@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1394: (2016-03-25 )
MAKDMDTIVSLAKHRGFVFPGSDIYGGLSNTWDYGPLGVELKNNVKKAWWQKFITQSPFNVGIDAAILMNPKVWEASGHLNNFNDPMIDNKDSKIRYRADKLIEDYMQDVKGDENFIADGLSFEQMKKIIDDEGIVCPVSKTANWTEIRQFNLMFKTFQGVTEDSTNEIFLRPETAQGIFVNYKNVQRSMRKKLPFGIGQIGKSFRNEITPGNFIFRTREFEQMELEFFCKPGEEIEWQNYWKTFASDWLTSLNMSSENMRLRDHDEDELSHYSNATTDIEYKFPFGWGELWGIASRTDFDLRKHAEHSGEDFRYHDPETNEKYIPYCIEPSLGADRVTLAFLCDAYDEEGVEGSKDARTVLHFHPALAPYKAAILPLSKKLSGEAIKIFEQLSSKFSIDFDESQSIGKRYRRQDEIGTPYCVTFDFDSLEDNQVTVRDRDSMEQVRMPISELEAFLTEKTKF
Atome Classification :
(20 SA)
.........10........20.....---...30.-.......40........50........60........70....-.-...80...-.....90........100.......110-----------..-------------.......120.......130.......140.......150.......160.......170.......180.......190.......200....---...210.......220-.......230..-.------------------------------------------.------------------------------------------...240.---......250...-.....260.....---------------------------..270..---------------------------------....--.280----------------------------------.----.---..-----------------------------------------------------------------------....290---......-..--.300....---------------...---------------310------------------------------------------------------------------------.----........320.......330.......340......-.350.......360.......370...-------....--380-.----------........390---....--..---.------..--400--..--.--..-...410.......420.......430--------.--.--.---------.....440..--.....450.......460.----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAK
D
M
D
T
I
V
S
L
A
KHR
G
F
VFPG
S
D
IYG---GLSNTW-DYGPL
G
V
E
L
K
N
N
V
K
K
A
W
W
Q
K
F
I
TQSPFNVGI
D
A
A
I
L
MNPK
V
W
E-A-SGHLNNFN-DPMIDNKDS
K
I
R
Y
R
A
D
K
L
I
E
D
Y
M
Q
D
V-------------KG-------------DENFIADGL
S
F
E
Q
M
K
K
I
IDDEG
I
V
CPVSKTA
N
W
T
E
I
R
Q
F
N
L
M
F
K
T
FQGVTEDSTN
E
I
F
LRPETA
Q
G
I
F
V
N
Y
K
N
V
Q
R
S
M
R
K
KLPF
G
I
G
Q
I
G
K
S
F
R
---NEITPG
N
F
I
F
R
TRE
F
E
-
Q
M
E
L
E
F
FCKPGE-E------------------------------------------I------------------------------------------
E
W
Q
N
Y
W
K
---
T
F
A
S
D
W
L
T
-SLN-MSSENMRLRDH
D
E
---------------------------
D
E
L
S
HYS---------------------------------NA
T
T
--
D
I
E
-----------------------------------
Y
----
K
---FP-----------------------------------------------------------------------FG
W
G
E
-----
L
WGIAS-RT--
D
F
D
L
R
K
H
A---------------EHS---------------G--------------------------------------------------------------------------E----DFRYHDPETNE
K
Y
I
P
Y
C
IEPSLGAD
R
V
T
L
A
F
L
CDAYD-EEGVEGSKD
A
R
T
V
L
H
FHPALAP
Y
K
A
A
I-------L
P
L
S
--
K
---K----------LS
G
E
A
I
K
I
F
-----
E
Q
L
S
--
S
K---
F
------
S
I--DF---DE--
S
--
Q
S
-
I
G
K
R
Y
R
R
QDEIGT
P
Y
C
V
T
F
DFDSLE---------D--N--
Q
---------
V
T
VRDRD
S
M
E
--
Q
V
RM
P
I
S
E
L
E
A
F
L
T
EKTKF----------------------
24
HHSearch
91.47
46%
-73
- C1 -
1ATI
-
SYG_THET8
A:
[2-504]
-
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
N
--------------------------------------------------------------------------------
W
T
P
P
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
KDQEALGITARVLRN
E
H
S
---------------
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
-
P
N
G
E
E
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
-------
I
P
L
V
--
K
---
N
R
P
E
-------
I
T
E
Y
A
K
R
L
K
-----
A
R
L
L
A
-
L
G
---
L
G
-----
R
V
--
L
Y
---
E
D
--
T
--
G
N
-
I
G
K
A
Y
R
R
H
D
E
V
G
T
P
F
A
V
T
V
D
Y
D
T
I
G
QSKDGTTRL
K
--
D
--
T
---------
V
T
V
R
D
R
D
T
M
E
--
Q
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
-----------------------
1
PsiBlast_PDB
91.27
41%
-74
- C1 -
1ATI
-
SYG_THET8
A:
[2-505]
-
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
N
--------------------------------------------------------------------------------
W
T
P
P
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
KDQEALGITARVLRN
E
H
S
---------------
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
P
N
G
E
E
-
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
-------
I
P
L
V
--
K
---
N
-----------
R
P
E
I
T
E
Y
A
-----
K
R
L
K
--
A
R
---
L
L
A
L
GL
G
R
V
--
L
Y
---
E
D
--
T
--
G
N
-
I
G
K
A
Y
R
R
H
D
E
V
G
T
P
F
A
V
T
V
D
Y
D
T
I
G
---------
Q
--
S
--
K
DGTTRLKD
T
V
T
V
R
D
R
D
T
M
E
--
Q
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
W
----------------------
21
PsiBlast_CBE
91.20
41%
-74
- C1 -
1ATI
1
SYG_THET8
B:
[2-505]
-
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
---------------------------------------------------------------------------------
W
T
P
P
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
KDQEALGITARVLRN
E
H
S
---------------
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
P
N
G
E
E
-
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
-------
I
P
L
V
--
K
---
N
-----------
R
P
E
I
T
E
Y
A
-----
K
R
L
K
--
A
R
---
L
L
A
L
GL
G
R
V
--
L
Y
---
E
D
--
T
--
G
N
-
I
G
K
A
Y
R
R
H
D
E
V
G
T
P
F
A
V
T
V
D
Y
D
T
I
G
---------
Q
--
S
--
K
DGTTRLKD
T
V
T
V
R
D
R
D
T
M
E
--
Q
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
W
----------------------
23
PsiBlast_CBE
89.08
40%
-69
- C1 -
1B76
1
SYG_THET8
B:
[2-442]
-
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
N
--
A
K
A
R
Y
-------------------------------------------------------------------------
W
T
P
P
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
KDQEALGITARVLRN
E
H
S
---------------
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
P
N
G
E
E
-
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
-------
I
P
L
V
--
K
---
N
-----------
R
P
E
I
T
E
Y
A
-----
K
R
L
K
--
A
R
---
L
LALGLG
R
V
--
L
Y
---
E
D
--
T
--
G
N
-
I
G
K
A
Y
R
R
H
D
E
V
G
T
P
F
A
V
T
V
D
Y
D
T
I
G
---------
Q
--
S
--
K
DGTTRLKDT
V
T
V
R
D
R
D
T
M
E
--
Q
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
W
----------------------
22
PsiBlast_CBE
88.49
40%
-70
- C1 -
1GGM
1
SYG_THET8
B:
[2-442]
-
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
N
--
A
K
A
R
Y
-------------------------------------------------------------------------
W
T
P
P
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
KDQEALGITARVLRN
E
H
S
---------------
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
P
N
G
E
E
-
R
I
V
L
K
L
K
P
Q
L
A
P
I
K
V
A
V
-------
I
P
L
V
--
K
---
N
-----------
R
P
E
I
T
E
Y
A
-----
K
R
L
K
--
A
R
---
L
LALGLG
R
V
--
L
Y
---
E
D
--
T
--
G
N
-
I
G
K
A
Y
R
R
H
D
E
V
G
T
P
F
A
V
T
V
D
Y
D
T
I
G
---------
Q
--
S
--
K
DGTTRLKDT
V
T
V
R
D
R
D
T
M
E
--
Q
I
R
L
H
V
D
E
L
E
G
F
L
R
E
R
L
R
W
----------------------
25
HHSearch
84.03
35%
-66
- C1 -
2ZT5
1
SYG_HUMAN
A:
[66-657]
---
D
R
A
K
M
E
D
T
L
K
R
R
F
F
Y
D
Q
A
F
A
I
Y
G
---
G
V
S
G
L
Y
-
D
F
G
P
V
G
C
A
L
K
N
N
I
I
Q
T
W
R
Q
H
F
I
Q
E
-
E
Q
I
L
E
I
D
C
T
M
L
T
P
E
P
V
L
K
-
T
-
S
G
H
V
D
K
F
A
-
D
F
M
V
K
D
V
K
N
G
E
C
F
R
A
D
H
L
L
K
A
H
L
Q
K
L
M
S
DKKCS
V
E
K
K
S
E
M
E
-------------
S
V
L
A
Q
L
D
N
Y
G
Q
Q
E
L
A
D
L
F
V
N
Y
N
V
K
S
P
I
T
G
N
D
-
L
S
P
P
V
S
F
N
L
M
F
K
T
F
I
G
P
G
G
--
N
M
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
F
K
R
L
L
E
F
N
Q
G
K
L
P
F
A
A
A
Q
I
G
N
S
F
R
---
N
E
I
S
P
R
S
G
L
I
R
V
R
E
F
T
-
M
A
E
I
E
H
F
V
D
P
S
E
-
K
DHPKFQNVAD
L
H
L
Y
L
Y
S
A
K
A
Q
V
S
G
Q
S
A
R
KMR
L
G
D
A
V
E
Q
GVIN
N
------------------------------------------
T
V
L
G
Y
F
I
---
G
R
I
Y
L
Y
L
T
-
K
V
G
-
I
S
P
D
K
L
R
F
R
Q
H
M
E
---------------------------
N
E
M
A
H
Y
A
---------------------------------
C
D
C
W
--
D
A
E
-----------------------------------
S
----
K
---
T
S
-----------------------------------------------------------------------
Y
G
W
I
E
-----
I
V
G
C
A
D
-
R
S
--
C
Y
D
L
S
C
H
A
---------------
R
A
T
K
V
P
L
V
A
E
K
P----------------------------------------------------------------------------------------------
Y
V
E
E
V
V
P
N
V
I
E
P
S
F
G
L
G
R
I
M
Y
T
V
F
E
H
T
F
H
-
V
R
E
G
---
D
E
Q
R
T
F
F
S
F
P
A
V
V
A
P
F
K
C
S
V
-------
L
P
L
S
--
Q
---
N
QE--------
F
M
P
F
V
K
E
L
S
-----
E
A
L
T
R
-
H
G
---
V
------
S
H
--
K
V
---
D
D
--
S
S-
G
S
-
I
G
R
R
Y
A
R
T
D
E
I
G
V
A
F
G
V
T
I
D
F
D
T
V
N
KT-------
P
--
H
--
T
---------
A
T
L
R
D
R
D
S
M
R
--
Q
I
R
A
E
I
S
E
L
P
S
I
V
Q
D
L
A
N
-----------------------
44
Fugue
83.85
33%
-69
- C1 -
2PMF
2
SYG_HUMAN
A:
[63-674]
D
I
V
D
R
A
K
M
E
D
T
L
K
R
R
F
F
Y
D
Q
A
F
A
I
Y
G
---
G
V
S
G
L
Y
-
D
F
G
P
V
G
C
A
L
K
N
N
I
I
Q
T
W
R
Q
H
F
I
Q
E
E
Q
I
-
L
E
I
D
C
T
M
L
T
P
E
P
V
L
K
-
T
-
S
G
H
V
D
K
F
A
-
D
F
M
V
K
D
V
K
N
G
E
C
F
R
A
D
H
L
L
K
A
H
L
Q
K
L
-------------
M
S
DKKCS
V
E
K
K
S
E
M
E
S
V
L
A
Q
L
D
N
Y
G
Q
Q
E
L
A
D
L
F
V
N
Y
N
V
K
S
P
I
T
G
N
-
D
L
S
P
P
V
S
F
N
L
M
F
K
T
F
I
G
--
P
G
G
N
M
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
F
K
R
L
L
E
F
N
Q
G
K
L
P
F
A
A
A
Q
I
G
N
S
F
R
---
N
E
I
S
P
R
S
G
L
I
R
V
R
E
F
T
-
M
A
E
I
E
H
F
V
D
P
S
E
-
K
------------------------------------------
D
HPKFQNVAD
L
H
L
Y
L
Y
S
A
K
A
Q
V
S
GQ
S
A
R
K
M
R
L
G
D
A
V
E
Q
GVINN
T
V
L
G
Y
F
I
---
G
R
I
Y
L
Y
L
T
-
K
V
G
-
I
S
P
D
K
L
R
F
R
Q
H
--------------------------------
M
E
N
A
---------------------------------
C
D
C
W
--
D
A
E
-----------------------------------
S
----
K
---
T
S
-----------------------------------------------------------------------
Y
G
W
I
E
-----
I
V
G
C
A
D
-
R
S
--
C
Y
D
L
S
C
H
A
---------------
R
R
F
---------------
Q
--------------------------------------------------------------------------
K
----
T
L
------
Y
V
E
E
V
V
P
N
V
I
E
P
S
F
R
L
G
R
I
M
Y
T
V
F
E
H
T
F
H
-
V
R
E
---
G
D
E
Q
R
T
F
F
S
F
P
A
V
V
A
P
F
K
C
S
V
-------
L
P
L
S
--
Q
---
N
QE--------
F
M
P
F
V
K
E
L
S
-----
E
A
L
T
--
R
H
---
G
V
S
----
H
K
--
V
D
---
D
S
--
S
--
G
S
-
I
G
R
R
Y
A
R
T
D
E
I
G
V
A
F
G
V
T
I
D
F
D
T
V
N
---------
K
TP
H
--
T
---------
A
T
L
R
D
R
D
S
M
R
--
Q
I
R
A
E
I
S
E
L
P
S
I
V
Q
D
L
A
N
G
NIT
W
A
D
V
E
A
R
Y
P
L
F
E
G------
47
Fugue
79.08
36%
-60
- C1 -
4QEI
1
SYG_HUMAN
A:
[1-617]
-
I
V
D
R
A
K
M
G
D
T
L
K
R
R
F
F
Y
D
Q
A
F
A
I
Y
G
---
G
V
S
G
L
Y
-
D
F
G
P
V
G
C
A
L
K
N
N
I
I
Q
T
W
R
Q
H
F
I
Q
E
E
Q
I
-
L
E
I
D
C
T
M
L
T
P
E
P
V
L
K
-
T
-
S
G
H
V
D
K
F
A
-
D
F
M
V
K
D
V
K
N
G
E
R
F
R
A
D
H
L
L
K
A
H
L
Q
K
L
-------------
Q
-------------------------
Q
E
L
A
D
L
F
V
N
------------------
F
N
L
M
F
K
T
F
I
G
--
P
G
G
N
M
P
G
Y
L
R
P
E
T
A
Q
G
I
F
L
N
F
K
R
L
L
E
F
N
Q
G
K
L
P
F
A
A
A
Q
I
G
N
S
F
R
---
N
E
I
S
P
R
S
G
L
I
R
V
R
E
F
T
-
M
A
E
I
E
H
F
V
D
P
S
E
-
K
DH----------------------------------------
P
------------------------------------------
K
F
Q
N
V
A
D
L
H
L
Y
L
Y
S
A
K
A
Q
-
V
S
G
-
Q
S
A
R
K
M
R
L
G
D
A
V
E
Q
GVINN
T
V
L
G
Y
F
I
G
R
I
Y
L
Y
L
T
K
V
GISP
D
K
L
R
F
R
Q
---------------------------------
H
M
E
D
C
W
D
A
E
-----------------------------------
S
----
K
---
T
S
-----------------------------------------------------------------------
Y
G
W
I
E
-----
I
V
G
C
A
D
-
R
S
--
C
Y
D
L
S
C
H
A
---------------
R
A
T
---------------
K
V
P
L
V
A
E
K
P
L
K
E
P
K
T
V
N
V
V
Q
F
E
P
S
K
G
A
I
G
K
A
Y
KK
D
A
K
L
V
M
E
Y
L
AICD
E
C
Y
I
T
E
M
E
M
L
L
N
E
K
G
E
F
T
I
E
TQLTKDM
I
N
----
V
K
R
F
Q
K
T
L
Y
V
E
E
V
V
P
N
V
I
E
P
S
F
G
L
G
R
I
M
Y
T
V
F
E
H
T
F
H
-
V
R
E
---
G
D
E
Q
R
T
F
F
S
F
P
A
V
V
A
P
F
K
C
S
V
-------
L
P
L
S
QN
Q
---
E
----------
F
M
P
F
V
K
E
L
S
-----
E
A
L
T
--
R
H
G
V
S
H
------
K
V
--
D
----
D
S
--
S
--
G
S
-
I
G
R
R
Y
A
R
T
D
E
I
G
V
A
F
G
V
T
I
D
F
D
T
V
N
---------
K
--
T
P
H
T
---------
A
T
L
R
D
R
D
S
M
R
--
Q
I
R
A
E
I
S
E
L
P
S
I
V
Q
D
L
A
N
G
NIT
W
A
D
V
E
A
R
YPLFEGQETGKK
45
Fugue
73.36
48%
-66
- C1 -
1ATI
-
SYG_THET8
A:
[1-394]
A
A
S
S
L
D
E
L
V
A
L
C
K
R
R
G
F
I
F
Q
S
S
E
I
Y
G
---
G
L
Q
G
V
Y
-
D
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
R
N
V
Y
E
R
D
D
M
E
G
L
D
A
S
V
L
T
H
R
L
V
L
H
-
Y
-
S
G
H
E
A
T
F
A
-
D
P
M
V
D
N
W
T
P
P
--------------------------------------------------------------------------------
R
Y
F
N
M
M
F
Q
D
L
R
G
P
R
G
G
R
G
L
L
A
Y
L
R
P
E
T
A
Q
G
I
F
V
N
F
K
N
V
L
D
A
T
S
R
K
L
G
F
G
I
A
Q
I
G
K
A
F
R
---
N
E
I
T
P
R
N
F
I
F
R
V
R
E
F
E
-
Q
M
E
I
E
Y
F
V
R
P
G
E
-
D
------------------------------------------
E
------------------------------------------
Y
W
H
R
Y
W
V
---
E
E
R
L
K
W
W
Q
-
E
M
G
-
L
S
R
E
N
L
V
P
Y
Q
Q
P
P
---------------------------
E
S
S
A
H
Y
A
---------------------------------
K
A
T
V
--
D
I
L
-----------------------------------
Y
----
R
---
F
P
-----------------------------------------------------------------------
H
G
S
L
E
-----
L
E
G
I
A
Q
-
R
T
--
D
F
D
L
G
S
H
T
---------------
K
D
Q
EALGITARVLRNEHS
T
--------------------------------------------------------------------------
Q
----
R
L
A
Y
R
D
P
E
T
G
K
W
F
V
P
Y
V
I
E
P
S
A
G
V
D
R
G
V
L
A
L
L
A
E
A
F
T
-
R
E
E
L
P
-
N
G
E
E
R
I
V
L
K
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
61.15
23%
-54
- C1 -
1G5H
2
DPOG2_MOUSE
A:
[25-438]
-----
E
A
L
V
D
L
C
R
R
R
H
F
L
S
G
T
P
Q
Q
L
S
T
A
A
L
L
S
G
C
H
A
R
F
G
P
L
G
V
E
L
R
K
N
L
A
S
Q
W
W
S
S
M
V
V
F
R
E
Q
V
F
A
V
D
S
L
H
Q
E
P
G
S
S
Q
P
-
R
-
D
S
A
F
R
L
V
S
P
E
S
I
R
E
I
L
Q
D
------------------------------------------------------
S
K
E
Q
L
--------------------------
V
A
F
L
E
N
L
-----
L
K
T
S
G
K
L
R
A
T
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
R
K
L
P
F
G
L
A
Q
I
G
V
C
F
H
---
P
V
S
------
T
R
V
G
E
K
T
-
E
A
S
L
V
W
F
T
P
T
R
T
-
S
------------------------------------------
S
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
L
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
A
D
C
Q
D
---------------------------
E
-
L
---
G
---------------------------------
R
K
G
S
--
K
L
Y
-----------------------------------
Y
----
S
---
F
P
-----------------------------------------------------------------------
W
G
K
E
P
-----
I
E
T
L
W
N
-
L
G
--
D
Q
E
L
L
H
T
Y
---------------
P
-----------------
G
--------------------------------------------------------------------------
N
----
V
S
T
I
Q
G
R
D
G
R
K
N
V
V
P
C
V
L
S
V
S
G
D
V
D
L
G
T
L
A
Y
L
Y
D
S
F
Q
-
L
---------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
L
-------
D
V
G
K
--
G
P
T
V
E
----------
L
R
Q
V
C
Q
G
L
L
-----
N
E
L
L
E
-
N
G
---
I
------
S
V
--
W
P
GY-
S
E
TV
H
--
S
S
-
L
E
Q
L
H
S
K
Y
D
E
M
S
V
L
F
S
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
Q
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
R
D
F
L
V
K
Y
L
A
-----------------------
26
HHSearch
60.17
24%
-56
- C1 -
3IKL
-
DPOG2_HUMAN
A:
[66-480]
----
S
E
A
L
L
E
I
C
Q
R
R
H
F
L
S
G
S
K
Q
Q
L
S
R
D
S
L
L
S
G
C
H
P
G
F
G
P
L
G
V
E
L
R
K
N
L
A
A
E
W
W
T
S
V
V
V
F
R
E
Q
V
F
P
V
D
A
L
H
H
K
P
G
P
L
L
P
----
G
D
------------
S
----------------------------------------------------------------------------------------------------
A
F
R
G
G
-
R
E
N
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
K
R
L
P
Y
G
L
A
Q
I
G
V
C
F
H
---
P
-------
V
K
S
I
G
E
K
T
-
E
A
S
L
V
W
F
T
P
P
R
T
-
S
------------------------------------------
N
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
Q
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
S
D
C
Q
D
---------------------------
E
--
E
--
G
---------------------------------
R
K
G
N
--
K
L
Y
-----------------------------------
Y
----
N
---
F
P
-----------------------------------------------------------------------
W
G
K
E
L
-----
I
E
T
L
W
N
-
L
G
--
D
H
E
L
L
H
M
Y
---------------
P
G
N
---------------
V
--------------------------------------------------------------------------
S
----
K
L
H
G
R
D
--
G
R
K
N
V
V
P
C
V
L
S
V
N
G
D
L
D
R
G
M
L
A
Y
L
Y
D
S
F
Q
-----------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
L
-------
D
V
G
R
--
G
PT
L
E
----------
L
R
Q
V
C
Q
G
L
F
-----
N
E
L
L
E
-
N
G
---
I
------
S
V
--
W
P
GYL
E
T
--
M
Q-
S
S
-
L
E
Q
L
Y
S
K
Y
D
E
M
S
I
L
F
T
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
H
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
K
D
F
L
I
K
Y
I
S
-----------------------
5
PsiBlast_PDB
58.46
23%
-60
- C1 -
1G5I
2
DPOG2_MOUSE
A:
[57-435]
-------------------------------------
F
G
P
L
G
V
E
L
R
K
N
L
A
S
Q
W
W
S
S
M
V
V
F
R
E
Q
V
F
A
V
D
S
-
L
H
Q
E
P
------------
G
S
S
-
Q
P
----
R
D
S
A
F
R
L
V
S
P
E
S
I
R
E
I
L
Q
D
-----------------------------
S
K
---------
E
Q
L
V
A
F
L
E
N
---------------------
L
L
K
T
S
G
K
----------
L
R
A
T
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
R
K
L
P
F
G
L
A
Q
I
G
V
C
F
H
P
V
S---------
T
R
V
G
E
K
T
-
E
A
S
L
V
W
F
T
P
T
R
T
-
S
------------------------------------------
S
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
L
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
A
D
-
C
Q
---------------------------
D
E
L
G
R
K
G
------------------------------------
S
--
K
L
Y
-----------------------------------
Y
----
S
---
F
P
-----------------------------------------------------------------------
W
G
K
E
P
-----
I
E
T
L
W
N
-
L
G
--
D
Q
E
L
L
H
T
Y
---------------
P
G
N
---------------
V
--------------------------------------------------------------------------
S
----
T
I
Q
G
R
D
G
R
K
N
--
V
V
P
C
V
L
S
V
S
G
D
V
D
L
G
T
L
A
Y
L
Y
D
S
F
Q
L----------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
--------
L
D
V
G
--
K
---
G
----------
P
T
V
E
L
R
Q
V
C
Q
G
L
L
N
E
L
L
E
--
N
G
---
I
------
S
V
W
P
G
Y
---
S
E
--
T
VH
S
S
-
L
E
Q
L
H
S
K
Y
D
E
M
S
V
L
F
S
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
Q
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
R
D
F
L
V
K
--------------------------
6
PsiBlast_PDB
57.46
22%
-57
- C1 -
1G5H
2
DPOG2_MOUSE
A:
[57-435]
-------------------------------------
F
G
P
L
G
V
E
L
R
K
N
L
A
S
Q
W
W
S
S
M
V
V
F
R
E
Q
V
F
A
V
D
S
-
L
H
Q
E
P
------------
G
S
S
-
Q
P
----
R
D
S
A
F
R
L
V
S
P
E
S
I
R
E
I
L
Q
D
-----------------------------
S
K
---------
E
Q
L
V
A
F
L
E
N
---------------------
L
L
K
T
S
G
K
----------
L
R
A
T
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
R
K
L
P
F
G
L
A
Q
I
G
V
C
F
H
P
V
S---------
T
R
V
G
E
K
T
-
E
A
S
L
V
W
F
T
P
T
R
T
-
S
------------------------------------------
S
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
L
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
A
D
-
C
Q
---------------------------
D
E
L
G
R
K
G
------------------------------------
S
--
K
L
Y
-----------------------------------
Y
----
S
---
F
P
-----------------------------------------------------------------------
W
G
K
E
P
-----
I
E
T
L
W
N
-
L
G
--
D
Q
E
L
L
H
T
Y
---------------
P
G
N
---------------
V
--------------------------------------------------------------------------
S
----
T
I
Q
G
R
D
G
R
K
N
--
V
V
P
C
V
L
S
V
S
G
D
V
D
L
G
T
L
A
Y
L
Y
D
S
F
Q
L----------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
--------
L
D
V
G
--
K
---
G
----------
P
T
V
E
L
R
Q
V
C
Q
G
L
L
N
E
L
L
E
--
N
G
---
I
------
S
V
WP
G
Y
---
S
E
--
T
VH
S
S
-
L
E
Q
L
H
S
K
Y
D
E
M
S
V
L
F
S
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
Q
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
R
D
F
L
V
K
--------------------------
31
HHSearch
55.00
18%
-54
- C1 -
1HC7
-
SYP_THET8
A:
[17-386]
------
W
Y
L
E
V
I
Q
K
A
E
L
A
D
Y
G
P
--------
V
R
G
T
I
-
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
K
E
--
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
----------
F
S
-
P
E
L
A
V
V
T
H
A
G
G
--------
E
-------------------------------------------------------------------------------------
E
L
E
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
I
R
S
W
-
R
D
L
P
Q
L
L
N
Q
W
G
N
V
V
R
---
W
E
M
R
-
T
R
P
F
L
R
T
S
E
F
L
-
W
Q
E
G
H
T
A
H
A
T
R
E
E
A
------------------------------------------
E
------------------------------------------
E
E
V
R
R
M
L
---
S
I
Y
A
R
L
A
R
-
E
Y
A
A
I
P
V
---
I
E
G
L
K
T
E
---------------------------
K
E
K
F
A
G
A
---------------------------------
V
Y
T
T
--
T
I
E
-----------------------------------
A
----
L
---
M
K
-----------------------------------------------------------------------
D
G
K
---------
A
L
Q
A
-
G
T
--
S
H
Y
L
G
E
-----------------
N
F
A
R
--------------
A
--------------------------------------------------------------------------
F
----
D
I
K
F
Q
D
-
R
D
L
Q
V
K
Y
V
H
T
T
S
W
G
L
S
-
W
R
F
I
G
A
I
I
M
T
H
G
D
-
D
----------
R
G
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
-------
V
P
I
Y
--
K
---
D
ES
R
E
R
-----
V
L
E
A
A
Q
G
L
R
-----
Q
A
L
L
A
-
Q
G
---
L
------
R
V
--
H
L
---
D
D
--
R
DQ
H
T
-
P
G
Y
K
F
H
E
W
E
L
K
G
V
P
F
R
V
E
L
G
P
K
D
L
E
---------
G
--
G
--
Q
---------
A
V
L
A
S
R
L
G
G
---
K
E
T
L
P
L
A
A
L
P
E
A
L
P
G
K
L
D
-----------------------
30
HHSearch
54.96
18%
-54
- C1 -
3IAL
5
?
A:
[28-408]
-------
F
D
A
I
M
D
A
A
E
L
V
D
R
R
Y
-------
P
V
K
G
C
V
-
V
F
R
P
Y
G
F
F
M
E
N
A
I
M
R
L
C
E
E
E
Y
A
K
--
V
G
I
S
Q
I
L
F
P
T
V
I
P
E
S
F
L
K
-
K
E
S
D
H
I
K
G
F
E
-
A
E
C
F
W
V
E
K
G
G
L
--------
Q
-------------------------------------------------------------------------------------
P
L
E
E
R
L
A
L
R
P
T
S
E
T
A
I
Y
S
M
F
S
K
W
V
R
S
Y
-
K
D
L
P
L
K
I
H
Q
T
C
T
I
F
R
---
H
E
T
K
N
T
K
P
L
I
R
V
R
E
I
H
-
W
N
E
A
H
C
C
H
A
T
A
E
D
A
------------------------------------------
V
------------------------------------------
S
Q
L
S
D
Y
W
---
K
V
I
D
T
I
F
S
D
E
L
C
-
F
K
G
Q
K
L
R
R
V
C
------------------------------
W
D
R
F
P
G
A
---------------------------------
D
Y
S
E
--
V
S
D
-----------------------------------
V
----
V
---
M
P
-----------------------------------------------------------------------
C
G
---------
R
V
L
Q
T
-
A
G
--
I
H
N
L
G
Q
-----------------
R
F
S
S
--------------
T
--------------------------------------------------------------------------
F
----
D
I
L
Y
A
N
-
K
A
N
E
S
V
H
P
Y
L
T
C
A
G
I
S
-
T
R
V
L
A
C
A
L
S
I
H
G
D
-
S
----------
G
G
L
V
L
P
P
L
I
A
P
I
H
V
V
I
-------
I
P
I
G
--
C
---
G
KKNN
Q
E
S
D
Q
Q
V
L
G
K
V
N
E
I
A
-----
D
T
L
K
SK
L
G
---
L
------
R
V
--
S
I
---
D
D
--
D
FS
K
S
-
M
G
D
K
L
Y
Y
Y
E
L
K
G
V
P
L
R
I
E
V
G
Q
R
D
L
A
---------
N
--
G
--
Q
---------
C
I
V
V
P
R
D
V
G
K
DQ
K
R
V
I
P
I
T
E
V
M
-------------------------------
38
HHSearch
54.73
15%
-57
- C1 -
2J3L
11
SYP_ENTFA
A:
[21-565]
------
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
V
---------
A
A
G
I
Y
-
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
--
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
-
E
-
S
G
R
Y
E
T
Y
G
-
P
N
L
Y
R
L
K
D
R
N
-------------------------------------------------------------------------------------------------
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
-
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
---
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
-
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
------------------------------------------
D
------------------------------------------
Q
S
Y
R
D
Y
E
---
K
A
Y
S
R
I
F
E
-
R
C
G
-
L
E
-
F
R
A
I
I
G
D
G
G
A
MGG
K
D
S
K
E
F
M
AISEIG-----------
E
D
T
I
C
Y
S
TESD
Y
A
A
N
LEMATSLYTPKKSH
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
--
T
I
A
E
V
A
N
F
F
EVEPQR
I
I
K
S
V
L
F
I
A
DE
E
P
V
M
V
L
V
RGD
H
D
V
N
D
V
K
L
K
N
F
L
G
ADFLDEAT
E
E
D
A
R
R
V
LGAGFGSIGPVNVSED
V
K
I
Y
A
D
L
A
V
Q
D
LAN
A
I
V
G
ANEDG
Y
H
L
T
NVNPDRDFQPISY
E
D
L
R
F
-----
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
EI
G
H
I
F
K-------
L
G
T
---------------
R
--------------------------------------------------------------------------
Y
S
D
A
M
G
A
T
V
L
D
-
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
-
E
----------
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
-------
V
Q
M
N
--
V
KD-
E
Y
---------
Q
T
K
L
S
Q
E
V
E
-----
A
M
M
T
E
-
A
G
---
Y
------
E
V
--
L
V
---
D
D
--
R
N-
E
R
-
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
------------
G
--
V
---------
V
E
V
K
I
K
R
T
G
E
--
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
------------------------
28
HHSearch
53.82
17%
-51
- C1 -
1NJ1
2
SYP_METTH
A:
[46-413]
---------
N
I
L
E
E
A
E
I
I
D
Q
R
Y
-------
P
V
K
G
M
H
-
V
W
M
P
H
G
F
M
I
R
K
N
T
L
K
I
L
R
R
I
L
-
D
--
R
D
H
E
E
V
L
F
P
L
L
V
P
E
D
E
L
A
K
E
-
A
I
H
V
K
G
F
E
-
D
E
V
Y
W
V
T
H
G
G
L
----
S
-----------------------------------------------------------------------------------------
K
L
Q
R
K
L
A
L
R
P
T
S
E
T
V
M
Y
P
M
F
A
L
W
V
R
S
H
-
T
D
L
P
M
R
F
Y
Q
V
V
N
T
F
R
---
Y
E
T
K
H
T
R
P
L
I
R
V
R
E
I
T
T
F
K
E
A
H
T
I
H
A
T
A
S
E
A
------------------------------------------
E
------------------------------------------
E
Q
V
E
R
A
V
---
E
I
Y
K
E
F
F
N
-
S
L
G
-
I
P
Y
---
L
I
T
R
R
P
P
---------------------------
W
D
K
F
P
G
S
---------------------------------
E
Y
T
V
--
A
F
D
-----------------------------------
T
----
L
---
M
P
-----------------------------------------------------------------------
D
G
---------
K
T
L
Q
I
-
G
T
--
V
H
N
L
G
Q
T
----------------
F
A
R
---------------
T
--------------------------------------------------------------------------
F
----
E
I
K
F
E
T
-
P
E
G
D
H
E
Y
V
H
Q
T
C
Y
G
L
S
-
D
R
V
I
A
S
V
I
A
I
H
G
D
-
E
----------
S
G
L
C
L
P
P
D
V
A
A
H
Q
V
V
I
-------
V
P
I
I
--
F
---
K
KA
A
E
E
-----
V
M
E
A
C
R
E
L
R
-----
S
R
L
E
A
-
A
G
---
F
------
R
V
--
H
L
---
D
D
--
R
D-
I
R
-
A
G
R
K
Y
Y
E
W
E
M
R
G
V
P
L
R
V
E
I
G
P
R
D
L
E
---------
K
--
G
--
A
---------
A
V
I
S
R
R
D
T
G
E
--
K
V
T
A
D
L
Q
G
I
E
E
T
L
R
E
L
M
K
-----------------------
29
HHSearch
53.53
19%
-50
- C1 -
1NJ8
-
SYP_METJA
A:
[6-376]
------
W
Y
S
D
I
L
E
K
A
E
I
Y
D
V
R
Y
-------
P
I
K
G
C
G
-
V
Y
L
P
Y
G
F
K
I
R
R
Y
T
F
E
I
I
R
N
L
L
D
E
--
S
G
H
D
E
A
L
F
P
M
L
I
P
E
D
L
L
A
-
K
E
A
E
H
I
K
G
F
E
-
D
E
V
Y
W
V
T
H
G
G
K
--------
T
-------------------------------------------------------------------------------------
Q
L
D
V
K
L
A
L
R
P
T
S
E
T
P
I
Y
Y
M
M
K
L
W
V
K
V
H
-
T
D
L
P
I
K
I
Y
Q
I
V
N
T
F
R
---
Y
E
T
K
H
T
R
P
L
I
R
L
R
E
I
M
T
F
K
E
A
H
T
A
H
S
T
K
E
E
A
------------------------------------------
E
------------------------------------------
N
Q
V
K
E
A
I
---
S
I
Y
K
K
F
F
D
-
T
L
G
-
I
P
Y
L
---
I
S
K
R
P
E
---------------------------
W
D
K
F
P
G
A
---------------------------------
E
Y
T
M
--
A
F
D
-----------------------------------
T
----
I
---
F
P
-----------------------------------------------------------------------
D
G
R
---------
T
M
Q
I
-
A
T
--
V
H
N
L
G
Q
-----------------
N
F
S
K--------------
T
--------------------------------------------------------------------------
F
----
E
I
I
F
E
T
-
P
T
G
D
K
D
Y
A
Y
Q
T
C
Y
G
I
S
-
D
R
V
I
A
S
I
I
A
I
H
G
D
-
E
----------
K
G
L
I
L
P
P
I
V
A
P
I
Q
V
V
I
-------
V
P
L
I
--
F
---
K
GK
E
D
I
-----
V
M
E
K
A
K
E
I
Y
-----
E
K
L
K
--
G
K
---
F
------
R
V
--
H
I
---
D
D
--
R
D-
I
R
-
P
G
R
K
F
N
D
W
E
I
K
G
V
P
L
R
I
E
V
G
P
K
D
I
E
---------
N
--
K
--
K
---------
I
T
L
F
R
R
D
T
M
E
--
K
F
Q
V
D
E
T
Q
L
M
E
V
V
E
K
T
L
N
-----------------------
3
PsiBlast_PDB
51.97
22%
-45
- C1 -
2G4C
-
DPOG2_HUMAN
A:
[99-477]
-------------------------------------
F
G
P
L
G
V
E
L
R
K
N
L
A
A
E
W
W
T
S
V
V
V
F
R
E
Q
V
F
P
V
D
A
----------------
L
H
H
K
P
-
G
P
L
L
P
G
-
D
S
A
F
R
L
V
S
A
E
T
L
R
E
I
L
Q
D
K
-------------
E
----------------------
L
S
K
E
Q
L
V
T
F
L
E
N
------
V
L
K
T
S
G
-------------------------
K
L
R
E
N
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
K
R
L
P
Y
G
L
A
Q
I
G
V
C
F
H
P
----------
V
K
S
I
G
E
K
T
-
E
A
S
L
V
W
F
T
P
P
R
T
-
S
------------------------------------------
N
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
Q
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
S
D
C
Q
D
---------------------------
E
E
----
G
---------------------------------
R
K
G
N
--
K
L
Y
-----------------------------------
Y
----
N
---
F
P
-------------------------------------------------------------------------
W
G
K
E
L
I
E
T
L
W
N
L
G
D
-
H
E
--
L
L
H
M
--------------------
Y
P
---------------
G
--------------------------------------------------------------------------
N
----
V
S
K
L
H
G
R
D
G
R
K
N
V
V
P
C
V
L
S
V
N
G
D
L
D
R
G
M
L
A
Y
L
Y
D
S
F
Q
-----------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
L
D
V
G
RGPT
L
E
L
R
--
Q
---
V
----------
C
Q
G
L
F
N
E
L
L
-----
E
N
G
I
--
S
V
---
W
------
P
G
--
Y
L
---
E
T
--
M
--
Q
S
S
L
E
Q
L
Y
S
K
Y
D
E
M
S
I
L
F
T
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
H
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
K
D
F
L
I
K
--------------------------
2
PsiBlast_PDB
50.89
22%
-47
- C1 -
3IKM
-
?
B:
[99-477]
-------------------------------------
F
G
P
L
G
V
E
L
R
K
N
L
A
A
E
W
W
T
S
V
V
V
F
R
E
Q
V
F
P
V
D
A
----------------
L
H
H
K
P
-
G
P
-----------------------------------------------------------------------------------
G
-------------------------
K
L
R
E
N
L
L
H
G
A
L
E
H
Y
V
N
C
L
D
L
V
N
K
R
L
P
Y
G
L
A
Q
I
G
V
C
F
H
P
----------
V
K
S
I
G
E
K
T
-
E
A
S
L
V
W
F
T
P
P
R
T
-
S
------------------------------------------
N
------------------------------------------
Q
W
L
D
F
W
L
---
R
H
R
L
Q
W
W
R
-
K
F
A
-
M
S
P
S
N
F
S
S
S
D
C
Q
D
---------------------------
E
E
----
G
---------------------------------
R
K
G
N
--
K
L
Y
-----------------------------------
Y
----
N
---
F
P
-------------------------------------------------------------------------
W
G
K
E
L
I
E
T
L
W
N
L
G
D
-
H
E
--
L
L
H
M
--------------------
Y
P
---------------
G
--------------------------------------------------------------------------
N
----
V
S
K
L
H
G
R
D
G
R
K
N
V
V
P
C
V
L
S
V
N
G
D
L
D
R
G
M
L
A
Y
L
Y
D
S
F
Q
-----------
R
K
V
L
K
L
H
P
C
L
A
P
I
K
V
A
L
D
V
G
RGPT
L
E
L
R
--
Q
---
V
----------
C
Q
G
L
F
N
E
L
L
-----
E
N
G
I
--
S
V
---
W
------
P
G
--
Y
L
---
E
T
--
M
--
Q
S
S
L
E
Q
L
Y
S
K
Y
D
E
M
S
I
L
F
T
V
L
V
T
E
T
T
L
E
---------
N
--
G
--
L
---------
I
H
L
R
S
R
D
T
T
M
--
K
E
M
M
H
I
S
K
L
K
D
F
L
I
K
--------------------------