@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1488: (2016-03-26 )
MEMKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGEGFIEIATTRPETMLGDTAIVVNPNDERYKDVIGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQLVKDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKTDDRIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWYHKETGEIYVGEEAPTDIENWQQDEDVLDTWFSSALWPFSTLGWPDLESEDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWNFINKIWNGARFSLMNIGEDFKVEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIWDDFCDWYIEMSKIPMNSNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHEGDTIVKASWPEVRESLIFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNISTDVEIPEKAMTSVVIAGKVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQEKYDGVKARIEQLKA
Atome Classification :
(20 SA)
-----------.........10........20.......-..30.--.--..--.....40........50........60........70........80........90.....---.-..100......--.110.......120.......130.......140.......150.......160.......170.......180...------------....--190.-------------------------------------------..-----------.....------.200-------------------------------------......--------------------------.------.210-----------..------......220.......230-----------..---------....---------.--------------------------------------.-----------------------------------.240---------------------------------.--------------------..-----....--..250-....----------------------------------.....260.......270.......280.......290.--......300...--------------.--...310.......320.......330.......340.......350.......360.......370.-......380.......-390.......400.......410.......420......-------------------.-------------------------------430----------------------..--..----------------.----------.--------------------------------.------------..----------440-----------------------------.---------------........450......-.460-----.----......470.......480------.......490.....----.------.500.......510.-------------------------..----------------------------------------------...-------.-----------------------------------------------------520.......530.......540.......550.......560..-...-..570.......580.......-590...-.....600.......610.......-620.......630.......640.......650-...--...-..660.........670.......680.......690.....-.-----.-700.......710..--.......720.----......730.......740.......750.......760....-----...770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MEMKPKYD
P
R
EVEA
G
R
Y
E
E
W
-
V
KNGYFK-PSE-D--K--SK--
E
T
Y
T
I
V
IPPPNV
T
G
K
L
H
LGHA
W
D
T
T
L
Q
D
I
I
T
R
M
K
R
MQGY
D
T
L
Y
LPGMDHAGIAT
Q
A
K
V
E
A
KL---N-EQGITRYD
L
G
R
--
E
K
F
L
E
Q
AW
D
W
K
E
E
Y
A
S
F
I
R
A
Q
W
A
K
LGLGLDYSRERF
T
L
D
E
G
L
S
K
A
V
K
K
V
F
V
D
L
YNK
G
I
I
YRG
E
R
I
INWDPKARTA
L
S
------------
D
I
E
V
--
I
--
H
-------------------------------------------
E
D-----------VQ
G
A
F
------
Y
H
F
--------------------------------------
K
Y
PYAD--------------------------G------E
G
F
------------
I
E
------
I
ATTRPETMLG
D
T
A
I
V
V-------------NP---------N
D
E
R
---------
Y
--------------------------------------
K
-----------------------------------
D
V-----------------------------------I--------------------G
K
-----
T
V
I
L
--
P
IV---GREL----------------------------------PILA
D
E
Y
V
D
I
DFGSG
A
M
K
VTPAHDPNDFEIGQRHQL
E
N
I
--
I
V
MDENGKMNDK--------------A--GKYEGM
D
R
F
D
C
R
K
Q
L
V
K
D
L
K
EQ
D
L
V
I
K
I
E
D
H
V
H
SVGHSERS
G
A
V
VEPYLS
T
Q
W
F
V
R
M
E
D
L
A
K
R
SLDN-QKTDDRIDF
Y
P
Q
R
F
E
H
-
T
F
N
Q
W
M
E
N
I
R
D
W
T
ISR
Q
L
WWGHQI
P
A
W
Y
HKETG
E
I
Y
VGE-------------------E-------------------------------A------------------------PT--
D
I
----------------
E
----------N--------------------------------W------------Q
Q
----------
D
-------------------------------
E
---------------
D
V
L
D
T
W
F
S
SALWPFSTL-GWPD-----L----E
S
E
D
F
K
R
YYPTNALV
T
G
Y
D
------
I
I
F
F
W
V
A
R
M
I
F
QGLE----F------TDRRP
F
N
D
V
L
L
H
G
L
V
-------------------------RA----------------------------------------------ED
G
-------
R
-----------------------------------------------------
K
M
S
K
S
LGNGV
D
P
M
D
V
I
D
EYG
A
D
S
L
R
Y
F
L
ATGSSPGHDLRY
S
T
E
K
V
-
E
S
V
-
W
N
F
I
N
K
IWNG
A
R
F
S
L
M
NIGED
F
-
K
-
V
E
D
I
-DLSGN
L
S
L
A
D
K
W
I
L
T
R
L
N
E
T
I
A
T
VT-DLSDKY
E
F
G
E
V
G
R
A
L
Y
N
F
I
W
D
D
F
C
D
W
Y
I
E
M
SK--IPM--NS
N
-
D
E
E
--
Q
K
Q
V
T
R
S
V
L
S
Y
T
L
D
N
I
M
R
M
L
H
P
F
M
P
F
V
T
E
K
I
W
Q
SLPH-E-----G-
D
T
I
V
KAS
W
P
E
V
--
R
E
--
S
L
I
F
E
E
S
K
Q
T
M
----
Q
Q
L
V
E
I
I
K
S
V
R
QSR
V
E
VNTPLSKEI
P
I
L
I
Q
AKD
K
E
I
E
T
T
L
SQN-----K
D
Y
L
I
K
FCNPS
T
L
NISTDVEI
P
E
K
A
M
T
S
V
V
I
A
G
K
V
V
LP
L
E
G
L
I
D
M
D
K
E
I
S
R
L
E
K
E
L
A
K
L
Q
S
E
L
D
R
V
D
K
K
LSNEN
F
V
S
KA
P
E
K
V
I
N
E
E
K
R
K
K
Q
D
Y
Q
E
K
Y
D
G
V
K
A
R
I
E
Q
LKA---
21
PsiBlast_CBE
97.21
40%
-63
- C1 -
1IVS
1
SYV_THETH
B:
[1-861]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
-
E
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
PERYL--------------
E
-------------------------------
D
------------------------
P
T
--
S
C
----------------
E
ACGSP-----
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
-
R
E
G
F
-
Q
-
A
K
E
-----
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
A
H
--
T
L
R
T
L
E
E
V
L
A
V
----
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
-
W
P
E
P
GG
R
D
------
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
----------
V
F
R
F
L
S
R
A
D
L
L
----
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
-----
22
PsiBlast_CBE
96.88
40%
-63
- C1 -
1GAX
3
SYV_THETH
B:
[1-861]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
-
E
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
PERYL--------------
E
-------------------------------
D
------------------------
P
T
--
S
C
----------------
E
ACGSP-----
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
-
R
E
G
F
-
Q
-
A
K
E
-----
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
A
H
--
T
L
R
T
L
E
E
V
L
A
V
----
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
-
W
P
E
P
GG
R
D
------
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
----------
V
F
R
F
L
S
R
A
D
L
L
----
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
-----
2
PsiBlast_PDB
96.87
40%
-66
- C1 -
1IVS
1
SYV_THETH
A:
[1-861]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
-
E
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
PERYL--------------
E
-------------------------------
D
------------------------
P
T
--
S
C
----------------
E
ACGSP-----
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
-
R
E
G
F
-
Q
-
A
K
E
-----
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
A
H
--
T
L
R
T
L
E
E
V
L
A
V
----
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
-
W
P
E
P
GG
R
D
------
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
----------
V
F
R
F
L
S
R
A
D
L
L
----
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
-----
1
PsiBlast_PDB
96.39
40%
-63
- C1 -
1GAX
3
SYV_THETH
A:
[1-861]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
-
E
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
PERYL--------------
E
-------------------------------
D
------------------------
P
T
--
S
C
----------------
E
ACGSP-----
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
-
R
E
G
F
-
Q
-
A
K
E
-----
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
A
H
--
T
L
R
T
L
E
E
V
L
A
V
----
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
-
W
P
E
P
GG
R
D
------
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
----------
V
F
R
F
L
S
R
A
D
L
L
----
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
-----
72
HHSearch
95.71
40%
-64
- C1 -
1GAX
3
SYV_THETH
A:
[1-862]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
---------------------------------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
-
R
G
D
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
P------------------
E
RYLEDPTSC----------------------
E
------------------------
A
C
--
G
S
----------------
P
----------
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
-----
E
-----
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
--
Q
--
A
----
K
E
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-------
E
E
L
A
L
E
A
W
P
E
P
--
G
G
----
R
D
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
----
P
V
E
E
N
-----
L
E
V
F
R
F
L
S
R
A
D
L
L
P
---
E
--
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
----
95
Fugue
95.41
40%
-59
- C1 -
1GAX
3
SYV_THETH
A:
[1-862]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
-
N
P
K
-
S
-----
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
E
-
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
--------------
R
VP
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
-
D
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
-------------------
P
-------------------------------
E
------------------------
R
Y
--
L
E
----------------
D
PTSCEACGSP
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
-
A
-
K
E
D
------
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-------
E
E
L
A
L
E
A
W
P
E
P
--
G
G
--
R
--
D
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
V
F
-----
R
F
L
S
---------
R
A
D
L
L
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
----
3
PsiBlast_PDB
81.28
40%
122
- C- -
1IYW
-
SYV_THETH
A:
[1-861]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
-
F
V
-
A
N
P
-
K
--
S
--
G
K
--
P
P
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
---
L
-
K
E
G
K
T
R
H
D
L
G
R
--
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
------------
D
L
E
V
--
E
--
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
------
Y
T
L
--------------------------------------
R
Y
-
E
V
E
--------------------------
G
------
G
G
F
------------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
---------
E
D
E
R
---------
Y
--------------------------------------
R
-----------------------------------
H
L
-----------------------------------
L
--------------------
G
K
-----
R
A
R
I
--
P
L
T
---
E
V
W
I
----------------------------------
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
--
S
V
I
N
L
E
G
R
M
E
G
E
RV------------
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
-
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
E
D
C
Q
A
V
N
V
P
R
PERYL--------------
E
-------------------------------
D
------------------------
P
T
--
S
C
----------------
E
ACGSP-----
R
--------------------------------
L
------------
K
R
----------
D
-------------------------------
E
---------------
D
V
F
D
T
W
F
S
S
A
L
W
P
L
S
T
L
-
G
W
P
E
----------
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
----
F
------
M
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
A
-
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
-
R
E
G
F
-
Q
-
A
K
E
-----
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
-
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
--
P
A
L
--
K
A
G
-
N
A
H
--
T
L
R
T
L
E
E
V
L
A
V
----
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
-
K
-----
E
-
E
L
A
L
E
A
-
W
P
E
P
G
G
R
D
------
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
N
L
E
----------
V
F
R
F
L
S
R
A
D
L
L
----
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
-----
77
HHSearch
79.26
26%
-71
- C1 -
2V0C
10
?
A:
[2-813]
---------------
E
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
-
E
E
K
G
F
M
K
-
A
K
D
-
L
--
P
G------
K
Q
Y
V
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
A
E
N
A
A
L
K
F
--------
G
V
H
--------------
P
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
------------
N
E
Q
V
--
V
--
E
-------------------------------------------
G
R
CWRHED
T
P
V
E
K
R
E
L
E
Q
------
W
Y
L
RITAY
A
E
R
L
L
K
D
LEGLNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
--------------------------
K
------
E
V
R
------------
I
P
------
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
-------------
A
P
---------
E
H
P
L
---------
T
--------------------------------------
L
ELAAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
AEGRE
K
T
G
V
F
-----------------------------------
L
--------------------
G
A
-----
Y
A
L
N
--
P
A
T
---
G
E
R
I
----------------------------------
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
F
A
R
K
F
G
L
P
I
K
--
K
V
I
E
R
P
G
E
P
L
P
E
PLERAYE
E
P
G
I
M
V
N
S
--
G
P
F
D
G
T
E
S
E
E
G
K
R
K
V
I
A
W
L
E
E
K
G
L
G
K
---------------------------------------------------------
G
----
R
V
T
Y
R
L
R
D
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
V
H
C
E
A
C
G
V
V
P
V
P
E
-------------------
E
ELPVLLPDLKDVEDIRPKGKSPLEAHPEFY
E
T
------------------------
T
C
PK
C
G
----------------
G
----------
P
--------------------------------
A
------------
K
R
----------
D
-------------------------------
T
---------------
D
T
M
D
T
F
F
D
S
S
W
Y
Y
L
R
Y
T
-
D
P
H
N
-----
D
RLPF
D
P
E
K
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
------
H
A
V
L
H
L
L
Y
S
R
F
F
T
K
F
----
L
H
D
L
GMV
K
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
-------------------------
L
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
G
T
L
H
L
W
K
P
A
-----------------------------------------------------
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
L
F
A
A
P
P
E
N
E
M
V
W
T
E
E
G
V
-
Q
G
A
-
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
T
--
S
-
G
V
---
F
Q
A
E
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
-
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
-
N
A
-
L
Y
E
Y
R
K
-----
D
R
---------------
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
H
W
F
W
P
---------
D
S
L
F
E
A
G
W
P
E
L
--
D
E
--
K
A
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
79.12
25%
-57
- C1 -
1ILE
2
SYI_THET8
A:
[4-821]
-------------
E
V
G
E
P
N
F
P
K
L
E
E
E
V
L
A
F
W
-
K
R
E
K
I
F
Q
-
K
S
V
-
E
--
N
R
K
G
G
--
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
---
G
L
K
S
K
R
E
I
E
A
Y
G
I
--
E
R
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
------------
S
H
E
V
A
L
G
--
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
------
V
Y
V
--------------------------------------
R
F
P
L
K
E
--------------------------
P
KKLGLE
K
A
S
------------
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
---------
E
Y
T
Y
---------
A
A
F
Q
V
GD
E
A
L
I
L
EE
G
L
G
R
K
LLGEGTQV
L
K
T
F
P
G------
K
-----------------------------------
A
L
-----------------------------------
E
--------------------
G
L
-----
P
Y
T
P
--
P
Y
P
QAL
E
K
G
Y
----------------------------------
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
L
L
--
K
T
V
D
E
E
G
K
L
L
V
------------------
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
L
F
K
D
E
L
I
R
N
-
N
Q
---
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
W
V
C
Q
A
C
G
K
E
E
A
I
G
S
F
Q
----------------
E
-------------------------------
L
K
A
R
ATKPLPEPFDPHR
P
Y
V
D
Q
V
E
L
A
C
A-
C
G
----------------
G
----------
T
--------------------------------
M
------------
R
R
----------
V
-------------------------------
P
---------------
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
S
L
-
H
Y
P
F
-----
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
Q
L
G
V
M
----
L
------
F
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
-
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
-
L
K
N
P
-
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
-
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
--
R
R
F
--
W
K
N
-
E
D
A
L-
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
R
-
S
VRLEA
K
-
E
S
V
H
L
A
D
W
P
E
A
--
D
P
--
A
L
A
D
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
S
G
V
----------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
78.60
25%
-60
- C1 -
1FFY
4
SYI1_STAAU
A:
[13-863]
------------
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
-
D
A
E
D
Q
Y
H
-
K
A
L
-
E
--
K
N
K
G
N
--
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
I
E
Q
A
L
T
K
K
--------
G
V
D
R
K
K
M
S
T
--
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
------------
E
A
E
I
--
E
--
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
------
I
Y
V
--------------------------------------
A
F
N
V
K
D
--------------------------
D
KGVVDA
D
A
K
------------
F
I
------
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
---------
E
L
K
Y
GQYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYTG---------
K
-----------------------------------
E
L
-----------------------------------
E
--------------------
W
V
-----
V
A
Q
H
--
P
F
L
---
D
R
E
S
----------------------------------
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
V
I
--
S
P
I
D
D
K
G
V
F
T
E
E
--------------
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
V
R
Q
D
I
L
D
A
-
I
E
---
N
T
N
F
K
V
N
W
G
K
T
-
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
F
Y
A
E
N
G
-
E
I
I
M
T
K
E
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
-------------------------------
R
EAKDLLPEGFTHP-----------
G
S
--
P
N
----------------
G
----------
T
--------------------------------
F
------------
T
K
----------
E
-------------------------------
T
---------------
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
V
L
-
E
T
R
---------------
P
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
----
T
------
R
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
-----------------------------------------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
-
T
D
Y
L
A
D
V
R
I
S
D
E
I
L
-
K
Q
T
-
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
--
N
-
P
D
T
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
-
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
--
D
I
L
--
Y
I
E
-
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
-
V
K----
E
-
E
S
V
H
L
A
D
M
P
K
V
--
V
E
----
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
-----
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.53
24%
-58
- C1 -
1FFY
4
SYI1_STAAU
A:
[29-863]
----------------------------
E
K
W
D
A
E
D
Q
Y
H
K
-
A
L
E
K
N
--
K
--
G
N
--
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
---
T
-
K
K
G
V
D
R
K
K
M
S
T
--
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
------------
E
A
E
I
--
E
--
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
------
I
Y
V
--------------------------------------
A
F
N
V
K
D
--------------------------
D
------
K
G
V
------------
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
ELKYGQYNV
N
G
E
K
---------
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
--------------
K
-----------------------------------
E
Y
-----------------------------------
T
--------------------
G
K
ELEWV
V
A
Q
H
--
P
F
L
---
D
R
E
S
----------------------------------
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
V
I
--
S
P
I
D
D
K
G
V
F
T
E
E
--------------
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
----
Y
N
M
-
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
F
Y
-
A
E
N
G
E
I
I
M
T
K
-------------------
E
-------------------------------
T
------------------------
V
N
--
H
V
----------------
A
----------
D
L
F
A
E
HGS
N
I
W
F
E
R
EAKDLLPEGFTHPGSPNG
T
F
------------
T
K
----------
E
-------------------------------
T
---------------
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
V
L
E
T
R
P
E
-----
L
----
S
-------
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
----
T
------
R
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
-----------------------------------------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
T
-
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
-
P
-
D
T
D
S
-
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
-
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
DI
L
Y
I
--
E
Q
R
-
D
S
H
--
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
V
K
-----
E
-
E
S
V
H
L
A
D
M
P
K
V
--
V
E
-----------
V
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
DKFN
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
-----------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.53
24%
-58
* C1 *
1QU2
4
SYI1_STAAU
A:
[29-863]
----------------------------
E
K
W
D
A
E
D
Q
Y
H
K
-
A
L
E
K
N
--
K
--
G
N
--
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
---
T
-
K
K
G
V
D
R
K
K
M
S
T
--
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
------------
E
A
E
I
--
E
--
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
------
I
Y
V
--------------------------------------
A
F
N
V
K
D
--------------------------
D
------
K
G
V
------------
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
ELKYGQYNV
N
G
E
K
---------
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
--------------
K
-----------------------------------
E
Y
-----------------------------------
T
--------------------
G
K
ELEWV
V
A
Q
H
--
P
F
L
---
D
R
E
S
----------------------------------
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
V
I
--
S
P
I
D
D
K
G
V
F
T
E
E
--------------
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
----
Y
N
M
-
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
F
Y
-
A
E
N
G
E
I
I
M
T
K
-------------------
E
-------------------------------
T
------------------------
V
N
--
H
V
----------------
A
----------
D
L
F
A
E
HGS
N
I
W
F
E
R
EAKDLLPEGFTHPGSPNG
T
F
------------
T
K
----------
E
-------------------------------
T
---------------
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
V
L
E
T
R
P
E
-----
L
----
S
-------
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
----
T
------
R
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
-----------------------------------------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
T
-
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
-
P
-
D
T
D
S
-
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
-
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
DI
L
Y
I
--
E
Q
R
-
D
S
H
--
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
V
K
-----
E
-
E
S
V
H
L
A
D
M
P
K
V
--
V
E
-----------
V
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
DKFN
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
-----------------------------------------------------------------------------------------
97
Fugue
78.43
23%
-49
- C1 -
1QU2
5
SYI1_STAAU
A:
[1-917]
MDYEKTLLMPK
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
-
D
A
E
D
Q
Y
H
-
K
A
L
-
E
K
N
K
--
G
N
--
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
----
L
P
I
E
Q
A
L
---
T
-
K
K
G
V
D
R
K
K
M
S
T
--
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
------------
E
A
E
I
--
E
--
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
------
I
Y
V
--------------------------------------
A
F
N
V
K
D
--------------------------
D
------
K
G
V
------------
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
---------
E
L
K
Y
---------
G
QYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYTG
K
-----------------------------------
E
L
-----------------------------------
E
--------------------
W
V
-----
V
A
Q
H
--
P
F
L
---
D
R
E
S
----------------------------------
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
V
I
--
S
P
I
D
D
K
G
V
F
T
E
E
--------------
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
V
R
Q
D
I
L
D
A
-
I
E
---
N
T
N
F
K
V
N
W
G
K
T
-
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
F
Y
A
E
N
G
E
I
I
M
T
K
E
-------------------
T
-------------------------------
V
------------------------
N
H
--
V
A
----------------
D
----------
L
--------------------------------
F
------------
A
E
----------
H
GS
N
I
W
F
E
R
EAKDLLPEGFTHPGSPNG
T
F
T
K
E
T
---------------
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
V
L
----------------
E
T
R
P
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
----
T
------
R
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
-----------------------------------------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
-
T
D
Y
L
A
D
V
R
I
S
D
E
I
L
-
K
Q
T
-
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
-
P
-
D
T
D
S
-
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
-
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
--
D
I
L
YI
E
Q
R
-
D
S
H
--
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
-
V
-----
K
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
----
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
-----
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
--------
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
---------------------------------
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
14
PsiBlast_PDB
78.43
21%
-69
- C1 -
3ZGZ
2
SYL_ECOLI
A:
[21-879]
-------------
M
Q
E
Q
Y
R
P
E
E
I
E
S
K
V
Q
L
H
W
-
D
E
K
R
T
F
E
-
V
T
E
-
D
--
E
--
S
K
--
E
K
Y
Y
C
L
S
M
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
-
V
K
N
---
N
-
T
A
P
A
P
-----------------
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
NEQVIDGCCWRC
D
T
K
V
--
E
--
R
-------------------------------------------
K
E
-----------
I
P
Q
W
F
------
I
K
I
--------------------------------------
T
-
A
Y
A
D
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
------
E
G
V
E
I
T
F
N
V
N
DYD
N
T
L
T
------
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
AGH
P
L
A
Q
K
A
A
E
N
N
P
---------
E
L
A
A
---------
F
--------------------------------------
I
-----------------------------------
D
E
-----------------------------------
C
R
N
TKVA
E
A
E
M
A
T
ME
K
K
G
V
D
T
G
F
-----
K
A
V
H
--
P
L
T
---
G
E
E
I
----------------------------------
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
F
A
S
K
Y
G
L
-
N
I
KP
V
I
L
A
A
D
G
S
E
P
D
--------------------------------
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
N
G
L
D
H
E
A
A
F
N
A
I
A
D
------------
K
L
T
A
M
G
V
G
E
-
R
K
V
N
Y
R
L
-------------------
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
-
V
T
L
E
D
G
T
V
M
P
T
P
-------------------
D
DQLPVI-------------------------
L
------------------------
P
E
--
D
V
VMDGITSPIKAD----
P
----------
E
--------------------------------
W
------------
A
K
T
T
V
NG
M
P
A
L
R
E
-------------------------------
T
---------------
D
T
F
D
T
F
M
E
S
S
-
W
Y
Y
A
R
Y
-
T
C
P
Q
YKEGM
L
----
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
HAI
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
----
V
------
N
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAGHELVYTGMS-----------------------------------
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
A
D
M
T
L
E
W
Q
E
S
G
V
-
E
G
A
-
N
R
F
L
K
R
V
W
K
-
L
V
Y
E
H
T
A
K
G
-
D
V
-
A
-
A
L
N
V
-
D
A
---
L
T
E
N
Q
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
I
M
E
L
-----------
M
N
K
--
L
A
K
--
A
P
T
-
D
G
E
--
Q
D
---
R
A
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
L
K
G
-
E
-----
G
-
D
-
I
D
N
A
P
W
P
V
A
--
D
E
--
K
A
M
V
E
D
S
T
L
V
V
------------------
V
Q
V
N
G
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
------
E
H
L
V
A
K
Y
L
D
G
V
T
--
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
78.29
24%
-59
- C1 -
1QU3
2
SYI1_STAAU
A:
[29-863]
----------------------------
E
K
W
D
A
E
D
Q
Y
H
K
-
A
L
E
K
N
--
K
--
G
N
--
E
T
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
---
T
-
K
K
G
V
D
R
K
K
M
S
T
--
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
------------
E
A
E
I
--
E
--
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
------
I
Y
V
--------------------------------------
A
F
N
V
K
D
--------------------------
D
------
K
G
V
------------
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
ELKYG
Q
Y
N
V
N
G
E
K
---------
Y
I
I
A
EAL
S
D
A
V
A
E
A
L
DWDKASIKLE--------------
K
-----------------------------------
E
Y
-----------------------------------
T
--------------------
G
K
ELE
W
V
V
A
Q
H
--
P
F
L
---
D
R
E
S
----------------------------------
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
V
I
--
S
P
I
D
D
K
G
V
F
T
E
E
--------------
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
----
Y
N
M
-
V
R
D
R
G
E
W
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
F
Y
-
A
E
N
G
E
I
I
M
T
K
-------------------
E
-------------------------------
T
------------------------
V
N
--
H
V
----------------
A
----------
D
L
F
A
E
H
GSNIWFEREAKDLLPEGFTHPGSPNG
T
F
------------
T
K
----------
E
-------------------------------
T
---------------
D
I
M
D
V
W
F
D
S
G
S
S
H
R
G
V
L
E
T
R
P
E
-----
L
----
S
-------
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
----
T
------
R
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
-----------------------------------------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
T
-
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
-
P
-
D
T
D
S
-
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
-
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
DI
L
Y
I
--
E
Q
R
-
D
S
H
--
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
V
K
-----
E
-
E
S
V
H
L
A
D
M
P
K
V
--
V
E
-----------
V
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
DKFN
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
-----------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.06
23%
-61
- C1 -
1JZQ
3
SYI_THET8
A:
[21-818]
------------------------------
W
-
K
R
E
K
I
F
Q
-
K
S
V
-
E
--
N
--
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
GLK
S
-
K
R
E
I
E
A
Y
G
I
E
R
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
----
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
------------
S
H
E
V
--
A
L
G
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
------
V
Y
V
--------------------------------------
R
F
P
L
K
E
--------------------------
P
------
K
K
L
GLE
K
A
S
------
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
---------
E
Y
T
Y
---------
A
--------------------------------------
A
-----------------------------------
F
Q
-----------------------------------
V
--------------------
G
D
-----
E
A
L
I
L
E
E
G
L
---
G
R
K
L
L
GEGTQVL
K
T
F
P
GKALEG
L
P
Y
T
P
PYPQALEKGY
F
V
V
L
A
D
-
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
L
L
--
K
T
V
D
E
E
G
K
L
--
L
--------------
V
--
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
L
F
K
D
E
L
I
R
N
-
N
Q
E
I
H
W
V
P
--
P
H
I
K
E
G
-
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
W
V
C
Q
A
C
G
K
----
E
-------------------
E
-------------------------------
A
I
GS
F
Q
E
L
K
A
R
ATKPLPE-------
P
F
--
D
P
----------------
H
----------
R
--------------------------------
P
------------
Y
V
----------
D
-------------------------------
Q
V
E
L
A
C
ACG
G
T
M
R
R
VP
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
S
L
-
H
Y
P
F
-----
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
Q
L
G
V
M
----
L
------
F
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
V
-
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
-
P
D
L
K
N
P
-
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
-
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
--
R
R
F
--
W
K
N
E
D
A
L
--
D
R
E
A
A
Y
A
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Y
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A
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L
V
A
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L
A
A
P
F
T
P
F
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A
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V
L
W
Q
N
L
V
R
-
S
VRLEA
K
-
E
S
V
H
L
A
D
W
P
E
A
--
D
P
--
A
L
A
D
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------
98
Fugue
78.03
24%
-62
- C1 -
2BYT
13
?
A:
[1-876]
-----------
M
E
---
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
-
E
E
K
G
F
M
K
A
K
D
L
-
P
--
G
--
G
R
--
G
K
Q
Y
V
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
A
E
N
A
A
L
K
F
G
---
V
-------------------
H
P
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
------------
N
E
Q
V
--
V
--
E
GRCWRHED
T
P
V
E
K
R
E
L
E
Q
W
Y
L
RITAY
A
E
R
L
L
K
D
LEGLNWP
E
K
V
K
A
-----------
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
--------------------------------------
L
F
P
V
E
G
--------------------------
K
------
E
V
R
------------
I
P
------
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
-------------
A
P
---------
E
H
P
L
---------
T
--------------------------------------
L
-----------------------------------
E
L
AAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
A
E
GR
E
K
T
G
V
F
L
--------------------
G
A
-----
Y
A
L
N
--
P
A
T
---
G
E
R
I
----------------------------------
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
F
A
R
K
F
G
L
P
I
K
--
K
V
I
E
R
P
G
E
P
L
P
E
-------------------------------------------
P
L
E
R
A
Y
E
E
P
G
I
M
V
N
S
G
P
F
------------------
D
G
T
E
S
-
E
E
G
K
R
K
V
I
A
W
L
E
E
K
G
L
-
G
K
G
R
V
T
Y
R
L
R
D
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
V
H
C
E
A
C
G
V
V
P
V
P
E
-------------------
E
-------------------------------
E
LPVLL-------------------
P
D
--
L
K
DVEDIRPKGKSPLEAH
P
----------
E
--------------------------------
F
YETTCPKCG
G
P
A
K
R
----------
D
-------------------------------
T
---------------
D
T
M
D
T
F
F
D
S
S
-
W
Y
Y
L
R
Y
-
T
D
P
H
NDRLP
F
----
D
P
E
K
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
HA----
V
L
H
L
L
Y
S
R
F
F
T
K
F
L
H
D
L
GM
V
------
K
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
-------------------------
L
A
----------------------------------------------
W
T
D
-------
F
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
EDG
T
L
H
L
W
K
P
A
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
L
F
A
A
P
P
E
N
E
M
V
W
T
E
E
G
V
-
Q
G
A
-
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
T
S
-
G
-
V
F
Q
----
A
E
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
-
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
-
N
A
L
Y
E
Y
-------------------
R
--
K
D
R
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
H
W
F
W
P
-
D
-----
S
---
L
F
E
A
G
W
P
E
L
--
D
E
--
K
A
L
E
K
D
V
--------
V
E
V
A
V
Q
V
N
G
R
V
R
G
T
I
H
I
P
K
D
A
P
L
E
V
A
R
A
E
A
L
K
V
R
N
V
R
A
H
L
E
G
K
-----
E
V
V
K
E
I
Y
V
P
G
K
I
L
N
L
V
V
------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.90
21%
-67
- C1 -
4AQ7
3
SYL_ECOLI
A:
[21-879]
-------------
M
Q
E
Q
Y
R
P
E
E
I
E
S
K
V
Q
L
H
W
-
D
E
K
R
T
F
E
-
V
T
E
-
D
--
E
--
S
K
--
E
K
Y
Y
C
L
S
M
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
-
V
K
N
---
N
-
T
A
P
A
P
-----------------
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
NEQVIDGCCWRC
D
T
K
V
--
E
--
R
-------------------------------------------
K
E
-----------
I
P
Q
W
F
------
I
K
I
--------------------------------------
T
-
A
Y
A
D
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
------
E
G
V
E
I
T
F
N
V
N
DYD
N
T
L
T
------
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
AGH
P
L
A
Q
K
A
A
E
N
N
P
---------
E
L
A
A
---------
F
--------------------------------------
I
-----------------------------------
D
E
-----------------------------------
C
R
NTKVA
E
A
E
M
A
T
ME
K
K
G
V
D
T
G
F
-----
K
A
V
H
--
P
L
T
---
G
E
E
I
----------------------------------
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
F
A
S
K
Y
G
L
-
N
I
K
P
V
I
L
A
A
D
G
S
E
P
D
--------------------------------
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
N
G
L
D
H
E
A
A
F
N
A
I
A
D
------------
K
L
T
A
M
G
V
G
E
-
R
K
V
N
Y
R
L
-------------------
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
-
V
T
L
E
D
G
T
V
M
P
T
P
-------------------
D
DQLPVI-------------------------
L
------------------------
P
E
--
D
V
VMDGITS
P
I
K
A
D
----
P
----------
E
--------------------------------
W
------------
A
K
T
T
V
NG
M
P
A
L
R
E
-------------------------------
T
---------------
D
T
F
D
T
F
M
E
S
S
-
W
Y
Y
A
R
Y
-
T
C
P
Q
YKEGM
L
----
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
HAIM
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
----
V
------
N
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAGHELVYTGMS-----------------------------------
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
A
D
M
T
L
E
W
Q
E
S
G
V
-
E
G
A
-
N
R
F
L
K
R
V
W
K
-
L
V
Y
E
H
T
A
K
G
-
D
V
-
A
-
A
L
N
V
-
D
A
---
L
T
E
N
Q
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
I
M
E
L
-----------
M
N
K
--
L
A
K
--
A
P
T
-
D
G
E
--
Q
D
---
R
A
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
L
K
G
-
E
-----
G
-
D
-
I
D
N
A
P
W
P
V
A
--
D
E
--
K
A
M
V
E
D
S
T
L
V
V
------------------
V
Q
V
N
G
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
------
E
H
L
V
A
K
Y
L
D
G
V
T
--
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
-----------------------------------------------------------------------------------
8
PsiBlast_PDB
77.75
23%
-61
- C1 -
1JZS
3
SYI_THET8
A:
[21-818]
------------------------------
W
-
K
R
E
K
I
F
Q
-
K
S
V
-
E
--
N
--
R
K
G
G
P
R
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
GLK
S
-
K
R
E
I
E
A
Y
G
I
E
R
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
----
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
------------
S
H
E
V
--
A
L
G
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
------
V
Y
V
--------------------------------------
R
F
P
L
K
E
--------------------------
P
------
K
K
L
GLE
K
A
S
------
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
---------
E
Y
T
Y
---------
A
--------------------------------------
A
-----------------------------------
F
Q
-----------------------------------
V
--------------------
G
D
-----
E
A
L
I
L
E
E
G
L
---
G
R
K
L
L
GEGTQVL
K
T
F
P
GKALEG
L
P
Y
T
P
PYPQALEKGY
F
V
V
L
A
D
-
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
L
L
--
K
T
V
D
E
E
G
K
L
--
L
--------------
V
--
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
L
F
K
D
E
L
I
R
N
-
N
Q
E
I
H
W
V
P
--
P
H
I
K
E
G
-
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
W
V
C
Q
A
C
G
K
----
E
-------------------
E
-------------------------------
A
I
G
S
F
Q
E
L
K
A
R
ATKPLPE-------
P
F
--
D
P
----------------
H
----------
R
--------------------------------
P
------------
Y
V
----------
D
-------------------------------
Q
V
E
L
A
C
ACG
G
T
M
R
R
VP
Y
V
I
D
V
W
Y
D
S
G
A
M
P
F
A
S
L
-
H
Y
P
F
-----
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
Q
L
G
V
M
----
L
------
F
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
-----------------------------------------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
V
-
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
-
P
D
L
K
N
P
-
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
-
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
--
R
R
F
--
W
K
N
E
D
A
L
--
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
R
-
S
VRLEA
K
-
E
S
V
H
L
A
D
W
P
E
A
--
D
P
--
A
L
A
D
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.63
21%
-64
- C1 -
4CQN
3
SYL_ECOLI
A:
[21-879]
-------------
M
Q
E
Q
Y
R
P
E
E
I
E
S
K
V
Q
L
H
W
-
D
E
K
R
T
F
E
-
V
T
E
-
D
--
E
--
S
K
--
E
K
Y
Y
C
L
S
M
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
-
V
K
N
---
N
-
T
A
P
A
P
-----------------
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
NEQVIDGCCWRC
D
T
K
V
--
E
--
R
-------------------------------------------
K
E
-----------
I
P
Q
W
F
------
I
K
I
--------------------------------------
T
-
A
Y
A
D
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
------
E
G
V
E
I
T
F
N
V
N
DYD
N
T
L
T
------
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
AGH
P
L
A
Q
K
A
A
E
N
N
P
---------
E
L
A
A
---------
F
--------------------------------------
I
-----------------------------------
D
E
-----------------------------------
C
RNTKVA
E
A
E
M
A
TME
K
K
G
V
D
T
G
F
-----
K
A
V
H
--
P
L
T
---
G
E
E
I
----------------------------------
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
F
A
S
K
Y
G
L
-
N
I
KP
V
I
L
A
A
D
G
S
E
P
D
--------------------------------
L
S
Q
Q
A
L
T
E
K
G
V
L
F
N
S
G
E
F
N
G
L
D
H
E
A
A
F
N
A
I
A
D
------------
K
L
T
A
M
G
V
G
E
-
R
K
V
N
Y
R
L
-------------------
R
D
W
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
-
V
T
L
E
D
G
T
V
M
P
T
P
-------------------
D
DQLPVI-------------------------
L
------------------------
P
E
--
D
V
VMDGITS
P
I
K
A
D
----
P
----------
E
--------------------------------
W
------------
A
K
T
T
V
NG
M
P
A
L
R
E
-------------------------------
T
---------------
D
T
F
D
T
F
M
E
S
S
-
W
Y
Y
A
R
Y
-
T
C
P
Q
YKEGM
L
----
D
S
E
A
A
N
Y
W
L
P
V
D
I
Y
I
G
G
I
E
HAI
M
H
L
L
Y
F
R
F
F
H
K
L
M
R
D
A
G
M
----
V
------
N
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVDAI
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAGHELVYTGMS-----------------------------------
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
A
D
M
T
L
E
W
Q
E
S
G
V
-
E
G
A
-
N
R
F
L
K
R
V
W
K
-
L
V
Y
E
H
T
A
K
G
-
D
V
-
A
-
A
L
N
V
-
D
A
---
L
T
E
N
Q
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
I
M
E
L
-----------
M
N
K
--
L
A
K
--
A
P
T
-
D
G
E
--
Q
D
---
R
A
L
M
Q
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
L
K
G
-
E
-----
G
-
D
-
I
D
N
A
P
W
P
V
A
--
D
E
--
K
A
M
V
E
D
S
T
L
V
V
------------------
V
Q
V
N
G
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
------
E
H
L
V
A
K
Y
L
D
G
V
T
--
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
-----------------------------------------------------------------------------------