@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1457: (2016-03-25 )
MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVVQKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGRYRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALVKHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70.........80........90...-.....100.......110.......120.......130.......140.......150....-.-..160.......170.......180.......190.......200.......210......---.--220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350...--.----...360.......370.......380.......390.......400...--....410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIKIPRGTQDILPEDS
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
RTPIFEST
D
L
F
ARGVGD
S
T
D
V
V
Q
K
E
M
Y
TFKDK-GD
R
S
I
T
LRPE
G
T
A
A
V
V
R
S
Y
I
E
H
K
M-QGNPNQ
P
I
K
L
Y
YNGPM
F
R
Y
E
R
K
QKGRY
R
Q
F
N
Q
FGVEAIGAENPSV
D
A
E
V
L
A
M
V
M
H
I
Y
Q
SF
G
L
-
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
LHTNP
M
R
I
L
D
CKVDR
D
K
E
A
I
K---T--A
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
DLGIPYIEDP
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
MMDNPNYDG
A
I
T
T
LCGGGR
Y
N
G
L
L
E
LLDGPSETGI
G
F
A
L
S
I
E
R
L
L
L
A
L
E
EEG
I
E
L
D
IEENL
D
L
F
I
V
TMGDQ
A
D
R
Y
A
V
K
L
L
N
H
L
R
HN--G----IKA
D
K
D
Y
L
Q
R
K
I
K
G
Q
M
K
Q
A
D
RLG
A
K
F
T
I
V
IGDQELENN
K
I
D
V
K
NMTTGE--S
E
T
I
E
L
D
A
L
V
E
Y
FKK
2
HHSearch
96.86
99%
-110
- C2 -
1QE0
-
SYH_STAAU
A:
[1-420]
M
I
K
I
P
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
-
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
M
Q
G
N
-
P
N
Q
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
-
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
---------------
T
--
A
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
N
Y
D
G
A
I
T
T
L
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
E
E
E
G
I
E
L
D
I
E
E
N
L
D
L
F
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
----
I
K
A
D
K
D
Y
L
Q
R
K
I
K
G
Q
M
K
Q
A
D
R
L
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
--
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
22
PsiBlast_PDB
96.69
99%
-109
- C2 -
1QE0
-
SYH_STAAU
A:
[1-420]
M
I
K
I
P
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
-
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
M
-
Q
G
N
P
N
Q
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
-
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
---------------
T
--
A
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
N
Y
D
G
A
I
T
T
L
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
E
E
E
G
I
E
L
D
I
E
E
N
L
D
L
F
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
----
I
K
A
D
K
D
Y
L
Q
R
K
I
K
G
Q
M
K
Q
A
D
R
L
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
--
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
60
PsiBlast_CBE
78.35
40%
-98
- C2 -
4E51
1
SYH_BURTA
B:
[36-454]
-----
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
------
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
G
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
-
L
--
Y
D
G
P
K
R
L
W
Y
I
G
P
M
F
R
H
E
R
-----
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
-
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
------
Q
R
R
L
Y
T
N
P
L
R
V
L
----
P
A
L
Q
E
I
V
R
---
N
--
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
--------
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
L
-
V
P
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
A
R
E
Q
A
F
I
V
A
E
R
L
R
D
T
--
G
L
D
V
I
L
H
C
S
A
D
G
A
G
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
----S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
--
3
HHSearch
77.68
42%
-87
- C2 -
1H4V
1
SYH_THET2
B:
[2-418]
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
------
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
-
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
----
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
---
E
LG
V
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
---------
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
--
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
31
PsiBlast_PDB
77.65
40%
-90
- C2 -
4E51
1
SYH_BURTA
A:
[36-454]
-----
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
G
I
G
E
V
T
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
G
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
-
L
--
Y
D
G
P
K
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
---
R
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
-
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
K
L
D
D
D
A
Q
R
R
L
Y
T
N
P
L
R
V
L
D
T
K
N
P
A
L
Q
E
I
V
R
---
N
--
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
K
-------
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
L
-
V
P
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
A
R
E
Q
A
F
I
V
A
E
R
L
R
D
T
--
G
L
D
V
I
L
H
C
S
A
D
G
A
G
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
----S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
--
45
PsiBlast_CBE
75.66
43%
-84
- C2 -
1ADJ
2
SYH_THET8
D:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
23
PsiBlast_PDB
75.55
43%
-83
- C2 -
1ADJ
2
SYH_THET8
A:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
47
PsiBlast_CBE
75.44
43%
-84
- C2 -
1ADJ
2
SYH_THET8
B:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
46
PsiBlast_CBE
75.38
43%
-85
- C2 -
1ADJ
2
SYH_THET8
C:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
43
PsiBlast_CBE
75.18
43%
-81
- C2 -
1ADY
2
SYH_THET8
C:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
42
PsiBlast_CBE
74.98
43%
-79
- C2 -
1ADY
2
SYH_THET8
D:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
24
PsiBlast_PDB
74.50
43%
-78
- C2 -
1ADY
2
SYH_THET8
A:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
44
PsiBlast_CBE
74.28
43%
-78
- C2 -
1ADY
2
SYH_THET8
B:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
25
PsiBlast_PDB
74.18
43%
-86
- C2 -
1H4V
1
SYH_THET2
B:
[7-403]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
------
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
----
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
ELG
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
---------
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
26
PsiBlast_PDB
73.89
43%
-83
- C2 -
4RDX
2
SYH_THET2
A:
[9-405]
-----
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
-----------
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
-
K
V
W
P
-
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
L
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
--
R
P
-
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
---
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
-------
L
R
A
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
-----------------
55
PsiBlast_CBE
72.60
38%
-81
* C2 *
1KMM
1
SYH_ECOLI
C:
[5-420]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
---------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
---
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
50
PsiBlast_CBE
72.44
38%
-83
- C2 -
2EL9
1
SYH_ECOLI
B:
[12-427]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
--------------------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
---
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
1
HHSearch
72.09
39%
-84
- C2 -
1HTT
2
SYH_ECOLI
A:
[3-420]
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
--
Y
N
Q
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
-
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
--------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
58
PsiBlast_CBE
71.87
38%
-86
- C2 -
1HTT
2
SYH_ECOLI
C:
[4-419]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
--------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
---
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
48
PsiBlast_CBE
71.83
38%
-82
- C2 -
2EL9
1
SYH_ECOLI
D:
[12-427]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
-----------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
---
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
30
PsiBlast_PDB
71.81
38%
-83
- C2 -
1HTT
2
SYH_ECOLI
A:
[4-419]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
--------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
---
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
59
PsiBlast_CBE
70.34
38%
-88
- C2 -
1HTT
2
SYH_ECOLI
B:
[4-419]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
-----------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
---
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-
57
PsiBlast_CBE
70.00
38%
-84
- C2 -
1HTT
2
SYH_ECOLI
D:
[4-419]
-
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
-
L
Y
N
Q
E
Q
--
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
-----------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
---
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
----
V
K
L
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
--
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
-