@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1391: (2016-03-25 )
MRIDQSIINEIKDKTDILDLVSEYVKLEKRGRNYIGLCPFHDEKTPSFTVSEDKQICHCFGCKKGGNVFQFTQEIKDISFVEAVKELGDRVNVAVDIEATQSNSNVQIASDDLQMIEMHELIQEFYYYALTKTVEGEQALTYLQERGFTDALIKERGIGFAPDSSHFCHDFLQKKGYDIELAYEAGLLSRNEENFSYYDRFRNRIMFPLKNAQGRIVGYSGRTYTGQEPKYLNSPETPIFQKRKLLYNLDKARKSIRKLDEIVLLEGFMDVIKSDTAGLKNVVATMGTQLSDEHITFIRKLTSNITLMFDGDFAGSEATLKTGQHLLQQGLNVFVIQLPSGMDPDEYIGKYGNDAFTTFVKNDKKSFAHYKVSILKDEIAHNDLSYERYLKELSHDISLMKSSILQQKAINDVAPFFNVSPEQLANEIQFNQAPANYYPEDEYGGYDEYGGYIEPEPIGMAQFDNLSRQEKAERAFLKHLMRDKDTFLNYYESVDKDNFTNQHFKYVFEVLHDFYAENDQYNISDAVQYVNSNELRETLISLEQYNLNDEPYENEIDDYVNVINEKGQETIESLNHKLREATRIGDVELQKYYLQQIVAKNKERM
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-...--......190.......200.......210.......220...-.-...230.......240.......250.......260.......270.......280.......290.......300.......310......---.320......---.---330.......340.......350.......360.......370.......380-.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MRI
D
Q
S
I
I
N
E
IKD
K
T
D
I
L
D
L
V
S
E
Y
V
K
L
E
KRGR
N
Y
I
G
LCPFHDEKTP
S
F
TVSED
K
Q
I
C
H
CFGCKKGG
N
V
F
Q
F
T
Q
E
IKD
I
S
F
V
E
A
V
K
E
LGDRV
N
V
A
V
D
I
E
ATQSNS
N
V
Q
IASD
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
TKTVE
G
E
Q
A
L
T
Y
L
Q
ERGF
T
D
A
L
I
K
ERGIGFAPDS
S
H
F
C
H
D
F
L
Q
KKGY
D
I
E
---
L
A
Y
--EAGLLSRNEEN
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
LKNAQ
G
R
I
V
GYSGRTYT-G-QEPKYLNSPET
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
KSDTA
G
L
K
N
V
V
A
T
MGTQLS
D
E
H
I
T
F
I
R
K
L
TS
N
I
T
L
M
FDGDFAGSEA---
T
L
K
T
G
Q
H
L
L
Q
---Q---GL
N
V
F
V
I
QLPSGM
D
P
D
E
Y
I
G
KYG
N
D
A
F
T
T
F
V
KNDKKSF
A
H
Y
K
V
S
I
L
K
D
E
IAHN-DL
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
KAINDVAPFFNV
S
P
E
Q
L
A
N
E
I
QFNQAPANYYPEDEYGGYDEYGGYIEPEPI
G
M
A
Q
F
DN
L
S
R
Q
E
K
A
E
R
A
F
L
K
H
L
MRD
K
D
T
F
L
N
Y
Y
E
SVDKDNF
T
N
Q
H
F
K
Y
V
F
E
V
L
H
D
F
YAENDQY
N
I
S
D
A
V
Q
YV
N
S
N
E
L
R
E
T
L
I
S
L
E
QYNLNDEP
Y
E
N
E
I
D
D
Y
V
N
V
I
N
EK
G
Q
E
T
I
E
S
L
N
H
K
L
R
E
A
TRI
G
D
V
E
L
Q
K
Y
Y
L
Q
Q
I
V
A
KNKERM
7
PsiBlast_PDB
95.79
99%
-107
- C2 -
4EE1
5
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.59
99%
-106
- C2 -
4EDV
5
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.56
99%
-107
- C2 -
4EDG
6
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.38
99%
-106
- C2 -
4EDT
4
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.25
99%
-107
- C2 -
4EDR
7
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.21
99%
-106
- C2 -
4EDK
7
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.11
99%
-109
- C2 -
4E2K
2
DNAG_STAAU
A:
[3-321]
--------------------------------------------------------------------------------------------------------------
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
--
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
95.07
99%
-106
- C2 -
4EDK
7
DNAG_STAAU
A:
[1-321]
------------------------------------------------------------------------------------------------------------
S
N
A
D
D
L
Q
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
K
T
V
E
G
E
Q
A
L
T
Y
L
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
D
S
S
H
F
C
H
D
F
L
Q
K
K
G
Y
D
I
E
---
L
A
Y
--
E
A
G
L
L
S
R
N
E
E
N
F
S
Y
Y
D
R
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
-
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
---
T
L
K
T
G
Q
H
L
L
Q
---
Q
---
G
L
N
V
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
H
N
-
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.07
31%
-86
- C2 -
2AU3
1
DNAG_AQUAE
A:
[3-405]
----
M
S
S
D
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
R
Y
G
K
K
L
D
L
E
K
I
S
---------
K
D
E
K
V
Y
V
A
L
D
R
V
C
D
F
Y
R
E
S
L
L
K
---
N
R
E
A
S
E
Y
V
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
S
S
-
E
A
L
V
K
V
L
K
E
N
D
L
L
E
A
---
Y
L
E
--
T
K
N
L
L
S
P
T
K
--
G
V
Y
R
D
L
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
-
E
D
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
I
K
E
E
G
F
A
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
---
M
K
S
A
I
P
L
L
L
S
---
A
---
G
V
E
V
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
R
L
I
N
-
S
S
G
E
L
F
E
T
L
I
K
T
A
R
E
N
L
E
--------
E
K
T
R
E
F
R
Y
Y
L
G
F
I
S
D
G
V
R
R
F
A
L
A
S
E
F
H
T
K
Y
K
V
P
M
E
I
L
L
M
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.78
33%
-74
- C2 -
2AU3
1
DNAG_AQUAE
A:
[4-352]
-----
S
S
D
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
R
Y
G
K
K
L
D
L
E
K
I
S
K
D
E
K
V
Y
V
A
L
D
R
---------
V
C
D
F
Y
R
E
S
L
L
K
N
R
E
A
S
E
---
Y
V
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
S
S
E
A
L
V
K
V
L
---
K
E
N
D
L
L
---
E
A
Y
L
E
T
K
N
L
L
S
P
T
K
G
--
V
Y
R
D
L
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
E
D
-
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
I
K
E
E
G
F
A
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
---
M
K
S
A
I
P
L
L
L
S
---
A
---
G
V
E
V
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
R
L
I
N
S
S
G
E
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
67.15
27%
-88
- C2 -
1DD9
1
DNAG_ECOLI
A:
[20-330]
------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q
-
P
V
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
---
S
L
I
--
D
A
G
M
L
V
T
N
----
R
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
---
A
W
R
A
L
E
T
A
L
P
YMT
D
---
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
-
Q
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
L
D
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
66.84
27%
-84
- C2 -
1DD9
1
DNAG_ECOLI
A:
[20-333]
------------------------------------------------------------------------------------------------------------------
T
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
-
Q
Q
P
V
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
---
S
L
I
--
D
A
G
M
L
V
T
N
R
----
S
Y
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
S
-
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
---
A
W
R
A
L
E
T
A
L
P
---
Y
MTD
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
S
T
-
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
T
L
R
I
Y
L
R
Q
E
L
G
N
K
L
G
I
L
D
D
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
62.14
34%
-84
- C2 -
3B39
1
DNAG_ECOLI
B:
[9-251]
-------------------------------------------------------------------------------------------------------------------
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q
P
V
-
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
---
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
S
L
I
--
D
A
G
M
L
V
T
N
D
Q
G
R
S
Y
-
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
---
D
---
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.21
34%
-84
- C2 -
1DD9
1
DNAG_ECOLI
A:
[21-263]
-------------------------------------------------------------------------------------------------------------------
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q
P
V
-
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
---
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
S
L
I
--
D
A
G
M
L
V
T
N
---
R
S
Y
-
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
---
D
---
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.08
34%
-81
- C2 -
1DDE
4
DNAG_ECOLI
A:
[21-263]
-------------------------------------------------------------------------------------------------------------------
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q
P
V
-
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
---
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
S
L
I
--
D
A
G
M
L
V
T
N
---
R
S
Y
-
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
---
D
---
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.45
34%
-84
- C2 -
3B39
1
DNAG_ECOLI
A:
[9-251]
-------------------------------------------------------------------------------------------------------------------
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
Q
P
V
-
A
T
S
A
R
Q
Y
L
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
P
G
---
W
D
N
V
L
K
R
F
G
G
N
P
E
N
R
Q
S
L
I
--
D
A
G
M
L
V
T
N
D
--
R
S
Y
-
D
R
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
-
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
---
D
---
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
50.58
53%
-73
- C2 -
1D0Q
1
DNAG_GEOSE
A:
[3-99]
-
H
R
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
K
A
G
V
D
L
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
49.43
53%
-72
- C2 -
1D0Q
1
DNAG_GEOSE
B:
[4-99]
--
R
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
K
A
G
V
D
L
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.35
53%
-69
- C2 -
1D0Q
1
DNAG_GEOSE
A:
[4-99]
--
R
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
K
A
G
V
D
L
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
48.50
50%
-63
- C2 -
1D0Q
1
DNAG_GEOSE
A:
[2-103]
G
H
R
I
P
E
E
T
I
E
A
I
R
R
G
V
D
I
V
D
V
I
G
E
Y
V
Q
L
K
R
Q
G
R
N
Y
F
G
L
C
P
F
H
G
E
K
T
P
S
F
S
V
S
P
E
K
Q
I
F
H
C
F
G
C
G
A
G
G
N
A
F
T
F
L
M
D
I
E
G
I
P
F
V
E
A
A
K
R
L
A
A
K
A
G
V
D
L
S
V
Y
E
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------