@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1491: (2016-03-26 )
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGDDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDEVMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFDTALSRIVK
Atome Classification :
(50 SA)
..-.......10........20....---....30........-40........50........60........70........80........90....----.----...100.......110.......120.......130.------..-----....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-....250.......260.......270.......280....--...290--.......----.300.......310.....--.-.--320.-.......330.......340....---...350........360.......370.......380.......390.......400.......410.......420......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR-YT
K
S
E
E
A
M
K
V
A
E
T
LMPGGVN
S
P
V
---
R
A
F
KSVDT
P
A
I
F
M
D-HGKG
S
K
I
Y
DIDG
N
E
Y
I
D
Y
V
LSWG
P
L
ILGHR
D
P
Q
V
I
S
H
L
H
E
A
I
DKGTSF
G
A
S
T
L
L
E
N
----
K
----
L
A
Q
L
V
I
D
RVP
S
I
E
K
V
R
M
VSSGT
E
A
T
L
D
T
L
R
L
ARGYTG------RN-----
K
I
V
K
F
E
G
C
YHGHSD
S
L
L
I
KAGS
G
V
A
T
LGLPDSPGVPEGIAK
N
T
I
T
V
PYND
L
D
A
L
K
I
A
F
E
K
FGD
D
I
A
G
V
I
V
EPVAGNMGVVP
P
I
E
G
F
L
Q
G
L
R
D
I
T
T
EYGA
L
L
I
F
D
E
V
M
T
G
F
-
R
V
G
Y
H
C
AQGYFGVT
P
D
L
T
C
L
G
K
V
IGGGLPVGAFG
G
K
K
E
I
M
D
--
H
IAP-L--GN
I
Y
QAG----TLSGN
P
L
A
MT
S
G
Y
E
T
L
S
Q
L--T-
P
--
E
-
T
Y
-
E
Y
F
N
M
L
G
D
I
L
E
D
G
L
K
R
V
F
A
KHNV
P
---
I
T
V
N-RAG
S
M
I
G
Y
F
LNEGPVT
N
F
E
QA
N
K
S
D
L
K
L
F
A
E
M
Y
R
E
M
A
KEGVFLPPSQFE
G
T
F
LSTAH
T
K
E
D
I
E
K
T
I
Q
A
F
D
T
A
L
S
R
IVK
1
PsiBlast_PDB
97.28
74%
-95
- C1 -
3BS8
1
GSA_BACSU
A:
[9-437]
M
R
S
Y
E
K
S
K
T
A
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
---
R
A
F
K
S
V
D
M
D
P
I
F
M
E
-
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
E
Y
G
T
S
F
G
A
P
T
E
V
E
N
----
E
----
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
N
-----
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
P
D
S
P
G
V
P
E
G
I
A
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
--
Q
I
A
P
-
S
--
G
P
I
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
Q
L
--
T
-
P
--
D
-
S
Y
-
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
P
---
H
T
F
N
-
R
A
G
S
M
I
G
F
F
F
T
N
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
I
S
R
9
PsiBlast_PDB
88.46
56%
-94
- C1 -
2HOZ
3
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
13
PsiBlast_PDB
86.27
56%
-91
- C1 -
3FQ8
2
GSA_SYNP6
A:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
12
PsiBlast_PDB
85.94
56%
-92
- C1 -
3FQA
3
GSA_SYNP6
A:
[2-427]
-
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
114
HHSearch
85.77
57%
-90
- C1 -
3FQ8
2
GSA_SYNP6
A:
[2-426]
-
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
--
R
-
Q
P-
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
---
6
PsiBlast_PDB
85.70
56%
-91
- C1 -
3FQ7
2
GSA_SYNP6
A:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
5
PsiBlast_PDB
85.50
57%
-91
- C1 -
3GSB
3
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
31
PsiBlast_CBE
85.27
56%
-91
- C1 -
3FQ8
2
GSA_SYNP6
B:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
21
PsiBlast_CBE
85.25
57%
-90
- C1 -
4GSA
2
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
10
PsiBlast_PDB
85.24
56%
-92
- C1 -
2HP1
3
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
4
PsiBlast_PDB
85.10
57%
-89
- C1 -
4GSA
2
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
25
PsiBlast_CBE
84.82
56%
-90
* C1 *
3FQ7
2
GSA_SYNP6
B:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
11
PsiBlast_PDB
84.46
56%
-92
- C1 -
2HP2
3
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
26
PsiBlast_CBE
84.40
56%
-90
- C1 -
2HP2
3
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
3
PsiBlast_PDB
84.32
57%
-89
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
101
Fugue
84.21
57%
-89
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
--
R
Q
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
28
PsiBlast_CBE
84.09
56%
-92
- C1 -
2HOZ
2
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
7
PsiBlast_PDB
83.42
56%
-89
- C1 -
3USF
3
GSA_SYNE7
A:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
29
PsiBlast_CBE
83.20
56%
-97
- C1 -
2HOY
2
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
----------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
27
PsiBlast_CBE
83.20
56%
-96
- C1 -
2HP1
3
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
-----------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
23
PsiBlast_CBE
82.53
57%
-89
- C1 -
2GSA
2
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
30
PsiBlast_CBE
82.42
56%
-89
- C1 -
3FQA
3
GSA_SYNP6
B:
[2-427]
-
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
24
PsiBlast_CBE
81.75
56%
-97
- C1 -
3USF
3
GSA_SYNE7
B:
[1-427]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
-------------------------
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
22
PsiBlast_CBE
81.70
57%
-89
- C1 -
3GSB
3
GSA_SYNP6
B:
[6-432]
F
K
-
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
-
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
----
V
----
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
-----
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
--
G
-
T
Y
-
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
2
PsiBlast_PDB
77.55
60%
-100
- C1 -
2CFB
1
GSA_THEEB
A:
[19-411]
--------------------------------------
P
I
V
F
D
-
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
E
K
G
T
S
F
G
A
P
C
L
L
E
N
----
I
----
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
------
R
E
-----
K
V
I
K
F
E
G
C
Y
H
G
H
A
----------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
--
M
V
A
P
-
A
--
G
P
---------
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
L
--
S
R
P
--
G
-
S
Y
-
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
E
---
V
C
G
G
-
H
I
S
G
M
F
G
L
F
F
T
A
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
--
14
PsiBlast_PDB
75.93
51%
-87
- C1 -
2E7U
4
GSA_THET8
A:
[6-424]
------
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
---
R
A
F
K
A
V
G
G
T
P
P
F
L
V
-
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
----
A
----
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
-----
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
-
P
--
G
-
Y
Y
-
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
-----
33
PsiBlast_CBE
75.81
43%
-90
- C1 -
2ZSM
4
GSA_AERPE
B:
[11-432]
-----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
--
E
P
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
113
HHSearch
75.71
51%
-84
- C1 -
2E7U
4
GSA_THET8
A:
[1-424]
M
E
-
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
---
R
A
F
K
A
V
G
G
T
P
P
F
L
V
-
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
----
A
----
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
-----
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
----
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
--
E
-
E
N
P
G
-
Y
Y
-
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
-----
15
PsiBlast_PDB
75.29
43%
-87
- C1 -
2EPJ
1
GSA_AERPE
A:
[11-432]
-----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
--
E
P
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
16
PsiBlast_PDB
75.12
43%
-87
- C1 -
2ZSL
1
GSA_AERPE
A:
[11-432]
-----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
--
E
P
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
17
PsiBlast_PDB
74.33
43%
-87
- C1 -
2ZSM
2
GSA_AERPE
A:
[11-432]
-----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
--
E
P
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
32
PsiBlast_CBE
74.11
43%
-88
- C1 -
2ZSM
4
GSA_AERPE
C:
[11-432]
-----
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
--
E
P
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
119
HHSearch
65.94
42%
-78
- C1 -
2EPJ
1
GSA_AERPE
A:
[9-432]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
A
V
K
--
P
Y
P
F
Y
V
K
-
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
----
L
----
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
-----
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
----
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
--
E
-
E
E
-
P
-
V
Y
-
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
-
A
Q
---
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
19
PsiBlast_PDB
65.93
33%
-85
- C1 -
4AO9
2
BFAT_VARPD
A:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
---
L
F
Y
A
P
F
P
---
L
T
I
A
-
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
----
R
----
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
-----
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
P
S
P
T
T
---
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
----
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F-
T
-
P
--
E
-
A
A
-
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
----------
35
PsiBlast_CBE
65.60
33%
-86
- C1 -
4AO9
3
BFAT_VARPD
B:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
---
L
F
Y
A
P
F
P
---
L
T
I
A
-
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
----
R
----
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
-----
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
P
S
P
T
T
---
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
----
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F-
T
-
P
--
E
-
A
A
-
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
----------
20
PsiBlast_PDB
63.80
33%
-84
- C1 -
4AOA
3
BFAT_VARPD
A:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
---
L
F
Y
A
P
F
P
---
L
T
I
A
-
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
----
R
----
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
-----
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
P
S
P
T
T
---
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
----
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F-
T
-
P
--
E
-
A
A
-
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
----------
34
PsiBlast_CBE
61.90
33%
-85
- C1 -
4AOA
2
BFAT_VARPD
B:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
---
L
F
Y
A
P
F
P
---
L
T
I
A
-
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
----
R
----
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
-----
K
I
V
V
F
S
G
G
Y
H
G
-----------
G
V
L
G
F
G
A
R
P
S
P
T
T
---
V
P
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
--
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
----
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F-
T
-
P
--
E
-
A
A
-
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
----------
42
PsiBlast_CBE
57.10
31%
-77
- C1 -
2YKX
6
?
C:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
48
PsiBlast_CBE
56.88
31%
-77
- C1 -
2YKU
6
?
C:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
39
PsiBlast_CBE
55.98
31%
-77
- C1 -
2YKY
10
?
C:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
41
PsiBlast_CBE
55.62
31%
-78
- C1 -
2YKY
11
?
A:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
44
PsiBlast_CBE
55.54
31%
-78
- C1 -
2YKX
8
?
A:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
50
PsiBlast_CBE
54.80
31%
-77
- C1 -
2YKU
9
?
A:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
49
PsiBlast_CBE
54.72
31%
-77
- C1 -
2YKU
9
?
B:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
43
PsiBlast_CBE
54.32
31%
-78
- C1 -
2YKX
4
?
B:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
40
PsiBlast_CBE
53.66
31%
-77
- C1 -
2YKY
13
?
B:
[64-457]
-------------
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
P
L
V
------
I
A
-
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
----
L
----
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
-----
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
----
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
--
Q
-
A
A
-
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------
A
F
A
E
A
L
A
D
F
I
-
85
PsiBlast_CBE
42.17
31%
-83
- C1 -
2E54
5
ARGD_THEMA
A:
[11-343]
-------------------------------------
P
A
T
F
V
--
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
--
L
I
H
C
S
N
L
F
W
N
----
R
P
Q
M
E
L
A
E
L
-
L
S
K
N
T
F
G
G
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
------
K
K
SEKKY
R
I
L
S
A
H
N
S
F
H
G
R
T
------
L
G
S
L
T
A
T
-
G
Q
P
K
Y
Q
K
P
F
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
V
E
D
L
R
---
R
K
M
S
E
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
V
P
I
G
A
V
-----
I
V
N
--
E
R
A
------
N
V
L
E
P
G
DHGT
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
--
T
-
K
--
E
-
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
---
A
D
V
R
-
G
M
G
L
M
I
G
I
Q
F
R
E
-
E
V
S
N
R
E
V
A
T
K
C
------------------------------------------------------
59
PsiBlast_CBE
28.66
34%
-70
- C1 -
4JEY
13
ARGD_SALTY
B:
[35-324]
----------------------------------
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
--
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
-
H
--
G
S
T
Y
---------
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
-
T
-
P
--
E
-
V
L
-
Q
-------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
26.52
34%
-71
- C1 -
2PB2
6
ARGD_SALTY
A:
[39-306]
--------------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
--
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
H
--
G
S
T
Y
---------
G
G
N
P
L
A
-------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
26.47
34%
-71
- C1 -
2PB0
5
ARGD_SALTY
A:
[35-306]
----------------------------------
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
--
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
-----
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
-------
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F--------
G
S
T
Y
---------
G
G
N
P
L
A
-------------------------------------------------------------------------------------------------------------------------------------