@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1388: (2016-03-25 )
MKIADLMTLLDHHVPFSTAESWDNVGLLIGDGDVEVTGVLTALDCTLEVVNEAIEKGYNTIISHHPLIFKGVTSLKANGYGLIIRKLIQHDINLIAMHTNLDVNPYGVNMMLAKAMGLKNISIINNQQDVYYKVQTYIPKDNVGPFKDKLSENGLAQEGNYEYCFFESEGRGQFKPVGEANPTIGQIDKIEDVDEVKIEFMIDAYQKSRAEQLIKQYHPYETPVFDFIEIKQTSLYGLGVMAEVDNQMTLEDFAADIKSKLNIPSVRFVGESNQKIKRIAIIGGSGIGYEYQAVQQGADVFVTGDIKHHDALDAKIHGVNLIDINHYSEYVMKEGLKTLLMNWFNIEKINIDVEASTINTDPFQYI
Atome Classification :
(20 SA)
----.........10........20....--.....30.-.......40........50........60........70----......-.-.80......---..90........100...-....--------------110.......120...-..-..130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230..-......240...----------....250.......260-..-.......-270.......280......--.--290.......300.......310..-.....320.......330.......340.......---350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
K
I
A
D
L
M
T
L
L
D
HHVPFSTAE-SWD
N
--
V
G
L
L
I
GDG-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
ISHH
P
L
I
FK
G
----
V
T
SLKA-N-
G
Y
G
L
I
I
R
K
L
---
I
Q
HDI
N
L
I
A
M
HTNLDVNP-Y
G
V
N
--------------
M
M
L
A
K
AMGL
K
N
I
S
I
IN-NQ-
Q
D
V
Y
Y
K
V
Q
T
YIPKDNVG
P
F
K
D
K
LSENGLAQEGNY
E
Y
C
F
FESEGRGQFKPVGEANPTIGQIDKIE
D
V
D
E
V
K
I
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
QYHPYETPV
F
D
F
I
E
I
-
K
QT-SLYG
L
G
V
M
A
EVD----------NQM
T
L
E
D
F
A
A
D
I
K
SK---LN-IP
S
V
R
F
V-GESN
Q
K
I
K
R
I
A
I
IGGSGIG--Y--
E
Y
Q
A
V
QQGA
D
V
F
V
TGDIKHHDALD
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
WF
N
I
E
K
I
---
N
I
D
V
E
A
STINTDPFQYI
22
PsiBlast_CBE
98.50
99%
-136
- C7 -
3LNL
3
GCH1L_STAAM
B:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
H
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
T
Y
I
P
K
D
N
V
G
P
F
K
D
K
L
S
E
N
G
L
A
Q
----
E
Y
C
F
F
E
S
E
G
R
G
Q
-----------------
E
D
V
D
E
V
K
I
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
Y
H
P
Y
E
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
---
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
81
Fugue
97.85
97%
-133
- C7 -
3LNL
3
GCH1L_STAAM
B:
[1-370]
AMDP
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
H
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
T
Y
I
P
K
D
N
V
G
P
F
K
D
K
L
S
E
N
G
----
L
A
Q
E
Y
C
F
F
E
S
E
G
R
G
Q
E
D
-----------------
V
D
E
V
K
I
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
Y
H
P
Y
E
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
---
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
21
PsiBlast_CBE
96.89
99%
-128
- C7 -
2NYD
2
GCH1L_STAAM
B:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
Y
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
T
Y
I
P
K
D
N
V
G
P
F
K
D
K
L
S
E
N
G
L
A
Q
E
G
N
Y
E
Y
C
F
F
E
S
E
----------------------
D
V
D
E
V
K
I
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
Y
H
P
Y
E
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
---
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
2
PsiBlast_PDB
92.22
99%
-143
- C7 -
3LNL
3
GCH1L_STAAM
A:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
H
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
-------------------------------------------------------------
K
I
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
Y
H
P
Y
E
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
---
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
1
PsiBlast_PDB
91.24
99%
-143
- C7 -
2NYD
2
GCH1L_STAAM
A:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
Y
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
---------------------------------------------------------------
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
-----
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
S
E
Y
V
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
K
I
---
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
62
HHSearch
89.64
95%
-142
- C7 -
2NYD
2
GCH1L_STAAM
A:
[5-370]
----
M
K
I
A
D
L
M
T
L
L
D
H
H
V
P
F
S
T
A
E
-
S
W
D
N
--
V
G
L
L
I
G
D
E
-
D
V
E
V
T
G
V
L
T
A
L
D
C
T
L
E
V
V
N
E
A
I
E
K
G
Y
N
T
I
I
S
H
H
P
L
I
F
K
G
----
V
T
S
L
K
A
-
N
-
G
Y
G
L
I
I
R
K
L
---
I
Q
H
D
I
N
L
I
A
M
H
T
N
L
D
V
N
P
-
Y
G
V
N
--------------
M
M
L
A
K
V
M
G
L
K
N
I
S
I
I
N
-
N
Q
-
Q
D
V
Y
Y
K
V
Q
---------------------------------------------------------------
E
F
M
I
D
A
Y
Q
K
S
R
A
E
Q
L
I
K
Q
-----
T
P
V
F
D
F
I
E
I
-
K
Q
T
-
S
L
Y
G
L
G
V
M
A
E
V
D
----------
N
Q
M
T
L
E
D
F
A
A
D
I
K
S
K
---
L
N
-
I
P
S
V
R
F
V
-
G
E
S
N
Q
K
I
K
R
I
A
I
I
G
G
S
G
I
G
--
Y
--
E
Y
Q
A
V
Q
Q
G
A
D
V
F
V
T
G
D
I
K
H
H
D
A
L
D
A
-
K
I
H
G
V
N
L
I
D
I
N
H
Y
-
S
E
Y
V
--
M
K
E
G
L
K
T
L
L
M
N
W
F
N
I
E
KI
N
I
D
V
E
A
S
T
I
N
T
D
P
F
Q
Y
I
82
Fugue
81.36
37%
-110
- C7 -
2GX8
6
?
A:
[28-397]
---I
P
N
G
H
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
-
E
G
D
K
--
I
G
L
Q
I
G
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
----
L
K
A
I
H
T
D
K
-
A
Y
G
K
I
I
E
K
C
---
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
-
G
G
V
N
--------------
D
L
L
A
E
A
L
G
L
Q
N
T
E
V
L
A
-
P
T
Y
A
E
E
M
K
K
V
V
V
F
V
P
V
T
H
A
E
E
V
R
K
A
L
G
D
A
G
A
G
H
I
G
N
Y
S
H
C
T
F
S
S
E
G
T
G
T
F
V
P
-----------
Q
Q
L
E
R
V
E
E
V
R
I
E
T
I
I
P
A
S
L
Q
R
K
V
I
K
A
M
V
T
A
H
P
Y
E
E
V
A
Y
D
V
Y
P
L
D
N
K
G
-
E
T
L
G
L
G
K
I
G
Y
L
Q
----------
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
---
L
D
-
V
K
G
A
R
V
V
-
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
N
K
--
Y
--
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
A
H
D
A
-
M
M
L
G
L
N
I
V
D
P
G
H
N
V
E
K
V
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
---
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
24
PsiBlast_CBE
81.04
37%
-111
- C7 -
2GX8
4
?
B:
[33-397]
--------
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
-
E
G
D
K
--
I
G
L
Q
I
G
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
----
L
K
A
I
H
T
-
D
K
A
Y
G
K
I
I
E
K
C
---
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
-
G
G
V
N
--------------
D
L
L
A
E
A
L
G
L
Q
N
T
E
V
L
A
P
T
Y
-
A
E
E
M
K
K
V
V
V
F
V
P
V
T
H
A
E
E
V
R
K
A
L
G
D
A
G
A
G
H
I
G
N
Y
S
H
C
T
F
S
S
E
G
T
G
T
F
V
P
Q
-----------
Q
L
E
R
V
E
E
V
R
I
E
T
I
I
P
A
S
L
Q
R
K
V
I
K
A
M
V
T
A
H
P
Y
E
E
V
A
Y
D
V
Y
P
L
D
N
K
G
-
E
T
L
G
L
G
K
I
G
Y
L
Q
----------
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
---
L
D
-
V
K
G
A
R
V
V
-
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
N
K
--
Y
--
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
A
H
D
A
-
M
M
L
G
L
N
I
V
D
P
G
H
N
V
E
K
V
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
---
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
3
PsiBlast_PDB
80.10
37%
-109
- C7 -
2GX8
6
?
A:
[33-397]
--------
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
-
E
G
D
K
--
I
G
L
Q
I
G
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
----
L
K
A
I
H
T
-
D
K
A
Y
G
K
I
I
E
K
C
---
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
-
G
G
V
N
--------------
D
L
L
A
E
A
L
G
L
Q
N
T
E
V
L
A
P
T
Y
-
A
E
E
M
K
K
V
V
V
F
V
P
V
T
H
A
E
E
V
R
K
A
L
G
D
A
G
A
G
H
I
G
N
Y
S
H
C
T
F
S
S
E
G
T
G
T
F
V
P
Q
-----------
Q
L
E
R
V
E
E
V
R
I
E
T
I
I
P
A
S
L
Q
R
K
V
I
K
A
M
V
T
A
H
P
Y
E
E
V
A
Y
D
V
Y
P
L
D
N
K
G
-
E
T
L
G
L
G
K
I
G
Y
L
Q
----------
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
---
L
D
-
V
K
G
A
R
V
V
-
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
N
K
--
Y
--
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
A
H
D
A
-
M
M
L
G
L
N
I
V
D
P
G
H
N
V
E
K
V
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
---
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
61
HHSearch
79.14
36%
-108
* C7 *
2GX8
6
?
A:
[29-397]
----
P
N
G
H
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
-
E
G
D
K
--
I
G
L
Q
I
G
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
----
L
K
A
I
H
T
D
K
-
A
Y
G
K
I
I
E
K
C
---
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
-
G
G
V
N
--------------
D
L
L
A
E
A
L
G
L
Q
N
T
E
V
L
A
-
P
T
Y
A
E
E
M
K
K
V
V
V
F
V
P
V
T
H
A
E
E
V
R
K
A
L
G
D
A
G
A
G
H
I
G
N
Y
S
H
C
T
F
S
S
E
G
T
G
T
F
V
P
Q
-----------
Q
L
E
R
V
E
E
V
R
I
E
T
I
I
P
A
S
L
Q
R
K
V
I
K
A
M
V
T
A
H
P
Y
E
E
V
A
Y
D
V
Y
P
L
-
D
N
K
G
E
T
L
G
L
G
K
I
G
Y
L
Q
----------
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
---
L
D
-
V
K
G
A
R
V
V
-
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
N
K
--
Y
--
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
A
H
D
A
-
M
M
L
G
L
N
I
V
D
P
G
H
N
-
V
E
K
V
--
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
KL
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
23
PsiBlast_CBE
78.18
37%
-108
- C7 -
2GX8
5
?
C:
[33-397]
--------
E
I
I
S
L
F
E
S
M
Y
P
K
H
L
A
M
-
E
G
D
K
--
I
G
L
Q
I
G
A
L
-
N
K
P
V
R
H
V
L
I
A
L
D
V
T
E
E
V
V
D
E
A
I
Q
L
G
A
N
V
I
I
A
H
H
P
L
I
F
N
P
----
L
K
A
I
H
T
-
D
K
A
Y
G
K
I
I
E
K
C
---
I
K
N
D
I
A
I
Y
A
A
H
T
N
V
D
V
A
K
-
G
G
V
N
--------------
D
L
L
A
E
A
L
G
L
Q
N
T
E
V
L
A
P
T
Y
-
A
E
E
M
K
K
V
V
V
F
V
P
V
T
H
A
E
E
V
R
K
A
L
G
D
A
G
A
G
H
I
G
N
Y
S
H
C
T
F
S
S
E
G
T
G
T
F
V
P
Q
E
G
--------
G
Q
L
E
R
V
E
E
V
R
I
E
T
I
I
P
A
S
L
Q
R
K
V
I
K
A
M
V
T
A
H
P
Y
E
E
V
A
Y
D
V
Y
P
L
D
N
K
G
-
E
T
L
G
L
G
K
I
G
Y
L
Q
----------
E
E
M
T
L
G
Q
F
A
E
H
V
K
Q
S
---
L
D
-
V
K
G
A
R
V
V
-
G
K
L
D
D
K
V
R
K
V
A
V
L
G
G
D
G
N
K
--
Y
--
I
N
Q
A
K
F
K
G
A
D
V
Y
V
T
G
D
M
Y
Y
H
V
A
H
D
A
-
M
M
L
G
L
N
I
V
D
P
G
H
N
V
E
K
V
M
K
Q
G
V
Q
K
Q
L
Q
E
K
V
D
A
K
K
L
---
N
V
H
I
H
A
S
Q
L
H
T
D
P
F
I
F
V
64
HHSearch
63.74
22%
-117
- C7 -
1NMO
2
GCH1L_ECOLI
A:
[1-240]
----
M
K
N
T
E
L
E
Q
L
I
N
E
K
L
N
S
A
A
I
S
-
D
Y
A
P
--
N
G
L
Q
V
E
G
--
K
E
T
V
Q
K
I
V
T
G
V
T
A
S
Q
A
L
L
D
E
A
V
R
L
G
A
D
A
V
I
V
H
H
G
Y
F
W
K
G
----
E
S
P
V
I
R
-
G
-
M
K
R
N
R
L
K
T
L
---
L
A
N
D
I
N
L
Y
G
W
H
L
P
L
D
A
H
P
E
L
G
N
N
--------------
A
Q
L
A
A
L
L
G
I
T
V
M
G
E
I
E
-------------------------------------------------------------------------------------------------------------------
P
L
V
P
W
G
E
L
T
----------
M
P
V
P
G
L
E
L
A
S
W
I
E
A
R
---
L
G
-
R
K
P
L
W
C
G
-
D
T
G
P
E
V
V
Q
R
V
A
W
C
T
G
G
G
Q
S
--
F
--
I
D
S
A
A
R
F
G
V
D
A
F
I
T
G
E
V
S
E
Q
T
I
H
S
A
-
R
E
Q
G
L
H
F
Y
A
A
G
H
H
A
T
E
R
G
--
G
I
R
A
L
S
E
W
L
N
E
N
T
D
-----
L
D
V
T
F
-----------
65
HHSearch
61.72
27%
-115
- C7 -
3WSF
3
?
A:
[9-244]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
-
E
G
D
N
--
I
G
L
Q
V
G
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
----
I
R
N
F
T
G
---
V
I
Y
K
K
L
K
I
L
---
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
-
N
G
L
N
--------------
D
A
L
A
E
L
Y
N
L
E
N
P
K
P
L
Y
-----------------------------------------------------------------------------------------------------------------
D
N
G
L
G
R
V
G
I
F
K
------------
G
S
F
E
E
F
L
E
I
T
K
K
Y
---
I
H
-
K
N
P
I
V
V
K
-
S
K
E
V
D
D
N
F
K
L
A
V
L
S
G
Y
G
L
S
Q
S
S
--
I
K
Y
V
-
A
E
K
A
D
V
Y
L
S
G
D
L
T
H
H
S
K
I
L
A
-
E
E
L
G
L
V
V
V
D
A
T
H
Y
S
T
E
V
F
--
G
L
K
K
F
K
E
F
L
S
S
N
L
D
---------------------
66
HHSearch
58.12
25%
-102
- C7 -
2YYB
-
?
A:
[1-236]
----
M
D
R
D
E
L
V
R
Y
L
D
A
Y
L
--
R
I
Q
D
F
P
Q
D
P
SL
N
G
L
Q
V
E
G
--
K
R
T
V
R
K
V
G
A
A
V
D
A
G
E
A
I
F
R
K
A
L
E
E
E
V
D
F
L
I
V
H
H
G
L
F
W
G
K
----
P
F
P
I
V
--
G
-
H
H
K
R
R
L
E
T
L
---
F
Q
G
G
I
N
L
Y
A
A
H
L
P
L
D
A
H
E
E
V
G
N
N
--------------
F
V
L
A
R
E
L
G
L
V
D
L
T
P
--------------------------------------------------------------------------------------------------------------------
W
D
V
G
V
K
G
R
F
P
----------
Q
P
T
P
L
L
Q
V
A
D
R
L
G
Q
L
---
T
G
-
M
Q
P
L
V
H
Q
-
G
G
L
-
D
H
V
E
T
V
I
L
V
S
G
S
G
T
G
--
L
--
L
P
K
---
V
D
A
D
L
F
V
T
G
E
P
K
H
S
V
F
H
E
T
-
F
E
R
G
L
N
V
I
Y
A
G
H
Y
D
T
E
T
F
--
G
V
K
A
L
A
A
H
L
E
A
R
F
G
-----
L
P
W
V
F
L
----------
67
HHSearch
50.98
15%
-100
- C7 -
3RXY
5
?
A:
[7-274]
----
L
S
T
A
E
L
V
D
I
A
L
E
M
A
--
E
M
R
T
-
L
P
A
D
--
S
A
V
Y
V
E
---
S
T
D
L
K
R
V
M
M
G
I
D
I
G
P
A
E
L
L
L
A
R
Q
L
G
C
D
G
V
I
A
H
H
P
A
G
G
S
A
------
T
L
N
F
P
E
-
V
L
T
R
H
V
E
L
M
---
V
E
H
G
V
P
A
T
A
A
R
D
---
A
I
Q
-
G
L
L
T
R
S
L
L
R
A
Q
S
ANHD
H
T
P
S
V
A
R
L
L
E
M
P
F
L
N
I
H
L
-
P
---------------------------------------------------------------------------------------------------------------
L
D
E
V
G
R
R
I
M
V
K
T
I
Q
E
A
VEPLG
D
E
A
R
V
Q
D
A
I
D
A
L
M
T
L
P
E
F
A
G
A
A
T
R
I
M
V
P
V
G
A
V
D
Q
P
L
G
K
I
A
V
V
H
G
A
G
T
N
GG
Y
A
V
A
R
A
Y
F
D
H
G
V
R
T
V
L
Y
I
H
I
A
P
E
E
A
E
R
L
R
R
E
G
G
G
N
L
I
V
T
G
H
I
A
S
D
L
V
--
G
I
N
R
Y
V
Q
A
L
E
E
-
R
-----
G
V
E
V
V
R
-----------
14
PsiBlast_PDB
50.29
26%
-126
- C7 -
1NMP
2
GCH1L_ECOLI
A:
[1-118]
----
M
K
N
T
E
L
E
Q
L
I
N
E
K
L
N
S
A
A
I
S
-
D
Y
A
P
--
N
G
L
Q
V
-
E
G
-
K
E
T
V
Q
K
I
V
T
G
V
T
A
S
Q
A
L
L
D
E
A
V
R
L
G
A
D
A
V
I
V
H
H
G
Y
F
W
K
G
ESPV
I
R
G
M
K
R
-
N
-----
R
L
K
T
L
---
L
A
N
D
I
N
L
Y
G
W
H
L
P
L
D
A
H
P
E
L
G
N
N
--------------
A
Q
L
A
A
L
L
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.25
33%
-111
- C7 -
4IWG
-
GCH1L_METJA
A:
[1-120]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
-
E
G
D
N
--
I
G
L
Q
V
G
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
----
I
R
-----
N
-
F
T
G
V
I
Y
K
K
L
K
I
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
-
N
G
L
N
--------------
D
A
L
A
E
L
Y
N
L
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
49.97
33%
-111
- C7 -
3WSE
3
?
A:
[9-128]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
-
E
G
D
N
--
I
G
L
Q
V
G
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
----
I
R
-----
N
-
F
T
G
V
I
Y
K
K
L
K
I
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
-
N
G
L
N
--------------
D
A
L
A
E
L
Y
N
L
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
49.95
33%
-114
- C7 -
3WSI
2
?
F:
[9-128]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
-
E
G
D
N
--
I
G
L
Q
V
G
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
----
I
R
-----
N
-
F
T
G
V
I
Y
K
K
L
KIL
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
-
N
G
L
N
--------------
D
A
L
A
E
L
Y
N
L
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.67
33%
-111
- C7 -
3WSD
3
?
A:
[9-128]
----
M
K
A
K
E
I
I
E
F
I
E
T
F
A
P
K
D
L
A
I
-
E
G
D
N
--
I
G
L
Q
V
G
D
N
L
D
K
E
I
K
K
L
G
I
A
L
D
P
S
L
S
V
I
K
K
A
E
K
E
G
V
D
F
L
F
T
H
H
P
L
L
K
D
P
----
I
R
-----
N
-
F
T
G
V
I
Y
K
K
L
K
I
L
M
E
N
D
I
I
L
Y
S
A
H
T
N
L
D
I
C
K
-
N
G
L
N
--------------
D
A
L
A
E
L
Y
N
L
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------