@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1339: (2016-03-24 )
MVTIKDVALKAGVSPSTVSRVIKGNKRISEATISKVKKVMEELNYFPNTAARTLITNQTYKIGLVLKGSEEPIRLNPFYINVLLGISETCNQHGYGTQTTVSNNMNDLMDEVYKMIKQRMVDAFILLYSKENDPIKQMLIDESMPFIVIGKPTSDIDHQFTHIDNDNILASENLTRHVIEQGVDELIFITEKGNFEVSKDRIQGFETVASQFNLDYQIIETSNEREVILNYMQNLHTRLKDPNIKQAIISLDAMLHLAILSVLYELNIEIPKDVMTATFNDSYLTEIASPPQTCIDIKPRMLGQQAGSAILNILKNKAQDVIELVIIDTELKIRKSTQR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110-........120.......130.......140........150.......160.......170...-....180.......190.......200.......210..---.....220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
T
I
K
D
V
A
L
KAGV
S
P
S
T
V
S
R
V
I
KGNKRI
S
E
A
T
I
S
K
V
K
K
V
M
E
E
LNYFPNT
A
A
R
T
L
ITNQ
T
Y
K
I
G
L
V
L
KGSEE
P
I
R
LN
P
F
Y
I
N
V
LLG
I
S
E
T
C
NQHGYGTQTTVSN
N
M
N
D
L
M
D
E
--
V
Y
K
M
I
K
Q
R
M
V
D
A
F
I
L
L
YSKEND
P
I
K
Q
M
L
ID-ESM
P
F
I
V
IGKPTSDIDHQFTHIDND
N
I
L
A
S
E
N
L
T
-
R
H
V
I
E
QGVD
E
L
I
F
I
TEKGN
F
E
V
S
K
D
R
I
Q
G
F
E
T
V
A
S
QFNL---
D
Y
Q
I
I
ETSN
E
R
E
V
I
L
N
Y
M
Q
N
L
H
T
RLKDP
N
I
K
Q
A
I
I
S
L
D
A
M
L
H
L
A
I
L
S
V
L
Y
E
LNIEI
P
K
D
V
M
TATFN
D
S
Y
L
T
E
IASPPQ
T
C
I
DI
K
P
R
M
L
G
Q
Q
A
G
S
A
I
L
N
I
L
K
N
K
A
Q
D
V
I
E
L
V
I
IDT
E
L
K
I
RKSTQR
21
PsiBlast_CBE
89.44
99%
-115
- C1 -
3HCW
1
?
B:
[4-287]
-------------------------------------------------------
T
N
Q
T
Y
K
I
G
L
V
L
K
G
S
E
E
P
I
R
L
N
P
F
Y
I
N
V
L
L
G
I
S
E
T
C
N
Q
H
G
Y
G
T
Q
T
T
V
S
N
N
M
N
D
L
M
D
E
--
V
Y
K
M
I
K
Q
R
M
V
D
A
F
I
L
L
Y
S
K
E
N
D
P
I
K
Q
M
L
I
D
-
E
S
M
P
F
I
V
I
G
K
P
T
S
D
I
D
H
Q
F
T
H
I
D
N
D
N
I
L
A
S
E
N
L
T
-
R
H
V
I
E
Q
G
V
D
E
L
I
F
I
T
E
K
G
N
F
E
V
S
K
D
R
I
Q
G
F
E
T
V
A
S
Q
F
N
L
---
D
Y
Q
I
I
E
T
S
N
E
R
E
V
I
L
N
Y
M
Q
N
L
H
T
R
L
K
D
P
N
I
K
Q
A
I
I
S
L
D
A
M
L
H
L
A
I
L
S
V
L
Y
E
L
N
I
E
I
P
K
D
V
M
T
A
T
F
N
D
S
Y
L
T
E
I
A
S
P
P
Q
T
C
I
D
I
K
P
R
M
L
G
Q
Q
A
G
S
A
I
L
N
I
L
K
N
---
D
V
I
E
L
V
I
I
D
T
E
L
K
I
R
K
S
T
Q
R
1
PsiBlast_PDB
89.40
99%
-116
- C1 -
3HCW
3
?
A:
[4-287]
-------------------------------------------------------
T
N
Q
T
Y
K
I
G
L
V
L
K
G
S
E
E
P
I
R
L
N
P
F
Y
I
N
V
L
L
G
I
S
E
T
C
N
Q
H
G
Y
G
T
Q
T
T
V
S
N
N
M
N
D
L
M
D
E
--
V
Y
K
M
I
K
Q
R
M
V
D
A
F
I
L
L
Y
S
K
E
N
D
P
I
K
Q
M
L
I
D
-
E
S
M
P
F
I
V
I
G
K
P
T
S
D
I
D
H
Q
F
T
H
I
D
N
D
N
I
L
A
S
E
N
L
T
-
R
H
V
I
E
Q
G
V
D
E
L
I
F
I
T
E
K
G
N
F
E
V
S
K
D
R
I
Q
G
F
E
T
V
A
S
Q
F
N
L
---
D
Y
Q
I
I
E
T
S
N
E
R
E
V
I
L
N
Y
M
Q
N
L
H
T
R
L
K
D
P
N
I
K
Q
A
I
I
S
L
D
A
M
L
H
L
A
I
L
S
V
L
Y
E
L
N
I
E
I
P
K
D
V
M
T
A
T
F
N
D
S
Y
L
T
E
I
A
S
P
P
Q
T
C
I
D
I
K
P
R
M
L
G
Q
Q
A
G
S
A
I
L
N
I
L
K
N
---
D
V
I
E
L
V
I
I
D
T
E
L
K
I
R
K
S
T
Q
R
5
PsiBlast_PDB
66.06
25%
-96
- C1 -
1QP7
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
4
PsiBlast_PDB
65.77
25%
-97
- C1 -
1BDH
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
KVP
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
7
PsiBlast_PDB
65.34
25%
-95
- C1 -
1QQB
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
6
PsiBlast_PDB
65.30
25%
-96
- C1 -
1QQA
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
17
PsiBlast_PDB
65.13
25%
-97
- C1 -
1QP4
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
16
PsiBlast_PDB
65.02
25%
-100
- C1 -
1QP0
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
KVP
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
3
PsiBlast_PDB
64.86
25%
-98
- C1 -
1JH9
4
PURR_ECOLI
A:
[1-314]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
R
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
11
PsiBlast_PDB
64.41
25%
-97
- C1 -
2PUD
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
12
PsiBlast_PDB
64.30
25%
-96
- C1 -
1JFT
3
PURR_ECOLI
A:
[1-314]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
A
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
8
PsiBlast_PDB
64.26
25%
-96
- C1 -
2PUA
2
PURR_ECOLI
A:
[1-314]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
18
PsiBlast_PDB
64.12
25%
-97
- C1 -
1QPZ
2
PURR_ECOLI
A:
[1-314]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
19
PsiBlast_PDB
64.09
25%
-95
- C1 -
1ZAY
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
KVP
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
13
PsiBlast_PDB
64.06
25%
-97
- C1 -
1PNR
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
KVP
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
20
PsiBlast_PDB
63.99
25%
-97
- C1 -
2PUE
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
15
PsiBlast_PDB
63.99
25%
-95
- C1 -
1WET
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
14
PsiBlast_PDB
63.87
25%
-95
- C1 -
1BDI
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
9
PsiBlast_PDB
63.58
25%
-95
- C1 -
2PUB
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
KVP
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------
10
PsiBlast_PDB
63.57
25%
-96
- C1 -
2PUC
2
PURR_ECOLI
A:
[2-314]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
-----
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
--
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
--
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
---
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
-------------------