@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1510: (2016-03-26 )
MSTNIAINGMGRIGRMVLRIALQNKNLNVVAINASYPPETIAHLINYDTTHGKYNLKVEPIENGLQVGDHKIKLVADRNPENLPWKELDIDIAIDATGKFNHGDKAIAHIKAGAKKVLLTGPSKGGHVQMVVKGVNDNQLDIEAFDIFSNASCTTNCIGPVAKVLNNQFGIVNGLMTTVHAITNDQKNIDNPHKDLRRARSCNESIIPTSTGAAKALKEVLPELEGKLHGMALRVPTKNVSLVDLVVDLEKEVTAEEVNQAFENAGLEGIIEVEHQPLVSVDFNTNPNSAIIDAKSTMVMSGNKVKVIAWYDNEWGYSNRVVDVAEQIGALLTSKETVSAS
Atome Classification :
(45 SA)
.........10........20.--.---.--.--.--...30.....-...40........50...-.....60-........70........80........90........100..----.....110........120.......130.......140.......150.......160.......170.......180.......190-.--......200.......210.......220.......230.......240.......250.-.......260.---..---.-------..-.270.......280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MST
N
I
A
I
N
G
M
G
R
I
G
R
M
V
L
R
I
A
L--Q---N--K--N--
L
N
V
V
A
I
NASY-
P
P
E
T
I
A
H
L
INYDTTH
G
K
Y
-
N
L
K
V
E
PI-ENGLQVG
D
H
K
I
K
L
V
ADRNPENLPW
K
E
L
D
I
D
I
A
I
DATGKFNHG
D
----
K
A
I
A
H
I
-KAG
A
K
K
V
L
L
TGPSKG
G
H
V
Q
M
V
V
KGVNDN
Q
L
D
I
E
A
F
D
I
FSNASCT
T
N
C
I
G
P
V
A
K
V
LNNQF
G
I
V
N
G
L
M
T
T
V
H
A
ITNDQKNID
N
P
-
H
--
K
D
L
R
R
A
R
SCNESIIPTST
G
A
A
K
A
L
K
E
V
L
P
E
L
EGKL
H
G
M
A
L
RVPTKN
V
S
L
V
D
L
V
VD
L
E
K-E-V
T
A
E
E
V
N
Q
A
F
E
---NA---G-------L
E
-
G
I
I
E
V
EHQ
P
L
V
S
V
D
FNTNPN
S
A
I
I
DAK
S
T
M
V
MSG
N
K
V
K
V
I
A
W
YDNEWGYSN
R
V
V
D
V
A
E
Q
I
G
A
L
LTSKETVSAS
22
PsiBlast_CBE
93.25
64%
-100
- C1 -
4DIB
1
?
F:
[5-324]
--
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
Q
A
I
--
K
---
E
--
S
--
A
--
F
E
I
V
A
I
N
A
S
Y
-
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
-
D
G
T
V
E
A
F
-
E
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
----
K
A
I
L
H
V
-
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
T
I
V
V
-
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
-----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
K
R
-
D
-
V
T
V
E
A
I
N
D
A
F
K
TVA
N
G
---
A
-------
L
K
-
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
---------------------
1
PsiBlast_PDB
92.88
64%
-102
- C1 -
4DIB
1
?
A:
[5-324]
--
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
Q
A
I
--
K
---
E
--
S
--
A
--
F
E
I
V
A
I
N
A
S
Y
-
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
-
D
G
T
V
E
A
F
-
E
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
----
K
A
I
L
H
V
-
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
T
I
V
V
-
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
Y
----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
K
R
-
D
-
V
T
V
E
A
I
N
D
A
F
K
T
V
A
N
G
---
A
-------
L
K
-
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
---------------------
24
PsiBlast_CBE
92.25
64%
-105
- C1 -
4DIB
2
?
C:
[5-324]
--
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
Q
A
I
--
K
---
E
--
S
--
A
--
F
E
I
V
A
I
N
A
S
Y
-
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
-
D
G
T
V
E
A
F
-
E
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
----
K
A
I
L
H
V
-
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
T
I
V
V
-
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
-----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
K
R
-
D
-
V
T
V
E
A
I
N
D
A
F
K
T
V
A
N
G
---
A
-------
L
K
-
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
---------------------
23
PsiBlast_CBE
91.86
64%
-104
- C1 -
4DIB
1
?
E:
[5-324]
--
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
Q
A
I
--
K
---
E
--
S
--
A
--
F
E
I
V
A
I
N
A
S
Y
-
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
-
D
G
T
V
E
A
F
-
E
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
----
K
A
I
L
H
V
-
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
T
I
V
V
-
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
Y
----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
K
R
-
D
-
V
T
V
E
A
I
N
D
A
F
K
TVA
N
G
---
A
-------
L
K
-
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
---------------------
21
PsiBlast_CBE
91.58
64%
-103
- C1 -
4DIB
2
?
H:
[5-324]
--
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
Q
A
I
--
K
---
E
--
S
--
A
--
F
E
I
V
A
I
N
A
S
Y
-
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
-
D
G
T
V
E
A
F
-
E
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
------
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
----
K
A
I
L
H
V
-
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
T
I
V
V
-
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
-----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
K
R
-
D
-
V
T
V
E
A
I
N
D
A
F
K
TVA
N
G
---
A
-------
L
K
-
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
---------------------
88
PsiBlast_CBE
90.90
51%
-90
- C1 -
3ZDF
2
?
B:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
RKA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
ETT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
87
PsiBlast_CBE
90.48
51%
-90
- C1 -
4BOY
1
?
A:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
R
KA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
E
TT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
86
PsiBlast_CBE
90.28
51%
-91
- C1 -
4BOY
1
?
B:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
RKA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
ETT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
89
PsiBlast_CBE
90.27
51%
-92
- C1 -
3ZDF
2
?
A:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
R
KA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
E
TT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
66
PsiBlast_CBE
89.93
54%
-89
- C1 -
3B1J
3
?
B:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
60
PsiBlast_CBE
89.67
54%
-90
- C1 -
3B20
4
?
P:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
58
PsiBlast_CBE
89.41
54%
-88
- C1 -
3B20
3
?
R:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
82
PsiBlast_CBE
89.24
48%
-85
- C1 -
3DOC
2
?
D:
[2-335]
-
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
--
E
---
S
GR
T
--
D
--
I
Q
V
V
A
I
N
D
L
G
-
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
-
P
K
E
V
E
V
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
----
K
A
A
L
H
L
-
E
A
G
A
K
R
V
I
V
S
A
P
A
D
G
A
D
L
T
-
V
V
Y
G
V
N
N
D
K
L
T
K
D
H
L
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
-
H
--
K
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
---
E
A
---
A
NGR----
L
K
-
G
I
L
G
Y
T
D
E
K
L
V
S
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
D
G
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
L
I
---------
15
PsiBlast_PDB
89.24
54%
-88
- C1 -
3B20
3
?
A:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
Q
TT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
62
PsiBlast_CBE
89.19
54%
-87
- C1 -
3B20
3
?
B:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
109
HHSearch
89.18
51%
-90
- C1 -
3HJA
6
G3P_BORBU
A:
[22-355]
--
M
K
L
A
I
N
G
F
G
R
I
G
R
N
V
F
K
I
A
F
--
E
---
R
-----
G
--
I
D
I
V
A
I
N
D
L
T
-
D
P
K
T
L
A
H
L
L
K
Y
D
S
T
F
G
V
Y
-
N
K
K
V
E
S
R
-
D
G
A
I
V
V
D
G
R
E
I
K
I
I
A
E
R
D
P
K
N
L
P
W
A
K
L
G
I
D
V
V
I
E
S
T
G
V
F
S
S
A
T
SDKG
G
Y
L
D
H
V
N
H
A
G
A
K
K
V
I
L
T
V
P
A
K
D
-
E
I
K
T
I
V
L
G
V
N
D
H
D
I
N
S
D
-
L
K
A
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
H
E
S
F
G
I
E
Q
G
L
M
T
T
V
H
A
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
S
D
L
R
R
A
R
A
A
A
L
S
I
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
N
G
T
S
M
R
V
P
V
P
T
G
S
I
V
D
L
T
V
Q
L
K
K
K
D
-
V
T
K
E
E
I
N
S
V
L
R
---
K
A
S
E
T
P
-------
E
L
K
G
I
L
G
Y
T
E
D
P
I
V
S
S
D
I
K
G
N
S
H
S
S
I
V
D
G
L
E
T
M
V
L
E
N
G
F
A
K
I
L
S
W
Y
D
N
E
F
G
Y
S
T
R
V
V
D
L
A
Q
K
L
V
------------
13
PsiBlast_PDB
89.17
54%
-89
- C1 -
3B1J
3
?
A:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
Q
TT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
50
PsiBlast_CBE
89.06
53%
-91
- C1 -
1NPT
3
G3P_GEOSE
Q:
[1-331]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
---
N
--
P
--
D
--
I
E
V
V
A
V
N
D
L
T
-
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-
D
A
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
----
D
A
A
K
H
L
-
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
-
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
-
E
-
V
T
V
E
E
V
N
A
A
L
K
---
A
A
---
A
EGE----
L
K
-
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
-----------
42
PsiBlast_CBE
89.04
53%
-92
- C1 -
4DBV
3
G3P_GEOSE
P:
[1-331]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
---
N
--
P
--
D
--
I
E
V
V
A
V
N
D
T
G
-
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-
D
A
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
----
D
A
A
K
H
L
-
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
-
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
-
E
-
V
T
V
E
E
V
N
A
A
L
K
---
A
A
---
A
EGE----
L
K
-
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
-----------
4
PsiBlast_PDB
89.00
53%
-89
- C1 -
3CMC
14
G3P_GEOSE
O:
[1-331]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
--
K
---
N
--
P
--
D
--
I
E
V
V
A
V
N
D
L
T
-
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-
D
A
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
----
D
A
A
K
H
L
-
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
-
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
-
E
-
V
T
V
E
E
V
N
A
A
L
K
---
A
A
---
A
EGE----
L
K
-
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
-----------
90
PsiBlast_CBE
88.91
51%
-88
- C1 -
3ZCX
1
?
B:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
RKA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
ETT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
91
PsiBlast_CBE
88.21
51%
-88
- C1 -
3ZCX
1
?
A:
[21-351]
----
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
--
Q
R
KA
N
--
S
--
K
--
L
E
I
V
G
I
N
D
T
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
----
G
A
S
K
H
L
-
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
---
E
A
---
S
E
TT----
M
K
-
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
-----------
99
PsiBlast_CBE
87.26
48%
-91
- C1 -
1DC6
1
G3P1_ECOLI
B:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
EGE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
65
PsiBlast_CBE
87.19
54%
-94
- C1 -
3B1K
4
?
B:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
108
HHSearch
86.82
52%
-82
- C1 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
--
E
RK-
N
--
P
--
D
--
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
----
K
A
E
L
H
L
-
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
-
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
-
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
---
E
A
TE-
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
----------
105
HHSearch
86.68
51%
-86
- C1 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
---
R
--
K
DS
P
--
L
D
V
V
V
I
N
D
T
G
-
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
D
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
----
G
A
G
K
H
L
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
A
-
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
---
E
S
AD-
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
--------
77
PsiBlast_CBE
86.68
52%
-84
- C1 -
1HDG
3
G3P_THEMA
Q:
[2-327]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
--
E
---
R
--
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
----
K
A
E
L
H
L
-
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
-
G
C
N
E
D
Q
L
K
P
E
-
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
---
E
A
---
T
EGR----
L
K
-
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
---------------
98
PsiBlast_CBE
86.44
48%
-92
- C1 -
1GAD
1
G3P1_ECOLI
O:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
EGE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
112
HHSearch
86.20
49%
-86
- C1 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
--
S
---
R
--
P
--
N
--
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
-
A
G
E
V
S
H
D
-
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
----
T
A
Q
K
H
I
-
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
--
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
S
D
-
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
-
S
H-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
-
E
-
T
T
Y
D
E
I
K
K
V
V
K
---
A
A
A
E
-
G
-------
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
-----------
14
PsiBlast_PDB
85.99
54%
-86
- C1 -
3B1K
3
?
A:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
Q
TT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
18
PsiBlast_PDB
85.84
52%
-82
- C1 -
1HDG
3
G3P_THEMA
O:
[2-327]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
--
E
---
R
--
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
----
K
A
E
L
H
L
-
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
-
G
C
N
E
D
Q
L
K
P
E
-
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
-
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
---
E
A
---
T
EGR----
L
K
-
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
---------------
20
PsiBlast_PDB
85.39
49%
-88
- C1 -
3L0D
1
?
A:
[22-349]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
--
E
---
S
GR
Q
--
D
--
I
E
V
V
A
L
N
D
L
G
-
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
-
P
G
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
----
K
A
S
A
H
L
-
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
T
-
V
V
Y
G
V
N
H
Q
F
L
S
K
E
-
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
-
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
---
T
A
---
A
Q
G
S----
L
K
-
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
----------------
81
PsiBlast_CBE
85.35
49%
-88
- C1 -
3L0D
1
?
B:
[22-349]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
--
E
---
S
GR
Q
--
D
--
I
E
V
V
A
L
N
D
L
G
-
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
-
P
G
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
----
K
A
S
A
H
L
-
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
T
-
V
V
Y
G
V
N
H
Q
F
L
S
K
E
-
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
-
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
---
T
A
---
A
QGS----
L
K
-
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
----------------
102
PsiBlast_CBE
85.31
47%
-91
- C1 -
1GAE
1
G3P1_ECOLI
O:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
EGE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
T
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
96
PsiBlast_CBE
85.25
47%
-87
- C1 -
1S7C
6
G3P1_ECOLI
A:
[2-329]
-
T
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
E
G
E
----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
63
PsiBlast_CBE
84.90
54%
-87
- C1 -
3B1K
4
?
H:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
100
PsiBlast_CBE
84.72
48%
-88
- C1 -
1DC6
1
G3P1_ECOLI
A:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
E
GE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
101
PsiBlast_CBE
84.66
47%
-89
- C1 -
1GAE
1
G3P1_ECOLI
P:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
EGE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
T
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
117
HHSearch
84.44
43%
-86
- C1 -
3H9E
10
G3PT_HUMAN
O:
[6-341]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
---
K
-----
G
--
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-
K
G
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
----
A
A
S
D
H
I
-
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
--
D
A
P
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
-
S
R-
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
-
P
-
A
P
Y
S
A
I
K
E
A
V
K
---
A
A
AK-
G
-------
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
A
E
-------
110
HHSearch
84.20
44%
-91
- C1 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
--
E
---
R
--
N
--
D
--
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
-
N
G
T
V
E
V
S
-
G
-
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
----
K
A
S
L
H
L
-
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
-
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
-
S
KG-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
---
E
A
S
N
-
G
-------
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
---------
93
PsiBlast_CBE
84.03
49%
-94
- C1 -
2I5P
2
G3P1_KLULA (first)
O:
[16-341]
---
S
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
--
E
---
R
--
K
--
N
--
I
D
V
V
A
I
N
D
P
F
I
S
V
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
K
Y
-
K
G
E
V
S
H
D
-
G
S
N
L
I
I
N
G
K
K
V
A
V
F
Q
E
K
D
P
A
T
L
P
W
G
K
L
G
V
D
I
A
V
D
S
T
G
V
F
K
E
L
D
----
S
A
Q
K
H
I
-
D
A
G
A
K
K
V
V
I
T
A
P
S
K
--
T
A
P
M
F
V
V
G
V
N
E
D
K
Y
N
G
E
--
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
----------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
-
A
-
A
T
Y
D
E
I
K
A
A
V
K
---
K
V
---
S
EGK----
L
K
-
D
V
V
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
I
Q
L
S
P
K
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
-------------
97
PsiBlast_CBE
83.82
48%
-92
- C1 -
1GAD
1
G3P1_ECOLI
P:
[4-328]
----
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
--
K
---
R
--
S
--
D
--
I
E
I
V
A
I
N
D
L
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-
D
G
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
R
D
P
A
N
L
K
W
D
E
V
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
----
T
A
R
K
H
I
-
T
A
G
A
K
K
V
V
M
T
G
P
S
K
-
D
N
T
P
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
--
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
-
A
-
A
T
Y
E
Q
I
K
A
A
V
K
---
A
A
---
A
EGE----
M
K
-
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
-------------
64
PsiBlast_CBE
83.66
54%
-87
- C1 -
3B1K
4
?
G:
[1-331]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
GR
Q
---
N
--
T
--
D
--
L
E
V
V
A
I
N
N
T
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
----
G
A
S
K
H
I
-
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
-
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
---
K
A
---
S
QTT----
M
K
-
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
---------------
92
PsiBlast_CBE
83.60
49%
-94
- C1 -
2I5P
2
G3P1_KLUMA
P:
[16-341]
---
S
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
--
E
---
R
--
K
--
N
--
I
D
V
V
A
I
N
D
P
F
I
S
V
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
K
Y
-
K
G
E
V
S
H
D
-
G
S
N
L
I
I
N
G
K
K
V
A
V
F
Q
E
K
D
P
A
T
L
P
W
G
K
L
G
V
D
I
A
V
D
S
T
G
V
F
K
E
L
D
----
S
A
Q
K
H
I
-
D
A
G
A
K
K
V
V
I
T
A
P
S
K
--
T
A
P
M
F
V
V
G
V
N
E
D
K
Y
N
G
E
--
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
----------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
-
A
-
A
T
Y
D
E
I
K
A
A
V
K
---
K
V
---
S
EGK----
L
K
-
D
V
V
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
I
Q
L
S
P
K
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
-------------
113
HHSearch
82.87
45%
-81
- C1 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
--
G
---
R
--
E
--
E
--
I
E
I
V
A
I
N
D
L
T
-
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
-
K
G
S
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
----
N
A
S
K
H
L
-
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
-
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
-
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
---
E
A
A
Q
-
K
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
----------