----
E
-
E
T
H
Y
S
K
T
--
V
I
I
T
A
G
--
N
G
A
F
K
P
R
K
L
E
L
E
N
A
E
Q
YE-------
G
-
K
-----------
N
L
--
H
--
Y
----------------
F
V
D
--
D
-
L
-------
Q
-----
K
-----
F
A
G
-----------
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
-----------------------
E
P
I
A
K
E
V
S
I
I
H
R
----
R
D
K
F
R
A
H
E
H
S
V
E
N
L
H
A
-
S
K
V
N
------
V
L
T
P
F
V
P
A
E
L
I
---
G
E
D
K
I
--------------
E
-
Q
-------
L
----
V
----
L
---
E
--
E
V
-----
K
--
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
--
S
L
-
G
P
--
I
--
K
N
W
G
L
D
I
E
K
N
S
-----
I
V
V
K
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
-----------------------------------------
85
HHSearch
71.22
16%
-98
- C1 -
3ICS
2
?
A:
[35-354]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
--
L
--
S
EE
D
-
E
I
I
M
V
-
E
R
----
G
E
Y
I
S
F
--
A
N
--------
C
G
--
L
P
Y
Y
I
----------------
G
G
--------
V
-------------
I
T
E
R
Q
K
L
-----------
L
-
V
Q
T
V
E
R
------------
M
-----------
S
K
R
F
N
L
D
I
R
V
L
S
E
V
V
K
I
-
N
K
E
E
-
K
T
I
T
I
K
--
N
--
V
TTN
E
T
-
Y
N
E
A
Y
D
V
--
L
I
L
S
P
G
--
A
---
K
P
I
V
P
S
I
P
G
I
E
E
A--------
K
-
A
-----------
L
F
--
T
L
R
N
----------------
V
-
P
--
D
-
T
D
R
I
K
A
Y
I
D
-----
E
-----
K
K
P
-----------
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
-----------------------
R
E
R
G
I
E
V
T
L
V
E
M
----
A
N
Q
V
M
P
---------
P
-
I
D
Y
E
------
M
A
A
Y
V
H
E
--
H
M
---
K
N
H
D
V
E
L
V
F
E
D
G
--
V
D
A
L
E
E
-
N
-------
G
----
A
----
V
---
V
--
R
L
-----
K
--
S
-
G
S
V
I
Q
T
-
D
M
L
I
L
A
I
G
V
Q
P
--
E
S
-
S
L
--
A
--
K
G
A
G
L
A
L
G
V
---
R
G
T
I
K
V
N
-
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
-
F
VTE
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
------