@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1409: (2016-03-25 )
MSKIIGIDLGTTNSCVTVLEGDEPKVIQNPEGSRTTPSVVAFKNGETQVGEVAKRQAITNPNTVQSIKRHMGTDYKVDIEGKSYTPQEISAMILQNLKNTAESYLGEKVDKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDKDEKVLVFDLGGGTFDVSILELGDGVFEVLSTAGDNKLGGDDFDQVIIDYLVAEFKKENGVDLSQDKMALQRLKDAAEKAKKDLSGVSQTQISLPFISAGENGPLHLEVNLTRSKFEELSDSLIRRTMEPTRQAMKDAGLTNSDIDEVILVGGSTRIPAVQEAVKKEIGKEPNKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIEILGGRMNTLIERNTTIPTSKSQIYSTAVDNQPSVDVHVLQGERPMAADNKTLGRFQLTDIPPAERGKPQIEVTFDIDKNGIVNVTAKDLGTNKEQRITIQSSSSLSDEEIDRMVKDAEVNAEADKKRREEVDLRNEADSLVFQVEKTLTDLGENIGEEDKKSAEEKKDALKTALEGQDIEDIKSKKEELEKVIQELSAKVYEQAAQQQQQAQGANAGQNNDSTVEDAEFKEVKDDDKK
Atome Classification :
(92 SA)
...--......10........20........30........40.-.--......50........60-.-.......70....-------------------------.------------------------.---------------------------..----80---.------------........90........100.......110.......120.......130.......140.......150....--.---.---.160.-......170.......180---........190--.......200.......210.......220.......230.......240.....--..250.......260.......270.......280.-......290.......300.......310.......320.....-.-.330.......340.......350...----....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.-......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
--
I
I
G
I
D
LGTTN
S
C
V
T
V
LEGDEP
K
V
I
QNPEGSRTT
P
S
V
V
A
F-K--NGE
T
Q
V
G
E
V
A
K
R
QAITN
P
-
N
-
T
V
Q
S
I
K
R
HMGT
D
Y
-------------------------
K
------------------------
V
---------------------------
D
I----E----G------------KSY
T
P
Q
E
I
S
A
M
I
L
Q
N
L
K
N
T
A
E
S
Y
L
G
E
KVD
K
A
V
I
T
VPAYFN
D
A
E
R
Q
A
TKDAGKIAGL
E
V
E
R
I
INEP
T
A
A
A
L
A
YGLD--K---T---DKD
E
K
-
V
L
V
F
DLGG
G
T
F
D
V
S
I
L
EL----G
D
G
V
F
E
V
L
S
TA--GDNKLG
G
D
D
F
D
Q
V
I
I
D
Y
L
V
A
E
F
K
KENGVDL
S
Q
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
D
LSGVS--Q
T
Q
I
S
L
P
F
I
SAGENG
P
L
H
L
E
V
NL
T
R
S
K
F
E
E
L
S
D
S
L
I
-
R
R
T
M
E
P
T
R
Q
A
M
K
DAGLTNSDI
D
E
V
I
L
VGGSTR
I
P
A
V
Q
E
A
V
K
K
E
I-G-KEPNKGV
N
P
D
E
V
V
A
MGAAIQG
G
V
I
TGD----V
K
D
V
V
L
L
DV
T
P
L
S
L
G
I
E
I
LG
G
R
M
N
T
L
IERNTTIPTSKS
Q
I
Y
S
TAVDNQP
S
V
D
V
H
V
LQGERPMAADNKTLG
R
F
QLTDIPPAERGK
P
Q
I
E
V
T
F
DIDKN
G
I
V
N
V
T
A
K
DLGTNK
E
Q
R
I
T
I
QS-SSSL
S
D
E
E
I
D
R
M
V
K
D
AEVN
A
E
A
D
K
K
R
R
E
E
VDLRN
E
A
D
S
L
V
F
Q
V
E
K
T
L
T
D
L
G
E
NIG
E
E
D
K
K
S
A
E
E
K
K
D
A
L
K
T
ALEGQ
D
I
E
D
I
K
S
K
K
E
E
L
E
K
V
I
Q
E
L
S
A
K
V
Y
E
Q
A
A
Q
Q
Q
Q
Q
AQGANAGQNNDSTVE
D
A
E
F
K
E
VKDDDKK
112
HHSearch
94.40
82%
-65
- C3 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
-------------------------
K
------------------------
V
---------------------------
E
I
----
E
----
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
E
----
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
A
T
A
--
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
--
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
---------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.40
81%
-66
- C2 -
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
-------------------------
K
------------------------
V
---------------------------
E
I
----
E
----
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-------
E
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
A
T
A
--
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
--
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.05
81%
-64
- C3 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
-------------------------
K
------------------------
V
---------------------------
E
I
----
E
----
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-------
E
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
A
T
A
--
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
--
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
---------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.89
55%
-59
- C2 -
4B9Q
1
DNAK_ECOLI
A:
[3-602]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
-----
E
I
A
---------------------------------
22
PsiBlast_CBE
90.49
55%
-56
- C2 -
4JN4
12
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
------------------------------------------
21
PsiBlast_CBE
90.30
55%
-54
- C2 -
4JNE
11
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
------------------------------------------
4
PsiBlast_PDB
90.17
55%
-57
- C2 -
4JN4
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
------------------------------------------
5
PsiBlast_PDB
89.73
55%
-56
- C2 -
4JNE
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
------------------------------------------
3
PsiBlast_PDB
89.57
56%
-62
* C3 *
2KHO
-
DNAK_ECOLI
A:
[4-603]
-----
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
IMP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
---
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
-----
E
I
A
Q
--------------------------------
7
PsiBlast_PDB
86.46
50%
-64
- C2 -
3C7N
9
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
YKG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.79
49%
-55
- C2 -
1YUW
-
HSP7C_BOVIN
A:
[1-553]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
------------------------------------------------------------------------------------------
102
Fugue
76.59
61%
-72
- C2 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
QD-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
-
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
QDEEVQRDVSIMPFKIIAADNGDA-
W
------------------------
V
---------------------------
E
V
-----KG---------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
--------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
----
D
E
K
T
F
E
V
L
A
--TN
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
--AQ
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G--
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
75.76
50%
-64
- C2 -
3GL1
6
HSP75_YEAST
A:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
-
S
S
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
-------------------------
D
D
E
S
V
Q
K
D
M
K
T
WP
F
K
V
---------
I
---------------------------
D
V
----
D
----
G
N
P
V
I
E
V
Q
Y
LE
E
T
K
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
---
S
---
E
K
E
R
H
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
K
S
T
S
--
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
T
--
Q
T
T
V
E
V
D
S
L
F
D
G
E
D
----
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
F
D
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
75.62
50%
-68
- C2 -
1HJO
2
HS71A_HUMAN
A:
[5-380]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
75.31
50%
-70
- C2 -
3A8Y
1
HS71A_HUMAN
A:
[11-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
MKHWP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.15
50%
-63
- C2 -
3GL1
7
HSP75_YEAST
B:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
-
S
S
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
-------------------------
D
D
E
S
V
Q
K
D
M
K
T
WP
F
K
V
---------
I
---------------------------
D
V
----
D
----
G
N
P
V
I
E
V
Q
Y
LE
E
T
K
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
---
S
---
E
K
E
R
H
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
K
S
T
S
--
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
T
--
Q
T
T
V
E
V
D
S
L
F
D
G
E
D
----
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
F
D
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.15
55%
-70
- C2 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
V
----
K
----
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-------
T
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D----
E
K
T
F
E
V
L
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
--
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
75.08
50%
-72
- C2 -
3D2F
2
HS71A_HUMAN
D:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GDPVVQSDMKHWPFQVINDGDKP--
K
------------------------
V
---------------------------
Q
V
SYKG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
75.05
50%
-67
- C2 -
2E88
1
HS71A_HUMAN
A:
[10-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
75.03
48%
-73
- C2 -
3FZM
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
YKG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
74.97
48%
-73
- C2 -
3LDQ
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.90
50%
-66
- C2 -
3LDP
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
---------------------------
D
I
----
G
----
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
74.81
49%
-65
- C2 -
4IO8
1
HS71A_HUMAN
A:
[7-379]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
Y
----
K
----
G
D
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
74.78
50%
-64
- C2 -
3ATU
4
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.69
50%
-65
- C2 -
3IUC
2
GRP78_HUMAN
A:
[28-404]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
---------------------------
D
I
----
G
----
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
74.51
50%
-60
- C2 -
3FE1
4
HSP76_HUMAN
B:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
AD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
--
K
------------------------
V
---------------------------
R
V
C
Y
RG
E
----
D
------------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.47
50%
-64
- C2 -
3ATV
3
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
74.33
48%
-69
- C2 -
1NGF
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
74.31
48%
-71
- C2 -
3FZH
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.29
47%
-68
- C2 -
2QWN
5
HSP7C_BOVIN
A:
[3-385]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.24
50%
-66
- C2 -
2E8A
2
HS71A_HUMAN
A:
[10-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.24
50%
-62
- C2 -
3FE1
2
HSP76_HUMAN
C:
[24-402]
-
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
AD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
--
K
------------------------
V
---------------------------
R
V
C
Y
RG
E
----
D
------------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.22
50%
-65
- C2 -
3AY9
5
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
74.17
47%
-67
- C2 -
2QWQ
5
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
74.07
48%
-69
- C2 -
1NGH
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
73.96
48%
-72
- C2 -
3FZF
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.93
50%
-64
- C2 -
3JXU
2
HS71A_HUMAN
A:
[29-403]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
73.92
48%
-66
- C2 -
3I33
3
HSP72_HUMAN
A:
[26-402]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
I
F
D
A
K
R
L
I
G
R
K
F
ED
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KGE
T
------------
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
KGC
A
---
G
G
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.86
48%
-69
- C2 -
1KAZ
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
E
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
73.83
48%
-72
- C2 -
3FZK
3
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.82
50%
-62
- C2 -
3IUC
3
GRP78_HUMAN
C:
[28-406]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
I
----
G
----
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
--------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
73.77
48%
-70
- C2 -
1ATS
2
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.76
48%
-70
- C2 -
1NGA
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.76
47%
-67
- C2 -
2QWP
7
HSP7C_BOVIN
A:
[4-389]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.76
50%
-63
- C2 -
3FE1
2
HSP76_HUMAN
A:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
AD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
--
K
------------------------
V
---------------------------
R
V
C
Y
RG
E
----
D
------------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
---
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.75
50%
-66
- C2 -
4J8F
14
F10A1_RAT (first)
A:
[14-389]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.74
47%
-64
- C2 -
2QWO
7
HSP7C_BOVIN
A:
[4-390]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
73.74
47%
-66
- C2 -
2QWR
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
73.74
48%
-70
- C2 -
1NGI
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.73
49%
-63
- C2 -
3QFU
3
GRP78_YEAST
A:
[20-394]
-----
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
-
T
I
F
D
I
K
R
L
I
G
L
K
Y
ND
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
------------------------
V
---------------------------
S
V
----
K
----
G
E
K
----------
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
S
---
D
K
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
A
T
S
--
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
--
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.67
50%
-65
- C2 -
3LDL
2
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
I
----
G
----
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
73.66
53%
-60
* C2 *
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
--
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
-
T
I
F
D
I
K
R
L
I
G
L
K
Y
-------------------------
N
------------------------
D
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
K
G
----
E
----
K
------------
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
S
---
D
K
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
A
T
S
--
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
--
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.62
48%
-68
- C2 -
3HSC
5
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
73.61
48%
-70
- C2 -
1NGE
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
73.60
52%
-64
- C2 -
3I33
3
HSP72_HUMAN
A:
[23-401]
-
M
P
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
I
F
D
A
K
R
L
I
G
R
K
F
-------------------------
E
------------------------
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K
G
----
E
----
T
------------
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
GCA
G
G
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.59
48%
-69
- C2 -
1NGG
1
HSP7C_BOVIN
A:
[3-381]
--
K
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
73.56
48%
-67
- C2 -
4H5T
3
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.53
48%
-70
- C2 -
1NGB
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
73.52
48%
-71
- C2 -
3M3Z
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KGE
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
73.51
48%
-70
- C2 -
3GDQ
3
HS71L_HUMAN
A:
[31-406]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
ND
P
V
V
Q
A
D
M
K
L
WP
F
Q
V
I
N
E
GG
K
P
--
K
------------------------
V
---------------------------
L
V
S
Y
KG
E
----
N
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
G
------
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
N
L
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.51
48%
-69
- C2 -
1HPM
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.50
48%
-70
- C2 -
1HX1
1
HSP7C_BOVIN
A:
[26-400]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.41
48%
-68
- C2 -
1BA1
4
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
73.40
48%
-69
- C2 -
2BUP
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
G
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.36
48%
-69
- C2 -
1NGD
3
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
73.34
48%
-69
- C2 -
1NGC
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
73.32
50%
-65
- C2 -
3A8Y
1
HS71A_HUMAN
B:
[11-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
HWP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
--
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.29
48%
-67
- C2 -
1BUP
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
73.20
49%
-65
- C2 -
1S3X
5
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
--
K
------------------------
V
---------------------------
Q
V
S
Y
KG
E
----
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
---
G
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
A
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
--
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
73.16
48%
-70
- C2 -
1KAY
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
A
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.16
48%
-66
- C2 -
1ATR
3
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
73.14
48%
-61
- C2 -
4H5R
10
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.11
48%
-63
- C2 -
1QQM
5
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
A
---
V
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
73.10
48%
-69
- C2 -
1BA0
5
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.98
48%
-66
- C2 -
2QWM
5
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DDAVVQSDMKHWPFMVVNDAGRP--
K
------------------------
V
---------------------------
Q
V
----
E
YKGE
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.97
48%
-67
- C2 -
1NGJ
2
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
72.95
48%
-68
- C2 -
3FZL
2
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.83
48%
-63
- C2 -
4H5R
8
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DDAVVQSDMKHWPFMVVNDAGRP--
K
------------------------
V
---------------------------
Q
V
----
E
YKGE
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.81
50%
-61
- C2 -
3LDO
1
GRP78_HUMAN
A:
[7-384]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
---------------------------
D
I
----
G
----
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.81
50%
-61
- C2 -
3LDL
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
---------------------------
D
I
----
G
----
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.74
48%
-64
- C2 -
4H5V
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.74
48%
-65
- C2 -
2QWM
5
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.71
48%
-66
- C2 -
2QWL
4
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DDAVVQSDMKHWPFMVVNDAGRP--
K
------------------------
V
---------------------------
Q
V
----
E
YKGE
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
72.69
48%
-67
- C2 -
1KAX
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
M
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
72.65
48%
-65
- C2 -
1QQN
6
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
A
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
A
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
72.60
48%
-66
- C2 -
1QQO
4
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
A
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.44
48%
-65
- C2 -
2QWL
4
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.34
48%
-65
- C2 -
4H5W
5
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.32
50%
-61
- C2 -
3LDO
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
I
----
G
----
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.07
48%
-59
- C2 -
4H5N
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
--
K
------------------------
V
---------------------------
Q
V
----
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.63
50%
-59
- C2 -
3LDP
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
I
----
G
----
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
---
E
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
A
T
N
--
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
--
Q
A
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.46
48%
-64
- C2 -
4H5W
4
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
DDAVVQSDMKHWPFMVVNDAGRP--
K
------------------------
V
---------------------------
Q
V
----
E
YKGE
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
---
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
--
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------