@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1446: (2016-03-25 )
MKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAVSGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDFSHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQMKVKSDDQVVEKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
Atome Classification :
(25 SA)
.........10........20.......-----.30........40........50-.-..-.....60........70.----.......80........90.......-----.100.......110.......120.......130.......140.......150..---------.--------.-...160.-......170.......180.......190.......200.......210---------...-------....220.......230.......---------------------240.......250.-----......260------......-----------------------------------------------.270---------------.......-------------------..280.......290.......300.......310......--.320.......330....--...340.......350.......360.......370.-......-380........390.......400.......410.......--420........430.......440..-...--..450.......460...---....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.-...--...-650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKL
K
A
S
E
I
R
Q
K
Y
L
D
F
F
V
EKGHMVEPSA-----
P
L
V
PIDDD
T
L
L
W
INS
G
V
A
T
L
K
K
Y
-F-DG-RETPKKPRIVNSQKAIRT----NDIENVGF
T
A
R
H
H
T
F
F
E
M
L
GNFS
I
G
D
-----
Y
F
K
Q
E
A
I
E
F
A
W
E
F
LTSDKWMGMEP
D
K
L
Y
V
T
IHPED
M
E
A
Y
N
I
W
H
KDIGLEE
S
R
I
I
R
I
---------E--------G-
N
F
W
DIGE-GPSGPNT
E
I
F
Y
DRGEAYGQDD
P
A
E
EMYPGGEN
E
R
Y
L
E
V
W
N
L
V
F
S
EFNHN---------KDH-------SYTPLPNKNIDTGM
G
L
E
R
M
A
S
V
S
Q
---------------------
N
VRTNYET
D
L
F
M
P
I
-----
M
N
E
I
E
K
VSG------K
Q
Y
L
VN-----------------------------------------------NE-----------------Q
D
V
A
F
K
V
-------------------
I
A
D
H
I
R
T
I
A
F
A
ISDGALPANEG
R
G
Y
V
L
R
R
L
L
R
R
A
V
R
F
S
Q
TL--GIN
E
P
F
M
Y
K
L
V
D
I
V
A
D
I
M
--
E
PYYP
N
V
K
E
K
A
D
F
I
K
R
V
I
K
S
E
E
E
R
F
H
E
T
L
E
D
G
L
A
I
L
N
-
E
L
I
K
K
A-K-ATTNEINGK
D
A
F
K
L
YDTYGF
P
I
E
L
T
E
E
I
A
V
QAGL
K
V
D
M
T
--
T
-
F
E
S
E
M
Q
Q
Q
R
D
R
A
R
Q
A
RQNS
Q
S
M
Q
V
-
Q
S
E
--
V
L
K
N
I
TSAS
T
F
V
G
YDTAT---
A
Q
T
T
L
T
H
L
I
YNG
E
E
V
S
QVEAG
E
T
V
Y
F
M
L
TET
P
F
Y
A
VSGG
Q
V
A
D
T
G
I
V
YNDN
F
E
I
A
V
S
E
VTKAPNG
Q
N
L
H
K
G
V
V
Q
FGQVNV
G
A
T
V
S
A
EVNQ
N
D
R
R
D
I
Q
K
NH
S
A
T
H
L
L
H
A
A
L
K
S
V
L
G
D
H
V
N
QAGSL
V
E
A
D
R
L
R
F
D
F
S
HFGPMTN
D
E
I
D
Q
V
E
R
L
V
N
E
E
I
WKGID
V
N
I
Q
EMDI
A
S
A
K
E
M
G
A
M
-
A
L
F
--
G
E
K-YG
D
V
V
R
V
V
NMA
P
F
S
I
E
L
CG
G
I
H
V
RNTSEI
G
L
F
K
I
V
SESGTG
A
G
V
R
R
I
E
A
LTG
K
A
A
F
L
Y
L
E
D
I
Q
E
K
F
N
T
M
K
S
Q
MKVK
S
D
D
Q
V
V
E
K
L
T
Q
L
Q
D
E
E
K
A
L
L
K
Q
L
E
Q
R
D
K
E
I
T
SLKMG
N
I
E
D
Q
V
E
EING
Y
K
V
L
V
T
E
VDVP
N
A
K
A
I
R
S
T
M
D
D
F
K
S
K
L
Q
D
T
I
I
I
L
ASNVD
D
K
V
S
M
V
A
T
V
P
K
S
L
TNNV
K
A
G
D
L
I
K
Q
M
A
P
I
VGGKGGGRPDMAQGGGTQ
P
E
N
I
S
K
S
L
S
F
I
K
D
Y
I
KNL
28
HHSearch
91.96
27%
-68
* C2 *
3WQY
1
SYA_ARCFU
A:
[57-903]
K
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
-----
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
-
V
-
T
S
G
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
--------------------------
V
Y
----------
K
--------
E
-
E
P
W
A
G
G
--
G
N
A
G
P
C
L
E
A
I
V
G
----------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
E
H
---------
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
---------------------
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
-----
V
D
T
I
I
D
N
S
N
------
V
S
F
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
-----------------
P
L
E
K
V
Y
S
-------------------
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
--
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
--
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
-
R
L
V
E
R
------
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
I
-
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
--
I
--------
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
LL
E
F
E
A
E
V
I
G
V
E
-------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
-
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
-
A
-
V
G
C
L
M
A
K
G
E
G
K
V
-
F
V
V
T
F
S
G
---
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
-
15
PsiBlast_PDB
89.06
26%
-67
- C2 -
3WQY
1
SYA_ARCFU
A:
[58-886]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
-----
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
-
V
T
S
G
-
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
Y
K
---------
E
--------
E
-
P
W
--
A
G
G
-
G
N
A
G
P
C
L
E
A
I
V
-----------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
PEGDIEI--
K
G
A
-------
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
GTPT
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
N
R
E
D
E
R
V
R
R
I
-----
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
G
E
R
L
N
Q
-----------------------------------------------
L
R
-----------------
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
GF
E
F
D
V
P
-----
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
-
R
L
V
E
R
K
-
K
-----
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
-----------
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
KI
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
----------
L
L
E
F
E
A
E
V
I
G
V
E
G
D
---
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
-
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
----
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
------------------
16
PsiBlast_PDB
88.62
26%
-70
- C2 -
3WQZ
2
SYA_ARCFU
A:
[58-886]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
-----
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
-
V
T
S
G
-
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
Y
K
---------
E
--------
E
-
P
W
--
A
G
G
-
G
N
A
G
P
C
L
E
A
I
V
-----------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
PEGDIEI--
K
G
A
-------
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
GTPT
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
N
R
E
D
E
R
V
R
R
I
-----
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
G
E
R
L
N
Q
-----------------------------------------------
L
R
-----------------
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
EL
G
L
D
---
L
Y
D
L
V
E
M
H
K
K
I
L
GF
E
F
D
V
P
-----
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
-
R
L
V
E
R
K
-
K
-----
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
-----------
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
KI
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
----------
L
L
E
F
E
A
E
V
I
G
V
E
G
D
---
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
-
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
----
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
------------------
17
PsiBlast_PDB
83.43
26%
-66
- C2 -
2ZZF
1
SYA_PYRHO
A:
[55-746]
-
R
K
Y
T
L
D
E
M
R
E
K
F
L
R
F
F
--
E
K
H
E
I
Y
P
H
G
R
V
K
R
Y
P
V
L
P
R
W
R
D
D
V
L
L
V
G
A
S
I
M
D
F
Q
P
W
V
I
-
S
G
-
E
A
D
P
P
A
N
P
L
V
I
S
Q
P
S
I
R
F
----
T
D
I
D
N
V
G
I
T
G
R
H
F
T
I
F
E
M
M
A
H
H
A
F
N
Y
PGKPI
Y
W
M
D
E
T
V
E
L
A
F
E
F
F
T
K
E
-----------
L
K
M
K
P
E
D
------------------
I
T
F
---------
K
--------
E
-
N
P
W
-
A
G
G
-
G
N
A
G
P
A
F
E
V
L
Y
----------------------
R
G
L
E
V
A
T
L
V
F
M
Q
Y
K
K
--------------------
K
Y
I
P
M
E
T
K
V
V
D
T
G
Y
G
L
E
R
L
V
W
M
S
Q
---------------------
G
T
P
T
A
Y
D
A
V
L
G
Y
V
V
E
P
L
K
K
M
A
G
I
E
K
I
D
E
------
K
I
L
M
E
N
-----------------------------------------------
S
R
L
A
G
M
F
DIEDLGD
L
R
Y
L
R
E
Q
V
A
K
R
V
GIT
V
E
E
L
E
K
A
I
R
P
Y
E
L
I
Y
A
I
A
D
H
T
K
A
L
T
F
M
L
A
D
G
V
V
P
S
N
V
K
A
G
Y
L
A
R
L
L
I
R
K
S
I
R
H
L
R
E
L
--
G
L
E
V
P
-
L
S
E
I
V
A
L
H
I
K
E
L
--
H
K
T
F
P
E
F
K
E
M
E
D
I
I
L
E
M
I
E
L
E
E
K
K
Y
A
E
T
L
R
R
G
S
D
L
V
R
R
E
I
A
K
L
K
-
K
-
K
G
I
K
E
I
P
V
E
K
L
V
T
F
Y
E
S
H
G
L
T
P
E
I
V
K
E
I
A
E
K
E
G
V
K
V
N
I
P
D-
N
-
F
Y
S
M
V
A
K
E
A
E
R
T
-------
L
---
V
-
D
F
E
--
L
L
K
D
L
P
D
T
R
R
L
Y
Y
E
D
P
F
M
---
K
E
-------
F
D
A
K
V
L
R
V
I
K
D
----
W
V
I
L
D
A
T
A
F
Y
P
E
G
G
G
Q
P
Y
D
T
G
V
L
I
V
N
G
R
E
V
K
V
T
N
V
Q
K
V
--
G
K
V
I
I
H
K
V
E
D
P
G
A
F
K
E
G
M
I
V
H
G
K
I
D
W
K
R
R
I
Q
H
M
R
H
H
T
G
T
H
V
L
M
G
A
L
V
R
V
L
G
R
H
V
W
Q
A
G
S
Q
L
T
T
D
W
A
R
L
D
I
S
H
Y
K
R
I
S
E
E
E
L
K
E
I
E
M
L
A
N
R
I
V
M
E
D
R
K
V
T
W
E
W
L
P
R
T
T
A
E
Q
K
Y
G
F
-
R
L
Y
QG
G
V
V
-
P
G
R
E
I
R
V
V
K
I
E
D
W
D
V
Q
A
C
G
G
T
H
L
P
S
T
G
L
V
G
P
I
K
I
L
R
T
E
R
I
Q
D
G
V
E
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
83.22
50%
-74
- C2 -
1YFS
1
SYA_AQUAE
A:
[2-458]
--
S
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
--
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
---------
G
E-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
------------
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
-
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------P
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.18
29%
-67
- C2 -
2ZTG
3
SYA_ARCFU
A:
[58-739]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
-----
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
-
V
-
T
S
G
V
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
V
--------------------------
Y
----------
K
--------
E
-
E
P
W
A
G
G
--
G
N
A
G
P
C
L
E
A
I
V
G
----------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
E
H
---------
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
---------------------
G
T
P
T
V
Y
D
A
-
I
F
P
E
V
-----
V
D
T
I
I
D
N
S
N
------
V
S
F
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
GIMGELRGERL
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
-----------------
P
L
E
K
V
Y
S
-------------------
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
--
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
--
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
-
R
L
V
E
R
------
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
--
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
--
I
--------
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
LL
E
F
E
A
E
V
I
G
V
E
-------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.05
48%
-75
- C2 -
1YFS
1
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
GE-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.85
48%
-76
- C2 -
1YFS
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.67
48%
-74
- C2 -
1YFT
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
82.45
49%
-72
- C2 -
3HY0
4
SYA_ECOLI
A:
[2-439]
---
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
---------
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
---
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
---------------------------------------------------
L
-----------------
S
N
K
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
A
K
L
----
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.23
48%
-74
- C2 -
1YGB
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.21
26%
-62
- C2 -
2ZZG
2
SYA_PYRHO
A:
[55-746]
-
R
K
Y
T
L
D
E
M
R
E
K
F
L
R
F
F
--
E
K
H
E
I
Y
P
H
G
R
V
K
R
Y
P
V
L
P
R
W
R
D
D
V
L
L
V
G
A
S
I
M
D
F
Q
P
W
V
I
-
S
G
-
E
A
D
P
P
A
N
P
L
V
I
S
Q
P
S
I
R
F
----
T
D
I
D
N
V
G
I
T
G
R
H
F
T
I
F
E
M
M
A
H
H
A
F
N
Y
P
GKPI
Y
W
M
D
E
T
V
E
L
A
F
E
F
F
T
K
E
-----------
L
K
M
K
P
E
D
------------------
I
T
F
---------
K
--------
E
-
N
P
W
-
A
G
G
-
G
N
A
G
P
A
F
E
V
L
Y
----------------------
R
G
L
E
V
A
T
L
V
F
M
Q
Y
K
K
A
PEQDQ
V
V
V
I
K
G
E
-------
K
Y
I
P
M
E
T
K
V
V
D
T
G
Y
G
L
E
R
L
V
W
M
S
Q
---------------------
G
T
P
T
A
Y
D
A
V
L
G
Y
V
V
E
P
L
K
K
M
A
G
I
E
K
I
D
E
------
K
I
L
M
E
N
-----------------------------------------------
S
R
L
AGMFDIEDL
R
Y
L
R
---
E
Q
V
A
K
R
V
GIT
V
E
E
L
E
K
A
I
R
P
Y
E
L
I
Y
A
I
A
D
H
T
K
A
L
T
F
M
L
A
D
G
V
V
P
S
N
V
K
A
G
Y
L
A
R
L
L
I
R
K
S
I
R
H
L
R
E
L
--
G
L
E
V
P
-
L
S
E
I
V
A
L
H
I
K
E
L
--
H
K
T
F
P
E
F
K
E
M
E
D
I
I
L
E
M
I
E
L
E
E
K
K
Y
A
E
T
L
R
R
G
S
D
L
V
R
R
E
I
A
K
L
K
-
K
-
K
G
I
K
E
I
P
V
E
K
L
V
T
F
Y
E
S
H
G
L
T
P
E
I
V
K
E
I
A
E
K
E
G
V
K
V
N
I
P
D-
N
-
F
Y
S
M
V
A
K
E
A
E
R
T
-------
L
---
V
-
D
F
E
--
L
L
K
D
L
P
D
T
R
R
L
Y
Y
E
D
P
F
M
---
K
E
-------
F
D
A
K
V
L
R
V
I
K
D
----
W
V
I
L
D
A
T
A
F
Y
P
E
G
G
G
Q
P
Y
D
T
G
V
L
I
V
N
G
R
E
V
K
V
T
N
V
Q
K
V
--
G
K
V
I
I
H
K
V
E
D
P
G
A
F
K
E
G
M
I
V
H
G
K
I
D
W
K
R
R
I
Q
H
M
R
H
H
T
G
T
H
V
L
M
G
A
L
V
R
V
L
G
R
H
V
W
Q
A
G
S
Q
L
T
T
D
W
A
R
L
D
I
S
H
Y
K
R
I
S
E
E
E
L
K
E
I
E
M
L
A
N
R
I
V
M
E
D
R
K
V
T
W
E
W
L
P
R
T
T
A
E
Q
K
Y
G
F
-
R
L
Y
QG
G
V
V
-
P
G
R
E
I
R
V
V
K
I
E
D
W
D
V
Q
A
C
G
G
T
H
L
P
S
T
G
L
V
G
P
I
K
I
L
R
T
E
R
I
Q
D
G
V
E
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.17
48%
-74
- C2 -
1YFR
3
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.88
48%
-77
- C2 -
3HTZ
-
SYA_AQUAE
A:
[2-453]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
---------
K
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.86
47%
-74
- C2 -
3HXZ
4
SYA_ECOLI
C:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.52
48%
-72
- C2 -
1YFR
4
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
-----
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
-
F
-
L
G
-
L
E
K
R
P
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
GE-------
E
--------
D
-
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
---------
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
---------------------
G
K
N
S
N
F
E
I
D
I
I
F
P
L
-----
I
Q
F
G
E
E
V
S
G
------
K
K
Y
G
E
K
-----------------------------------------------
F
E
-----------------
T
D
V
A
L
R
V
-------------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
--
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
--
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
-
E
V
I
Q
K
A
L
E
-
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
-
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
--
H
L
K
E
L
G
K
T
S
A
F
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.50
47%
-74
- C2 -
3HXU
5
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.49
47%
-73
- C2 -
3HXW
5
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.46
47%
-73
- C2 -
3HXZ
6
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.42
47%
-74
- C2 -
3HY0
4
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.35
47%
-76
- C2 -
3HXY
5
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.26
47%
-76
- C2 -
3HXX
3
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.17
47%
-73
- C2 -
3HXV
6
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.96
47%
-73
- C2 -
3HY0
4
SYA_ECOLI
B:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.73
47%
-71
- C2 -
3HY1
4
SYA_ECOLI
A:
[5-438]
------
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
-----
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
-
F
-
L
G
-
L
D
K
R
N
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
---
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
---------
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
---------------------
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
-----
I
Q
A
V
A
K
V
T
G
------
A
T
D
L
S
N
-----------------------------------------------
K
---------------------
S
L
R
V
-------------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
--
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
--
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
-
E
E
L
--
A
-
K
-
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
-
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------