@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1320: (2016-03-24 )
MNKINDRDLTELSSYWVYQDINKDNDFTVNGKRFKQVDEYNDNGNKNKKGASDLKIYELLDEKGKPTGEQTMIYQGTSNEAINPNNPLKSLDIGDDWLQNAKLMDNSNKSTDYLKQSDEFADLYRDKLNDANKLSKYNFTQKYGVSPNNYKNKTIVADGGNSEGGAGAKYQGAKHPNEKVVATDPAMVPYAAWQKFARPRFDNMISFNSTNDLLTWLQDPFIKDMPGKRVNISDGVPRLDALIDSHVGYKRKLNRKDNTYDTVPLIKIKSVKDTEIKNGKKVKKTINITLDMDGRIPINVWTGDSIARSGRGTLIKLNLENLDALSKLITGETSGMLAECVIFLNESFNISENENKNFADRKQQLSEGFKDKINLFQLEEMERTLISKINSLEEVADETIESISAVKHLLPDFALDALKERINELFKGIKSFIEKVYDSIDNEILEIFKNIDHDFRDGVSEEMMKHLKVVKQNIERIKNQNDIYGRQIAEIRSIMKQQDATILDGNFQINCSGENMVQGLVIPSNYLGRKMKILKDHIDDGIKKIADYVQSIYDEYASKIVDVIKYLINTIPKIRKNLRHAIEMLNVKKKEFLSLIPNVTCNYIKTKLEELDNTLGKWEPFLNDLKAVSPILDNHLDDIVKNMKPLIVQMLFEPSHYDDMFILNTQAHARLDQMAQQFEVVCNGLNENEGQAIQTMDQSASLIRSNLIQVKEQLEKLAVY
Atome Classification :
(20 SA)
------------.........10........20..----....--------..30........40........50........60........70........80.....----...90........100.......--110-.--....-----....120.......130....-----------------...140-.......150-........160.......170...--------------.------...180....---------...190-----------.....-..--------------200.......210......----.-220..----.......230.......240.......250.......260.......270---..---......280---......----.290.......300..-.....-310.......320.......330....-------------------...340--........---350.......360.......370.....-----..380.......390---------........400.....-..------410..-.------------------....420--......-..430..---..----------...440------------........450..--...--..-460.......470....-...480........490-----......--------...500.......510.....-..520.......--530...-----....540....-...550....----.-----..560..--.....570........580-.....--....590------....-----..-----------.600.......610....---...620.......630.......640.......650......----.660-------.......670.......680-----.......690.......700.......710.......720------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MNKIN
D
R
D
L
T
E
L
S
S
Y
W
V
Y
QDINK----DN
D
F
--------
T
VN
G
K
R
F
K
QVDEYNDNGNKNKKGAS
D
L
K
I
Y
E
L
L
DEKGKPTGE
Q
T
M
I
Y
QGTSNEAINPNN----PLKSLDI
G
D
D
W
L
Q
NAKLMDNSNK--S---
T
--
D
Y
L
K-----Q
S
D
E
F
A
D
L
Y
R
D
KLNDANKLSK-----------------YNF
T
Q
K-YGVSPNNYK--N
K
T
I
V
A
DGGNSEGGAGAKYQGAKH--------------P------NE
K
V
VATDPA---------MV
P
Y
A
A
-----------
W
Q
K
FA-RP--------------RFD
N
M
I
SFNST
N
D
L
L
T
W
L
Q----D-P--
F
I
----KDMPG
K
R
VNISDGV
P
R
L
D
A
L
I
D
SHVG
Y
K
R
KLNRKDNTYDT
V
P
L
I
K
I
KSV----KD---TEIKNG
K
K
V
---
K
K
T
I
N
I
----
T
L
DMDG
R
I
P
I
N
V
WTGD-
S
I
ARS-GRG
T
L
I
K
L
NLE
N
L
D
A
L
S
K
L
ITGETS
G
M
-------------------
L
A
E
C
V
---
I
F
LNESFN---ISENENK
N
F
A
D
R
K
Q
Q
L
S
E
G
F
K
DK
I
N
L
F
Q
-----
L
E
E
M
E
R
T
L
I
S
K
I
N
S
----------
L
E
E
V
A
D
E
T
I
E
S
I
S
A
V
K
-
H
L
------
L
P
D
F
A
-
L
------------------
D
A
L
K
E
R
---
I
N
E
L
F
K
-
G
I
K
S
F
I
E
---
K
V
----------
Y
D
SI
D
-------------
N
E
I
L
E
I
F
K
NI
D
H
D
--
F
R
D
--
G
V
-
S
E
E
M
M
K
H
L
K
V
V
K
Q
N
I
E
R
-IKNQ-NDI
Y
G
R
Q
I
A
E
-------
I
R
S
I
M
K
--------QQD
A
T
I
LDG
N
F
Q
I
N
CSGEN
M
V
-
Q
G
L
V
IP
S
N
YL
G
R
--
K
M
K
I
L
K
-----
D
H
I
D
D
G
I
K
K
I
A
-
D
Y
V
Q
S
I
Y
D
E
Y
----
A
-----
S
K
I
V
D
V
I
--
K
Y
L
I
N
T
I
-
P
K
I
R
K
N
L
R
H
---
A
I
E
M
L--NV
K
K
K
E
F
------
L
S
LI-----PN-----------V
T
C
N
Y
I
K
T
K
L
E
E
L
D
N
T
LG---
K
W
E
P
F
L
N
D
L
K
A
V
S
P
I
L
D
N
H
L
D
D
I
V
K
N
M
K
P
L
I
V
Q
M
LFEPSHYD----
D
M
F
I
-------
L
N
T
Q
A
H
A
R
L
D
Q
M
A
Q
Q
F
E
V
V
C-----NGLNENEG
Q
A
I
Q
T
M
D
Q
S
A
S
L
I
R
S
N
L
I
Q
V
K
E
Q
L
E
K
LAVY--------
44
Fugue
75.75
14%
6
* C4 *
3AHC
15
?
A:
[25-826]
---VIGTPWQKL
D
R
P
V
S
E
E
A
I
E
G
M
D
K
Y
W
R
V
T
N
Y
M
S
----
I
G
Q
I
--------
Y
L
R
----------
S
N
P
L
M
K
E
P
F
T
R
D
D
V
K
-
H
R
L
V
G
H
W
G
--
T
T
P
G
L
N
F
L
L
A
H
I
N
R
L
I
A
D
H
Q
QN
T
V
F
I
M
G
P
G
H
G
G
P
A
G
T
S
Q
S
Y
V
D
G
T
Y
T
--
E
---
Y
Y
P
N
I
T
K
-----
D
E
A
G
L
Q
K
F
F
R
Q
-
F
S
Y
P
G
G
I
P
S
HFAPETPGSIHEGGELG
Y
A
L
S
H
A
-
Y
G
A
V
M
N
N
P
S
L
F
V
P
C
I
I
G
D
G
E
A
E
T
G
P
L
A
T
G
W
Q
S
N
K
L
--------------
V
------
N
---
P
R
T
D
G
I
---------
V
L
P
I
L
H
-----------
L
N
G
Y
--
K
I
--------------
A
N
P
T
I
L
A
R
I
S
D
E
E
L
H
D
F
F
R
G
M
GY
H
-
P
--
Y
E
F
V
A
G
F
D
N
E
D
H
M
S
I
H
R
R
F
A
E
L
F
E
T
I
F
D
E
I
C
D
I
K
A
A
A
Q
T
D
D
M
T
R
P
F
Y
P
M
L
I
F
R
T
P
----
K
G
WTC
P
K
F
I
D
G
K
K
T
EGS
W
R
A
H
Q
V
----
P
L
A
S
A
R
D
T
E
E
H
F
E
V
L
K
-
G
W
M
E
S
Y
K
P
E
E
L
F
N
A
D
G
S
I
K
D
D
V
T
A
F
M
P
K
G
E
L
R
I
GANPNANGGVIREDLKLPE
L
D
Q
Y
E
---
V
T
G
V
K
E
Y
G
HGW
G
Q
V
E
A
P
R
A
L
G
A
Y
C
R
D
I
I
K
N
N
P
D
S
F
R
I
F
G
-----
P
D
E
T
A
S
N
R
L
N
A
T
Y
E
VTDKQWDNGY
L
S
G
L
V
D
E
H
M
A
V
T
G
Q
V
T
-
E
Q
------
L
S
E
H
Q
-
C
------------------
E
G
F
L
E
A
---
Y
L
L
T
G
R
H
G
I
W
S
S
Y
E
SFV
H
V
----------
I
D
S
M
L
-------------
N
Q
H
A
K
W
L
E
A
T
V
R
E
IP
W
R
K
--
P
I
S
S
V
N
L
L
V
S
S
H
V
W
R
Q
D
H
N
G
-
F
S
H
Q
-
D
P
G
V
T
S
L
L
I
N
K
TFNNDH
V
T
N
I
Y
F
--------
A
T
D
A
N
M
L
L
A
I
S
E
K
C
F
K
S
T
N
K
I
-
N
A
I
F
A
G
K
Q
P
A
P
T
W
V
T
L
D
E
A
R
-----
A
E
L
E
A
G
A
A
E
W
--
K
W
A
S
N
A
E
N
N
D
----
E
-----
V
Q
V
V
L
A
S
A
G
D
V
P
T
Q
E
L
-
M
A
A
S
D
A
L
N
K
M
G
I
K
F
K
V
V
--
N
V
V
--
D
L
------
L
K
L
Q
-----
S
R
-----------
E
N
N
D
E
A
L
T
-
D
E
E
F
T
E
L
F
T
---
A
D
K
P
V
L
F
A
Y
H
S
Y
A
Q
D
V
R
G
L
I
Y
D
-
R
P
N
H
D
N
F
H
V
V
G
Y
K
E
Q
G
S
T
T
T
P
F
-
D
M
V
R
-------
V
N
-----
D
M
D
R
Y
A
L
Q
A
A
A
L
K
-----
L
I
D
A
D
K
Y
A
D
K
I
D
E
L
N
A
F
R
K
K
A
F
Q
F
A
V
D
N
G
Y
D
I
P
E
F
T
D
W
VYPDV---
47
Fugue
59.33
10%
-28
- C1 -
3RIP
9
GCP4_HUMAN
A:
[1-654]
-------------------
M
I
H
E
L
--
L
L
A
L
S
G
Y
P
G
----
S
I
F
T
--------
W
N
K
R
S
G
L
Q
V
S
Q
D
F
P
F
L
H
P
S
E
T
S
V
L
N
R
L
C
R
L
G
T
D
Y
I
R
F
T
E
F
I
E
Q
------------
Y
T
G
H
----
G
G
L
H
G
I
Y
L
R
A
F
C
T
G
L
D
S
V
----------------
L
Q
-----
P
Y
R
Q
A
L
L
D
L
E
Q
E
F
L
G
D
P
H
L
S
I
-----------------
S
H
V
N
Y
F
-
L
D
Q
F
Q
L
L
F
P
--
S
V
M
V
V
V
E
Q
I
K
S
Q
K
I
H
G
C
Q
I
L
E
T
V
Y
--------------
K
------
H
S
C
G
G
L
P
P
V
R
---------
S
A
L
E
K
I
-----------
L
A
V
C
H
-
G
V
--------------
M
Y
K
Q
L
S
A
W
M
L
H
G
L
L
L
D
Q
H
E
----
E
-
F
--
F
I
----
K
Q
G
S
L
K
Q
F
S
L
R
------------------------------------------------------------------------------------------------------------
V
E
I
L
P
S
Y
I
P
V
R
-------------------
V
A
E
K
I
---
L
F
V
G
E
S
V
Q
---
M
F
E
N
N
V
N
L
--------
T
S
I
L
K
N
Q
E
D
T
F
A
-----
A
E
L
H
R
L
K
Q
Q
P
L
F
S
---------------
L
V
D
F
E
Q
V
V
D
R
I
R
-
S
T
------
V
A
E
H
L
-
W
------------------
K
L
M
V
E
E
----
S
D
L
L
G
-
Q
L
K
I
I
K
D
---
F
Y
----------
L
L
G
R
G
-------------
E
L
F
Q
A
F
I
D
T
A
Q
H
M
--
L
K
T
--
P
P
-
T
A
V
T
E
H
D
V
N
V
A
F
Q
Q
S
A
H
-
K
V
L
L
-
D
--
D
D
N
L
L
P
L
-------
L
H
L
T
I
E
--------
Y
H
G
A
S
G
W
A
-
A
L
G
L
S
Y
K
V
Q
W
P
L
-
H
I
-
L
F
T
P
A
V
L
E
K
--
Y
N
V
V
F
K
Y
L
L
S
V
R
R
V
Q
A
E
L
Q
H
C
W
-
A
L
Q
M
Q
R
K
H
L
K
----
S
-----
N
Q
T
D
A
I
K
--
W
R
L
R
N
H
M
-
A
F
L
V
D
N
L
Q
Y
---
Y
L
-
Q
V
--
D
V
L
E
S
Q
F
------
S
Q
L
L
-----
H
Q
-----------
I
N
------
S
T
R
D
F
E
S
I
R
L
---
A
H
D
H
F
L
S
N
L
L
A
Q
S
F
I
L
L
K
P
V
F
H
C
L
N
E
I
L
D
L
C
H
S
F
C
S
L
V
S
Q
N
L
----
L
-----------
D
E
R
G
A
A
Q
L
S
I
L
V
K
G
F
S
R
Q
S
-----
S
L
L
F
K
I
L
S
S
V
R
N
H
Q
I
N
------
S
D
L
A
Q
L
L
L
R
L
D
Y
N
K
Y
Y
--------
2
PsiBlast_PDB
59.06
26%
-39
- C3 -
4GCT
1
SLMA_VIBCH
A:
[50-142]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
S
K
T
R
M
F
E
G
L
---
I
E
F
I
E
E
S
L
M
S
R
I
N
R
----------
I
F
D
E
E
K
D
T
L
N
R
I
R
L
V
M
-
Q
L
------
L
L
A
F
A
-
E
R
N
P
G
L
T
R
I
L
S
GHALMFEN
E
R
L
R
D
R
---
I
N
Q
L
F
E
-
R
I
E
T
S
L
R
---
Q
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
56.00
26%
-21
- C3 -
4GFK
-
SLMA_VIBCH
A:
[50-137]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
S
K
T
R
M
F
E
G
L
---
I
E
F
I
E
E
S
L
M
S
R
I
N
R
----------
I
F
D
E
E
K
D
T
L
N
R
I
R
L
V
M
-
Q
L
------
L
L
A
F
A
-
E
R
N
P
G
L
T
R
I
L
S
GHALMFEN
E
R
L
R
D
R
---
I
N
Q
L
F
E
-
R
I
E
T
S
L
R
---
Q
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
55.09
12%
-2
- C2 -
1B7T
2
MYS_ARGIR
A:
[5-835]
FSDPDFQYLAVD-------
A
F
D
G
K
K
N
C
W
V
P
-
D
E
K
E
------
G
F
--------
A
S
A
E
I
Q
S
S
K
G
D
E
I
T
V
K
I
V
A
D
S
S
T
R
T
V
K
K
D
D
I
Q
S
M
N
P
P
K
F
E
K
L
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
----
L
R
S
R
Y
T
S
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
--
Y
---
R
--
R
L
P
I
-----
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
-----------------
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
--
N
Q
S
C
L
I
T
G
---
E
S
G
A
G
-
K
T
E
N
T
K
K
V
I
M
Y
L
A
K
V
ACAEGS
L
------
E
D
Q
I
I
Q
A
N
P
V
---------
L
E
A
Y
G
N
A
K
T
TRNNNSSR
F
G
K
F
I
-
R
I
--------------
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
----
K
-
S
--
R
V
----
T
Y
Q
Q
S
A
E
R
N
Y
-
H
I
F
Y
Q
I
C
S
N
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
N
Q
G
-
C
L
T
V
DNID
D
V
---
E
E
F
K
L
C
D
E
A
---
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
------
Q
A
E
S
D
G
T
A
E
A
E
K
V
A
F
L
C
G
I
N
A
G
D
L
-------------------
L
K
A
L
L
KPK-------
V
---
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
-----
V
R
R
V
N
K
T
L
D
T
K
A
K
R
----------
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
------
F
E
Q
L
C
-
I
------------------
N
Y
T
N
E
R
---
L
Q
Q
F
F
N
-
H
H
M
F
I
L
E
---
Q
E
E
Y
K
KEG
I
A
W
E
F
I
D
F
G
-------------
M
D
L
Q
M
C
I
D
L
I
E
K
----
P
M
--
G
I
-
L
S
I
L
E
E
E
C
M
F
P
K
A
D
D
K
S
-
F
Q
D
K
L
Y
Q
N
H
M
G
K
N
R
M
-------
F
T
K
P
G
K
--------
P
T
R
P
N
Q
G
P
A
H
F
E
L
H
H
Y
A
G
N
V
P
-
Y
S
I
---
T
G
W
L
E
K
--
N
K
D
P
I
N
-----
E
N
V
V
A
L
L
G
A
S
K
E
P
L
V
A
E
L
F
K
A
------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
---
L
M
K
N
L
--
Y
S
T
H
P
H
F
------
V
R
C
I
I
----
P
N
ELKQPGLVD
A
E
L
V
L
H
Q
L
Q
------
C
N
G
R
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
S
I
L
A
P
N
A
I
P
D
G
K
T
V
S
E
K
I
L
A
G
L
Q
M
D
P
A
E
Y
R
LGTT
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
S
K
I
I
S
M
F
Q
A
H
I
-----
R
G
Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
I
G
L
S
V
I
Q
R
N
I
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
KP
15
PsiBlast_PDB
53.94
21%
-29
- C2 -
3G67
-
?
A:
[42-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------------
E
E
V
K
E
R
F
V
N
L
N
R
L
F
Q
-
E
L
V
G
D
F
Q
---
A
K
----------
S
D
Q
L
V
-------------
S
V
I
Q
D
M
E
K
-------
I
S
E
--
N
I
-
M
E
E
L
K
K
S
G
T
N
V
D
Q
I
V
E
R
-
V
K
E
A
-
S
S
Q
I
G
E
T
L
E
N
-------
I
R
S
I
E
K
L
I
Q
N
I
M
R
I
A
R
E
T
N
I
L
A
L
N
A
T
I
E
A
A
R
A
G
E
A
G
K
G
F
M
I
V
A
N
------
E
V
Q
N
L
S
-----
N
E
T
N
E
V
T
K
Q
I
V
-
E
K
A
R
E
I
L
-
E
S
----
S
-----
Q
R
S
L
E
N
L
--
E
F
M
A
N
L
F
-
E
T
V
G
K
T
L
Q
N
---
M
V
R
F
M
E
N
N
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.47
20%
-24
- C2 -
3G6B
-
?
A:
[42-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------------
E
E
V
K
E
R
F
V
N
L
N
R
L
F
Q
-
E
L
V
G
D
F
Q
---
A
K
----------
S
D
Q
L
V
-------------
S
V
I
Q
D
M
E
K
-------
I
S
E
--
N
I
-
M
E
E
L
K
K
S
G
T
N
V
D
Q
I
V
E
R
-
V
K
E
A
-
S
S
Q
I
G
E
T
L
E
N
-------
I
R
S
I
E
K
L
I
Q
N
I
M
R
I
A
R
E
T
N
I
L
A
L
N
A
T
I
E
A
A
R
A
G
E
A
G
K
G
F
M
I
V
A
N
------
E
V
Q
N
L
S
-----
N
E
T
N
E
V
T
K
Q
I
V
-
E
K
A
R
E
I
L
-
E
S
----
S
-----
Q
R
S
L
E
N
L
--
E
F
M
A
N
L
F
-
E
T
V
G
K
T
L
Q
N
---
M
V
R
F
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
52.21
13%
-45
- C4 -
3TXN
4
PSD11_DROME
A:
[10-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
E
E
R
I
R
I
K
E
Q
G
I
L
Q
Q
G
E
L
Y
K
Q
E
G
K
-----
A
K
E
L
A
D
L
I
K
V
T
R
P
F
----------
L
S
S
I
S
K
A
K
A
A
K
L
--
V
R
-
S
L
------
V
D
M
F
L
D
M
------------------
D
A
G
T
G
I
---
E
V
Q
L
C
K
-
D
C
I
E
W
A
K
---
Q
E
----------
K
R
T
F
L
-------------
R
Q
S
L
E
A
-
R
L
I
A
L
Y
--
F
D
T
--
A
L
-
Y
T
E
A
L
A
L
G
A
Q
L
L
R
E
L
K
K
-
L
D
D
K
-
N
L
L
V
E
V
Q
L
L
E
-------
S
K
T
Y
H
A
--------
L
S
N
L
P
K
A
R
A
A
L
T
S
A
R
T
T
A
N
A
I
-
Y
C
P
P
K
V
Q
G
A
L
D
L
--
Q
S
G
I
L
H
-----
A
A
D
E
R
D
F
K
T
A
F
-
S
Y
F
Y
E
A
F
E
G
F
DSVD
S
-----
V
K
A
L
T
S
L
--
K
Y
M
L
--
L
-
C
K
I
M
L
G
Q
S
D
---
D
V
N
Q
L
--
V
S
G
K
L
A
I
T
Y
SG
R
D
I
D
A
M
-----
K
S
-----------
V
A
E
A
S
H
K
R
S
L
A
D
F
Q
A
A
L
K
---
E
Y
K
K
E
L
A
E
----
D
V
I
V
Q
A
H
L
G
T
L
Y
D
T
M
L
E
Q
N
L
C
R
I
I
E
P
Y
S
R
V
----
Q
V
A
H
-------
V
A
E
S
I
Q
L
P
M
P
Q
V
E
K
K
L
S
Q
M
I
L
D
KKF
S
G
I
L
D
Q
G
E
G
V
L
I
V
F
E
E
------------------------------
26
HHSearch
51.53
16%
37
- C3 -
1TIB
-
LIP_THELA
A:
[12-225]
-------------------
L
F
A
Q
Y
S
A
-
A
A
Y
C
G
K
N
N
D
APA
G
T
N
I
T
C
T
GNAC
P
E
V
E
K
A
D
A
T
F
L
Y
S
F
E
D
S
---
G
V
G
D
V
T
G
F
-
L
A
L
-----
D
N
T
N
K
L
I
V
L
S
F
R
G
S
R
S
I
------------------
E
N
W
I
G
N
L
N
F
D
L
K
E
I
-------
N
--
D
I
C
S
-----
G
-
C
R
G
H
D
G
F
T
S
S
---
W
R
S
V
-
A
-----------------
D
T
L
R
Q
K
-
V
E
D
A
V
R
E
H
P
--
D
Y
R
-
V
V
F
T
G
H
S
L
G
G
A
L
A
T
V
A
G
A
D
L
RGNG----------
Y
------
D
I
D
V
F
S
Y
G
A
P
---------
R
V
G
N
R
A
-----------
F
A
E
F
L
T
V
Q
--------------
T
G
G
T
L
Y
R
I
T
H
T
N
D
I
V
P
R
L
P
----
P
R
E
--
F
G
----
Y
S
H
S
S
P
E
Y
W
I
K
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
50.10
10%
-35
- C2 -
4U0R
-
?
A:
[160-504]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
D
I
L
Q
-----
E
K
E
G
H
L
D
F
V
I
I
P
H
Y
----------
T
F
L
D
Y
Y
K
H
L
S
Y
N
S
I
Y
H
-
K
S
------
S
T
Y
G
K
-
Y
------------------
I
A
V
D
A
F
---
I
K
K
I
N
E
-
A
Y
D
K
V
K
S
---
K
C
----------------------------
N
D
I
K
N
D
L
I
A
T
I
K
K
--
L
E
H
--
P
Y
-
F
K
K
M
M
D
E
Y
N
T
K
K
K
K
L
I
K
C
I
K
N
H
-
E
N
D
F
N
K
I
C
M
D
-------
M
K
N
Y
G
T
--------
N
L
F
E
Q
L
S
C
Y
N
N
N
F
C
N
T
N
G
I
R
Y
-
H
Y
D
E
Y
I
H
K
L
I
L
S
--
V
K
S
K
N
L
-----
N
K
D
L
S
D
M
T
N
I
L
-
Q
Q
S
E
L
L
L
T
N
L
----
N
K
K
M
GS
Y
I
Y
I
D
T
I
--
K
F
I
H
K
E
M
-
K
H
I
F
N
R
I
E
Y
---
H
T
K
I
I
--
N
D
K
T
K
I
I
------
Q
D
K
I
K
L
N
IW
R
T
-----------
F
Q
K
D
E
L
L
K
R
I
L
D
M
S
N
E
Y
S
---
L
F
I
T
S
D
H
L
R
Q
M
L
Y
N
T
F
Y
S
K
E
K
H
L
N
N
I
F
H
H
L
I
Y
V
L
Q
M
K
-------------------------------------------------------------------------------------------
21
HHSearch
48.27
16%
42
- C3 -
3NGM
-
?
A:
[14-244]
-------------------
F
Y
I
Q
H
G
A
-
A
A
Y
C
N
S
E
A
PA--
G
A
K
V
TCSGNGC
P
T
V
Q
S
N
G
A
T
I
V
A
S
F
T
G
----
S
K
T
G
I
G
G
Y
-
V
A
T
-----
D
P
T
R
K
E
I
V
V
S
F
R
G
S
I
N
------------------
I
R
N
W
L
T
N
L
D
F
D
Q
D
D
C
S
LT
S
---
G
--
C
G
V
-----------
H
S
G
F
Q
N
A
W
---
N
E
I
-
S
-----------------
A
A
A
T
A
A
-
V
A
K
A
R
K
A
N
P
--
S
F
K
-
V
V
S
V
G
H
S
L
G
G
A
V
A
T
L
A
G
A
N
L
R
I
G
G----------
T
------
P
L
D
I
Y
T
Y
G
S
P
---------
R
V
G
N
T
Q
-----------
L
A
A
F
V
-
S
N
--------------
Q
A
G
G
E
F
R
V
T
N
A
K
D
P
V
P
R
L
P
----
P
-
L
I-
F
G
----
Y
R
H
T
S
P
E
Y
W
L
S
G
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
47.80
14%
61
- C3 -
3O0D
7
?
A:
[51-253]
-------------------------------------------------------
P
N
V
E
L
I
E
E
F
H
D
P
--
R
L
I
F
D
V
S
G
Y
-
L
A
V
-----
D
H
A
S
K
Q
I
Y
L
V
I
R
G
T
H
S
L
------------------
E
D
V
I
T
D
I
R
I
M
Q
A
P
L
T
--
N
FDL
A
--
A
N
I
S
STATC
D
D
C
L
V
H
N
G
F
I
Q
S
Y
---
N
N
T
-
Y
-----------------
N
Q
I
G
P
K
-
L
D
S
V
I
E
Q
Y
P
--
D
Y
Q
-
I
A
V
T
G
H
S
L
G
G
A
A
A
L
L
F
G
I
N
L
K
V
N
G----------
H
------
D
P
L
V
V
T
L
G
Q
P
---------
I
V
G
N
A
G
-----------
F
A
N
W
V
-
D
K
L
FFGQENPDVSKVS
K
D
R
K
L
Y
R
I
T
H
R
G
D
I
V
P
Q
V
P
----
F
-
W
--
D
G
----
Y
Q
H
C
S
G
E
V
F
I
D
W
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.95
18%
30
- C2 -
2CH7
2
MCP2_THEMA
A:
[161-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
---
V
V
A
D
E
I
R
K
L
A
E
E
S
Q
Q
A
S
E
N
V
R
R
V
V
N
E
I
R
S
I
A
E
D
A
G
K
V
S
S
E
I
T
A
R
V
E
E
----------
G
T
K
L
A
D
E
A
D
E
K
L
N
S
I
V
-
G
A
------
V
----------------------------
E
R
---
I
N
E
M
L
Q
-
N
I
A
A
A
I
E
---
E
Q
----------
T
A
A
V
D
E
I
T
T
A
M
T
E
N
A
K
N
A
E
E
I
T
N
S
V
K
E
V
N
A
R
--
L
Q
E
I
S
A
S
-
T
E
E
V
T
S
R
V
Q
T
I
R
E
N
V
Q
M
-
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
46.76
12%
-5
- C2 -
2LSE
-
?
A:
[1-101]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
Q
------------------
E
E
R
K
K
L
---
L
E
K
L
E
K
-
I
L
D
E
V
T
D
---
G
A
----------
P
D
E
A
R
-------------
E
R
I
E
K
L
A
K
D
V
K
D
E
--
L
E
E
--
G
D
-
A
K
N
M
I
E
K
F
R
D
E
M
E
Q
M
Y
K
-
D
A
P
--
N
A
V
M
E
Q
L
L
E
E
-------
I
E
K
L
L
K
--------
K
A
G
S
L
V
P
R
G
S
Y
L
E
H
H
H
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
45.73
13%
49
- C3 -
3G7N
6
?
A:
[13-213]
-------------------
R
A
A
K
L
S
S
-
A
A
Y
T
G
C
I
-----
G
K
A
-------------
F
D
V
T
I
V
K
R
I
Y
D
----
L
V
T
D
T
N
G
F
-
V
G
Y
-----
S
T
E
K
K
T
I
A
V
I
M
R
G
S
T
T
------------------
I
T
----
D
I
D
I
A
L
I
T
P
E
--
L
S
--
G
--
V
T
F
P
-----
S
D
V
K
I
M
R
G
V
H
R
P
W
---
S
A
V
-
H
-----------------
D
T
I
I
T
E
-
V
K
A
L
I
A
K
Y
P
--
D
Y
T
-
L
E
A
V
G
H
S
L
G
G
A
L
T
S
I
A
H
V
A
L
--------------
A
Q
N
F
PD
K
S
L
V
S
N
A
L
N
A
F
---------
P
I
G
N
Q
A
-----------
W
A
D
F
G
-
T
A
--------------
Q
A
G
T
F
N
R
G
N
N
V
L
D
G
V
P
N
M
Y
----
S
-
S
PL
V
N
----
F
K
H
Y
G
T
E
Y
Y
S
S
G
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.20
25%
10
- C3 -
4I0B
3
CRP_ECOLI
A:
[129-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
-
L
A
F
L
--
D
V
T
G
R
I
A
Q
T
-------
L
L
N
L
A
K
--------
Q
P
D
A
M
T
L
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
-
Q
I
V
G
C
S
R
E
T
V
G
R
--
I
L
K
M
L
E
-----
D
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
44.99
13%
28
- C2 -
1M5I
-
APC_HUMAN
A:
[130-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
G
Y
-----
L
E
E
L
E
K
E
R
S
L
L
L
A
D
----------
L
D
K
E
E
K
E
K
D
W
Y
Y
A
Q
L
Q
-
N
L
T
K
R
I
D
S
L
P
S
L
Q
-
T
------------------
D
M
T
R
R
Q
---
L
E
Y
E
A
R
-
Q
I
R
V
A
M
E
---
E
Q
----------
L
G
T
---------------
C
Q
D
M
E
K
R
A
Q
R
R
I
A
--
R
I
Q
--
Q
I
-
E
K
D
I
L
R
I
R
Q
L
L
Q
S
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
41.75
14%
41
- C3 -
3UUE
3
?
A:
[21-227]
------------------
S
L
A
A
G
L
V
Q
-
Q
T
Y
C
D
S
T
E
----
N
G
-----------
L
K
I
G
D
S
E
L
L
Y
T
M
G
E
----
G
Y
A
R
Q
R
V
N
-
I
Y
H
-----
S
P
-
S
L
G
I
A
V
A
I
E
G
T
N
L
F
S
----------------
L
N
S
D
L
H
D
A
K
F
W
Q
E
D
P
N
--
E
RY-
I
--
Q
Y
Y
P
-----
K
G
T
K
L
M
H
G
F
Q
Q
A
Y
---
N
D
L
-
M
-----------------
D
D
I
F
T
A
-
V
K
K
Y
K
K
E
K
N
--
E
K
R
-
V
T
V
I
G
H
S
L
G
A
A
M
G
L
L
C
A
M
D
I
E
L
RMDG--------
G
------
L
Y
K
T
Y
L
F
G
L
P
---------
R
L
G
N
P
T
-----------
F
A
S
F
V
D
Q
K
--------------
I
G
D
K
F
H
S
I
I
N
G
R
D
W
V
P
T
V
P
----
P
-
R
A-
L
G
----
Y
Q
H
P
S
D
Y
V
W
I
Y
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
41.48
27%
98
- C3 -
4F2T
2
PLC_STAAE
A:
[182-295]
-------------------------------------------------------------------------------------------------------------------------
G
I
Q
W
A
D
N
A
T
F
E
T
K
I
N
N
--
G
---
S
--
L
N
L
K
-----
V
Q
D
E
Y
K
D
Y
Y
D
K
K
V
E
A
V
K
N
L
L
A
-----------------
K
A
K
T
D
S
-
N
--
K
D
N
V
Y
V
--
N
F
L
S
V
A
S
G
G
-
S
A
F
N
S
T
S
N
Y
--
A
S
H
--------------
I
------
N
P
E
I
A
K
T
I
K
A
N
GKART
G
W
L
I
V
D
Y
A
G
--------------
Y
T
-
W
P
--------------
G
Y
D
D
I
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.31
27%
98
- C3 -
3V18
-
PLC_STAAE
A:
[181-294]
-------------------------------------------------------------------------------------------------------------------------
G
I
Q
W
A
D
N
A
T
F
E
T
K
I
N
N
--
G
---
S
--
L
N
L
K
-----
V
Q
D
E
Y
K
D
Y
Y
D
K
K
V
E
A
V
K
N
L
L
A
-----------------
K
A
K
T
D
S
-
N
--
K
D
N
V
Y
V
--
N
F
L
S
V
A
S
G
G
S
A
---
F
N
S
T
Y
N
Y
A
S
H
--------------
I
------
N
P
E
I
A
K
T
I
K
A
N
GKART
G
W
L
I
V
D
Y
A
G
--------------
Y
T
-
W
P
--------------
G
Y
D
D
I
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------