@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1377: (2016-03-25 )
MTKIILAADVGGTTCKLGIFTPELEQLHKWSIHTDTSDSTGYTLLKGIYDSFVEKVNENNYNFSNVLGVGIGVPGPVDFEKGTVNGAVNLYWPEKVNVREIFEQFVDCPVYVDNDANIAALGEKHKGAGEGADDVVAITLGTGLGGGIISNGEIVHGHNGSGAEIGHFRADFDQRFKCNCGRSGCIETVASATGVVNLINFYYPKLTFRSSILELIKENKVTAKAVFDAAKAGDQFCIFITEKVANYIGYLCSIISVTSNPKYIVLGGGMSTAGPILIENIKTEYHNLTFAPAQFETEIVQAKLGNDAGITGAAGLIKTYVLDKEGVK
Atome Classification :
(23 SA)
------------------------------------------------------------------------.........10........20........30-.-........40........50........60........70........80........90-.--....-....100.......110.......120.......130........140.......150.......160.......170..---------...---------..180.......190.......200....--..---.210.......220---........230.......240.......250.......260.......270.-......280.....-..290-.-.......300.......310...-....320--........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------M
T
K
I
I
L
A
ADVGG
T
T
C
K
L
G
I
F
T
P
E
L
E
Q
L
H
K
W
--
S
-
I
HTDTSDST
G
Y
T
L
L
K
G
I
Y
D
S
F
V
E
K
VNENNYNFS
N
V
L
G
VGIGVPGPVDFEKGTVNG
A
V
N
L
--Y--WPEK-V
N
V
R
E
I
F
E
Q
FVDC
P
V
Y
VDNDANIAALGEKHKGAGEG-AD
D
V
V
A
I
T
LGTGLGGGIISNG
E
I
V
HGHNGSGAEIG
H
F
RAD
F
D
Q
---------
R
F
K---------CNCGRS
G
C
I
E
T
V
A
S
A
T
G
V
V
N
L
I
N
F
YYPK
L
--
T
F
---
R
S
S
I
L
E
L
I
K
ENK-
V
---
T
A
K
A
V
F
D
A
AKAG
D
Q
F
C
I
F
I
T
E
K
V
A
N
Y
I
G
Y
L
C
S
I
I
SVTSNP
K
Y
I
V
LGGGMSTA-GP
I
L
I
E
N
I
K
T
E
YHN-
L
T
FA--P-
A
Q
F
E
T
E
I
V
Q
A
KLGNDAGIT
G
A
A
G
-
L
I
K
T
Y
----
V
LDKEGVK
1
PsiBlast_PDB
97.38
39%
-117
- C1 -
2QM1
5
?
A:
[6-324]
--------------------------------------------------------------------------
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
--
S
-
I
E
T
N
I
L
E
D
-
G
K
H
I
V
P
S
I
I
E
S
I
R
H
R
I
D
L
Y
N
M
K
K
E
D
F
V
G
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
V
V
G
A
Y
N
L
--
N
--
W
T
T
V
-
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
-
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
-
P
N
---------
G
F
D
---------
C
T
C
G
K
R
G
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
R
H
L
S
E
E
F
--
A
G
---
D
S
E
L
K
Q
A
I
D
D
G
Q
D
V
---
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
A
-
G
E
F
L
R
S
R
V
E
K
Y
F
Q
E
-
F
T
F
P
--
Q
-
V
R
N
S
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
-
L
A
L
Q
F
----
S
K
------
28
HHSearch
94.14
40%
-109
- C1 -
2QM1
5
?
A:
[4-324]
------------------------------------------------------------------------
M
D
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
--
S
-
I
E
T
N
I
L
E
D
G
K
H
I
-
V
P
S
I
I
E
S
I
R
H
R
I
D
L
Y
N
M
K
K
E
D
F
V
G
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
V
V
G
A
Y
N
L
--
N
--
W
-
T
T
V
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
-
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
P
-
N
---------
G
F
D
---------
C
T
C
G
K
R
G
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
R
H
L
S
E
E
F
AG
D
S
---
E
L
K
Q
A
I
D
-
D
G
Q
D
-
V
---
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
A
-
G
E
F
L
R
S
R
V
E
K
Y
F
Q
E
-
F
T
F
P
--
Q
-
V
R
N
S
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
-
L
A
L
Q
F
----
S
K
------
25
PsiBlast_CBE
85.29
31%
-101
- C1 -
3VGK
1
?
D:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
24
PsiBlast_CBE
84.20
31%
-100
- C1 -
3VGK
2
?
E:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
4
PsiBlast_PDB
83.96
31%
-95
- C1 -
3VGM
3
?
A:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
22
PsiBlast_CBE
83.49
31%
-99
- C1 -
3VGK
1
?
G:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
23
PsiBlast_CBE
83.39
31%
-97
- C1 -
3VGK
1
?
F:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
2
PsiBlast_PDB
83.09
31%
-98
- C1 -
3VGK
1
?
A:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
3
PsiBlast_PDB
82.66
31%
-94
- C1 -
3VGL
4
?
A:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
26
PsiBlast_CBE
82.14
31%
-96
- C1 -
3VGK
1
?
C:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
21
PsiBlast_CBE
81.96
31%
-96
- C1 -
3VGK
1
?
H:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
27
PsiBlast_CBE
81.60
31%
-98
- C1 -
3VGK
2
?
B:
[3-311]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
T
-------
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
G
H
-
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
R
H
E
--
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
----------
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
---
N
A
A
V
L
L
G
L
G
D
G
S
-
V
DGI
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
--
E
-
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
--------------
29
HHSearch
79.23
30%
-93
- C1 -
3VGL
4
?
A:
[2-313]
--------------------------------------------------------------------------
G
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
--
K
-
V
A
T
P
P
--
T
A
E
G
I
-
V
D
A
I
C
A
A
V
A
G
A
S
-----
E
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
--
D
--
W
-
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
-
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
-
D
---------
G
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
--
P
E
NA
A
V
L
L
G
L
G
D
G
S
V
D
G
-
I
---
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
-
G
E
L
V
L
D
P
I
R
K
S
F
R
R
-
W
L
I
G
--
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
-
L
A
R
Q
G
------------
31
HHSearch
77.96
28%
-98
- C1 -
3VOV
3
?
A:
[1-300]
--------------------------------------------------------------------------
M
K
V
V
G
L
D
L
G
G
T
K
I
A
A
G
V
F
D
G
-
K
R
L
L
S
K
V
--
V
-
V
P
T
P
K
E
-
G
G
E
R
V
-
A
E
A
L
A
E
A
A
E
R
A
E
R
E
---
A
G
V
R
G
E
A
I
G
L
G
T
P
G
P
L
D
F
R
R
G
V
I
R
---
N
I
P-
G
--
V
-
Q
D
-
F
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
A
Q
G
-
E
E
S
S
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
H
L
T
L
L
P
-
G
---------
G
P
A
---------
C
G
C
G
L
E
G
C
L
E
A
L
A
A
G
R
A
L
E
R
D
A
T
Y
A
F
Q
-------------------
R
P
-
V
---
D
T
R
E
L
F
R
L
F
Q
A
G
D
P
K
A
E
R
L
V
L
Q
A
A
R
Y
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
N
A
P
E
G
Y
W
E
A
L
L
E
A
Y
R
R
-
Y
L
Q
G
-----
W
E
A
P
P
L
R
R
A
R
L
G
A
E
A
G
L
L
G
A
A
L
-
T
A
Y
L
E
----
V
K
D
G
----
5
PsiBlast_PDB
76.70
28%
-94
- C1 -
4DB3
5
NAGK_VIBVU
A:
[30-323]
--------------------------------------------------------------------------------
D
V
G
G
T
K
I
E
F
G
A
F
N
E
K
L
E
R
V
A
T
E
--
R
-
V
P
T
P
T
D
D
---
Y
P
L
L
L
E
T
I
A
G
L
V
A
K
Y
D
Q
E
---
F
A
C
E
G
K
I
G
L
G
L
P
G
M
E
D
A
D
D
A
T
V
L
-
T
V
N
V
--
P
--
A
A
K
G
-
K
P
L
R
A
D
L
E
A
K
I
G
R
S
V
K
I
E
N
D
A
N
C
F
A
L
S
E
A
W
D
E
E
L
Q
D
-
A
P
S
V
M
G
L
I
L
G
T
G
F
G
G
G
L
I
Y
E
G
K
V
F
S
G
R
N
N
V
A
G
E
L
G
H
M
R
L
P
L
D
A
---------
W
F
H
L
GDNAPLLG
C
G
C
G
K
K
G
C
L
D
S
Y
L
S
G
R
G
F
E
L
L
Y
A
H
Y
Y
G
E
--------
E
K
K
A
I
D
I
I
K
A
N
---------------
A
A
G
D
E
K
A
A
E
H
V
E
R
F
M
E
L
L
A
I
C
F
G
N
I
F
T
A
N
D
P
H
V
V
A
L
G
G
G
L
S
N
F
--
E
L
I
Y
E
E
M
P
K
R
V
P
K
-
Y
L
L
S
--
V
-
A
K
C
-
P
K
I
I
K
A
K
H
G
D
S
G
G
V
R
G
A
A
F
-
L
----------------
52
Fugue
76.17
23%
-102
- C1 -
1Z05
8
?
A:
[34-429]
D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
KGPIS
R
I
D
L
S
K
E
S
ELA
P
A
S
I
T
K
I
T
R
E
L
I
D
A
HLIHETT
V
Q
E
A
I
S
R
G
R
P
A
V
G
L
QTNN
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
--
K
-
I
D
I
H
E
I
D
--
Q
D
D
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
T
Y
A
A
Q
L
D
R
V
T
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
V
L
Q
M
P
H
Y
--
N
--
V
K
-
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
-
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
Q
G
---------
K
-
R
---------
C
H
C
G
N
Y
G
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
T
A
R
I
Q
A
---------
G
E
P
S
C
L
A
T
V
E
E
-
I
---
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
A
-
K
S
I
L
Y
P
S
I
E
Q
C
I
R
E
-
Q
S
L
P
--
V
-
Y
H
Q
D
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
-
I
K
Q
A
L
Y
D
G
L
L
L
M
K
V
V
E
G
37
HHSearch
74.71
28%
-97
- C1 -
2AP1
1
NAGK_SALTY
A:
[24-326]
--------------------------------------------------------------------------
A
M
Y
Y
G
F
D
I
G
G
T
K
I
A
L
G
V
F
D
S
T
R
R
L
Q
W
E
K
--
R
-
V
P
T
P
H
T
-
S
Y
S
A
F
-
L
D
A
V
C
E
L
V
E
E
A
D
Q
R
----
F
G
V
K
G
S
V
G
I
G
I
P
G
M
P
E
T
E
D
G
T
L
Y
A
A
N
V
P
--
A
--
A
-
S
G
-
K
P
L
R
A
D
L
S
A
R
L
D
R
D
V
R
L
D
N
D
A
N
C
F
A
L
S
E
A
W
D
D
E
F
T
Q
-
Y
P
L
V
M
G
L
I
L
G
T
G
V
G
G
G
L
V
L
N
G
K
P
I
T
G
Q
S
Y
I
T
G
E
F
G
H
M
R
L
P
V
D
A
L
T
L
M
GFDFP
L
R
R
---------
C
G
C
G
Q
M
G
C
I
E
N
Y
L
S
G
R
G
F
A
W
L
Y
Q
H
Y
Y
D
-------------------
Q
S
-
L
---
Q
A
P
E
I
I
A
L
W
E
Q
G
D
E
Q
A
H
A
H
V
E
R
Y
L
D
L
L
A
V
C
L
G
N
I
L
T
I
V
D
P
D
L
L
V
I
G
G
G
L
S
N
F
--
T
A
I
T
T
Q
L
A
E
R
L
P
R
-
H
L
L
P
--
V
--
A
R
A
P
R
I
E
R
A
R
H
G
D
A
G
G
M
R
G
A
A
F
-
L
H
L
T
-------------
30
HHSearch
74.70
23%
-100
- C1 -
1Z6R
1
MLC_ECOLI
A:
[85-398]
--------------------------------------------------------------------------
W
H
Y
L
S
L
R
I
S
R
G
E
I
F
L
A
L
R
D
L
S
S
K
L
V
V
E
E
--
S
-
Q
E
L
A
L
K
D
-
D
L
P
L
-
L
D
R
I
I
S
H
I
D
Q
F
F
I
R
H
Q
K
K
L
E
R
L
T
S
I
A
I
T
L
P
G
I
I
D
T
E
N
G
I
V
H
R
M
P
F
Y
--
E
D-
V
-
K
E
-
M
P
L
G
E
A
L
E
Q
H
T
G
V
P
V
Y
I
Q
H
D
I
S
A
W
T
M
A
E
A
L
F
G
A
S
R
G
-
A
R
D
V
I
Q
V
V
I
D
H
N
V
G
A
G
V
I
T
D
G
H
L
L
H
A
G
S
S
S
L
V
E
I
G
H
T
Q
V
D
P
-
Y
---------
G
K
R
---------
C
Y
C
G
N
H
G
C
L
E
T
I
A
S
V
D
S
I
L
E
L
A
Q
L
R
L
N
Q
S
--
M
S
---
S
M
--
L
---
H
G
Q
P
-
L
---
T
V
D
S
L
C
Q
A
A
L
R
G
D
L
L
A
K
D
I
I
T
G
V
G
A
H
V
G
R
I
L
A
I
M
V
N
L
F
N
P
Q
K
I
L
I
G
S
P
L
S
K
A
-
A
D
I
L
F
P
V
I
S
D
S
I
R
Q
-
Q
A
L
P
--
A
-
Y
S
Q
H
I
S
V
E
S
T
Q
F
S
N
Q
G
T
M
A
G
A
A
--
L
V
K
D
A
----
M
Y
N
G
S
---
34
HHSearch
74.46
26%
-93
* C1 *
2AA4
1
NANK_ECOLI
A:
[1-289]
--------------------------------------------------------------------------
M
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
R
--
E
-
L
P
T
P
A
S
Q
T
P
E
-----
A
L
R
D
A
L
S
A
L
V
S
P
L
---
Q
A
H
A
Q
R
V
A
I
A
S
T
G
I
I
R
D
G
S
L
L
A
L
N
P
H
N
L
--
G
G-
L
-
L
H
-
F
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
-
G
D
-
I
T
D
M
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
A
D
P
-
H
---------
G
P
V
---------
C
G
C
G
R
T
G
C
V
E
A
I
A
S
G
R
G
I
A
A
A
A
Q
G
E
L
A
--------------------
G
-
A
---
D
A
K
T
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
A
--
E
G
Y
L
A
L
V
E
T
Y
L
A
Q
-
E
P
A
------
A
F
H
V
D
L
L
A
A
H
Y
R
H
D
A
G
L
L
G
A
A
L
-
L
A
Q
G
E
------------
39
HHSearch
72.96
24%
-108
- C1 -
2GUP
4
?
A:
[4-290]
--------------------------------------------------------------------------
M
T
I
A
T
I
D
I
G
G
T
G
I
K
F
A
S
L
T
P
D
G
K
I
L
D
K
T
--
S
-
I
S
T
P
E
------
N
-
L
E
D
L
L
A
W
L
D
Q
R
L
S
-----
E
Q
D
Y
S
G
I
A
M
S
V
P
G
A
V
N
Q
E
T
G
V
I
D
G
F
S
A
V
--
P
Y-
I
-
H
G
-
F
S
W
Y
E
A
L
S
-
S
Y
Q
L
P
V
H
L
E
N
D
A
N
C
V
G
L
S
E
L
L
A
H
P
--
E
-
L
E
N
A
A
C
V
V
I
G
T
G
I
G
G
A
M
I
I
N
G
R
L
H
R
G
R
H
G
L
G
G
E
F
G
Y
M
T
T
L
A
-
P
-----------------------
A
E
K
L
N
N
W
S
Q
L
A
S
T
G
N
M
V
R
Y
V
I
E
K
S
G
H
------------------
T
D
-
W
---
D
G
R
K
I
Y
Q
E
A
A
A
G
N
I
L
C
Q
E
A
I
E
R
M
N
R
N
L
A
Q
G
L
L
N
I
Q
Y
L
I
D
P
G
V
I
S
L
G
G
S
I
S
Q
N
--
P
D
F
I
Q
G
V
K
K
A
V
E
D
-
F
V
D
A
Y
E
E
-
Y
T
V
A
P
V
I
Q
A
C
T
Y
H
A
D
A
N
L
Y
G
A
L
V
-
N
W
L
Q
E
----
E
K
------
10
PsiBlast_PDB
70.39
30%
-107
- C1 -
2YHY
13
A:
[33-296]
-----------------------------------------------------------------------------
L
A
V
D
L
G
G
T
N
L
R
V
A
I
V
S
M
K
G
E
I
V
K
K
Y
--
T
Q
F
N
P
K
T
Y
E
E
R
I
N
L
I
L
Q
M
C
V
E
A
A
A
E
A
V
K
L
N
----
C
R
I
L
G
V
G
I
S
T
G
G
R
V
N
P
R
E
G
I
V
L
H
S
T
K
L
--
I
QE
W
-
N
S
-
V
D
L
R
T
P
L
S
D
T
L
H
L
P
V
W
V
D
N
D
G
N
C
A
A
L
A
E
R
K
F
G
Q
G
K
G
-
L
E
N
F
V
T
L
I
T
G
T
G
I
G
G
G
I
I
H
Q
H
E
L
I
H
G
S
S
F
C
A
A
E
L
G
H
L
V
V
S
L
D
G
---------
P
-
D
---------
C
S
C
G
S
H
G
C
I
E
A
Y
A
S
G
M
A
L
Q
R
E
A
K
K
L
H
D
E
D
--
L
L
---
L
V
E
G
M
S
-----
A
-
V
---
G
A
L
H
L
I
Q
A
A
K
L
G
N
A
K
A
Q
S
I
L
R
T
A
G
T
A
L
G
L
G
V
V
N
I
L
H
T
M
N
P
S
L
V
I
L
S
G
V
L
A
S
------------------------------------------------------------------
11
PsiBlast_PDB
70.03
30%
-107
- C1 -
2YI1
12
A:
[33-296]
-----------------------------------------------------------------------------
L
A
V
D
L
G
G
T
N
L
R
V
A
I
V
S
M
K
G
E
I
V
K
K
Y
--
T
Q
F
N
P
K
T
Y
E
E
R
I
N
L
I
L
Q
M
C
V
E
A
A
A
E
A
V
K
L
N
----
C
R
I
L
G
V
G
I
S
T
G
G
R
V
N
P
R
E
G
I
V
L
H
S
T
K
L
--
I
QE
W
-
N
S
-
V
D
L
R
T
P
L
S
D
T
L
H
L
P
V
W
V
D
N
D
G
N
C
A
A
L
A
E
R
K
F
G
Q
G
K
G
-
L
E
N
F
V
T
L
I
T
G
T
G
I
G
G
G
I
I
H
Q
H
E
L
I
H
G
S
S
F
C
A
A
E
L
G
H
L
V
V
S
L
D
G
---------
P
-
D
---------
C
S
C
G
S
H
G
C
I
E
A
Y
A
S
G
M
A
L
Q
R
E
A
K
K
L
H
D
E
D
--
L
L
---
L
V
E
G
M
S
-----
A
-
V
---
G
A
L
H
L
I
Q
A
A
K
L
G
N
A
K
A
Q
S
I
L
R
T
A
G
T
A
L
G
L
G
V
V
N
I
L
H
T
M
N
P
S
L
V
I
L
S
G
V
L
A
S
------------------------------------------------------------------
48
HHSearch
61.14
30%
-91
- C1 -
1WOQ
3
?
A:
[11-263]
-------------------------------------------------------------------------
N
A
P
L
I
G
I
D
I
G
G
T
G
I
K
G
G
I
V
D
L
K
K
G
K
L
L
G
E
R
F
R
-
V
P
T
P
Q
P
A
T
P
E
S
V
-
A
E
A
V
A
L
V
V
A
E
L
S
A
R
-
P
E
A
P
A
A
G
S
P
V
G
V
T
F
P
G
I
I
Q
H
--
G
V
V
H
S
A
A
N
V
DK
S
--
W
-
L
N
-
T
D
I
D
A
L
L
T
A
R
L
G
R
P
V
E
V
I
N
D
A
D
A
A
G
L
A
E
A
R
Y
G
A
G
A
G
V
K
G
T
V
L
V
I
T
L
G
T
G
I
G
S
A
F
I
F
D
G
K
L
V
P
N
-----
A
E
L
G
H
L
E
I
D
G
-----------------------------
H
D
A
E
T
K
A
S
A
V
A
R
E
---------------------------------------------
R
D
---
G
L
S
W
D
E
Y
S
V
L
L
Q
R
Y
F
S
H
V
E
F
L
F
S
P
E
L
F
I
V
G
G
G
I
S
K
R
-
A
D
E
Y
L
P
N
L
R
L
----------------
R
T
P
I
V
P
A
V
L
R
N
E
A
G
I
V
G
A
A
I
E
I
A
L
Q
H
------------